Azide Or Acyclic Nitrogen Containing Patents (Class 548/109)
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Patent number: 11401281Abstract: A method for synthesizing an energetic compound via direct assembly. The energetic compound being characterized by a local structure that features four crystallographically unique copper atoms bound by nine unique azide molecules and one tetrazole molecule with potassium ions to form a salt.Type: GrantFiled: January 19, 2021Date of Patent: August 2, 2022Assignee: The United States of America as representing by the Secretary of the NavyInventors: Coit T. Hendley, IV, Andrew T. Kerr, Owen T. O'Sullivan
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Patent number: 11286269Abstract: Methods for synthesizing in situ two energetic compounds. A first energetic compound being characterized by a first local structure that features metal centers bound by 1-tetrazole, 4-cyanobenzene and azide molecules, while a second energetic compound is characterized by a second local structure that features metal centers bound by 1-methyltetrazole and azide molecules. Both energetic compounds may further be characterized as crystalline coordination polymers (CPs).Type: GrantFiled: August 27, 2020Date of Patent: March 29, 2022Assignee: The United States of America as represented by the Secretary of the NavyInventors: Andrew T. Kerr, Colt T. Hendley, IV, Owen T. O'Sullivan
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Patent number: 11174560Abstract: A composition including copper(I) 5-nitrotetrazolate, wherein the composition has a carbon content of less than 7 weight percent, based on a total weight of the copper(I) 5-nitrotetrazolate.Type: GrantFiled: May 9, 2019Date of Patent: November 16, 2021Assignee: ENSIGN-BICKFORD AEROSPACE & DEFENSE COMPANYInventor: Richard Kellett
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Patent number: 10464908Abstract: Described are methods for purifying a 5-nitrotetrazolate solution with a copper(II) modified cation exchange resin. The method can be performed as a stand-alone system or as a system integrated into a continuous flow reactor.Type: GrantFiled: September 7, 2017Date of Patent: November 5, 2019Assignee: Pacific Scientific Energetic Materials CompanyInventors: John W. Fronabarger, Jason B. Pattison, Lily F. W. Walsh
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Patent number: 9440934Abstract: A method of manufacture of the primary explosive material copper(I) 5-nitrotetazolate (DBX-1) by a synthesis starting with 5-aminotetrazolate (5-AT); wherein, the synthesis provides intermediates acid copper salt of 5-NT and sodium 5-nitrotetrazolate (NaNT) sodium 5-nitrotetrazolate (NaNT)—that are both, free of any 5-aminotetrazolate (5-AT) starting material—such that the subsequent production of the DBX-1 is not inhibited. Further, this method utilizes an internal filter within the reactor—to minimize handling of explosively dangerous intermediates.Type: GrantFiled: February 23, 2015Date of Patent: September 13, 2016Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Neha Mehta, Karl Oyler, Gartung Cheng, Jerry Salan, Shannon Lenahan
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Publication number: 20150104367Abstract: According to one embodiment, a catalyst includes a metal ion, and an acyclic ligand having at least one aza-containing moiety, where the ligand is complexed to the metal ion.Type: ApplicationFiled: October 10, 2013Publication date: April 16, 2015Applicant: Lawerence Livermore National Security, LLCInventors: William C. Floyd, III, Carlos A. Valdez, Roger Aines, Sarah Baker, Joe H. Satcher, JR.
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Publication number: 20150065688Abstract: A method for generating layered structures is disclosed. The method comprises reacting an azide-functionalized material with an alkyne-functionalized material, one of which can be a nanoparticle or a microparticle and the other can be a substrate or another nanoparticle or microparticle. The method also includes generating layered structures having multiple layers which can be built up in multiple azide-alkyne reaction steps.Type: ApplicationFiled: August 29, 2014Publication date: March 5, 2015Inventors: Regina Ragan, Sri Sivakumar, Raj Ganesh S. Pala, Arun Prakash Upadhyay
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Publication number: 20150065723Abstract: The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. In some cases, a wide variety of catalysts may be synthesized from a single catalyst precursor. Methods of the invention may also include the preparation of catalysts which, under reaction conditions known in the art, may have been difficult or impossible to prepare and/or isolate due to, for example, steric crowding at the metal center. The present invention also provides catalyst compositions, and precursors thereof, which may be useful in various chemical reactions including olefin metathesis. In some cases, methods of the invention may reduce the number of synthetic and purification steps required to produce catalysts and/or other reaction products, as well as reducing time, cost, and waste production.Type: ApplicationFiled: September 8, 2014Publication date: March 5, 2015Inventors: Adam S. Hock, Richard R. Schrock
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Patent number: 8927733Abstract: A sensor that includes a) a silicon (Si) substrate having a surface; and b) a monolayer of oligoethylene glycol (OEG) bonded to the surface via silicon-carbon bonds. Regions of the OEG monolayer distal to the surface are functionalized with a molecular probe serving as a recognition element for a bioanalyte. A method of making a silicon surface that recognizes a biological specimen includes 1) hydrosilylating with a mixture that includes an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and capped at the opposing end of the OEG and an oligoethylene glycol (OEG) substituted with an alkene at one end of the OEG and an alkyne having a protecting group at the opposing end of the OEG and 2) removing the protecting group from the alkyne; and 3) reacting the alkyne with a reagent in a 1,3-dipolar cycloaddition.Type: GrantFiled: March 25, 2013Date of Patent: January 6, 2015Assignee: University of HoustonInventors: Chengzhi Cai, Chi Ming Yam, Jianhua Gu
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Publication number: 20140341805Abstract: A method of imaging a region in a subject includes administering to the subject a complex of a metal chelated to a compound, and obtaining an image of the region in the subject.Type: ApplicationFiled: July 29, 2014Publication date: November 20, 2014Applicant: MOLECULAR INSIGHT PHARMACEUTICALS, INC.Inventors: John W. BABICH, Craig ZIMMERMAN, John JOYAL, Kevin P. MARESCA, John MARQUIS, Genliang LU, Jian-cheng WANG, Shawn HILLIER
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Publication number: 20140315079Abstract: A method for preparing an imidazole compound with the following formula: wherein Rf is a fluorinated alkyl group comprising between 1 and 5 carbon atoms, said method including: (a) the reaction of the diaminomaleonitrile with the following formula: with the compound with the following formula: wherein Y represents a chlorine atom or the OCORf group to form the salified amide compound with the following formula: at temperature T1, and (b) the dehydration of the salified amide compound with formula (IVa) and/or the corresponding amino (IVb) to form the imidazole compound with formula (III), at temperature T2 higher than T1.Type: ApplicationFiled: October 29, 2012Publication date: October 23, 2014Inventors: Gregory Schmidt, Miguel Flasque
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Publication number: 20140221645Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.Type: ApplicationFiled: January 31, 2014Publication date: August 7, 2014Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
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Publication number: 20140220349Abstract: The present invention discloses a metal nickel-imidazolate chiral nano clathrate complex and preparation method thereof. The new type of metal nickel-imidazolate chiral nano clathrate complex of the present invention has the following chemical formula: [Ni14(Im)24].4NO3, in which Im is N-1-methyl-(4-imidazole) methylene imine. The complex can be obtained directly from a reaction of starting materials or prepared through first initiating a reaction between the compound ligand Im and a nickel salt under solvothermal conditions, and the complex obtained is of higher purity. The nano clathrate complex of the present invention has single chirality, and higher thermal stability, and thus has potential application in chiral catalytic materials.Type: ApplicationFiled: September 14, 2011Publication date: August 7, 2014Applicant: Golight, Inc.Inventors: Dan LI, Xiaoping Zhou, Jie Liu
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Publication number: 20140200348Abstract: A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.Type: ApplicationFiled: September 20, 2012Publication date: July 17, 2014Applicant: Dow Corning CorporationInventors: Kurt Brandstadt, Simon Cook, Avril Surgenor, Richard Taylor, Ming-Shin Tzou, Binh Nguyen
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Patent number: 8753743Abstract: The invention relates to a material composed of nanoparticles essentially comprising a spin transition compound. The compound corresponds to the formula [ ( Fe 1 - y ? M y ? L 3 ) w ? L 3 ] [ X 2 x ? ( 1 - z x ? ) ? Y 2 ? ? z x ? ] w in which L represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; X is an anion having the valency x, 1?x?2; Y is an anion other than X having the valency x?, 1?x??2; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?y?1; 0?z?2; 3?w?1500. Applications: thermochromic pigment, data storage, optical limiters, contrast agent.Type: GrantFiled: September 14, 2012Date of Patent: June 17, 2014Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-Francois Letard, Olivier Nguyen, Nathalie Daro
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Publication number: 20140127138Abstract: Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.Type: ApplicationFiled: November 5, 2013Publication date: May 8, 2014Applicant: Board of Trustees of Southern Illinois UniversityInventors: Yong Gao, Boyd Goodson
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Patent number: 8709599Abstract: A material is composed of at least one spin transition compound that corresponds to the formula Fe1-mMm(R-Trz)3XbYc (I) in which M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?m?1; R-Trz represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; X represents at least one noncoloring monovalent or divalent anion; Y represents at least one anion which has a coloring group; and b and c are chosen so that the electrical neutrality of the compound (I) is adhered to. A process for the preparation of this material and to its use as thermochromic pigment, as support for data storage or as optical limiter.Type: GrantFiled: June 11, 2008Date of Patent: April 29, 2014Assignee: Centre National de la Recherche ScientifiqueInventors: Jean-François Letard, Nathalie Daro, Sandie Auffret
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Publication number: 20140088312Abstract: The present invention discloses zeolite metal bis(imidazole) coordination polymers and preparation method thereof. The new class of zeolite coordination polymers of the present invention is a chemical compound with the following general chemical formula {[M(Blm)]×xDMF×yC2H6O×zH2O}?, in which when M=Zn, x=0.9, y=0, z=0; when M=Cu, x=1.2, y=0, z=0; when M=Mn, x=2.0, y=0, z=0; when M=Ni, x=0.4, y=1.2, z=1.0, Blm is 1,2-bis((5H-imidazol-4-yl)methylene)hydrazine, DMF is N,N-dimethyl formamide, H2O is water. A solvothermal method or slow diffusion is used on the compounds to obtain crystals of high purity. The coordination polymers of the present invention have good thermal stability, and have strong adsorption performance for CO2 under conditions of 0° C. and normal pressure as adsorbent materials.Type: ApplicationFiled: September 14, 2011Publication date: March 27, 2014Inventors: Dan Li, Xiaoping Zhou, Jie Liu
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Patent number: 8680003Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.Type: GrantFiled: December 29, 2010Date of Patent: March 25, 2014Assignee: Chevron Phillips Chemical Company LPInventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
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Publication number: 20140058106Abstract: Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein.Type: ApplicationFiled: July 29, 2013Publication date: February 27, 2014Inventors: Tobias Ritter, Takeru Furuya, Hanns M. Kaiser
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Publication number: 20130296574Abstract: A sensor that includes a) a silicon (Si) substrate having a surface; and b) a monolayer of oligoethylene glycol (OEG) bonded to the surface via silicon-carbon bonds. Regions of the OEG monolayer distal to the surface are functionalized with a molecular probe serving as a recognition element for a bioanalyte. The molecular probe is covalently bonded in these regions as a cycloadduct of a 1,3-dipolar cycloaddition reaction. A composition having use as a catalyst for a 1,3-dipolar cycloaddition reaction includes Cu(I) and a triazole ligand having an oligoethylene glycol substituent.Type: ApplicationFiled: March 25, 2013Publication date: November 7, 2013Inventors: Chengzhi Cai, Chin Ming Yam, Jianhua Gu
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Patent number: 8563739Abstract: The invention relates to a novel class of ruthenium complexes containing phosphine and hybrid amine ligands, their preparation and use as catalysts in the reduction of simple ketones to alcohols by molecular hydrogenation. The reactivity and enantioselectivity of such complexes in the asymmetric hydrogenation of simple ketones could be enhanced by the addition of some selective additives.Type: GrantFiled: June 12, 2009Date of Patent: October 22, 2013Assignees: Enantiotech Corporation Limited, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Christian A Sandoval, Yue-hui Li
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Publication number: 20130224225Abstract: An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.Type: ApplicationFiled: April 29, 2013Publication date: August 29, 2013Applicant: Yeda Research and Development Co., Ltd.Inventor: Yeda Research and Development Co., Ltd.
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Publication number: 20130213822Abstract: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.Type: ApplicationFiled: September 25, 2012Publication date: August 22, 2013Applicant: Roche Diagnostics Operations, Inc.Inventor: Roche Diagnostics Operations, Inc.
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Publication number: 20130204005Abstract: Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture.Type: ApplicationFiled: September 13, 2012Publication date: August 8, 2013Applicant: PACIFIC SCIENTIFIC ENERGETIC MATERIALS COMPANYInventors: John W. Fronabarger, Michael D. Williams, William B. Sanborn
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Publication number: 20130127947Abstract: The invention relates to a treatment for printing a surface with an ink that comprises a compound that exhibits a change of electronic spin state as a function of temperature, imparting optical properties such that the ink is visible in a temperature range that includes an ambient temperature of around 20° C. and is transparent in the visible spectrum when the ink is brought to a temperature above said range and then brought back down to a temperature within the range.Type: ApplicationFiled: July 21, 2011Publication date: May 23, 2013Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRSInventor: Jean-Francois Letard
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Publication number: 20130090478Abstract: The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.Type: ApplicationFiled: November 30, 2012Publication date: April 11, 2013Inventor: Jannsen Pharmaceutica, N.V.
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Publication number: 20130090472Abstract: The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn bonds (n=4-17; n?=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C-1-C6 amide, C-1-C6 ether, or C-1-C6 ester groups, R-R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1- C-12 alkyl, amine, C-1-C6 alkylamine, C-1-C6 amide, nitro, cyano, carboxyl, C-1-C6 ester, phosphane, thiol, C-1-C6 thioether, OR?, and suitable pairs of adjacent R groups (R-R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R? is independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, C-1-C6 ester,Type: ApplicationFiled: June 14, 2011Publication date: April 11, 2013Applicant: UNIVERSITY OF KWAZULU-NATALInventors: Orde Quentin Munro, Kate Julie Akerman, Piers Akerman
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Publication number: 20130066128Abstract: The present invention describes a novel catalytic composition comprising at least one nickel complex, said complex being obtained from a mixture comprising at least one nickel precursor A with at least one imino-imidazole ligand B and a method of oligomerization of olefins using said catalytic composition.Type: ApplicationFiled: September 5, 2012Publication date: March 14, 2013Applicant: IFP Energies nouvellesInventors: Pierre-Alain BREUIL, Adrien BOUDIER, Lionel MAGNA, Helene OLIVIER-BOURBIGOU
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Patent number: 8383673Abstract: The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.Type: GrantFiled: March 19, 2010Date of Patent: February 26, 2013Assignees: City University of Hong Kong, Versitech LimitedInventors: Tai Chu Lau, Yun Wah Lam, Wai Lun Man, Wen Xiu Ni, Chi-Ming Che
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Publication number: 20130011680Abstract: The invention relates to a material composed of nanoparticles essentially comprising a spin transition compound. The compound corresponds to the formula [ ( Fe 1 - y ? M y ? L 3 ) w ? L 3 ] [ X 2 x ? ( 1 - z x ? ) ? Y 2 ? ? z x ? ] w in which L represents a 1,2,4-triazole ligand carrying an R substituent on the nitrogen in the 4 position; X is an anion having the valency x, 1?x?2; Y is an anion other than X having the valency x?, 1?x??2; R is an alkyl group or an R1R2N— group in which R1 and R2 represent, each independently of the other, H or an alkyl radical; M is a metal having a 3d4, 3d5, 3d6 or 3d7 configuration, other than Fe; 0?y?1; 0?z?2; 3?w?1500. Applications: thermochromic pigment, data storage, optical limiters, contrast agent.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: Centre National De La Recherche ScientifiqueInventors: Jean-François LETARD, Olivier NGUYEN, Nathalie DARO
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Publication number: 20120309965Abstract: N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.Type: ApplicationFiled: December 29, 2010Publication date: December 6, 2012Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Orson L. Sydora, Michael Carney, Brooke L. Small, Jeffery C. Gee, Steven Hutchison
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Publication number: 20120271018Abstract: The present invention provides imino carbene compounds and their derivatives, catalyst compositions containing these compounds in combination with an activator, and polymerization processes using these catalyst compositions to polymerize one or more olefins.Type: ApplicationFiled: April 10, 2012Publication date: October 25, 2012Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Rex E. Murray, LeGrande Mancel Slaughter, III, Dipesh Prema, Jinhui Chen
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Publication number: 20120215004Abstract: Described are compounds and materials that may be used as a lead-free primary explosive,such as copper(I) nitrotetrazolate. Copper(I) nitrotetrazolate may he prepared by a process comprising the steps of: combining cupric salt, water and 5-nitrotetrazolate salt to form a mixture, heating the mixture, adding a reducing agent and stirring with continued heating. The method may also include combining cupric chloride, sodium 5-nitrotetrazolate and sodium ascorbate.Type: ApplicationFiled: March 14, 2012Publication date: August 23, 2012Applicant: PACIFIC SCIENTIFIC ENERGETIC MATERIALS COMPANYInventors: JOHN W. FRONABARGER, Michael D. Williams
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Publication number: 20120172566Abstract: A metal cyanide complex catalyst and its preparation and application are disclosed. The formula of this catalyst is M1a[M2(CN)bL1c]d(X)m(L2)n·xSu·yL3·zH2O and its preparation method comprises: (A) adjusting pH of a mixed solution I? of L3, M3e[M2(CN)bL1c]f, de-ionized water I, alcohol and/or ether solvent to less than 7.0, and adding it into a mixed solution II? of M1(X)g salt, Su or Su precursor, de-ionized water II, stirring for reaction under 20° C.-120° C. for 0.5-200 hours, separating and drying to obtain a solid product; and (B) repeatedly dispersing the solid into an anhydrous organic solvent containing L2 to form a slurry, distilling, separating and drying to obtain the metal cyanide complex catalyst. The catalyst is useful in preparing polyethers, polycarbonates and polyesters by homopolymerization of epoxides, or copolymerization of epoxides with carbon dioxide or anhydrides.Type: ApplicationFiled: December 13, 2010Publication date: July 5, 2012Applicant: ZHEJIANG UniversityInventors: Xinghong Zhang, Guorong Qi, Binyang Du, Renjian Wei, Xueke Sun
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Patent number: 8211402Abstract: A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV.Type: GrantFiled: December 4, 2009Date of Patent: July 3, 2012Assignee: Molecular Insight Pharmaceuticals, Inc.Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
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Patent number: 8211401Abstract: A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.Type: GrantFiled: December 4, 2009Date of Patent: July 3, 2012Assignee: Molecular Insight Pharmaceuticals, Inc.Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
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Publication number: 20120108820Abstract: Novel chemical compounds of the general formula K+A? useful as industrial solvents, especially as ligands, for efficient catalyst recycling.Type: ApplicationFiled: December 16, 2011Publication date: May 3, 2012Inventors: Paul Dyson, Dongbin Zhao, Zhaofu Fei
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Publication number: 20120034165Abstract: The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.Type: ApplicationFiled: April 6, 2010Publication date: February 9, 2012Inventors: ALexander Jackson, Véronique Morisson-Iveson
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Publication number: 20110319630Abstract: This disclosure relates to porous frameworks for gas separation, sensing and drug/biomolecule delivery. More particularly, the disclosure relates to reactive porous frameworks for functionalization.Type: ApplicationFiled: December 18, 2009Publication date: December 29, 2011Applicants: BASF SE, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Omar M. Yaghi, Alexader U. Czaja, William Morris, Joseph R. Hunt, David Kyle Britt, Chain Lee
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Publication number: 20110311884Abstract: The invention relates to a pentacyclic anion salt and to the use thereof in electrolyte compositions. The compound comprises an inorganic, organic or organometallic cation M of valency m (1?m?3) and m anions corresponding to the formula (I) in which Rf is a —CFZ?Z? group in which Z? is F or a perfluoroalkyl group having from 1 to 3 carbon atoms, and Z? is an H, F or Cl group, an optionally fluorinated or perfluorinated alkoxy group having from 1 to 5 carbon atoms, an optionally fluorinated or perfluorinated oxaalkoxy group having from 1 to 5 carbon atoms or an optionally fluorinated or perfluorinated alkyl group having from 1 to 5 carbon atoms; Z? being other than F when Z? is F. An electrolyte composition comprises said salt in solution in a liquid solvent or a polymer solvent.Type: ApplicationFiled: August 28, 2009Publication date: December 22, 2011Inventors: Michel Armand, Sylvie Grugeon, Stephane Laruelle, Maria Bukowska, Przemyslaw Szczecinski, Wladyslaw Wieczorek, Leszek Niedzicki, Bruno Scrosati, Stefania Panero, Priscilla Realle
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Publication number: 20110301354Abstract: Lead-free primary explosives of the formula [MII(A)R(BX)S](CY)T, where A is 1,5-diaminotetrazole, and syntheses thereof are described. Substantially stoichiometric equivalents of the reactants lead to high yields of pure compositions thereby avoiding dangerous purification steps.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Applicant: LOS ALAMOS NATIONAL SECURITY, LLCInventor: My Hang V. Huynh
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Patent number: 8017599Abstract: The present invention relates to sequence selective compounds for targeting therapeutic or diagnostic groups to polynucleotides. More particularly, the present invention relates to sequence selective targeting of metallocomplexes, such as metallodrugs and metallodiagnostics, to polynucleotides.Type: GrantFiled: October 7, 2004Date of Patent: September 13, 2011Assignee: University of Western SydneyInventors: David Jaramillo, Craig Brodie, Warren Howard, Robin Taleb, Janice Aldrich-Wright
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Publication number: 20110207902Abstract: The present invention generally relates to metal-ligand complexes, catalysts comprising or prepared from the metal-ligand complexes, processes of catalyzing olefin polymerization reactions with the catalysts to prepare polyolefins, polyolefins prepared thereby, processes of making the metal-ligand complexes and catalysts, and intermediate compounds useful therefor.Type: ApplicationFiled: February 8, 2011Publication date: August 25, 2011Inventors: Jerzy Klosin, Ruth Figueroa, Philip P. Fontaine
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Patent number: 7812042Abstract: Therapeutic applications, such as prevention, treatment and supplementation, for the use of novel and other thiolatocobalamins to protect human cells against the effects of oxidative stress. In particular, this invention relates to the use of a novel synthetic thiolatocobalamin, N-acetyl-L-cysteinylcobalamin (NACCbl) to protect animal cells against oxidative stress damage. This invention also relates to the use of thiolatocobalamins, such as NACCbl, in lieu of current, commercially available forms of vitamin B12 for the treatment and prevention of conditions associated with oxidative stress damage and for dietary supplementation.Type: GrantFiled: September 20, 2007Date of Patent: October 12, 2010Assignees: Kent State University, University of ChesterInventors: Nicola E. Brasch, Catherine Stephanie Birch, John Henry Howatson Williams
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Publication number: 20100233188Abstract: The present invention relates to a compound having the general Formula (I): wherein: m and n are each independently an integer from 1 to 6; X1-X3 and Y1-Y3 are each independently O or S; R1-R3 are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and R is (CH2)x—C(?O)NR?—(CH2)y—NR?R? whereas: x and y are each independently an integer from 1 to 6; and R? and R? are each independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl; and to an antibody comprising an antigen recognition region capable of specifically binding the above compound.Type: ApplicationFiled: February 21, 2008Publication date: September 16, 2010Inventors: Irit Sagi, Tamar Danon, Netta Sela, Abraham Shanzer, Rina Arad-Yellin, Raghavendra Kikkeri
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Publication number: 20100228031Abstract: The invention provides ruthenium-comprising catalysts, and methods of making and using them, for conjugating double bonds in polyunsaturated hydrocarbons, including polyunsaturated fatty acid derivatives, such as natural fats and oils which comprise (contain) more than one carbon to carbon double bond—where the double bonds are separated by, e.g., a methylene, ethylene or propylene or longer group. The invention provides compositions and methods for treating fats and oils comprising “interrupted” (e.g., “methylene-, ethylene- or propylene-interrupted”) double bonds to generate isomers with “conjugated” double bonds. The invention also provides compositions, and methods of making and using them, for making catalysts on a solid support. In one aspect, these catalysts are for alkene isomerization or exchange of alkene hydrogens for other isotopes.Type: ApplicationFiled: July 25, 2008Publication date: September 9, 2010Applicant: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATIONInventor: Douglas Grotjahn
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Publication number: 20100178247Abstract: A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV.Type: ApplicationFiled: December 4, 2009Publication date: July 15, 2010Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
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Publication number: 20100178246Abstract: A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is radioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.Type: ApplicationFiled: December 4, 2009Publication date: July 15, 2010Inventors: John W. Babich, Craig Zimmerman, John Joyal, Kevin P. Maresca, Genliang Lu, Shawn Hillier
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Publication number: 20100152154Abstract: A series of platinum compounds and methods of treating cancer by said platinum compounds are disclosed.Type: ApplicationFiled: December 12, 2009Publication date: June 17, 2010Inventors: Jiajiu Shaw, Fenlai Tan