Abstract: Novel 13-spiro-2'-[tetrahydrofuran]-milbemycins of the formula I ##STR1## in which X represents one of the groups --CH(OR.sub.1)--, --C(.dbd.O)-- or --C(.dbd.N--OH)--;R.sub.1 represents hydrogen or a OH-protecting group;R.sub.2 represents methyl, ethyl, isopropyl or sec.-butyl or the group --C(CH.sub.3).dbd.CH--A in which A represents methyl, ethyl or isopropyl; andR.sub.3 represents hydrogen; C.sub.1 -C.sub.10 -alkyl; C.sub.1 -C.sub.10 -alkyl substituted by at least one substituent selected from the group consisting of halogen, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.6 -alkoxyalkoxy C.sub.3 -C.sub.9 -alkoxyalkoxyalkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.3 -alkyl-substituted C.sub.3 -C.sub.7 -cycloalkyl, hydroxy, benzyloxy, C.sub.1 -C.sub.6 -acyl and C.sub.1 -C.sub.6 -acyloxy, it being possible for each of the above-mentioned radicals representing or containing an alkoxy group to be terminally substituted at a terminal alkoxy group by hydroxy, halogen, C.sub.1 -C.sub.

Abstract: Novel coating compositions contain a radiation polymerizable acrylic monomer or oligomer and an ultraviolight-light absorbing effective amount of a UV-absorbing multimeric benzotriazole compound.

Abstract: Compounds of the Formula I, II, III, VI and VII ##STR1## wherein the symbols have defined meanings are herbicides, plant growth regulators or intermediates thereof.

Abstract: A process for efficiently preparing 2-amino-5-nitrophenol derivatives in which benzoxazole derivatives are subjected to nucleophilic substitution reaction at the 5 position thereof to obtain corresponding benzoxazole derivatives, and the oxazole ring of the benzoxazole derivatives is then subjected to ring-opening to obtain 2-amino-5-nitrophenol derivatives. The 2-amino-5-nitrophenol derivatives are useful as industrial starting materials, reducing agents or antioxidants and intermediates for cyan-image-forming couplers.

Abstract: Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.

Abstract: A process for preparing a compound of formula (I) ##STR1## wherein X phenyl optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sup.1 is hydrogen or C.sub.1-6 alkyl; and n is an integer of from 1 to 6; which process comprises, cyclizing a compound of formula (II): ##STR2## wherein X, R.sup.1 and n are as defined in relation to formula (I); Y is an hydroxy or an acid activating group and R.sup.x is hydrogen or an N- protecting group and thereafter if desired carrying out one or more of the following steps: (i) removing any protecting group R.sup.x, (ii) preparing a salt of the compound of formula (I).

Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2, or 3; the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides.

Abstract: This invention provides certain azole derivatives and their pharmaceutical formulations. Also provided is a method of inhibiting aromatase and treating or preventing estrogen-dependent diseases in mammals by administering the azole derivatives.

Abstract: Compound of the formula ##STR1## wherein X is --C(O)Hal, --CN, or --C(O)Y in which Y is OR.sup.1 or NR.sup.1 R.sup.2 in which R.sup.1 and R.sup.2 are H or hydrocarbyl or the like and R are certain optionally substituted hydrocarbyl and heterocyclic groups, are useful as herbicides and plant growth regulators or intermediates thereto. The intermediate 6-hydroxy and 6-oxo-2-oxabicyclo[2.2.1]heptane-4-carbonitriles are also new.

Abstract: Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine followed by reduction. These compounds were found to be potent topical anti-inflammatory agents.

Abstract: Novel amine oxide compounds of the formula ##STR1## in which m is the integer 1 or 2, A is a through-conjugated radical of a fluorescent brightener system, which radical contains unsubstituted or non-chromophorically substituted aromatic carbocyclic and/or heterocyclic rings, X is a direct bond between A and Y, an oxygen atom or sulfur atom or a group of the formula --SO.sub.2 --, --SO.sub.2 --O--, --COO--, --CON(R)-- or --SO.sub.2 N(R)--, in which R is hydrogen or unsubstituted or non-chromophorically substituted alkyl, Y is an unsubstituted or non-chromophorically substituted straight-chain or branched alkylene or alkyleneoxyalkylene group, and R.sub.1 and R.sub.2 independently of one another are cycloalkyl, unsubstituted or non-chromophorically substituted alkyl or phenyl, or R.sub.1 and R.sub.

Abstract: Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

Abstract: Novel compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are H or alkyl and R is an optionally-substituted unsaturated, cycloalkyl, secondary-alkyl, aromatic or heterocyclic group, are useful as plant growth regulators and herbicides. Certain intermediates are also novel.

Abstract: Oxidation in lubricants is reduced by adding to the lubricant a small portion of a triazole/dithiophosphate reaction product.

Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen or C.sub.1-6 alkyl, and R.sub.2 is hydroxy, C.sub.1-4 alkylsulphonyloxy or p-toluenesulphonyloxy are useful for the prophylaxis and treatment of diseases due to allergic response in mammals. Processes for their preparation are described.

Abstract: Novel antibacterially-active analogs of the antibiotics nodusmicin and nargenicin A.sub.1. These compounds are prepared by selectively blocking active hydroxyl groups at the 9, 11 and 18 positions of nodusmicin, and the 11 and 18 positions of nargenicin A.sub.1. Antibacterially-active compounds can be used in various environments to control or eradicate susceptible bacteria. The techniques for such use are well known in the art.

Abstract: Cationic fluorescent whitening agents of the formula ##STR1## wherein B is a fluorescent whitening agent containing basic tertiary amino groups, m is the number of basic amino groups, and each of R.sub.1, R.sub.2 and R.sub.3 is alkyl of 1 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups, or is alkenyl of 2 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups. These compounds have good solubility in water and they make it possible to prepare concentrated solutions and can be used for whitening organic material.

Abstract: Cationic fluorescent whitening agents of the formula ##STR1## wherein B is a fluorescent whitening agent containing basic tertiary amino groups, m is the number of basic amino groups, and each of R.sub.1, R.sub.2 and R.sub.3 is alkyl of 1 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups, or is alkenyl of 2 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups. These compounds have good solubility in water and they make it possible to prepare concentrated solutions and can be used for whitening organic material.

Abstract: A compound of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-6 alkyl;R.sub.2, R.sub.3 and R.sub.4 are the same or different and are chosen from hydrogen, hydroxyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and C.sub.1-4 alkanoyl;G is H or OH; andm and n are independently 1 to 3; with the proviso that when G is OH, one of m or n is 1; is useful in the prophylaxis and treatment of diseases whose symptoms are controlled by the mediators of the allergic response, for example asthma, hay fever, rhinitis and allergic eczema.

Abstract: Optical brighteners of the formula ##STR1## wherein B denotes a direct bond or the 1,4-phenylene radical andR.sub.1 and R.sub.2 independently of one another denote hydrogen, optionally substituted alkyl, aralkyl, cycloalkyl or aryl, or together form a fused aromatic ring,or the quaternisation products and protonation products thereof, are outstandingly suitable for the white tinting of polyester fibres or acrylic fibres. They are distinguished by a good build-up capacity and a small tendency to develop a green tone.

Abstract: Compounds of the formula (I), or pharmaceutically acceptable salts thereof ##STR1## wherein X is phenyl, optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6, pharmaceutical compositions containing them and a process for their preparation. These compounds are useful in the prophylaxis or treatment of diseases due to a histamine-mediated allergic response.

Abstract: A non-chromophoric conjugated derivative of 7-styryl coumarin for use as an optical brightener in which the lactone ring of the coumarinyl group may have a benzene ring fused to it to form a 3,4-benzocoumarinyl-7 group, the phenyl group of the styryl is substituted by a conjugated group which contains a group derived from an acid in its conjugation and which group is so located as to conjugate with the ethylene group.

Abstract: Cationic fluorescent whitening agents of the formula ##STR1## wherein B is a fluorescent whitening agent containing basic tertiary amino groups, m is the number of basic amino groups, and each of R.sub.1, R.sub.2 and R.sub.3 is alkyl of 1 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups, or is alkenyl of 2 to 4 carbon atoms which is unsubstituted or substituted by non-chromophoric groups. These compounds have good solubility in water and they make it possible to prepare concentrated solutions and can be used for whitening organic material.

Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.

Abstract: Novel antibiotic U-61,732 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against gram-positive bacteria, for example, Staphylococcus aureus. Also disclosed are the 11-acyl esters of U-61,732. Thus, these compounds can be used in various environments to eradicate or control such bacteria.

Abstract: Aryl-imidazol-1-yl vinyl ethers and their acid addition salts are disclosed, wherein the imidazolyl vinyl ether has the formula: ##STR1## Ar in the formula represents a substituted or unsubstituted aryl or heterocyclic radical; R represents hydrogen or a C.sub.1 -C.sub.12 alkyl or cycloalkyl (saturated or unsaturated) or Ar as above; Im represents a 1-H-imidazol-1-yl group (unsubstituted or substituted); and Y represents a saturated or unsaturated C.sub.1 -C.sub.12 alkyl or a group --Z--Ar in which Ar has the above meaning and --Z-- is a saturated or unsaturated C.sub.1 -C.sub.12 alkylene wherein each of the alkyl and the alkylene may have a carbon chain once or twice interrupted by or, in the case of the alkylene, terminated on its Ar-end by oxy, thio, sulfinyl or sulfonyl bridges, always with the proviso that at least one of Ar and Y is a heterocyclic radical. These compounds are wide-spectrum fungicides and bactericides, and the preferred compounds among them are hydrophilic.

Abstract: Coumarin compounds of the formula ##STR1## in which the substituents have the meanings given inthe description,are valuable whiteners for natural fibre materials, such as wool, or synthetic polycondensates. They can also be used as scintillators and laser dyestuffs.

Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamide azimido compounds and derivatives thereof are disclosed as for example N-(1-allyl-2-pyrrolidylmethyl)-7,8-azimido-1,4-benzodioxane-5-carboxamide and N-(1-allyl-2-pyrrolidylmethyl)-6,7-azimido-1,4-benzodioxane-5-carboxamide. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.

Abstract: A fluorescent pigment consisting of N-substituted iminocoumarins of the general formula I, ##STR1## wherein X.sub.1 is a cyano group, a carboxamido group or an aryl or a heteroaryl radical linked directly or through a --CO or --SO.sub.2 group,X.sub.2 is an amino group, hydroxy group or an alkoxy group and when it is an amino group, may carry an optionally substituted alkylene or alkylidene group bound in ortho position to the nitrogen atom and in para position with respect to the coumarin oxygen atom,X.sub.3 is a hydrogen atom, a halogen atom or a cyano group andX.sub.4 is a functionally converted carboxyl groups. The new dyestuffs dye polyester fiber in orange or red shades with good fastness.

Abstract: Triazoles of the formula ##STR1## in which R.sub.1 is hydrogen or a substituent of the type indicated in the description,R.sub.2 is a substituent, orR.sub.1 and R.sub.2, together with the triazole ring carbon atoms to which they are bonded, form a carbocyclic or heterocyclic ring, andR.sub.3 is the radical of an aromatic-carbocyclic or aromatic-heterocyclic system,are obtained in an elegant manner when compounds of the formula II are treated with a basic compound, preferably a tertiary amine. The triazoles are, inter alia, valuable starting materials for the preparation of optical brighteners.

Abstract: Compounds of the formula ##STR1## in which R.sub.1 denotes aryl, alkyl, aralkyl, styryl or alkoxy,R.sub.2 denotes hydrogen, cyano, carboxyl or alkoxycarbonyl, inter alia,R.sub.3, R.sub.4, R.sub.6 and R.sub.7 denote hydrogen, alkyl, alkoxy or halogen,R.sub.5 denotes hydrogen, alkyl or aryl,R.sub.8 and R.sub.9 denote hydrogen, cycloalkyl, alkenyl, alkyl or aralkyl,A.sup..crclbar. denotes an anion,w denotes the valency of the anion A andn denotes 0 or 1,are outstandingly suitable for optically brightening synthetic fibre materials, in particular acrylic fibres.The new brighteners are prepared and used in accordance with methods which are in themselves known.

Abstract: Optical brighteners of the formula ##STR1## wherein the radicals R.sub.1 to R.sub.9 are substituents customary in brightener chemistry,A.sup..crclbar. denotes a colorless anion,w denotes the valency of the anion A andn denotes 0 or 1,are obtained in a simple manner when a compound of the formula ##STR2## is heated to 110.degree.-200.degree. C. in an inert solvent, without the addition of a catalyst.

Abstract: Dyestuffs of the formula ##STR1## wherein R.sup.1, R.sup.2, R denote H, alkyl, alkenyl, cycloalkyl, aralkyl etc.R.sup.3, R.sup.4 denote H, alkyl, aralkyl, aryl, alkoxy, halogen, CN, COOH, alkoxycarbonyl, alkylsulfonyl, arylsulfonyl etc.Z denotes O, S or --N(R)--,p and q denote 0 or 1, but not simultaneously 0 andG stands for the remaining members of a ring system,with the proviso that R.sub.3 is not alkyl if G is a thiazole ring, are outstanding suitable for dyeing fibre materials of all kinds in clear yellow to violet shades with good fastness properties.

Abstract: Coumarine compounds of the formula ##STR1## in which R.sub.1 and R.sub.2 denote hydrogen, alkyl, cycloalkyl, aralkyl, aryl, nitrile, carboxyl, carboxylic acid ester or carboxylic acid amide groups, or together form a nonaromatic 5-membered or 6-membered ring system,R.sub.3 represents hydrogen, or alkyl or aryl radicals and Hal represents bromine or preferably chlorine as well as their production and use as optical brighteners.

Abstract: Novel substituted 2,3-alkylene bis (oxy) benzamides and derivatives thereof are disclosed. Also disclosed is a method for producing said compounds. The compounds have anxiolytic, psychostimulant, disinhibiting and thymoanaleptic properties useful therapeutically in the psychofunctional field, particularly in gastro-enterology, cardiology, urology, rheumatology and gynaecology.

Abstract: Polyester, cotton, polyamide and polyacrylonitrile fabrics and foils of polyvinylchloride are optically brightened by the addition of a compound of the formula ##STR1## in which each of R.sub.1 and R.sub.2 represents a hydrogen atom or an aliphatic, alicyclic, araliphatic, halogen- or alkyl-substituted araliphatic, aromatic, or halogen- or alkyl-substituted aromatic radical,R.sub.3 represents a hydrogen or halogen atom or a low molecular weight alkyl or alkoxy radical.