The Phosphorus Is Part Of A Substituent Which Is Attached Directly To Ring Carbon Of The Five-membered Hetero Ring Patents (Class 548/119)
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Patent number: 4952707Abstract: Chemiluminescent 1,2-dioxetane compounds are disclosed in which the molecule is stabilized at the 3-position on the dioxetane ring against decomposition prior to the molecule's coming in contact with a labile group-removing substance (e.g., an enzyme that will cleave the labile group to cause the molecule to decompose to form at least one light-emitting fluorophore) and substituted at the 4-position on the dioxetane ring with a fused polycyclic ring-containing fluorophore moiety bearing a labile ring substituent whose point of attachment to the fused polycyclic ring, in relation to this ring's point(s) of attachment to the dioxetane ring, is such that the total number of ring atoms separating these points of attachment, including the ring atoms at the points of attachment, is an odd whole number. These odd pattern substituted compounds decompose to emit light of greater intensity and of a different wavelength than that emitted by the corresponding even pattern substituted isomers.Type: GrantFiled: June 30, 1988Date of Patent: August 28, 1990
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Patent number: 4939130Abstract: Alkanediphosphonic acids, in particular heteroarylalkanediphosphonic acids of formula ##STR1## wherein R.sub.1 is a 5-membered heteroaryl radical which may be fused with benzene or cyclohexene nuclei and which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy and/or halogen, or by lower alkoxy, hydroxy, di-lower alkylamino, lower alkylthio and/or halogen, and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen, and R.sub.2 is hydrogen, hydroxy, amino, lower alkylthio or halogen, and salts thereof, have regulatory action on calcium metabolism and can be used as medicaments for the treatment of diseases associated with impairment of calcium metabolism. The compounds are obtained for example by converting, in a compound of formula ##STR2## wherein X.sub.Type: GrantFiled: February 27, 1989Date of Patent: July 3, 1990Assignee: Ciba-Geigy CorporationInventors: Knut A. Jaeggi, Leo Widler
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Patent number: 4933328Abstract: The invention provides fungicidal compositions containing phosphonium salts of formula: ##STR1## in which n represents 0, 1, 2 or 3, R represents a halogen atom or an optionally substituted alkyl, haloalkyl, alkoxy or haloalkyl group, R.sup.1, R.sup.2 and R.sup.3 independently represent an optionally substituted alkyl, cycloalkyl, phenyl or benzyl group and X represents an anion; certain novel phosphonium salts, a process for the preparation of such compounds and a method of combating plant pathogenic fungi using such compositions or compounds.Type: GrantFiled: July 18, 1988Date of Patent: June 12, 1990Assignee: Shell Internationale Research Maatshappij B.V.Inventors: Jurgen Curtze, Christo Drandarevski, Guido Albert, Arthur A. Ramsey
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Patent number: 4916129Abstract: Imidazole compounds such as ##STR1## which have angiotensin II antagonizing properties as well as .beta.-adrenoceptor antagonizing properties are useful as antihypertensives and for treatment of congestive heart failure.Type: GrantFiled: January 19, 1989Date of Patent: April 10, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventors: David J. Carini, John J. V. Duncia
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Patent number: 4908357Abstract: Thiazole compounds of the following structural formula are photodynamic insecticides and acaricides, as well as nematicides: ##STR1##Type: GrantFiled: September 22, 1988Date of Patent: March 13, 1990Assignee: FMC CorporationInventor: Kathryn A. Lutomski
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Patent number: 4898878Abstract: Therapeutic antioxidant compounds, useful for relieving the pathogenesis of oxidative stress, of formula ##STR1## wherein substituents R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are individually selected from among hydrogen, methyl, or other atoms and groups that do not adversely affect the overall spectrum of redox activity of the 4-thiohistidine. N-3 is unsubstituted or is substituted as described for R.sub.1 to R.sub.4. R.sub.6 is preferably hydrogen or --SR.Type: GrantFiled: October 2, 1987Date of Patent: February 6, 1990Assignee: The Board of Regents of the University of WashingtonInventors: Bennett M. Shapiro, Eric E. Turner, Paul B. Hopkins, Rachel E. Klevit, Tod P. Holler, Andreas Spaltenstein
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Patent number: 4877439Abstract: Herbicidal 1-arylpyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen or nitro,R.sup.2 represents hydrogen or alkyl,R.sup.3 and R.sup.4 independently of one another each represent alkyl, halogenoalkyl or optionally substituted aryl,Ar represents optionally substituted phenyl or optionally substituted pyridyl,x represents a number 0 or 1 andy represents a number 0 or 1.Type: GrantFiled: June 23, 1988Date of Patent: October 31, 1989Assignee: Bayer AktiengesellschaftInventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
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Patent number: 4857513Abstract: A compound of the formula: ##STR1## wherein R.sup.1 --A-- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, andX is O or S, andR.sup.2 is hydrogen or lower alkyl, provided that when R.sup.1 is lower alkyl, thenR.sup.1 --A-- is a group of the formula: ##STR3## in which R.sup.1 and X are each as defined above, and pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.Type: GrantFiled: April 24, 1987Date of Patent: August 15, 1989Assignee: Fujisiwa Pharmaceutical Co., Ltd.Inventors: Teruo Oku, Eishiro Todo, Chiyoshi Kasahara, Katsuya Nakamura, Hiroshi Kayakiri, Masashi Hashimoto
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Patent number: 4826993Abstract: 4-Substituted 1-(optionally substituted)diazolidinones are intermediates to 7-substituted bicyclic pyrazolidinone antimicrobials.Type: GrantFiled: May 14, 1986Date of Patent: May 2, 1989Assignee: Eli Lilly and CompanyInventors: Richard E. Holmes, Louis N. Jungheim
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Patent number: 4806542Abstract: Isohexide nucleosides of the formula I ##STR1## in which R and B have the meaning given in the description, processes for their preparation and their use as medicaments, in particular as cytostatics, virustatics and immunostimulants.Type: GrantFiled: February 26, 1987Date of Patent: February 21, 1989Assignee: Heinrich Mack Nachf.Inventors: Peter Stoss, Elmar Kaes
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Patent number: 4795815Abstract: 1,2,4-Trisubstituted diazolidinones are intermediates to bicyclic pyrazolidinone antimicrobial compounds.Type: GrantFiled: October 29, 1987Date of Patent: January 3, 1989Assignee: Eli Lilly and CompanyInventor: Robert J. Ternansky
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Patent number: 4790868Abstract: This invention relates to herbicidally active substituted benzoxazolone (or benzthiazolone) compounds and to the use of such compounds to control the growth of noxious plants, i.e., weeds.Type: GrantFiled: January 7, 1987Date of Patent: December 13, 1988Assignee: PPG Industries, Inc.Inventor: Donald R. Nielsen
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Patent number: 4788182Abstract: Described are phosphatidyl compounds of the formula I ##STR1## in which R.sup.1 represents C.sub.3-14 -alkanoyl, benzoyl, the acyl radical of an .alpha.-aminocarboxylic acid that is other than glycine, L-alanine and derivatives thereof having a substituted amino group, and of which the .alpha.-amino group may be substituted by lower alkanoyl, lower alkoxycarbonyl or by benzyloxycarbonyl, or the acyl radical of a .beta.-aminocarboxylic acid or an .alpha.- or .beta.-hydroxycarboxylic acid,T represents a group NH that is unsubstituted or is substituted by lower alkyl, or oxygen,Y represents dimethylene that is unsubstituted or is substituted by free, etherified or amidated carboxy,W represents hydrogen, andZ represents a 1,2-dihydroxyethyl, 2-hydroxyethyl or hydroxymethyl group, in which at least one of the hydroxy groups is esterified by an aliphatic C.sub.8-30 -carboxylic acid or is etherified by an aliphaticC.sub.Type: GrantFiled: October 23, 1987Date of Patent: November 29, 1988Assignee: Ciba-Geigy CorporationInventors: Gerhard Baschang, Bruno Fechtig, Albert Hartmann, Bohumir Lukas, Oskar Wacker
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Patent number: 4784993Abstract: The present invention provides diphosphonates of the general formula: ##STR1## wherein Het is 1,2,3-triazole, or 1,2,4-triazole radical, which is optionally substituted by alkyl, alkoxy, halogen, hydroxyl, carboxyl, an amino group optionally substituted by alkyl or acyl radicals or is a benzyl radical optionally substituted by alkyl, nitro, amino or aminoalkyl, A is a straight-chained or branched, saturated or unsaturated hydrocarbon chain containing 2 to 8 carbon atoms, X is a hydrogen atom, optionally substituted by acyl, or an amino group optionally substituted by alkyl or acyl radicals and R is a hydrogen atom or an alkyl radical; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these diphosphonates and pharmaceutical compositions containing them.Type: GrantFiled: July 23, 1987Date of Patent: November 15, 1988Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall
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Patent number: 4782158Abstract: The present invention involves certain thiazol-4-yl-acetic acid compounds which are valuable intermediates for the preparation of cephem antibiotics. Said intermediates have the following structure: ##STR1## wherein R.sup.1 is an amino or a protected amino group; R.sup.2 is a group of the formula 13 CONH--R.sup.5 or --NHCO--R.sup.5 wherein R.sup.5 is pyridyl, thiazolyl or an isoxazolyl ring having lower alkyl and halogen substituted phenyl substituents, and A is lower alkylene, or a non-toxic salt thereof.Type: GrantFiled: July 8, 1986Date of Patent: November 1, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Kunihiko Tanaka, Tsutomu Teraji, Yoshiharu Nakai
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Patent number: 4777163Abstract: The present invention produces alkyldiphosphonic acid derivative of the general formula: ##STR1## wherein Het is a heteroaromatic five-membered ring containing to 3 heteroatoms which can be partly hydrogenated and optionally substituted one or more times by alkyl, alkoxy, phenyl, cyclohexyl, cyclohexylmethyl, halogen or amino, and two adjacent alkyl substituents can together also form a ring, Y is a hydrogen atom or a lower alkyl radical, X is a hydrogen atom, a hydroxyl group or an amino group optionally substituted by lower alkyl and R is a hydrogen atom or a lower alkyl radical, with the proviso that Het is not a pyrazole ring; as well as the pharmacologically acceptable salts thereof.Type: GrantFiled: July 24, 1987Date of Patent: October 11, 1988Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall
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Patent number: 4770692Abstract: Novel herbicidal and plant-growth regulating pyrazoles of the formula ##STR1## in which R.sup.1 represents hydrogen, alkyl or halogenoalkyl,R.sup.2 represents nitro or cyano,R.sup.3 represents optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl or optionally substituted aryl,Ar represents phenyl which is substituted twice or more, or optionally substituted pyridyl, andY represents O, S, SO or SO.sub.2.Several intermediates therefor are also new.Type: GrantFiled: July 14, 1987Date of Patent: September 13, 1988Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Reinhold Gehring, Otto Schallner, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
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Patent number: 4703043Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: December 16, 1985Date of Patent: October 27, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4686298Abstract: Compounds of the formula ##STR1## are useful in the preparation of .alpha.-acyloxy phosphonate compounds. The final products are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: February 4, 1987Date of Patent: August 11, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Tamara Dejneka
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Patent number: 4670422Abstract: Compounds of the formula ##STR1## wherein X is various amino or imino acids and esters are disclosed. These compounds are useful as anti-hypertensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.Type: GrantFiled: March 27, 1986Date of Patent: June 2, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Tamara Dejneka
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Patent number: 4666895Abstract: The present invention provides diphosphonic acid derivatives of the general formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another or also together, signify hydrogen atoms or lower alkyl radicals, whereby R.sub.1 and X or R.sub.3 and Y or R.sub.4 and Z, together with the nitrogen atom to which they are attached, can form a five- or six-membered ring, X and Y, which can be the same or different, represent a straight-chained or branched alkylene chain with up to 6 carbon atoms which can optionally be substituted by aromatic or heteroaromatic radicals, Z is a straight-chained or branched alkylene chain with up to 6 carbon atoms, which can be interrupted by heteroatoms and can optionally also be substituted by aromatic or heteroaromatic radicals, n is 0, 1 or 2 and A is a hydrogen atom or a hydroxyl group, and the pharmacologically acceptable salts thereof.Type: GrantFiled: March 31, 1986Date of Patent: May 19, 1987Assignee: Boehringer Mannheim GmbHInventors: Elmar Bosies, Rudi Gall
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Patent number: 4665023Abstract: The present invention provides imidazole derivatives of the general formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are defined hereinbelow. The present invention is also concerned with processes for the preparation of these imidazole derivatives and with the use thereof as redox indicators.Type: GrantFiled: March 29, 1985Date of Patent: May 12, 1987Assignee: Boehringer Mannheim GmbHInventors: Ulfert Deneke, Werner Guthlein, Manfred Kuhr, Hartmut Merdes, Hans-Rudiger Murawski, Hans Wielinger
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Patent number: 4659657Abstract: Compounds of the formula ##STR1## wherein Y is ##STR2## M is hydrogen, or an alkali metal or ammonium ion, X is --O-- or an amino group,R is H, Cl, Br, CN or carbamoyl,R.sup.1 is H or --SO.sub.3 H, andA is one of several particular organic radicals,are especially useful in the photometric or fluorimetric determination of phosphatase or sulphatase activity in a liquid sample.Type: GrantFiled: December 14, 1983Date of Patent: April 21, 1987Assignee: Bayer AktiengesellschaftInventors: Horst Harnisch, Otto S. Wolfbeis
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Patent number: 4643993Abstract: Compounds of the formula ##STR1## wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is --SO.sub.3 H or ##STR2## R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors.Type: GrantFiled: May 18, 1983Date of Patent: February 17, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Antonio Giachetti, Piero del Soldato
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Patent number: 4640929Abstract: A novel 1,3-dithiane of the formula ##STR1## wherein R.sup.1 is a di-substituted amino group; R.sup.2 and R.sup.3 are such that one of them is an electron-withdrawing group with the other being a hydrogen atom, a hydrocarbon group or heterocyclic group of the class consisting of thienyl, triazolyl, and pyridyl, which may optionally be substituted or that R.sup.2 and R.sup.3 taken together with the adjacent carbon atom form a spiro ring provided that at least one of R.sup.2 and R.sup.3 is a carbonyl group; X.sup.1 and X.sup.2 each is a sulfur atom and at least one of X.sup.1 and X.sup.2 may be oxidized, or a salt thereof, possesses very useful pesticidal actions.Type: GrantFiled: August 23, 1983Date of Patent: February 3, 1987Assignee: Takeda Chemical Industries, Ltd.Inventors: Hiroyuki Mitsudera, Kazuo Konishi, Yasuo Sato
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Patent number: 4617295Abstract: Oxime N-alkyl-N-.alpha.-(alkylthio-phosphorothio)acyl carbamates represented the structure: ##STR1## wherein the R represents various imino radicals, Q is oxygen or sulfur and the numbered R groups represent various alkyl substituents, which exhibit superior insecticidal and miticidal activity.Type: GrantFiled: October 3, 1985Date of Patent: October 14, 1986Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4616005Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: December 16, 1985Date of Patent: October 7, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4568671Abstract: Oxime N-alkyl-N-.alpha.-(alkylthio-phosphorothio)acyl carbamates represented the structure: ##STR1## wherein the R represents various imino radicals, Q is oxygen or sulfur and the numbered R groups represent various alkyl substituents, which exhibit superior insecticidal and miticidal activity.Type: GrantFiled: June 30, 1983Date of Patent: February 4, 1986Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: 4567166Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: March 19, 1984Date of Patent: January 28, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4562185Abstract: The present invention relates to combating pests with five-membered nitrogen-containing heterocyclic compounds of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3, X and Y have the meaning given in the description. Many of the compounds are new.Type: GrantFiled: March 15, 1984Date of Patent: December 31, 1985Assignee: Bayer AktiengesellschaftInventors: Gerhard Jager, Rudolf Fauss, Kurt Findeisen, Benedikt Becker, Bernhard Homeyer
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Patent number: 4560681Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.Type: GrantFiled: March 9, 1984Date of Patent: December 24, 1985Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4560680Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.Type: GrantFiled: May 10, 1984Date of Patent: December 24, 1985Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
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Patent number: 4551447Abstract: Novel compounds of the formula ##STR1## wherein R.sup.1 is (halo)alkyl or optionally substituted phenyl; R.sup.2 is H, or alkyl; R.sup.3 and R.sup.4 each is alkyl; and X and Y each is O or S, are useful as insecticides and miticides.Type: GrantFiled: April 24, 1985Date of Patent: November 5, 1985Assignee: Shell Oil CompanyInventor: Willy D. Kollmeyer
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Patent number: 4533658Abstract: Oxadiazole compounds of the formula ##STR1## wherein X is sulfur or oxygen; Y is sulfur or oxygen; R.sub.1 is methyl, ethyl isopropyl or cyclopropyl; and R.sub.2 is ethyl or isopropyl, provided that when R.sub.1 is methyl or ethyl, R.sub.2 is not ethyl, are effective as corn root worm insecticides.Type: GrantFiled: April 19, 1984Date of Patent: August 6, 1985Assignee: Chevron Research CompanyInventor: William F. King
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Patent number: 4506076Abstract: The present invention relates to new 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities and to processes for preparation thereof, to pharmaceutical compositions comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in humans and animals.This division relates to intermediate compounds, namely amino or amido-thiazolyl, substituted oxyimino disubstituted acetic acid of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is --CONH--R.sup.5, --NHCO--R.sup.5, or ##STR2## R.sup.5 is aryl or heterocyclic, either of which may be substituted, R.sup.6 is hydrogen or lower alkyl, andA is lower alkylene, or a salt thereof.Type: GrantFiled: April 29, 1981Date of Patent: March 19, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takashi Kamiya, Kunihiko Tanaka, Tsutomu Teraji, Yoshiharu Nakai
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Patent number: 4503049Abstract: Diphosphonic acid derivatives of Formula I ##STR1## wherein R is hydrogen, an alkali metal atom, an alkaline earth metal atom, or an alkyl group of 1-4 carbon atoms andA is derived from a carboxylic acid having anti-inflammatory and antiphlogistic activity and containing an aromatic or heteroaromatic group, of Formula IIACOOH (II),are pharmacologically efficacious compounds.Type: GrantFiled: January 27, 1983Date of Patent: March 5, 1985Assignee: Schering AktiengesellschaftInventors: Helmut Biere, Clemens Rufer, Irmgard Boettcher
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Patent number: 4497804Abstract: An organophosphate of the formula ##STR1## wherein R.sup.1 is an alkyl group containing 3 to 4 carbon atoms or an alkoxyethyl group having an alkoxy moiety containing 1 to 4 carbon atoms,R.sup.2 is a hydrogen atom or a methyl group, andR.sup.3 is an alkyl group containing 1 to 4 carbon atoms or a phenyl group which may be substituted by at least one member selected from the group consisting of a halogen atom, a trifluoromethyl group, a nitro group, an alkyl group containing 1 to 4 carbon atoms, and an alkoxy group containing 1 to 4 carbon atoms,which possesses pesticidal, e.g. insecticidal, acaricidal and nematocidal, activity.Type: GrantFiled: November 12, 1982Date of Patent: February 5, 1985Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Akio Kudamatsu, Toyohiko Kume, Shinichi Tsuboi
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Patent number: 4496730Abstract: Phosphorous diketonate electron accepting compounds are disclosed for use as sensitizers in electron donating photoconductive compositions. Methine dyes having a phosphorous diketonate component and a method of making same are also disclosed.Type: GrantFiled: September 20, 1982Date of Patent: January 29, 1985Assignee: Eastman Kodak CompanyInventors: Chin H. Chen, Thomas E. Goliber, Jerome H. Perlstein, George A. Reynolds
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Patent number: 4479946Abstract: Novel phosphorus esters of amidoximes and methods of preparing same. This invention is also directed to pesticidal compositions comprising an acceptable carrier and a pesticidally effective amount of a compound of this invention, as well as to a method of controlling pests which comprises subjecting the pests to a pesticidally effective amount of a compound of this invention.Type: GrantFiled: June 17, 1982Date of Patent: October 30, 1984Assignee: Union Carbide CorporationInventors: Leonard E. Hodakowski, Dean F. Bushey
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Patent number: 4475942Abstract: The invention provides diiminourea, isothiourea and diisothiourea salts of N-Phosphonomethylglycine. The invention also provides phytotoxic compositions containing the same.Type: GrantFiled: August 27, 1982Date of Patent: October 9, 1984Assignee: Geshuri Laboratories Ltd.Inventor: Izhak Bakel
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Patent number: 4469877Abstract: This invention relates to photographic products and processes employing silver halide solvent precursors of the formula ##STR1## wherein R.sup.1 is a monovalent organic radical; R.sup.2 is hydrogen or a monovalent organic radical; Z is a moiety that undergoes .beta.-elimination in aqueous alkaline solution and preferably is a moiety that undergoes .beta.-elimination in aqueous alkaline solution to release a photographically useful reagent; and n is an integer 3, 4 or 5.Type: GrantFiled: March 14, 1983Date of Patent: September 4, 1984Assignee: Polaroid CorporationInventors: Alan L. Borror, Ernest W. Ellis
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Patent number: 4452790Abstract: Phosphonyl hydroxyacyl amino acids of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: June 23, 1982Date of Patent: June 5, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4452791Abstract: Compounds of the structure ##STR1## are provided which are inhibitors of angiotensin converting enzyme and are useful in the treatment of hypertension.Type: GrantFiled: March 15, 1982Date of Patent: June 5, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Denis E. Ryono, Edward W. Petrillo, Jr.
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Patent number: 4450157Abstract: Heterocyclic compounds of the formula ##STR1## wherein A is a group ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and X are as defined hereinafter, process for their preparation, as well as pesticidal compositions containing one or more of these compounds as the active ingredient and methods for using the pesticidal compositions for the control of pests, particularly insects, mites and nematodes, are described.Type: GrantFiled: June 11, 1982Date of Patent: May 22, 1984Assignee: Hoffmann-La Roche Inc.Inventor: Christoph Luthy
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Patent number: 4448772Abstract: This invention is directed to phosphinylmethylaminocarbonyl imino acid compounds of the formula ##STR1## wherein X represents various unsubstituted or substituted imino acids or esters.Type: GrantFiled: April 22, 1982Date of Patent: May 15, 1984Assignee: E. R. Squibb & Sons, Inc.Inventor: Donald S. Karanewsky
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Patent number: 4444765Abstract: Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.Type: GrantFiled: July 14, 1982Date of Patent: April 24, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4432971Abstract: Phosphonamidates of the formula ##STR1## wherein X is a substituted or unsubstituted imino or amino acid or ester. These compounds possess angiotensin converting enzyme activity and are thus useful as hypotensive agents.Type: GrantFiled: June 28, 1982Date of Patent: February 21, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Donald S. Karanewsky, Edward W. Petrillo, Jr.
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Patent number: 4425338Abstract: Novel alpha-heterocyclic carbinol phosphates have been found to exhibit insecticidal and miticidal activity.Type: GrantFiled: March 31, 1982Date of Patent: January 10, 1984Assignee: Union Carbide CorporationInventor: Jamin Huang
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Patent number: 4399287Abstract: There are described compounds of the formula I, ##STR1## in which R.sup.5 is methyl or halomethyl,R.sup.2 is --CN, --CONRyRz, --COOR.sup.6 or --COSR.sup.6,R.sup.1 and R.sup.6 each represent hydrogen, a cation or an optionally substituted alkyl, alkenyl, alkynyl or aryl,Ry and Rz each represent hydrogen, alkyl or aryl,A represents hydrogen, orA and one of --XR.sup.3 and --ZR.sup.4 together form a double bond, and the other of --XR.sup.3 and --ZR.sup.4 represents --OR.sup.10 or --NHR.sup.11 in which R.sup.10 is alkyl or acyl and R.sup.11 is alkyl, aryl or acyl,X and Z (when not forming part of a double bond with A), which may be the same or different, each represent oxygen, sulphur or a group --NR.sup.7 --,R.sup.7 represents hydrogen or alkyl,R.sup.3 and R.sup.4 each represent alkyl or R.sup.3 and R.sup.4 together form an optionally substituted alkylene or arylene chainor --XR.sup.3 and --ZR.sup.4 together form .dbd.C(CN).sub.2 or .dbd.NR.sup.8, in which R.sup.Type: GrantFiled: December 5, 1980Date of Patent: August 16, 1983Assignee: FBC LimitedInventors: Alister C. Baillie, Brian J. Wright, Kenneth Wright, Christopher G. Earnshaw
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Patent number: 4379146Abstract: There are disclosed substituted phosphonamides and related compounds which are useful as converting enzyme inhibitors and as antihypertensives.Type: GrantFiled: November 5, 1981Date of Patent: April 5, 1983Assignee: Merck & Co., Inc.Inventors: William J. Greenlee, Elbert E. Harris, Arthur A. Patchett, Eugene D. Thorsett