Boron Or Silicon Containing Patents (Class 548/110)
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Publication number: 20120040826Abstract: Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides.Type: ApplicationFiled: July 30, 2008Publication date: February 16, 2012Applicant: SYNGENTA LIMITEDInventors: Stephane André Marie Jeanmart, Christopher John Mathews, John Benjamin Taylor, Steve Smith
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Publication number: 20120040932Abstract: Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.Type: ApplicationFiled: August 8, 2011Publication date: February 16, 2012Applicant: Rempex Pharmaceuticals, Inc.Inventors: Gavin Hirst, Raja Reddy, Scott Hecker, Maxim Totrov, David C. Griffith, Olga Rodny, Michael N. Dudley, Serge Boyer
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Publication number: 20120034165Abstract: The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.Type: ApplicationFiled: April 6, 2010Publication date: February 9, 2012Inventors: ALexander Jackson, Véronique Morisson-Iveson
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Publication number: 20120035131Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R1, R2, R3A, R3B, R4, R5, R6, R7, R8, and X are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, and intermediates are also disclosed.Type: ApplicationFiled: October 20, 2011Publication date: February 9, 2012Inventors: Marvin J. Meyers, Graciela B. Arhancet, Xiangyang Chen, Susan Hockerman, Scott A. Long, Matthew W. Mahoney, David B. Reitz, Joseph G. Rico
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Publication number: 20120029192Abstract: This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivatives thereof, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives. The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such, the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).Type: ApplicationFiled: October 7, 2011Publication date: February 2, 2012Inventors: Lyn Howard Jones, Charles Eric Mowbray, David Anthony Price, Matthew Duncan Selby, Paul Anthony Stupple
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Publication number: 20120022265Abstract: The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinkable monomer which does not have UV-A and/or UV-B and/or UV-C filter activity are subjected to a crosslinking reaction in the absence of non-crosslinkable chromophores with UV-A and/or UV-B and/or UV-C filter activity and microcapsules obtainable by this process.Type: ApplicationFiled: August 2, 2011Publication date: January 26, 2012Inventor: Katja BERG-SCHULTZ
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Publication number: 20120022266Abstract: The present invention is directed to a fluorosilane represented by (L)3-Si—(CH2)n—(Z1)a—[C(X1)]x—(Z2)l-Q1-Rf where each n is independently an integer from 1 to 12; L is independently chosen from a hydrolysable or non-hydrolysable monovalent group; Rf is chosen from a C2-C12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoroalkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q1 is chosen from the group consisting of a C2-C12 hydrocarbylene optionally interrupted by at least one divalent organic group; X1 is chosen from O or S; —Z2 is —NH— and Z1 is from the group consisting of —O—, and —S—; each R1 is independently chosen from hydrogen, phenyl, or a monovalent C1-C8 alkyl optionally terminated by —C6H5, preferably H or CH3.Type: ApplicationFiled: September 23, 2011Publication date: January 26, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20120022267Abstract: The present invention is directed to a fluorosilane represented by (L)3-Si—(CH2)n—N(-Q3-Rf)-Q1-Rf where each n is independently an integer from 1 to 12; L is independently chosen from a hydrolysable or non-hydrolysable monovalent group Rf is chosen from a C2-C12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoroalkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q1 is chosen from the group consisting of a C2-C12 hydrocarbylene optionally interrupted by at least one divalent organic group; X1 is chosen from O or S; and b) Q1 and Q3 are independently chosen from the group consisting of a C2-C12 hydrocarbylene interrupted by at least one of —C(O)—O— or —O—C(O)—, and optionally further interrupted by at least one divalent organic group.Type: ApplicationFiled: September 23, 2011Publication date: January 26, 2012Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20120018676Abstract: The present invention relates to novel tricyanoborates of the general formula Catn+ [B(CN)3(XR1)]—n, wherein R1 is C1-6 alkyl, C2-6 alkenyl, C6-10 aryl or benzyl; X is oxygen or sulfur; and Catn+ is a cation with n being 1 or 2, which is selected from the group consisting of an inorganic cation and an organic cation; and also their preparation and use.Type: ApplicationFiled: January 26, 2010Publication date: January 26, 2012Applicant: LONZA LTD.Inventors: Wolfgang Wenger, Cornelia Zur Taschler
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Publication number: 20120004384Abstract: The present invention provides an article of manufacture formed from a substrate and a benzazoloporphyrazine bound to the substrate. The article may take a variety of different forms and may be for example an electrochromic display, a molecular capacitor, a battery, a solar cell, or a molecular memory device. Methods of making such articles, along with compounds, methods and intermediates useful for making such benzazoloporphyrazines, are also described.Type: ApplicationFiled: February 25, 2011Publication date: January 5, 2012Inventors: W. Justin Youngblood, Jonathan S. Lindsey
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Publication number: 20110319359Abstract: Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof:Type: ApplicationFiled: June 23, 2011Publication date: December 29, 2011Applicant: DAIICHI SANKYO COMPANY, LIMITEDInventors: Akira Nakao, Kentoku Gotanda, Kazumasa Aoki, Shimpei Hirano, Yoshiharu Hiruma, Takeshi Shiiki
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Patent number: 8084617Abstract: The invention relates to compounds of the formula (I), in which X, -Q1-Q2- and RF have the meaning indicated in Claim 1, as ionic liquids, and to a process for the preparation thereof.Type: GrantFiled: January 3, 2005Date of Patent: December 27, 2011Assignee: Merck Patent GmbHInventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, German Bissky, Helge Willner, Andriy Kucheryna
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Publication number: 20110306771Abstract: An acoustic wave biosensor comprising a surface of a mixed self-assembling monolayer for receiving a probe-biomolecule is described herein. The biosensor surface may comprise a piezoelectric quartz crystal,—for detection purposes with the electromagnetic piezoelectric acoustic sensor (EMPAS)—upon which a mixed self-assembling monolayer is formed, which includes at least one linker, such as 2,2,2-trifluoroethyl-13-trichlorosilyl-tridecanoate (TTTA); its oligoethylene glycol (OEG) analog OEGylated TTTA (OEG-TTTA); S-(2-(2-(2-(3-trichlorosilyl-propyloxy)-ethoxy)-ethoxy)-ethyl)-benzenethiosulfonate (OEG-TU BTS). Linker/diluent systems for attaching a functionalizing entity to the surface of a biosensor are described, as well as methods for preparing a biosensor surface with an oligoethylene glycol linker.Type: ApplicationFiled: June 6, 2011Publication date: December 15, 2011Applicant: ECONOUS SYSTEMS INC.Inventors: Michael THOMPSON, Sonia SHEIKH, Jack Chih-Chieh SHENG, Christophe BLASZYKOWSKI
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Publication number: 20110306743Abstract: Provided is a crosslinked hexaaryl bisimidazole compound which can achieve photochromic characteristics, i.e., visually showing decoloring simultaneously with the stop of light irradiation and enables precise control of color tone, density and so on in coloring. Also provided are a method for producing the aforesaid compound whereby the degrees of freedom in molecular design and synthesis can be increased, and a precursor compound to be used in the production method.Type: ApplicationFiled: November 24, 2009Publication date: December 15, 2011Applicant: KANTO KAGAKU KABUSHIKI KAISHAInventors: Jiro Abe, Yuta Kishimoto, Daisuke Kato, Atsushi Kimoto
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Publication number: 20110300116Abstract: A method for generating a recombinant clonal cell line expressing a target cell surface receptor at a specific level of expression from a cell population comprising cells transfected with a plasmid encoding the cDNA sequence of the target receptor and expressing the target cell surface receptor, the method comprising (c) incubating the cell population with a receptor specific fluorescent ligand (d) selecting single cells from step (c) expressing the target cell surface receptor by monitoring the specific binding of the fluorescent ligand using flow cytometry; and novel fluorescent ligands.Type: ApplicationFiled: September 29, 2008Publication date: December 8, 2011Applicant: CELLAURA TECHNOLOGIES LTDInventors: Stephen John Hill, Barrie Kellam, Richard John Middleton
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Publication number: 20110293852Abstract: This invention relates to organometallic precursor compounds represented by the formula (H)mM(R)n wherein M is a metal or metalloid, R is the same or different and is a substituted or unsubstituted, saturated or unsaturated, heterocyclic radical containing at least one nitrogen atom, m is from 0 to a value less than the oxidation state of M, n is from 1 to a value equal to the oxidation state of M, and m+n is a value equal to the oxidation state of M, a process for producing the organometallic precursor compounds, and a method for producing a film or coating from the organometallic precursor compounds.Type: ApplicationFiled: December 19, 2007Publication date: December 1, 2011Inventor: Scott Houston Meiere
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Publication number: 20110287473Abstract: The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.Type: ApplicationFiled: December 28, 2009Publication date: November 24, 2011Inventors: Jean De Barry, Corinne Liegeois, Alexandre Haefele, Thomas Bura, Gilles Ulrich, Raymond Ziessel
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Publication number: 20110287369Abstract: There is provided a resist underlayer film forming composition for lithography for forming a resist underlayer film capable of being used as a hardmask. A resist underlayer film forming composition for lithography comprising a silane compound containing an anion group, wherein the silane compound containing an anion group is a hydrolyzable organosilane in which an organic group containing an anion group is bonded to a silicon atom and the anion group forms a salt structure, a hydrolysis product thereof, or a hydrolysis-condensation product thereof. The anion group may be a carboxylic acid anion, a phenolate anion, a sulfonic acid anion, or a phosphonic acid anion. The hydrolyzable organosilane may be a compound of Formula (1): R1aR2bSi(R3)4?(a+b) (1).Type: ApplicationFiled: December 16, 2009Publication date: November 24, 2011Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Wataru Shibayama, Makoto Nakajima, Yuta Kanno
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Patent number: 8058463Abstract: Fluoroalkyl silanes are a class of compounds useful for various industrial purposes. For example, fluoroalkyl silanes which have hydrolysable groups (called hydrolysable fluoroalkyl silanes), are compounds useful as surface treatment agents which provide durable hydrophobic and oleophobic coatings. In general, hydrolysable fluoroalkyl silanes can be represented with the following formula: (RO—)3Si—RT wherein R is H or an alkyl; and RT is a monovalent organic compound terminated by a perfluoroalkyl group. When used to coat a surface, the (RO—)3 moiety reacts (via hydrolysis) with various chemical groups of the surface (e.g., hydroxyl, amine, or other reactive groups) thereby bonding the fluoroalkyl silane to the surface The RT moiety comprises a divalent organic linking group which links the silicon atom to a terminal group rich in fluorine atoms whose unique electronic properties impart desirable hydrophobic and oleophobic properties in a surface coating.Type: GrantFiled: November 26, 2008Date of Patent: November 15, 2011Assignee: E. I. du Pont de Nemours and CompnayInventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20110275826Abstract: Chiral compounds of the formula (1), which are optically pure or highly optically enriched in which R0 is C1-C12-alkyl which is unsubstituted or substituted by 1 to 2 C1-C4-alkoxy; cyclo-pentyl or cyclohexyl, which is unsubstituted or substituted by 1 to 3 C1-C4-alkyl or C1-C4-alkoxy; or benzyl, phenyl or naphtyl which is unsubstituted or substituted by 1 to 3 C1-C4-alkyl, C1-C4-alkoxy, C1-C4-fluoroalkyl or C1-C4-fluoroalkoxy, F or Cl, or R0 is —CR5R6OH or —CR5R6OSi(C1-C8-alkyl)3 wherein R5 and R6 are independently selected from the group consisting of H, unsubstituted C1-C12 alkyl, substituted C1-C12 alkyl, unsubstituted C4-C8 cyclo alkyl, substituted C4-C8 cyclo alkyl, unsubstituted aryl, substituted aryl or wherein R5 and R6 can form an unsubstituted 5-6 membered aliphatic carbocycle or a substituted 5-6 membered aliphatic carbocycle, each of R1 and R?1 independently is hydrogen or has the meaning of R0 whereby R1, R?1 and R0 can be same or different, R2 and R3 are independently a C-bonded hydrocarbon radiType: ApplicationFiled: December 22, 2009Publication date: November 10, 2011Inventors: Andreas Pfaltz, Marcus Georg Schrems, Benoît Pugin
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Publication number: 20110269962Abstract: Process for the preparation of ?-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.Type: ApplicationFiled: April 22, 2011Publication date: November 3, 2011Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Maurizio TADDEI, Evita BALDUCCI, Emanuele ATTOLINO, Simone MANTEGAZZA, Gianmaria DELL'ANNA
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Publication number: 20110269714Abstract: The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.Type: ApplicationFiled: March 30, 2011Publication date: November 3, 2011Applicant: Tetraphase Pharmaceuticals, Inc.Inventors: Xiao-Yi Xiao, Roger Clark, Diana Hunt, Magnus Rönn, Louis Plamondon, Minsheng He, Joyce Sutcliffe, Trudy Grossman
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Patent number: 8044212Abstract: Various embodiment of the present invention are directed to organic molecules that are reconfigurable under application of an external electric field. One organic molecule embodiment of the present invention has the structure: where L1X1 and L2X2 are optional connector groups, A represents an electron acceptor group, D represents an electron donor group, R and R? represent spacer molecules, and R1, R2, R3, R4, R5, R6, R7, and R8 represent atoms and hydrocarbons.Type: GrantFiled: April 30, 2007Date of Patent: October 25, 2011Assignee: Hewlett-Packard Development Company, L.P.Inventors: Zhang-Lin Zhou, Zhiyong Li
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Publication number: 20110257128Abstract: Novel 2-alkylcycloalk(en)ylcarboxamides of the formula (I) in which X, s, R1, L, R2 and A are as defined in the description, a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.Type: ApplicationFiled: June 30, 2011Publication date: October 20, 2011Applicant: Bayer CropScience AGInventors: Ralf DUNKEL, Hans-Ludwig Elbe, Jörg Nico Greul, Benoit Hartmann, Herbert Gayer, Thomas Seitz, Ulrike Wachendorff-Neumann, Peter Dahmen, Karl-Heinz Kuck
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Publication number: 20110257235Abstract: The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by a Plasmodium or Babesia parasite in a subject in need thereof. The triazolium and imidazolium salts are compounds of the Formula (I) or (II): wherein R1-R4, R1?-R3?, R8-R11, X, X?, X?, Y, Y? and Y? are as defined in the disclosure.Type: ApplicationFiled: September 4, 2009Publication date: October 20, 2011Inventors: Ian E. Crandall, Walter A. Szarek, Jason Z. Vlahakis
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Publication number: 20110240980Abstract: In accordance with various embodiments, an organic electronic device includes an n-type dopant material including an imidazole-based material having a hydrogen-based material bonded between nitrogen atoms. The n-type dopant material n-dopes an organic material, and can be used to mitigate degradation in mobility due to conditions such as exposure to ambient atmosphere, which can effect an undesirable reduction in charge transport. Other embodiments are directed to carbon nanotubes or graphene structures with this type of n-type dopant, wherein the Fermi level for the carbon nanotubes or graphene structures is below ?2.5 eV to effect such n-type doping.Type: ApplicationFiled: April 5, 2011Publication date: October 6, 2011Inventors: Peng Wei, Zhenan Bao
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Publication number: 20110245203Abstract: The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.Type: ApplicationFiled: March 30, 2011Publication date: October 6, 2011Applicant: Millennium Pharmaceuticals, Inc.Inventors: Paul E. Fleming, Jing Li
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Publication number: 20110245507Abstract: A 1,2,3-triazole coordinated borane such as where the B and the R3 groups can be on any of the three N positions and R1, R2, R3, R4, and R5 can be one or more of H, any alkyl, aryl, or substituted alkyl or aryl groups and the position of the final products are the combination of any N position; i.e. N1—R3—N3—BH etc. The triazole-borane compounds can be synthesized in a single-step from simple organic molecules under mild reactions. The 1,2,3-triazole coordinated borane can be synthesized by use of about a 1 to 1 equivalent of the benzole-triazole and the BR3 can be added together without solution or dissolved in an organic solvent (between about 5 M to about 0.001 M for each reactant). The solution can be stirred for about 1 to about 5 hours at an effective temperature to yield the triazole-borane.Type: ApplicationFiled: April 1, 2010Publication date: October 6, 2011Inventor: Xiaodong Shi
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Publication number: 20110243846Abstract: This invention relates to compounds (benzothiazoles) suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.Type: ApplicationFiled: November 28, 2009Publication date: October 6, 2011Inventors: Jorma Hassfeld, Ulrike Roehn, Matthias Friebe, Lutz Lehmann, Tobias Heinrich, Sabine Krause, Damian Brockschnieder, Thomas Dyrks, Andrea Thiele, Ulf Boemer, Ursula Moenning, Markus Berger, Stephan Siegel
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Publication number: 20110237801Abstract: The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.Type: ApplicationFiled: June 9, 2011Publication date: September 29, 2011Applicant: SANOFI-AVENTISInventors: Kirsten BJERGARDE, Mark DODSON, Jacques MAUGER, Anil NAIR, Marcel PATEK, Michel TABART
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Publication number: 20110223134Abstract: The present invention relates to novel Fused Tricyclic Silyl Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, C, D, M1, X1 and X2 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Silyl Compound, and methods of using the Fused Tricyclic Silyl Compounds for treating or preventing HCV infection in a patient.Type: ApplicationFiled: March 4, 2011Publication date: September 15, 2011Inventors: Anilkumar Gopinadhan Nair, Kerry M. Keertikar, Seong Heon Kim, Joseph A. Kozlowski, Stuart Rosenblum, Oleg B. Selyutin, Michael Wong, Wensheng Yu, Qingbei Zeng
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Publication number: 20110224427Abstract: This invention relates to sulfur based compounds useful in methods of carbon dioxide or sulfur dioxide removal.Type: ApplicationFiled: March 11, 2011Publication date: September 15, 2011Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventor: Mark A. Scialdone
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Publication number: 20110212918Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.Type: ApplicationFiled: November 11, 2010Publication date: September 1, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Vincent S. Hernandez, Xianfeng Li, Suoming Zhang, Tsutomu Akama, Yanchen Zhang, Yang Liu, Jacob J. Plattner, Michael Richard Kevin Alley, Yasheen Zhou, James A. Nieman
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Patent number: 8008495Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.Type: GrantFiled: January 5, 2009Date of Patent: August 30, 2011Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Ralf Lock, Werner Belzer, Rainer Hamm, Monika Hofmann
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Publication number: 20110207036Abstract: An electrophoretic particle salt that includes a cationic electrophoretic particle and an anionic group ionically associated with the cationic electrophoretic particle is employed in an electrophoretic display. A spacer group chemically bonds a cationic moiety to a surface of the electrophoretic particle. A method of making the electrophoretic particle salt includes particle surface modification, nucleophilic substitution to create an interim salt and anion exchange. The electrophoretic particle salt has an ionization constant that favors dissociation into a positively charged electrophoretic particle and the anionic group in a nonpolar medium. The electrophoretic display includes a pair of electrodes and a dispersion of the electrophoretic particle salt in a nonpolar medium in a gap between the pair of electrodes.Type: ApplicationFiled: October 30, 2008Publication date: August 25, 2011Inventors: Yoocharn Jeon, Zhang-Lin Zhou
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Publication number: 20110207702Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: October 15, 2009Publication date: August 25, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Robert Jacobs, Matthew Orr, Stephen Wring, Daitao Chen, Huchen Zhou, Dazhong Ding, Yiqing Feng, Long Yi, Vincent S. Hernandez, Yong-Kang Zhang, Jacob J. Plattner
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Publication number: 20110207701Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: August 16, 2010Publication date: August 25, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Huchen Zhou, Dazhong Ding, Yasheen Zhou, Yong-Kang Zhang, Jacob J. Plattner
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Publication number: 20110201806Abstract: Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks containing complex and/or pharmaceutically important structures, and/or provide simple or complex protected organoboronic acid building blocks. A first method includes reacting an imino-di-carboxylic acid and an organoboronate salt. A second method includes reacting a N-substituted morpholine dione and an organoboronic acid.Type: ApplicationFiled: February 18, 2011Publication date: August 18, 2011Inventors: Martin D. Burke, Graham R. Dick, David M. Knapp, Eric P. Gillis, Jenna A. Klubnick
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Publication number: 20110190235Abstract: This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.Type: ApplicationFiled: August 6, 2010Publication date: August 4, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Daitao Chen, Matthew Orr, Jessica Sligar, Robert Jacobs, Jacob J. Plattner
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Publication number: 20110190480Abstract: The present invention relates to dyes of the general formula CAT+ Y? (I), where Y? is an anion selected from the group of the cyanoborates, fluoroalkylphosphates, fluoroalkylborates or imidates and CAT+ is a cation selected from the group of the azine, xanthene, polymethine, styryl, azo, tetrazolium, pyrylium, benzopyrylium, thiopyrylium, benzothiopyrylium, thiazine, oxazine, triarylmethane, diarylmethane, methine, acridine, quinoline, isoquinoline or quaternary azafluorenone dyes, for colouring plastics and plastic fibres, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp ink, for colouring leather and paper, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry.Type: ApplicationFiled: April 11, 2011Publication date: August 4, 2011Inventors: Nikolai (Mykola) IGNATYEV, Urs Welz-Biermann, Helge Willner, Maik Finze, Eduard Bernhardt, Andriy Kucheryna
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Publication number: 20110184175Abstract: Disclosed is a method for producing a BSH derivative, which comprises a step of addition-reacting BSH with an ?,?-unsaturated nitrile compound in the presence of a base. Various BSH derivatives obtained by the method are also disclosed.Type: ApplicationFiled: July 23, 2009Publication date: July 28, 2011Applicant: STELLA PHARMA CORPORATIONInventors: Mitsunori Kirihata, Tomoyuki Asano, Kohki Uehara, Yoshihide Hattori
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Publication number: 20110183939Abstract: The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist. A compound represented by the formula (I); wherein Z1 is optionally protected hydroxy, etc.; Z2 is —C(?O)—, etc.; Z3a and Z3b are taken together ?O or ?S; t is an integer of 0 to 4; R4a and R4b are each independently, hydrogen or substituted or unsubstituted lower alkyl, etc.; m and n are each independently an integer of 0 to 2; k is an integer of 0 or 1; Ring A is an aromatic carbocyclic ring or a heterocyclic ring, etc.; B is aromatic carbocyclic ring-diyl or heterocyclic ring-diyl, etc.; R1a and R1b are each independently halogen, hydroxy, substituted or unsubstituted lower alkyl, etc.; R2 is substituted or unsubstituted alkyl, etc.; R3 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; or its pharmaceutically acceptable salt, or a solvate thereof is provided.Type: ApplicationFiled: September 24, 2009Publication date: July 28, 2011Applicant: SHIONOGI & CO., LTD.Inventors: Hiroyuki Kai, Yoshiyuki Taoda, Takeshi Endoh, Tohru Horiguchi, Kentaro Asahi, Hiroyuki Tobinaga
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Publication number: 20110178007Abstract: The present invention relates to compounds of the general formula: (I) wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.Type: ApplicationFiled: September 30, 2009Publication date: July 21, 2011Inventors: Andrew Stamford, Michael W Miller, Duane Eugene Demong, William J Greenlee, Joseph A Kozlowski, Brian J Lavey, Michael K.C. Wong, Wensheng Yu, Xing Dai, De-Yi Yang, Guowei Zhou
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Publication number: 20110178258Abstract: The present invention relates to the covalent anchorage of non-coordinating anions on mineral supports to prepare supported ionic liquids and to their use as activating supports for the polymerisation of ethylene and alpha-olefins. The invention also discloses the concomitant covalent anchorage of zwitterionic systems containing both the non-coordinating anion and the counter cation parts of the ionic liquids and of the activating supports.Type: ApplicationFiled: October 2, 2008Publication date: July 21, 2011Applicants: Total Petrochemicals Research Feluy, Centre National de la Recherche Scientifique (CNRS)Inventors: Abdelkrim El Kadib, Karine Molvinger, Daniel Brunel, Floran Prades, Abbas Razavi
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Patent number: 7982046Abstract: A method for producing functionalized CH-acidic five-ring heterocycles, the resultant five-ring heterocycles and the use thereof for producing pharmaceuticals and crop protection preparations.Type: GrantFiled: October 24, 2006Date of Patent: July 19, 2011Assignee: Chemetall GmbHInventors: Ute Emmel, Peter Rittmeyer, Ulrich Wietelmann
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Publication number: 20110172187Abstract: This invention relates to, among other items, 6-substituted benzoxaborole compounds and their use for treating bacterial infections.Type: ApplicationFiled: November 11, 2010Publication date: July 14, 2011Applicant: Anacor Pharmaceuticals, Inc.Inventors: Vincent S. HERNANDEZ, Xiangeng Li, Suoming ZHANG, Tsutomu AKAMA, Yanchen ZHANG, Yang LIU, Jacob J. PLATTNER, Michael Richard Kevin ALLEY, Yasheen ZHOU, James A. NIEMAN
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Publication number: 20110172186Abstract: The present invention provides compounds, and pharmaceutically acceptable compositions thereof, encompassed by any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof. The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH by administering a therapeutically effective amount of a compound or composition comprising a compound of any of formulae (I), (II), (III), (IV), (V), or (VI), or subgenera thereof, to a patient in need thereof.Type: ApplicationFiled: October 8, 2010Publication date: July 14, 2011Inventors: Mark L. Behnke, Alfredo C. Castro, Catherine A. Evans, Louis Grenier, Michael J. Grogan, Tao Liu, Daniel A. Snyder, Thomas T. Tibbitts
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Publication number: 20110166102Abstract: The present invention is directed to a novel 2-substituted benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.Type: ApplicationFiled: March 17, 2011Publication date: July 7, 2011Inventors: Vernon C. ALFORD, JR., James C. LANTER, Raymond A. NG
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Patent number: 7973171Abstract: The invention relates to a process for the synthesis of dialkoxyorganoboranes, in particular to a process for the synthesis of dialkoxyorganoboranes by an ester exchange reaction. Moreover, the invention relates to a process for the synthesis of organo-oxazaborolidine catalysts (organo-CBS) and of trialkylboroxins. Furthermore, the invention relates to methods of using dialkoxyorganoboranes for the preparation of organo-CBS catalysts and in Suzuki-type coupling reactions.Type: GrantFiled: November 16, 2010Date of Patent: July 5, 2011Inventors: Elizabeth Burkhardt, William Atkins
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Publication number: 20110150736Abstract: The present invention provides a method of producing a tetracyanoborate-containing ionic compound in a milder condition more efficiently and less expensively than conventional methods, and a tetracyanoborate-containing ionic compound having a reduced content of impure components. An ionic compound of the present invention is represented by the following general formula (I), has a content of fluorine atom-containing impurities of 3 mol % or less per 100 mol % of the ionic compound, and a method for producing an ionic compound represented by the general formula (I) of the present invention comprises a step of reacting starting materials containing a cyanide and a boron compound. (In the formula, Ktm+ denotes an organic cation [Ktb]m+ or an inorganic cation [Ke]m+; and m denotes an integer of 1 to 3.Type: ApplicationFiled: August 21, 2009Publication date: June 23, 2011Inventors: Yuji Hagiwara, Takanori Ochi, Kazunobu Ohata, Taisuke Kasahara, Taketo Toba, Keiichiro Mizuta, Hiromoto Katsuyama, Satoshi Ishida, Toshifumi Nishida