Phosphorus Attached Directly To The Five-membered Hetero Ring By Nonionic Bonding Patents (Class 548/111)
  • Patent number: 4317773
    Abstract: The invention relates to new chemical compounds corresponding to the followings formula ##STR1## in which R is a non-hydrolyzable radical and Az represents aziridinyl ##STR2## These compounds may be used as medicaments.
    Type: Grant
    Filed: June 25, 1980
    Date of Patent: March 2, 1982
    Assignee: Agence Nationale de Valorisation de la Recherche (ANVAR)
    Inventors: Jean-Francois Labarre, Francois Sournies, Johan C. van de Grampel, Andriaan A. van der Huizen
  • Patent number: 4282213
    Abstract: Amidine phosphonates carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'-[2-(2-thiazolylmethylthio)ethyl]amidinophosphonic acid monoethyl ester and N'-methyl-N"-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]guanidinophospho nic acid monobenzyl ester, are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: August 4, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Rodney C. Young, Zev Tashma
  • Patent number: 4259492
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.18 alkyl,R.sub.2 is hydrogen or C.sub.1 -C.sub.18 alkyl, andA is a substituted primary or secondary aliphatic or alicyclic, aromatic or araliphatic amine, in which the substituents are identical or different, a heterocyclic amine or a hydrazine derivative.
    Type: Grant
    Filed: May 18, 1979
    Date of Patent: March 31, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Michael Rasberger
  • Patent number: 4237122
    Abstract: An imidazolidinedione compound of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom, Y is an oxygen atom or a sulfur atom, and R.sub.1 and R.sub.2 are each a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkylthio group, an ar(C.sub.1 -C.sub.4)alkylthio group, a C.sub.1 -C.sub.4 alkoxy(C.sub.2 -C.sub.4)alkoxy group, a phenyl group, a phenoxy group, a C.sub.1 -C.sub.4 alkylthiophenoxy group, a C.sub.1 -C.sub.8 alkylamino group, a C.sub.2 -C.sub.8 alkenylamino group or a cyano(C.sub.1 -C.sub.4)alkylamino group, which is useful as an agricultural chemical such as insecticides, acaricides, nematocides and/or fungicides with high safety to mammalian animals and human beings.
    Type: Grant
    Filed: June 15, 1979
    Date of Patent: December 2, 1980
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shuichiro Asao, Shigeo Yamamoto, Yoshio Hisada, Yoshinori Nakayama, Chiyozo Takayama
  • Patent number: 4232011
    Abstract: Compounds of the formula I ##STR1## wherein R.sub.1 and R.sub.2 are each methyl or chlorine, R.sub.3 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sub.4 is methyl or ethyl, R.sub.5 is methoxy, ethoxy, C.sub.1 -C.sub.4 -alkylthio or phenyl and X is oxygen or sulphur have valuable pesticidal in particular acaricidal properties.
    Type: Grant
    Filed: October 22, 1979
    Date of Patent: November 4, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Manfred Boger, Jozef Drabek, Gunter Mattern, Walter Traber
  • Patent number: 4232162
    Abstract: The present invention is related to a process in which an oxazolidinone is reacted with phosphorus pentachloride and the resulting mixture is reacted with a nucleophilic agent in an inert solvent to give P-substituted N,N'-bis-(3-oxazolidinyl-2-one)phosphoramides having the general formula ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4 are each a group selected from among hydrogen, C.sub.1 -C.sub.4 alkyls or an aromatic nucleus and X is a group which may be introduced by nucleophilic substitution. The invention is also related to the compounds thus obtained.
    Type: Grant
    Filed: July 24, 1978
    Date of Patent: November 4, 1980
    Assignee: Antibiotics, S.A.
    Inventors: Antonio L. P. Coll, Jose D. Meseguer
  • Patent number: 4230849
    Abstract: A process for the activation of carboxylic acids which is useful for the subsequent conversion of said carboxylic acids into their corresponding amides or esters, based on reacting a 2-oxazolidinone with phosphorus pentachloride and subsequent addition of a salt of the carboxylic acid to be activated.
    Type: Grant
    Filed: July 2, 1979
    Date of Patent: October 28, 1980
    Assignee: Antibioticos, S.A.
    Inventors: Antonio L. Palomo Coll, Jose Diago Meseguer
  • Patent number: 4172863
    Abstract: Novel halogen-containing organic phosphorous compounds having the formula ##STR1## wherein N IS THE WHOLE NUMBER 1 OR 2;X represents chlorine or bromine;Z represents oxygen or sulfur;A represents a bivalent radical containing one or more oxy linkages;A' represents a bivalent radical containing one or more oxy linkages or the direct P-C bond;B represents a chloro, bromo, hydroxy, alkoxy, alkenyloxy, or ureidohydrocarbyl isocyanate radical;R.sub.1 repesents a chloro, bromo, hydroxy, hydrocarbyl or hydrocarbyl-oxy radical;R.sub.2 represents bromo, chloro, amino, hydrazino, hydroxy, --R.sub.1, --OMe where Me is the salt of a metal selected from Na, K, Li, Zn, Mg, Ni, Ca, Ba, Sb, Ti, V, Sn, or --O--Q where Q represents an epoxy ester derivative of acrylic or methacrylic acid;R.sub.1 and R.sub.2, together form an arylenedioxy radical when n is 1; andR.sub.3 represents a hydrocarbyl or hydrocarbyloxy radical.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: October 30, 1979
    Inventor: John J. Waldmann