Additional Unsaturated Hetero Ring Attached Directly Or Indirectly To The Triazole Ring By Nonionic Bonding Patents (Class 548/266.2)
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Publication number: 20080249084Abstract: The present invention provides a triazole compound of the following formula: a prodrug thereof or a pharmaceutically acceptable salt thereof. The above-mentioned triazole compound is useful as a therapeutic drug for the treatment of diabetes, obesity or metabolic syndrome.Type: ApplicationFiled: October 27, 2004Publication date: October 9, 2008Inventors: Jay P. Powers, Mario G. Cardozo, Hiroyuki Goto, Kazuhito Harada, Katsuaki Imamura, Makoto Kakutani, Isamu Matsuda, Yasuhiro Ohe, Shinji Yata
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Publication number: 20080249150Abstract: Compounds useful for lowering beta amyloid levels are provided. The compounds have the structure of formula Ia: wherein, R1 is lower alkyl, substituted lower alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl, benzyloxy, substituted benzyloxy, or SO2R5; R5 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, alkyl, or substituted alkyl; R2 is lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, or cycloalkyl; R3 is hydrogen, lower alkyl, or substituted lower alkyl; R4 is phenyl, substituted phenyl, heterocycle, substituted heterocycle, thiophene, or substituted thiophene; R6 is hydrogen, lower alkyl, substituted lower alkyl, CF3, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, substituted phenyl, cycloalkyl, or substituted cycloalkyl; W, X and Y are independently CR7 or N; and R7 is hydrogen, halogen, lower alkyl, or substituted lower alkyl.Type: ApplicationFiled: June 19, 2008Publication date: October 9, 2008Applicant: WyethInventors: Lynn Resnick, Donna M. Huryn, Joan E. Sabalski, Joshua D. Berkowitz, Anthony Frank Kreft, Dennis Martin Kubrak, Thomas Joseph Caggiano, Koi Michele Morris
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Patent number: 7407972Abstract: The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.Type: GrantFiled: December 20, 2004Date of Patent: August 5, 2008Assignee: Pfizer Inc.Inventor: Jeremy John Edmunds
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Patent number: 7390827Abstract: A description is given of derivatives of benzoylpyrazoles of the formula (I) and of their use as herbicides. In this formula (I) R1a, R1b, R1c, R2, R3, R4 and R5 stand for various radicals, X for a bridging atom, L for a carbon chain and Y for a chalcogen atom.Type: GrantFiled: February 16, 2005Date of Patent: June 24, 2008Assignee: Bayer CropScience AGInventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Hubert Menne
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Publication number: 20080132524Abstract: This invention pertains to compounds of Formula I, their N-oxides and suitable salts wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally including one or two ring members selected from the group consisting of C(?O), SO or S(O)2, each ring optionally substituted with from one to four R2; each J is independently a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system, wherein each ring or ring system is optionally substituted with from one to four R3; and R1, R2, R3, R4 and n are as defined in the disclosure. A composition comprising a compound of Formula I, and a method for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I are also disclosed.Type: ApplicationFiled: December 19, 2007Publication date: June 5, 2008Inventors: David Alan Clark, Bruce Lawrence Finkelstein, George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
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Patent number: 7378433Abstract: The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.Type: GrantFiled: December 13, 2006Date of Patent: May 27, 2008Assignee: Janssen Pharmaceutica, N.V.Inventors: Marc Gaston Venet, Dominique Jean-Pierre Mabire, Jean Fernand Armand Lacrampe, Gerard Charles Sanz
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Patent number: 7365196Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.Type: GrantFiled: March 15, 2001Date of Patent: April 29, 2008Assignees: Merck Sharp & Dohme Ltd., Merck Frosst Canada & Co.Inventors: Patrice Charles Belanger, Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Edward Giles McIver, Alan John Nadin, Joseph George Neduvelil, Mark Steven Shearman, Adrian Leonard Smith, Timothy Jason Sparey, Graeme Irvine Stevenson, Martin Richard Teall
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Publication number: 20080081815Abstract: A novel heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The prevention also provide a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.Type: ApplicationFiled: September 29, 2006Publication date: April 3, 2008Applicant: GREEN CROSS CorporationInventors: Jinhwa Lee, Jeong Min Kim, Chong-Hwan Jonathan Chang, Suk Youn Kang, Hee Jeong Seo, Kwang-Seop Song, Sung-Han Lee, Kwang-Woo Ahn
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Patent number: 7317031Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.Type: GrantFiled: February 1, 2005Date of Patent: January 8, 2008Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Ronghui Lin, Shenlin Huang, Steven K. Wetter, Peter J. Connolly, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
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Patent number: 7303590Abstract: Bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a composition for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic fused 5-5 heteroaromatic keratin dyeing compounds with two or three heteroatoms. This invention further relates to a method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.Type: GrantFiled: January 21, 2005Date of Patent: December 4, 2007Assignee: The Procter & Gamble CompanyInventors: Bryan Patrick Murphy, Robert Wayne Glenn, Jr., Mu-Ill Lim, John Michael Gardlik, Stevan David Jones, William David Laidig, John David Shaffer
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Publication number: 20070225280Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.Type: ApplicationFiled: March 14, 2007Publication date: September 27, 2007Inventors: Kevin William Anderson, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kevin Richard Guertin, Nancy-Ellen Haynes, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Lida Qi, Pamela Loreen Rossman, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Qiang Zhang
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Patent number: 7253169Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.Type: GrantFiled: April 17, 2001Date of Patent: August 7, 2007Assignee: Gliamed, Inc.Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
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Patent number: 7230023Abstract: A triazole compound of the formula (I) or a pharmacologically salt thereof: wherein X represents a group of formula X—OH which has antifungal activity, L represents an -(adjacently substituted C6-C10 aryl)-CH2 group and R represents a —P(?O)(OH)2 group.Type: GrantFiled: August 20, 2003Date of Patent: June 12, 2007Assignee: Sankyo Company, LimitedInventors: Makoto Mori, Yoshiko Kagoshima, Takuya Uchida, Toshiyuki Konosu, Takahiro Shibayama
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Patent number: 7229480Abstract: Bicyclic 5-5 heteroaromatic compounds having a ring junction nitrogen and incorporating thia or oxa heteroatoms heteroatoms. Compositions for the oxidative dyeing of keratin fibers, comprising a medium suitable for dyeing and one or more bicyclic 5-5 heteroaromatic compounds having a ring junction nitrogen and incorporating thia or oxa heteroatoms heteroatoms. A method for oxidative dyeing of keratin fibers, comprising applying such compositions in the presence of an oxidizing agent, for a period sufficient to develop the desired coloration.Type: GrantFiled: January 21, 2005Date of Patent: June 12, 2007Assignee: The Procter & Gamble CompanyInventors: Robert Wayne Glenn, Jr., Mu'Ill Lim, Charles Wayne Rees, Oleg Alekseevich Rakitin, William David Laidig, John David Shaffer, John Michael Gardlik, Bryan Patrick Murphy
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Patent number: 7226939Abstract: The invention relates to novel antifungal compounds and its pharmaceutically acceptable salts, having as part of its structure, imidazolyl or benzimidazolyl derivatives. The imidazolyl derivative may be substituted at 2 position from among the group consisting of aroyl, p-chloroaroyl, phenyl hydroxy methine or p-chloro phenyl hydroxy methine or with n-butyl at 2 position and chlorine at 4 and 5 position. In the alternative, when it is a benzimadazolyl derivative, with hydrogen at 6 position, the substituent at 2 position may be selected from among methyl, ethyl, isopropyl, 2-oxopropl-1-yl, n-propyl, methoxy methyl, propen-1-yl, phenyl, p-chlorophenyl, p-toluyl, benzyl, 4-pyridyl, p-methoxy phenyl, 3-pyridyl, o-methoxy phenyl, styryl, 2-cyano methyl, p-hydroxy phenyl, p-amino phenyl, p-toluyl sulfonyl methyl or p-(t-butyl) phenyl group and if hydrogen is at 2 position, the substituent at the 6 position is selected from among nitro, trifluoromethyl or methoxy group.Type: GrantFiled: February 11, 2003Date of Patent: June 5, 2007Inventors: Mohan A. Chandavarkar, Vithal Madhavrao Kulkarni, Pranavkumar Shivkumar, Ravindra S. Shetty, Uday Rojaram Bapat
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Patent number: 7205312Abstract: The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.Type: GrantFiled: November 2, 2004Date of Patent: April 17, 2007Assignee: Janssen Pharmaceutica, N.V.Inventors: Marc Gaston Venet, Dominique Jean-Pierre Mabire, Jean Fernand Armand Lacrampe, Gerard Charles Sanz
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Patent number: 7205323Abstract: The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of the formula: wherein X, Y, a, R1, and R2 are as defined herein.Type: GrantFiled: October 12, 2005Date of Patent: April 17, 2007Assignee: Glenmark Pharmaceuticals S.A.Inventors: Abraham Thomas, Gopalan Balasubramanian, V. S. Prasada Rao Lingam, Daisy Manish Shah
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Patent number: 7132437Abstract: Renal-selective compounds are described which, in one embodiment, are prodrugs preferentially converted in the kidney to compounds capable of blocking angiotensin II (AII) receptors. These prodrugs are conjugates formed from two components, namely, a first component provided by an AII antagonist compound and a second component which is capable of being cleaved from the first component when both components are chemically linked within the conjugate. The two components are chemically linked by a bond which is cleaved selectively in the kidney, for example, by an enzyme. The liberated AII antagonist compound is then available to block AII receptors within the kidney.Type: GrantFiled: May 24, 2004Date of Patent: November 7, 2006Assignee: G.D. SearleInventors: David B. Reitz, Robert E. Manning
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Patent number: 7129361Abstract: The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.Type: GrantFiled: February 13, 2004Date of Patent: October 31, 2006Assignee: Laboratorios del Dr. Esteve, S.A.Inventors: Ramon Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa
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Patent number: 7119209Abstract: The present invention refers to a process for preparing indolinone derivatives of the general formula (VI) as defined in the specification and intermediates of that process.Type: GrantFiled: February 14, 2003Date of Patent: October 10, 2006Assignee: Pharmacia & Upjohn CompanyInventors: Qingwu Jin, Michael A. Mauragis, Paul D. May
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Patent number: 7056940Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5?-arylthien-2-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.Type: GrantFiled: September 17, 2003Date of Patent: June 6, 2006Assignee: Dow AgroSciences LLCInventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover
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Patent number: 6949576Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5?-arylthien-3-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.Type: GrantFiled: September 17, 2003Date of Patent: September 27, 2005Assignee: Dow AgroSciences LLCInventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover
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Patent number: 6924302Abstract: The present invention provides substituted triazole diamine derivatives as selective kinase or dual-kinase inhibitors and a method for treating or ameliorating a selective kinase or dual-kinase mediated disorder.Type: GrantFiled: December 21, 2001Date of Patent: August 2, 2005Assignee: Ortho McNeil Pharmaceutical, Inc.Inventors: Ronghui Lin, Peter J. Connolly, Steven K. Wetter, Shenlin Huang, Stuart L. Emanuel, Robert H. Gruninger, Steven A. Middleton
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Patent number: 6894173Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.Type: GrantFiled: February 10, 2003Date of Patent: May 17, 2005Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Lin-Hua Zhang, Lei Zhu
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Patent number: 6884892Abstract: An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base. wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.Type: GrantFiled: December 31, 2002Date of Patent: April 26, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Weiqi Wang, Tetsuya Ikemoto
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Patent number: 6849636Abstract: Triazole derivatives of structural formula I are selective inhibitors of the 11?-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.Type: GrantFiled: December 18, 2003Date of Patent: February 1, 2005Assignee: Merck & Co., Inc.Inventors: Sherman T. Waddell, Gina M. Santorelli, Milana M. Maletic, Aaron H. Leeman, Xin Gu, Donald W. Graham, James M. Balkovec, Susan D. Aster
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Patent number: 6833375Abstract: The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, hydroxy, C1-6alkyl or aryl; R2 is hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl, optionally substituted pyrrolidinyl or aryl; R3 is hydrogen, optionally substituted C1-6alkyl or aryl; Het is an optionally substituted unsaturated heterocycle selected from imidazolyl, triazolyl, tetrazolyl and pyridinyl; is an optionally substituted unsaturated mono- or bicyclic heterocycle; and aryl is optionally substituted phenyl. The present invention also relates to processes for their preparation and compositions comprising said new compounds, as well as their use as a medicine.Type: GrantFiled: September 10, 2002Date of Patent: December 21, 2004Assignee: Janssen Pharmaceutica, N.V.Inventors: Marc Gaston Venet, Dominique Jean-Pierre Mabire, Jean Fernand Armand Lacrampe, Gerard Charles Sanz
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Publication number: 20040236105Abstract: The invention provides compounds of formula I,Type: ApplicationFiled: March 26, 2004Publication date: November 25, 2004Applicant: Pfizer, Inc.Inventors: Stuart Green, Peter T. Stephenson, Charles W. Murtiashaw, Martha Murtiashaw
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Publication number: 20040198790Abstract: A triazole compound of the formula (I) or a pharmacologically salt thereof: 1Type: ApplicationFiled: August 20, 2003Publication date: October 7, 2004Applicant: SANKYO COMPANY, LIMITEDInventors: Makoto Mori, Yoshiko Kagoshima, Takuya Uchida, Toshiyuki Konosu, Takahiro Shibayama
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Patent number: 6787620Abstract: The invention relates to complexes of ruthenium of the structural formula I where X is an anionic ligand, Z is a monodentate to tridentate ligand which contains a metal and is nonionically bound to the ruthenium center, R1 and R2 are identical or different and are each hydrogen or/and a hydrocarbon group, but may also form a ring, and Ligand L is an N-heterocyclic carbene, and also to a process for preparing acyclic olefins having two or more carbon atoms or/and cyclic olefins having three or more carbon atoms and the use of at least one complex of the formula I in olefin metathesis.Type: GrantFiled: February 20, 2003Date of Patent: September 7, 2004Assignee: Degussa AGInventors: Wolfgang Anton Herrmann, Florian J. Kohl, Thomas Weskamp
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Publication number: 20040171661Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5′-arylthien-2-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.Type: ApplicationFiled: September 17, 2003Publication date: September 2, 2004Inventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover
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Patent number: 6784195Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1, R2, T and Ht are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.Type: GrantFiled: October 5, 2001Date of Patent: August 31, 2004Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Hale, James Janetka, Francois Maltais, Jingrong Cao
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Publication number: 20040162271Abstract: The invention concerns novel azole or triazole derivatives of formula (Ia) or (Ib), wherein: X, Ar1, Ar2, Ar3, A, B and R1 are such as defined in the description, the method for preparing same and their use as fungicides.Type: ApplicationFiled: January 9, 2004Publication date: August 19, 2004Applicant: Aventis Pharma S.A.Inventors: Didier Babin, John Bernard Weston
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Publication number: 20040162324Abstract: The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.Type: ApplicationFiled: February 13, 2004Publication date: August 19, 2004Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.Inventors: Ramon Merce-Vidal, Blas Andaluz-Mataro, Jordi Frigola-Constansa
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Publication number: 20040162278Abstract: The invention provides compounds of formula (I), 1Type: ApplicationFiled: October 24, 2003Publication date: August 19, 2004Applicant: Pfizer IncInventors: Robert Duncan Armour, Andrew Douglas Baxter, Justin Stephen Bryans, Kevin Neil Dack, Patrick Stephen Johnson, Russell Andrew Lewthwaite, Julie Newman, David James Rawson, Thomas Ryckmans
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Publication number: 20040152699Abstract: The present invention relates to new compounds of formula I, 1Type: ApplicationFiled: August 8, 2003Publication date: August 5, 2004Applicant: AstraZeneca and NPS Pharmaceuticals, Inc.Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald A. McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas M. Stormann, David Wensbo, Tao Xin, Helena Gyback, Martin Johansson, Annika Kers, John Malmberg, Alexander Minidis, Karin Oscarsson, Mangus Waldman, Ulrika Yngve, Christoffer Osterwall
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Publication number: 20040152891Abstract: The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.Type: ApplicationFiled: November 7, 2003Publication date: August 5, 2004Inventors: Dashyant Dhanak, Timothy F. Gallagher, Steven D. Knight
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Insecticial 3-(2,6-disubstituted phenyl)-5-[4- or 5-arylthien-2- or -3-yl]-1,2,4-triazoles
Patent number: 6770665Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, arylthien-2- or -3-yl in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.Type: GrantFiled: September 13, 2002Date of Patent: August 3, 2004Assignee: Dow AgroSciences LLCInventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover -
Publication number: 20040143116Abstract: A sulfamoyl compound of the general formulae (1): 1Type: ApplicationFiled: July 9, 2003Publication date: July 22, 2004Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Toshiaki Takeyama, Toshimasa Hamada, Hiroaki Takahashi, Junichi Watanabe, Kazuhiro Yamagishi, Masanori Nishioka, Hiroyuki Suzuki
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Publication number: 20040132726Abstract: The present invention relates to new compounds of formula I, 1Type: ApplicationFiled: August 8, 2003Publication date: July 8, 2004Applicant: AstraZeneca AB and NPS Pharmaceuticals, Inc.Inventors: Jalaj Arora, Louise Edwards, Methvin Isaac, Donald A. McLeod, Abdelmalik Slassi, Tomislav Stefanac, Thomas M. Stormann, David Wensbo, Tao Xin, Annika Kers, Johan Malmberg, Karin Oscarsson
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Publication number: 20040133011Abstract: Triazole derivatives of structural formula I are selective inhibitors of the 11&bgr;-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.Type: ApplicationFiled: December 18, 2003Publication date: July 8, 2004Inventors: Sherman T. Waddell, Gina M. Santorelli, Milana M. Maletic, Aaron H. Leeman, Xin Gu, Donald W. Graham, James M. Balkovec, Susan D. Aster
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Publication number: 20040106664Abstract: Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: 1Type: ApplicationFiled: October 30, 2003Publication date: June 3, 2004Inventors: Steven H. Olson, James M. Balkovec, Yuping Zhu
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Publication number: 20040106804Abstract: A new process is disclosed for the synthesis of fluconazole monohydrate and for crystal modifications of fluconazole which comprises the step of hydrolyzing a silyl ether of the formula (II) 1Type: ApplicationFiled: September 22, 2003Publication date: June 3, 2004Applicant: RICHTER GEDEON VEGYESZETI GYAR RT.Inventors: Janos Kreidl, Laszlo Czibula, Csaba Szantay, Jenone Farkas, Ida Deutschne Juhasz, Istvan Hegedus, Eva Werkne Papp, Judit Nagyne Bagdy, Agnes Piller, Janosne Kreidl nee Regina Hegedus
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Publication number: 20040097732Abstract: PDF inhibitors and novel methods for their use are provided.Type: ApplicationFiled: August 28, 2003Publication date: May 20, 2004Inventors: Kelly M Aubart, Jia-Ning Xiang, Siegfried B Christensen, XIangmin Liao, Maxwell D Cummings
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Publication number: 20040082631Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1Type: ApplicationFiled: October 16, 2003Publication date: April 29, 2004Inventors: Michael Hale, James Janetka, Francois Maltais
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Publication number: 20040077650Abstract: Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the modulation of the cannabinoid receptors in animals are described herein.Type: ApplicationFiled: October 6, 2003Publication date: April 22, 2004Applicant: Pfizer Inc.Inventor: Robert L. Dow
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Publication number: 20040077856Abstract: PDF inhibitors and novel methods for their use are provided.Type: ApplicationFiled: August 29, 2003Publication date: April 22, 2004Inventors: Jia-Ning Xiang, Siegfried B. Christensen IV, Xiangmin Liao, Maxwell D. Cummings
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Publication number: 20040072887Abstract: Triazole compounds having a 2,6-disubstituted-phenyl group in the 3-position, 5′-arylthien-3-yl group in the 5-position and an alkyl group in the 1-position are effective in controlling lepidoptera, coleoptera, mites and other sucking pests.Type: ApplicationFiled: September 17, 2003Publication date: April 15, 2004Inventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Maurice Chee Hoong Yap, Denise Marie Perreault, Francis Eugene Tisdell, Leonard Paul Dintenfass, James Edwin Dripps, James Michael Gifford, Katherine Anne Guenthenspberger, Laura Lee Karr, Joe Raymond Schoonover
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Publication number: 20040058931Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure 1Type: ApplicationFiled: November 15, 2002Publication date: March 25, 2004Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
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Patent number: RE39663Abstract: The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heterocycles include pyridine, quinoline, pyrazine, and the like. Substrates include polynucleotides, nucleosides, nucleotides, peptides, proteins, carbohydrates, and ligands.Type: GrantFiled: April 6, 2004Date of Patent: May 29, 2007Assignee: Applera CorporationInventors: Krishna G. Upadhva, Steven M. Menchen, Weiguo Zhen