Abstract: The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests.
Type:
Grant
Filed:
September 9, 2008
Date of Patent:
June 4, 2013
Assignee:
Syngenta Crop Protection LLC
Inventors:
Anthony Cornelius O'Sullivan, Thomas Pitterna, Jürgen Harry Schaetzer, Christoph Luethy
Abstract: Methods for the enantioselective synthesis of (+) and (?) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene involve converting (+) or (?) 1-methyl-1-[2,6-dichlorophenoxy]ethanamide to an (+) or (?) imino-ether intermediate by electrophilic attack of the amide oxygen by a trimethoxonium ion and, without isolation, converting the (+) or (?) imino-ether intermediate to (+) or (?) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene by adding ethylene diamine; and optionally converting the (+) or (?) 2-[1-(2,6-dichlorophenoxy)-ethyl]1,3-diazacyclopent-2-ene into a pharmaceutically acceptable acid addition salt thereof.
Type:
Grant
Filed:
October 6, 2009
Date of Patent:
January 24, 2012
Assignee:
University of Kentucky Research Foundation
Abstract: The invention provides compositions and methods for treating nasal congestion through ophthalmic delivery. The provided compositions and methods utilize low concentrations of selective ?-2 adrenergic receptor agonists. The compositions preferably include brimonidine.
Abstract: The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests.
Type:
Application
Filed:
September 9, 2008
Publication date:
November 4, 2010
Applicant:
SYNGENTA CROP PROTECTION, INC.
Inventors:
Christoph Luethy, Anthony Cornelius O'Sullivan, Thomas Pitterna, Jurgen Harry Schaetzer
Abstract: The present invention relates to imidazoline derivatives and their use as insecticidal and acaricidal agents. The invention also extends to insecticidal and acaricidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect and acarine pests. In particular the present invention relates to phenoxy-imidazoline derivatives wherein the phenoxy moiety is substituted with a nitro group. A method of combating and/or controlling an insect or acarid pest, which comprises applying to said pest, or to the locus of said pest, or to a plant susceptible to attack by said pest, a compound of formula (I): or salt or N-oxide thereof.
Type:
Application
Filed:
October 24, 2008
Publication date:
October 21, 2010
Applicant:
SYNGENTA CROP PROTECTION, INC.
Inventors:
Christoph Luethy, Anthony Cornelius O'Sullivan, Thomas Pitterna, Jurgen Harry Schaetzer
Abstract: The present invention relates to imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests. In particular the present invention relates to imidazolines with alkyl and fluoro substituents.
Type:
Application
Filed:
January 28, 2008
Publication date:
May 13, 2010
Applicant:
SYNGENTA CROP PROTECTION, INC.
Inventors:
Christoph Luethy, Anthony Cornelius O'Sullivan, Jürgen Harry Schaetzer
Abstract: The present invention relates to imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests. In particular the present invention relates to imidazolines with alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl or heterocyclyl substituents.
Type:
Application
Filed:
January 18, 2008
Publication date:
May 13, 2010
Applicant:
SYNGENTA CROP PROTECTION, INC.
Inventors:
Anthony Cornelius O'Sullivan, Christoph Luethy, Jurgen Harry Schaetzer
Abstract: This application provides a method for the enantioselective synthesis of (+) and (?) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene.
Type:
Application
Filed:
October 6, 2009
Publication date:
April 8, 2010
Applicant:
University of Kentucky Research Foundation
Abstract: The invention relates to methods for treatment of CNS disease and pathologies using non-racemic mixtures of lofexidine enantiomers. The invention also relates to processes for the manufacture of chirally pure enantiomers of lofexidine.
Type:
Application
Filed:
March 14, 2006
Publication date:
December 25, 2008
Inventors:
George Digenis, Peter A. Crooks, Abeer Al-Ghananeem
Abstract: The invention relates to novel diphenylimidazolines of the formula (I)
in which
Ar1, Ar2 and R are each as defined in the description,
and a plurality of processes for their preparation and to their use for controlling animal pests.
Type:
Grant
Filed:
February 5, 2001
Date of Patent:
April 30, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Alan Graff, Andrew Plant, Christoph Erdelen, Norbert Mencke, Andreas Turberg