2-position Substituent Contains Nitrogen, Other Than As Nitro Or Nitroso Patents (Class 548/238)
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Patent number: 4863946Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group,X represents O or NR.sup.o wherein R.sup.o represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, an alkanoyl group substituted or unsubstituted in the alkyl moiety, or an arylalkyl moiety substituted or unsubstituted in the aryl moiety.n represents an integer 1 or 2,m represents an integer 1 or 2,p represents an integer 2 or 3, andq represents an integer in the range of from 1 to 12; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.Type: GrantFiled: December 1, 1986Date of Patent: September 5, 1989Assignee: Beecham Group plcInventor: John M. Berge
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Patent number: 4851422Abstract: The compound represented by the formula: ##STR1## where R.sup.1 stands for amino or an organic residue bonded through nitrogen; R.sup.2 stands for carboxyl or a group derivable therefrom; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently stand for hydrogen or an organic residue, including the case where R.sup.5 or R.sup.6 forms a chemical bond or a ring with R.sup.7 or R.sup.8 ; X stands for hydrogen, methoxy or formylamino; or a salt thereof, produceable by the present method, exhibits excellent antimicrobial activity, and is utilized as antimicrobial agents.Type: GrantFiled: April 30, 1986Date of Patent: July 25, 1989Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideaki Natsugari, Yasuhiko Kawano, Akira Morimoto, Kouichi Yoshioka
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Patent number: 4841065Abstract: Substituted isoxazoles of the formula ##STR1## in which R.sub.1 denotes C.sub.1 -C.sub.4 alkyl, R.sub.2 denotes hydrogen, C.sub.1 -C.sub.4 alkyl chlorine or bromine, R.sub.3 and R.sub.4, which are the same or different are hydrogen or C.sub.1 -C.sub.4 alkyl, but not both hydrogen and n denotes the interger 6, 7, or 8. The novel ocmpounds have a pronounced antiviral action and can be employed for the treatment and prophylaxis of virus diseases.Type: GrantFiled: January 11, 1988Date of Patent: June 20, 1989Assignee: CL Pharma AktiengesellschaftInventors: Dieter Binder, Franz Rovenszky, Hubert P. Ferber
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Patent number: 4835280Abstract: The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.Type: GrantFiled: July 14, 1987Date of Patent: May 30, 1989Assignee: Boehringer Mannheim GmbHInventors: Alfred Martens, Jens-Peter Holck, Herbert Berger, Bernd Muller-Beckman, Klaus Strein, Egon Roesch
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Patent number: 4833252Abstract: Substituted N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts thereof with amines, alkali metal bases or alkaline earth metal bases, or with quaternary ammonium bases, have good pre- and postemergence selective herbicidal and growth regulating properties.In the above formula the symbols have the following meanings:R.sup.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, --CO--R.sup.8, --NR.sup.9 R.sup.10, --CO--NR.sup.11 R.sup.12 or --SO.sub.2 --NR.sup.13 R.sup.14,R.sup.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl,R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or cyano,R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl,R.sup.5 is hydrogen, C.sub.Type: GrantFiled: September 28, 1988Date of Patent: May 23, 1989Assignee: Ciba-Geigy CorporationInventors: Werner Topfl, Georg Pissiotas
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Patent number: 4832732Abstract: Novel herbicidal 1-methyl-1H-imidazole -5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Further the invention also relates to a process for making these novel compounds.Type: GrantFiled: December 17, 1987Date of Patent: May 23, 1989Assignee: Janssen Pharmaceutica N.V.Inventors: William R. Lutz, Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren
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Patent number: 4824472Abstract: Novel herbicidal 1-cyclyl or polycyclyl substituted 1H-imidazole-5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Processes for making these novel compounds.Type: GrantFiled: December 23, 1987Date of Patent: April 25, 1989Assignee: Janssen Pharmaceutica N.V.Inventors: Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren, William R. Lutz
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Patent number: 4812472Abstract: Substituted isoxazole derivatives of the formula ##STR1## in which R.sub.1 denotes lower alkyl, n denotes the integer 6, 7 or 8, A denotes a group of the formula ##STR2## and R.sub.2 denotes hydrogen, methyl, chlorine or bromine. The novel compounds have a pronounced antiviral action and can be employed for the treatment and prophylaxis of virus diseases.Type: GrantFiled: November 12, 1987Date of Patent: March 14, 1989Assignee: Chemie Linz AkteingesellschaftInventors: Dieter Binder, Franz Rovenszky
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Patent number: 4772309Abstract: A 5-Acylamino-pyrazole derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen or nitro,R.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl or optionally substituted cycloalkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen or alkyl,X represents oxygen or sulphur,n represents the integer 0, 1 or 2,Ar represents in each case optionally substituted phenyl or pyridyl andHet represents an optionally substituted 5- or 6- membered heterocyclic radical linked via a carbon atom,which exhibit herbicidal and plant growth regulating activity.Type: GrantFiled: March 19, 1987Date of Patent: September 20, 1988Assignee: Bayer AktiengesellschaftInventors: Jorg Stetter, Reinhold Gehring, Otto Schallner, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
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Patent number: 4740231Abstract: 1-Aryl-5-alkoximinoalkylamino-pyrazoles of the formula ##STR1## in which R represents cyano or nitro, or represents an optionally substituted heterocyclic radical,R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen or alkyl, or represents optionally substituted aryl,R.sup.3 represents hydrogen, alkyl or alkenyl, or represents in each case optionally substituted aralkyl or aryl andAr represents optionally substituted phenyl or pyridyl,are active as herbicides and plant growth regulants. Compounds of the formula ##STR2## in which R" has the same definition as R other than cyano, are also active and useful as intermediates as well.Type: GrantFiled: May 22, 1986Date of Patent: April 26, 1988Assignee: Bayer AktiengesellschaftInventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
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Patent number: 4721790Abstract: Fluoronitroaralkyloxazolines are prepared by reacting a fluoronitroaromatic compound with an alpha-substituted 2-alkyloxazoline in an inert solvent and in the presence of a base. Fluoronitroaralkyloxazolines are useful intermediates for the synthesis of pharmaceuticals, such as flurbiprofen.Type: GrantFiled: November 13, 1984Date of Patent: January 26, 1988Assignee: Ethyl CorporationInventor: Kenneth C. Lilje
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Patent number: 4709039Abstract: This invention relates to new organic compounds, including 2-(2-allyloxy-1-methylethyl)-2-oxazoline and 2-(vinylbenzyloxy-1-methylethyl)-2-oxazoline. Its method of preparation comprises condensing 2-(3-hydroxy-2-propyl)-2-oxazoline with allyl chloride and vinylbenzyl chloride, respectively, in a phase transfer process. The invention is also directed to a method of copolymerizing 2-ethyloxazoline with such compounds.Type: GrantFiled: March 21, 1986Date of Patent: November 24, 1987Assignee: The Dow Chemical CompanyInventor: Richard T. Chou
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Patent number: 4639535Abstract: Disclosed are trisubstituted benzene derivatives of the formula ##STR1## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.2 R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran. Said compounds are valuable intermediates in the preparation of certain anti-allergic chromone or thiochromone-5-oxamic acid derivatives.Type: GrantFiled: October 30, 1985Date of Patent: January 27, 1987Assignee: Miles Laboratories, Inc.Inventors: Trevor S. Abram, Peter Norman, Brian T. Warren
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Patent number: 4629794Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.Type: GrantFiled: January 23, 1986Date of Patent: December 16, 1986Assignee: Pfizer Inc.Inventor: John P. Dirlam
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Patent number: 4599410Abstract: Methine dyes are disclosed which contain a 2-halo or pseudohalo substituted 1,2,5-oxatellurazole ring fused with an aromatic nucleus, the aromatic nucleus being substituted with a methine linkage terminating in an auxochrome providing a conjugated resonance chromophore. The dyes can be formed by condensing a methine linkage precursor with a compound containing an oxatellurazole ring fused with an aromatic nucleus. The dyes are useful in optical recording elements and in photographic elements.Type: GrantFiled: February 19, 1985Date of Patent: July 8, 1986Assignee: Eastman Kodak CompanyInventor: Wolfgang H. H. Gunther
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Patent number: 4584385Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.Type: GrantFiled: February 4, 1985Date of Patent: April 22, 1986Assignee: Pfizer Inc.Inventor: John P. Dirlam
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Patent number: 4518782Abstract: Disclosed are fuel compositions including alcohol-extended fuels containing friction-reducing, anti-corrosion and detergent amounts of at least one fuel soluble glycine derivative of the formula:RNHCH.sub.2 Xwherein R is a hydrocarbyl group having 6 to 18 carbons and X is ##STR1## wherein R.sub.1 is lower alkyl having 1 to 5 carbon atoms; R.sub.2 is alkylene having 1 to 5 carbon atoms; R.sub.3 is an alkylamino or alkylpolyamino group having 1 to 5 carbon atoms.Type: GrantFiled: August 10, 1981Date of Patent: May 21, 1985Assignee: Texaco Inc.Inventors: Rodney L. Sung, Benjamin J. Kaufman, Peter Dorn
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Patent number: 4513004Abstract: The invention relates to indole derivatives identified herein by Formula (I) and a method for their preparation.Also included in the invention are compositions containing said indoles and methods for their use as antiphlogistic agents.Type: GrantFiled: February 3, 1983Date of Patent: April 23, 1985Assignee: Troponwerke GmbH & Co. KGInventors: Karl-Heinz Boltze, Harald Horstmann
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Patent number: 4440940Abstract: This disclosure describes 2- or 3-[(unsaturated or cyclopropylated alkyl)amino]phenyl compounds and derivatives useful as hypolipidemic and antiatherosclerotic agents.Type: GrantFiled: November 19, 1981Date of Patent: April 3, 1984Assignee: American Cyanamid CompanyInventor: Robert G. Shepherd
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Patent number: 4391814Abstract: Compounds of Formula I ##STR1## wherein R.sub.1 is the residue of an antiphlogistically effective carboxylic acid of the formula R.sub.1 COOH,n is an integer 1, 2, or 3, andX is oxygen, sulfur, or optionally alkylated nitrogenhave valuable antiinflammatory activity.Type: GrantFiled: December 23, 1981Date of Patent: July 5, 1983Assignee: Schering AktiengesellschaftInventor: Helmut Vorbruggen
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Patent number: 4378357Abstract: This invention relates to novel heterocyclic fungicides which are effective in controlling a broad spectrum of phytopathogenic fungi found in the four main classes of fungi namely Phycomycetes, Ascomycetes, Fungi Imperfecti, and Basidiomycetes. Certain of these compounds are especially effective in controlling sclerotial forming fungi such as Whetzelinia sclerotiorum=(Sclerotinia sclerotiorium) and Botrytis cinerea.Type: GrantFiled: December 16, 1977Date of Patent: March 29, 1983Assignee: Rohm and Haas CompanyInventors: George A. Miller, Lendon N. Pridgen
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Patent number: 4294772Abstract: Tin-containing oxime derivatives of the formula ##STR1## wherein n is 0, 1 or 2,m is 0 or 1,Ar is an optionally substituted phenyl radical or an optionally substituted naphthyl radical, or when m is 0, Ar may also be an ester group,X is hydrogen, --CN, halogen, lower alkyl, lower alkanoyl, --COOH, a carboxylic acid ester radical, a carbamoyl radical andR.sub.8, R.sub.9 and R.sub.10, each independently of the other, are alkyl, aryl, aralkyl or C.sub.3 -C.sub.7 cycloalkyl, are suitable for protecting cultivated plants from the phytotoxic action of aggressive agrochemicals, in particular herbicides preferred are compounds of the above formula in whichAr is alkylphenyl, alkoxyphenyl, halophenyl, naphthyl or amido,X is cyano or a carboxylic acid ester radical, andR.sub.8, R.sub.9 and R.sub.10 are the same and are C.sub.1 -C.sub.4 alkyl, benzyl or phenyl.Type: GrantFiled: August 20, 1979Date of Patent: October 13, 1981Assignee: Ciba-Geigy CorporationInventor: Henry Martin
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Patent number: 4292184Abstract: Thio-bis-(hydrocarbon-bisoxazolines) which are the reaction products of thio-bis-(hydrocarbon substituted dicarboxylic acid material), for example, thio-bis-(polyisobutenyl succinic anhydride), with 2,2-disubstituted-2-amino-1-alkanols, such as tris-(hydroxymethyl) amino-methane (THAM), and their derivatives are useful additives in oleaginous compositions, such as sludge dispersants for lubricating oil, or anti-corrosion agents for fuels.Type: GrantFiled: March 27, 1980Date of Patent: September 29, 1981Assignee: Exxon Research & Engineering Co.Inventors: Stanley J. Brois, Antonio Gutierrez
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Patent number: 4263317Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as antidepressants, tranquilizers, analgesics and anticonvulsants.Type: GrantFiled: September 6, 1979Date of Patent: April 21, 1981Assignee: Hoechst-Roussel Pharmaceuticals, Inc.Inventors: Lawrence L. Martin, Manfred Worm
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Patent number: 4253982Abstract: Lubricant compositions are provided containing antiwear improving amounts of a bis-oxazoline having an alkyl group containing from about 4 to about 24 carbon atoms.Type: GrantFiled: August 1, 1975Date of Patent: March 3, 1981Assignee: Mobil Oil CorporationInventors: Robert F. Bridger, Kirk D. Schmitt
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Patent number: 4225336Abstract: Phenoxyalkyloxyzolines corresponding to the formula ##STR1## wherein R is hydrogen or methylZ is a Phenyl-or Pyridyl-radical ##STR2## R.sub.1 is halogen, trifluoromethyl, cyano or nitro R.sub.2 is hydrogen, halogen or cyanoR.sub.3 is halogen trifluoromethyl or cyano andn is 1 or 2.are effective herbicides which are tolerant towards cereal.Type: GrantFiled: July 30, 1979Date of Patent: September 30, 1980Assignee: Ciba-Geigy CorporationInventors: Werner Fory, Hermann Rempfler, Georg Pissiotas, Otto Rohr, Beat Bohner
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Patent number: 4169836Abstract: Derivatives of Oxazoline reaction products of hydrocarbon substituted dicarboxylic acid, ester, or anhydride, for example octadecenylsuccinic anhydride and polyisobutenylsuccinic anhydride with 2,2-disubstituted-2-amino-1-alkanols, such as tris-hydroxymethylaminomethane (THAM) are useful additives in oleaginous compositions, such as sludge dispersants for lubricating oil, or anti-rust agents for gasoline.Type: GrantFiled: July 5, 1977Date of Patent: October 2, 1979Assignee: Exxon Research & Engineering Co.Inventors: Jack Ryer, James Zielinski, Harold N. Miller, Stanley J. Brois