2-position Substituent Contains Nitrogen, Other Than As Nitro Or Nitroso Patents (Class 548/238)
  • Patent number: 4863946
    Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Z represents a residue of a substituted or unsubstituted aryl group,X represents O or NR.sup.o wherein R.sup.o represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, an alkanoyl group substituted or unsubstituted in the alkyl moiety, or an arylalkyl moiety substituted or unsubstituted in the aryl moiety.n represents an integer 1 or 2,m represents an integer 1 or 2,p represents an integer 2 or 3, andq represents an integer in the range of from 1 to 12; pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine.
    Type: Grant
    Filed: December 1, 1986
    Date of Patent: September 5, 1989
    Assignee: Beecham Group plc
    Inventor: John M. Berge
  • Patent number: 4851422
    Abstract: The compound represented by the formula: ##STR1## where R.sup.1 stands for amino or an organic residue bonded through nitrogen; R.sup.2 stands for carboxyl or a group derivable therefrom; R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 independently stand for hydrogen or an organic residue, including the case where R.sup.5 or R.sup.6 forms a chemical bond or a ring with R.sup.7 or R.sup.8 ; X stands for hydrogen, methoxy or formylamino; or a salt thereof, produceable by the present method, exhibits excellent antimicrobial activity, and is utilized as antimicrobial agents.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: July 25, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Hideaki Natsugari, Yasuhiko Kawano, Akira Morimoto, Kouichi Yoshioka
  • Patent number: 4841065
    Abstract: Substituted isoxazoles of the formula ##STR1## in which R.sub.1 denotes C.sub.1 -C.sub.4 alkyl, R.sub.2 denotes hydrogen, C.sub.1 -C.sub.4 alkyl chlorine or bromine, R.sub.3 and R.sub.4, which are the same or different are hydrogen or C.sub.1 -C.sub.4 alkyl, but not both hydrogen and n denotes the interger 6, 7, or 8. The novel ocmpounds have a pronounced antiviral action and can be employed for the treatment and prophylaxis of virus diseases.
    Type: Grant
    Filed: January 11, 1988
    Date of Patent: June 20, 1989
    Assignee: CL Pharma Aktiengesellschaft
    Inventors: Dieter Binder, Franz Rovenszky, Hubert P. Ferber
  • Patent number: 4835280
    Abstract: The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: May 30, 1989
    Assignee: Boehringer Mannheim GmbH
    Inventors: Alfred Martens, Jens-Peter Holck, Herbert Berger, Bernd Muller-Beckman, Klaus Strein, Egon Roesch
  • Patent number: 4833252
    Abstract: Substituted N-phenylsulfonyl-N'-pyrimidinylureas and N-phenylsulfonyl-N'-triazinylureas of the general formula ##STR1## and the salts thereof with amines, alkali metal bases or alkaline earth metal bases, or with quaternary ammonium bases, have good pre- and postemergence selective herbicidal and growth regulating properties.In the above formula the symbols have the following meanings:R.sup.1 is hydrogen, halogen, nitro, cyano, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkylsulfinyl, --CO--R.sup.8, --NR.sup.9 R.sup.10, --CO--NR.sup.11 R.sup.12 or --SO.sub.2 --NR.sup.13 R.sup.14,R.sup.2 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl or C.sub.1 -C.sub.4 alkylsulfonyl,R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl or cyano,R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl,R.sup.5 is hydrogen, C.sub.
    Type: Grant
    Filed: September 28, 1988
    Date of Patent: May 23, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Topfl, Georg Pissiotas
  • Patent number: 4832732
    Abstract: Novel herbicidal 1-methyl-1H-imidazole -5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Further the invention also relates to a process for making these novel compounds.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: May 23, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: William R. Lutz, Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren
  • Patent number: 4824472
    Abstract: Novel herbicidal 1-cyclyl or polycyclyl substituted 1H-imidazole-5-carboxylic acid derivatives, compositions containing these compounds as active ingredients, and a method for controlling weeds, preferably selectively in crops of useful plants. Processes for making these novel compounds.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: April 25, 1989
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Guy R. E. Van Lommen, Victor Sipido, Wim G. Verschueren, William R. Lutz
  • Patent number: 4812472
    Abstract: Substituted isoxazole derivatives of the formula ##STR1## in which R.sub.1 denotes lower alkyl, n denotes the integer 6, 7 or 8, A denotes a group of the formula ##STR2## and R.sub.2 denotes hydrogen, methyl, chlorine or bromine. The novel compounds have a pronounced antiviral action and can be employed for the treatment and prophylaxis of virus diseases.
    Type: Grant
    Filed: November 12, 1987
    Date of Patent: March 14, 1989
    Assignee: Chemie Linz Akteingesellschaft
    Inventors: Dieter Binder, Franz Rovenszky
  • Patent number: 4772309
    Abstract: A 5-Acylamino-pyrazole derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, halogen or nitro,R.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl or optionally substituted cycloalkyl,R.sup.3 represents hydrogen or alkyl,R.sup.4 represents hydrogen or alkyl,X represents oxygen or sulphur,n represents the integer 0, 1 or 2,Ar represents in each case optionally substituted phenyl or pyridyl andHet represents an optionally substituted 5- or 6- membered heterocyclic radical linked via a carbon atom,which exhibit herbicidal and plant growth regulating activity.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: September 20, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jorg Stetter, Reinhold Gehring, Otto Schallner, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
  • Patent number: 4740231
    Abstract: 1-Aryl-5-alkoximinoalkylamino-pyrazoles of the formula ##STR1## in which R represents cyano or nitro, or represents an optionally substituted heterocyclic radical,R.sup.1 represents hydrogen or alkyl,R.sup.2 represents hydrogen or alkyl, or represents optionally substituted aryl,R.sup.3 represents hydrogen, alkyl or alkenyl, or represents in each case optionally substituted aralkyl or aryl andAr represents optionally substituted phenyl or pyridyl,are active as herbicides and plant growth regulants. Compounds of the formula ##STR2## in which R" has the same definition as R other than cyano, are also active and useful as intermediates as well.
    Type: Grant
    Filed: May 22, 1986
    Date of Patent: April 26, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Otto Schallner, Jorg Stetter, Hans-Joachim Santel, Robert R. Schmidt, Klaus Lurssen
  • Patent number: 4721790
    Abstract: Fluoronitroaralkyloxazolines are prepared by reacting a fluoronitroaromatic compound with an alpha-substituted 2-alkyloxazoline in an inert solvent and in the presence of a base. Fluoronitroaralkyloxazolines are useful intermediates for the synthesis of pharmaceuticals, such as flurbiprofen.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: January 26, 1988
    Assignee: Ethyl Corporation
    Inventor: Kenneth C. Lilje
  • Patent number: 4709039
    Abstract: This invention relates to new organic compounds, including 2-(2-allyloxy-1-methylethyl)-2-oxazoline and 2-(vinylbenzyloxy-1-methylethyl)-2-oxazoline. Its method of preparation comprises condensing 2-(3-hydroxy-2-propyl)-2-oxazoline with allyl chloride and vinylbenzyl chloride, respectively, in a phase transfer process. The invention is also directed to a method of copolymerizing 2-ethyloxazoline with such compounds.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: November 24, 1987
    Assignee: The Dow Chemical Company
    Inventor: Richard T. Chou
  • Patent number: 4639535
    Abstract: Disclosed are trisubstituted benzene derivatives of the formula ##STR1## wherein B is selected from the group consisting of --NHCOC(CH.sub.3).sub.3, 1,3-oxazolinyl and --CONHR, wherein R is methyl, phenyl, or t-butyl; Y is selected from the group consisting of CO.sub.2 H, CHO, CO.sub.2 R' and COR', wherein R' is a lower alkyl having from 1 to 4 carbon atoms; and A is H or tetrahydropyran. Said compounds are valuable intermediates in the preparation of certain anti-allergic chromone or thiochromone-5-oxamic acid derivatives.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: January 27, 1987
    Assignee: Miles Laboratories, Inc.
    Inventors: Trevor S. Abram, Peter Norman, Brian T. Warren
  • Patent number: 4629794
    Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.
    Type: Grant
    Filed: January 23, 1986
    Date of Patent: December 16, 1986
    Assignee: Pfizer Inc.
    Inventor: John P. Dirlam
  • Patent number: 4599410
    Abstract: Methine dyes are disclosed which contain a 2-halo or pseudohalo substituted 1,2,5-oxatellurazole ring fused with an aromatic nucleus, the aromatic nucleus being substituted with a methine linkage terminating in an auxochrome providing a conjugated resonance chromophore. The dyes can be formed by condensing a methine linkage precursor with a compound containing an oxatellurazole ring fused with an aromatic nucleus. The dyes are useful in optical recording elements and in photographic elements.
    Type: Grant
    Filed: February 19, 1985
    Date of Patent: July 8, 1986
    Assignee: Eastman Kodak Company
    Inventor: Wolfgang H. H. Gunther
  • Patent number: 4584385
    Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.
    Type: Grant
    Filed: February 4, 1985
    Date of Patent: April 22, 1986
    Assignee: Pfizer Inc.
    Inventor: John P. Dirlam
  • Patent number: 4518782
    Abstract: Disclosed are fuel compositions including alcohol-extended fuels containing friction-reducing, anti-corrosion and detergent amounts of at least one fuel soluble glycine derivative of the formula:RNHCH.sub.2 Xwherein R is a hydrocarbyl group having 6 to 18 carbons and X is ##STR1## wherein R.sub.1 is lower alkyl having 1 to 5 carbon atoms; R.sub.2 is alkylene having 1 to 5 carbon atoms; R.sub.3 is an alkylamino or alkylpolyamino group having 1 to 5 carbon atoms.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: May 21, 1985
    Assignee: Texaco Inc.
    Inventors: Rodney L. Sung, Benjamin J. Kaufman, Peter Dorn
  • Patent number: 4513004
    Abstract: The invention relates to indole derivatives identified herein by Formula (I) and a method for their preparation.Also included in the invention are compositions containing said indoles and methods for their use as antiphlogistic agents.
    Type: Grant
    Filed: February 3, 1983
    Date of Patent: April 23, 1985
    Assignee: Troponwerke GmbH & Co. KG
    Inventors: Karl-Heinz Boltze, Harald Horstmann
  • Patent number: 4440940
    Abstract: This disclosure describes 2- or 3-[(unsaturated or cyclopropylated alkyl)amino]phenyl compounds and derivatives useful as hypolipidemic and antiatherosclerotic agents.
    Type: Grant
    Filed: November 19, 1981
    Date of Patent: April 3, 1984
    Assignee: American Cyanamid Company
    Inventor: Robert G. Shepherd
  • Patent number: 4391814
    Abstract: Compounds of Formula I ##STR1## wherein R.sub.1 is the residue of an antiphlogistically effective carboxylic acid of the formula R.sub.1 COOH,n is an integer 1, 2, or 3, andX is oxygen, sulfur, or optionally alkylated nitrogenhave valuable antiinflammatory activity.
    Type: Grant
    Filed: December 23, 1981
    Date of Patent: July 5, 1983
    Assignee: Schering Aktiengesellschaft
    Inventor: Helmut Vorbruggen
  • Patent number: 4378357
    Abstract: This invention relates to novel heterocyclic fungicides which are effective in controlling a broad spectrum of phytopathogenic fungi found in the four main classes of fungi namely Phycomycetes, Ascomycetes, Fungi Imperfecti, and Basidiomycetes. Certain of these compounds are especially effective in controlling sclerotial forming fungi such as Whetzelinia sclerotiorum=(Sclerotinia sclerotiorium) and Botrytis cinerea.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: March 29, 1983
    Assignee: Rohm and Haas Company
    Inventors: George A. Miller, Lendon N. Pridgen
  • Patent number: 4294772
    Abstract: Tin-containing oxime derivatives of the formula ##STR1## wherein n is 0, 1 or 2,m is 0 or 1,Ar is an optionally substituted phenyl radical or an optionally substituted naphthyl radical, or when m is 0, Ar may also be an ester group,X is hydrogen, --CN, halogen, lower alkyl, lower alkanoyl, --COOH, a carboxylic acid ester radical, a carbamoyl radical andR.sub.8, R.sub.9 and R.sub.10, each independently of the other, are alkyl, aryl, aralkyl or C.sub.3 -C.sub.7 cycloalkyl, are suitable for protecting cultivated plants from the phytotoxic action of aggressive agrochemicals, in particular herbicides preferred are compounds of the above formula in whichAr is alkylphenyl, alkoxyphenyl, halophenyl, naphthyl or amido,X is cyano or a carboxylic acid ester radical, andR.sub.8, R.sub.9 and R.sub.10 are the same and are C.sub.1 -C.sub.4 alkyl, benzyl or phenyl.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: October 13, 1981
    Assignee: Ciba-Geigy Corporation
    Inventor: Henry Martin
  • Patent number: 4292184
    Abstract: Thio-bis-(hydrocarbon-bisoxazolines) which are the reaction products of thio-bis-(hydrocarbon substituted dicarboxylic acid material), for example, thio-bis-(polyisobutenyl succinic anhydride), with 2,2-disubstituted-2-amino-1-alkanols, such as tris-(hydroxymethyl) amino-methane (THAM), and their derivatives are useful additives in oleaginous compositions, such as sludge dispersants for lubricating oil, or anti-corrosion agents for fuels.
    Type: Grant
    Filed: March 27, 1980
    Date of Patent: September 29, 1981
    Assignee: Exxon Research & Engineering Co.
    Inventors: Stanley J. Brois, Antonio Gutierrez
  • Patent number: 4263317
    Abstract: Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as antidepressants, tranquilizers, analgesics and anticonvulsants.
    Type: Grant
    Filed: September 6, 1979
    Date of Patent: April 21, 1981
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Lawrence L. Martin, Manfred Worm
  • Patent number: 4253982
    Abstract: Lubricant compositions are provided containing antiwear improving amounts of a bis-oxazoline having an alkyl group containing from about 4 to about 24 carbon atoms.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: March 3, 1981
    Assignee: Mobil Oil Corporation
    Inventors: Robert F. Bridger, Kirk D. Schmitt
  • Patent number: 4225336
    Abstract: Phenoxyalkyloxyzolines corresponding to the formula ##STR1## wherein R is hydrogen or methylZ is a Phenyl-or Pyridyl-radical ##STR2## R.sub.1 is halogen, trifluoromethyl, cyano or nitro R.sub.2 is hydrogen, halogen or cyanoR.sub.3 is halogen trifluoromethyl or cyano andn is 1 or 2.are effective herbicides which are tolerant towards cereal.
    Type: Grant
    Filed: July 30, 1979
    Date of Patent: September 30, 1980
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Hermann Rempfler, Georg Pissiotas, Otto Rohr, Beat Bohner
  • Patent number: 4169836
    Abstract: Derivatives of Oxazoline reaction products of hydrocarbon substituted dicarboxylic acid, ester, or anhydride, for example octadecenylsuccinic anhydride and polyisobutenylsuccinic anhydride with 2,2-disubstituted-2-amino-1-alkanols, such as tris-hydroxymethylaminomethane (THAM) are useful additives in oleaginous compositions, such as sludge dispersants for lubricating oil, or anti-rust agents for gasoline.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: October 2, 1979
    Assignee: Exxon Research & Engineering Co.
    Inventors: Jack Ryer, James Zielinski, Harold N. Miller, Stanley J. Brois