Plural 1,2-diazoles (including Hydrogenated) Patents (Class 548/365.1)
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Publication number: 20090182152Abstract: Disclosed is a compound of the formula and dimers thereof, wherein R, R?, X, (Y)m, and (Z)n are as defined herein. The compounds are useful as colorants, particularly in applications such as phase change inks.Type: ApplicationFiled: March 25, 2009Publication date: July 16, 2009Inventors: Jeffrey H. Banning, James D. Mayo, Rina Carlini
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Patent number: 7553798Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: GrantFiled: June 21, 2005Date of Patent: June 30, 2009Assignee: Syngenta Crop Protection, Inc.Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
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Publication number: 20090163569Abstract: The present invention relates to a process for the preparation of compounds of formula (I) wherein R1 and R2 are each independently of the other hydrogen or C1-C5alkyl and R3 is CF3 or CF2H, by a) reaction of a compound of formula (II) wherein R1 and R2 are as defined for formula (I), with at least one reducing agent to form a compound of formula (III) wherein R1 and R2 are as defined for formula (I), and b) reaction of that compound with at least one reducing agent to form a compound of formula (IV) wherein R1 and R2 are as defined for formula (I), and (c) reaction of that compound with a compound of formula (V) wherein Q is chlorine, fluorine, bromine, iodine, hydroxy or C1-C6alkoxy and R3 is as defined for formula (I), to form the compound of formula (I); and to novel intermediates for use in that process.Type: ApplicationFiled: September 14, 2006Publication date: June 25, 2009Applicants: SYNGENTA CROP PROTECTION, INC., SYNGENTA LIMITEDInventors: Hans Tobler, Harald Walter, Josef Ehrenfreund, Camilla Corsi, Fanny Giordano, Martin Zeller, Gottfried Seifert, Shailesh Shah, Neil George, Ian Kevin Jones, Paul Edward Bonnett
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Publication number: 20090156642Abstract: The present invention provides 5-membered heterocycle compounds represented by the following general formula (I): The present compounds have a superior acid secretion inhibitory effect, and shows an antiulcer activity and the like.Type: ApplicationFiled: September 24, 2008Publication date: June 18, 2009Applicant: Takeda Pharmaceutical Company LimitedInventors: Haruyuki Nishida, Yasuyoshi Arikawa, Keizo Hirase
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Publication number: 20090105230Abstract: Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.Type: ApplicationFiled: June 9, 2006Publication date: April 23, 2009Inventors: Daniel L. Flynn, Peter A. Petillo
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Publication number: 20080311179Abstract: This invention concerns compounds of the general formula (1). and derivatives thereof, which are antagonists of 5-HT6 receptors, wherein the symbols have the meanings given in the description.Type: ApplicationFiled: September 21, 2007Publication date: December 18, 2008Inventors: Arnold Van Loevezijn, Wouter I. Iwema Bakker, Hiskias G. Keizer, Jan Zorgdrager, Martina A.W. Van Der Neut, Cornelis G. Kruse
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Publication number: 20080312238Abstract: A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protists, treatment of Alzheimer's disease or as anti neurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors.Type: ApplicationFiled: September 1, 2005Publication date: December 18, 2008Applicant: Institute of Experimental Bontany of the Academy of Sciences of the Czech Republic, v.v.i.Inventors: Petr Cankar, Iveta Frysova, Vladimir Krystof, Rene Lenobel, Jan Slouka, Miroslav Strnad, Peter Martin Fischer
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Publication number: 20080311075Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.Type: ApplicationFiled: May 14, 2008Publication date: December 18, 2008Inventors: Carol Bachand, Makonen Belema, Daniel H. Deon, Andrew C. Good, Jason Goodrich, Lawrence G. Hamann, Clint A. James, David R. Langley, Rico Lavoie, Omar D. Lopez, Alain Martel, Nicholas A. Meanwell, Van N. Nguyen, Jeffrey Lee Romine, Edward H. Ruediger, Lawrence B. Snyder, Denis R. St. Laurent, Gan Wang, Fukang Yang
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Publication number: 20080249290Abstract: Disclosed is a compound of the formula and dimers thereof, wherein R, R?, X, (Y)m, and (Z)n are as defined herein. The compounds are useful as colorants, particularly in applications such as phase change inks.Type: ApplicationFiled: April 4, 2007Publication date: October 9, 2008Inventors: Jeffrey H. Banning, James D. Mayo, Rina Carlini
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Publication number: 20080207853Abstract: Compounds are provided that are useful as precatlysts in the polymerization of olefins such as ethylene and propylene. Other compounds are useful as intermediates in the production of such precatalysts.Type: ApplicationFiled: February 23, 2007Publication date: August 28, 2008Inventors: Omofolami Tesileem Ladipo, Richard Eaves, Alexey Zazybin, Sean Parkin
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Publication number: 20080188535Abstract: The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I), R is H, alkyl, cycloalkyl, aryl or heteroaryl; R1 is H, alkyl, cycloalkyl, aryl or heteroaryl; R2 is H, alkyl, cycloalkyl, aryl or heteroaryl; A1 and A2 each independently represent an optionally substituted C1-C20-alkyl group which may contain one or more group(s) Z, or a monocyclic or polycyclic optionally substituted aromatic or non-aromatic ring system which may contain one or more group(s) X, and in case of a polycyclic ring system, said system contains at least one aromatic ring; Z is selected from the group consisting of S, O, N, NR4, CO, CO2, CS, SO or SO2 X is selected from the group consisting of S, O, N, NR4, SO or SO2;Type: ApplicationFiled: December 28, 2007Publication date: August 7, 2008Inventors: Aldo Ammendola, Katharina Aulinger-Fuchs, Astrid Gotschlich, Bernd Kramer, Martin Lang, Wael Saeb, Udo Sinks, Andreas Wuzik
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Publication number: 20080176865Abstract: This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.Type: ApplicationFiled: December 13, 2007Publication date: July 24, 2008Applicant: PFIZER LIMITEDInventors: Denis Billen, Jessica Boyle, Douglas James Critcher, David Morris Gethin, Kim Thomas Hall, Graham Michael Kyne
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Publication number: 20080132557Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: ApplicationFiled: June 21, 2005Publication date: June 5, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
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Publication number: 20080125416Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.Type: ApplicationFiled: August 29, 2005Publication date: May 29, 2008Inventors: Christian Laggner, Maria Rosa Cuberes-Altisent, Joerg Holenz, Juana Maria Berrocal-Romero, Maria Montserrat Contijoch-Llobet
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Publication number: 20080036373Abstract: A platinum complex represented by the general formula (1) below, useful as a phosphorescence emission material, a tetradentate ligand useful for synthesizing the platinum complex, and a light-emitting device containing at least one of the platinum complex. wherein ring B represents a nitrogen-containing aromatic heterocyclic ring; rings A, C and D each independently represent an aromatic or aromatic heterocyclic ring, while either of the rings C and D represents five-membered ring, the other represents a five- or six-membered ring; RA, RB, RC, and RD respectively represent substituents on the rings A, B, C, and D; two of XA, XB, XC, and XD represent a nitrogen atom that may be bound with the platinum atom by a coordinate bond, the others each independently represent a carbon atom or nitrogen atom that may be bound with the platinum atom by a covalent bond; Q represents a bivalent atom or atomic group bridging the rings B and C; and YC and YD each independently represent a carbon atom or nitrogen atom.Type: ApplicationFiled: August 8, 2007Publication date: February 14, 2008Inventors: Hisanori Itoh, Takeshi Iwata, Yoshimasa Matsushima
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Patent number: 7285569Abstract: The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.Type: GrantFiled: September 23, 2005Date of Patent: October 23, 2007Assignee: Hoff Hoffmann-La Roche Inc.Inventors: Georges Guy, Bernhard Goller, Hans-Willi Krell, Klaus-Peter Kuenkele, Anja Limberg, Petra Rueger, Matthias Rueth
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Publication number: 20070225280Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.Type: ApplicationFiled: March 14, 2007Publication date: September 27, 2007Inventors: Kevin William Anderson, Nader Fotouhi, Paul Gillespie, Robert Alan Goodnow, Kevin Richard Guertin, Nancy-Ellen Haynes, Michael Paul Myers, Sherrie Lynn Pietranico-Cole, Lida Qi, Pamela Loreen Rossman, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar, Jefferson Wright Tilley, Qiang Zhang
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Patent number: 7253169Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.Type: GrantFiled: April 17, 2001Date of Patent: August 7, 2007Assignee: Gliamed, Inc.Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton
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Patent number: 7176321Abstract: The invention provides a method for producing a compound represented by the following formula (II), comprising executing alkali hydrolysis of a compound represented by the following formula (I) with an alkali metal hydroxide in the presence of a barium compound to from the compound represented by formula (II), precipitating the barium compound in the form of a barium halide, and eliminating the barium halide: wherein L represents a thiocyano group, an aryloxy group, an alkoxy group, an alkylthio group, an arylthio group, a heterocyclic thio group, an imide group, an imidazolyl group, a pyrazolyl group or a triazolyl group; R1 represents an unsubstituted or substituted alkyl group, or an unsubstituted or substituted aryl group; R2 represents a substituent; and n represents an integer of 0 to 5; in a case where n is 2 or larger, R2 may be the same or different.Type: GrantFiled: March 11, 2004Date of Patent: February 13, 2007Assignee: Fuji Photo Film Co., Ltd.Inventor: Hideto Mori
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Patent number: 7101533Abstract: Disclosed is an agent for inducing receptor potential, which comprises an organic dye compound capable of inducing/evoking receptor potential in response to photostimulation in the optic nerve, wherein the organic dye compound is a polymethine organic dye compound. Also disclosed is a substituent material for the retina comprising the agent.Type: GrantFiled: September 30, 2003Date of Patent: September 5, 2006Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Toshihiko Matsuo, Yasufumi Dan-Oh, Sadaharu Suga
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Patent number: 6916798Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.Type: GrantFiled: August 2, 2002Date of Patent: July 12, 2005Assignee: Vertex Pharmaceuticals IncorporatedInventors: Jeremy Green, Michael J. Arnost, Albert Pierce
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Patent number: 6906199Abstract: It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative of formula wherein R is a bromine or chlorine atom; or a pharmaceutically acceptable salt thereof. The compounds of formula (I) are useful in therapy as antitumor agents.Type: GrantFiled: November 7, 2001Date of Patent: June 14, 2005Assignee: Pharmacia Italia S.p.A.Inventors: Francensco Caldarelli, Lucio Ceriani, Ilaria Candiani
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Patent number: 6831163Abstract: Disclosed is a molecule containing a first chromophore that exhibits a first absorption maximum above 700 nm and a second chromophore that exhibits a second absorption maximum different from the first absorption maximum, wherein the absorption of the first and second chromophores are substantially independent of each other. The molecule exhibits improved stability.Type: GrantFiled: December 26, 2002Date of Patent: December 14, 2004Assignee: Eastman Kodak CompanyInventors: Ruizheng Wang, Ann L. Carroll-Lee, Kevin W. Williams, Linda A. Kaszczuk, Charles H. Weidner
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Patent number: 6831039Abstract: The invention relates to 3-(heterocyclyl)-substituted benzoylpyrazois of formula (I), wherein the variables have the following meanings: X is O, NH or N-alkyl; R1 is alkyl; R2, R3, R4, R5 are hydrogen, alkyl or alkyl halide; R6 is halogen, nitro, alkyl halide, alkoxy, halogenalkoxy, alkylthio, halogenalkylthio, alkylsulfonyl or halogenalkylsulfonyl; R7 is hydroxy, alkoxy, alkenyloxy, alkylsulfonyloxy, alkylcarboyloxy, alkylthiocarbonyloxy, phenylsulfonyloxy or phenylcarbonyloxy, and the phenyl radical can be substituted; R8, R9 are alkyl; R10 is hydrogen or alkyl; and R11 is hydrogen or alkyl; and to their agriculturally useable salts. The invention also relates to intermediate products and methods for producing the inventive compounds and to the use of these compounds or products containing them for combating undesirable plants.Type: GrantFiled: May 21, 2001Date of Patent: December 14, 2004Assignee: BASF AktiengesellschaftInventors: Ulf Neidlein, Norbert Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Ulf Misslitz, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
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Patent number: 6831075Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: GrantFiled: August 22, 2002Date of Patent: December 14, 2004Assignee: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Publication number: 20040204589Abstract: The invention provides a method for producing a compound represented by the following formula (II), comprising executing alkali hydrolysis of a compound represented by the following formula (I) with an alkali metal hydroxide in the presence of a barium compound to from the compound represented by formula (II), precipitating the barium compound in the form of a barium halide, and eliminating the barium halide: 1Type: ApplicationFiled: March 11, 2004Publication date: October 14, 2004Inventor: Hideto Mori
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Patent number: 6774229Abstract: The invention relates to a process for the preparation of heterocycles, characterised in that the following components: i) a propargyl derivative of the general structural formula I a wherein Het is an optionally substituted hetero atom and A is a substituted or unsubstituted aromatic entity, a substituted or unsubstituted aromatic heterocycle, a substituted or unsubstituted vinyl arene and/or a derivative thereof, an olefin, an alkyne, an acceptor group or a nitrile; (ii) a compound of the general structural formula II, B—X II, wherein B is an electron-deficient substituted or unsubstituted aromatic entity with or without an acceptor group, an electron-deficient substituted or unsubstituted heteroaromatic entity with or without an acceptor group, an electron-deficient olefin and/or alkyne, a metal complex, and X is a leaving group; (iii) a nucleophile of the general structural formula III, Y—Cn—Z III, wherein Y and/or Z, eachType: GrantFiled: May 20, 2002Date of Patent: August 10, 2004Assignee: Morphochem AGInventors: Thomas Mueller, Markus Ansorge
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Patent number: 6753316Abstract: Compounds which are acryloyl substituted distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; m is 1 or 2; X and Y are the same or different and are selected, independently for each heterocyclic ring of the polyetherocyclic chain, from N and CH; R1 and R2, which are the same or different, are selected from hydrogen, halogen, and C1-C4 alkyl; R3 is hydrogen or halogen; B is selected from (a), (b), (c), (d), (e), (f), (g) and —C≡N; wherein R4, R5, R6, R7, R8, R10, R11, and R12 are, independently from each other, hydrogen or C1-C4 alkyl; and R9 is hydrogen or hydroxy, or pharmaceutically acceptable salt thereof; provided that a) at least one of R4, R5 and R6 is alkyl b) at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrole; and c) X and Y are not both N for the same heterocyclic ring; are useful as antitumor agents.Type: GrantFiled: September 19, 2000Date of Patent: June 22, 2004Assignee: Pharmacia & Upjohn S.p.A.Inventors: Paolo Cozzi, Pier Giovanni Baraldi, Italo Beria, Marina Caldarelli, Laura Capolongo, Romeo Romagnoli
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Patent number: 6746989Abstract: The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), R1 represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, R2 represents hydrogen, cyano, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkoxycarbonyl or cycloalkyl, R3 represents hydrogen, nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, R4 represents nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, Y represents hydrogen or represents in each case optionally substitutedType: GrantFiled: September 26, 2001Date of Patent: June 8, 2004Assignee: Bayer AktiengesellschaftInventors: Klaus-Helmut Müller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Heinz-Jürgen Wroblowsky, Mark Wilhelm Drewes, Dieter Feucht, Rolf Pontzen, Ingo Wetcholowsky
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Publication number: 20040082631Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1Type: ApplicationFiled: October 16, 2003Publication date: April 29, 2004Inventors: Michael Hale, James Janetka, Francois Maltais
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Patent number: 6716257Abstract: The new diaminopyrazole compounds are bridged 4,5-diaminopyrazole compounds or salts thereof.Type: GrantFiled: December 14, 2001Date of Patent: April 6, 2004Assignee: Wella AktiengesellschaftInventors: Otto Goettel, Aline Pirrello, André Hayoz, Emmanuel Morand
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Publication number: 20040014971Abstract: Polyarylcarboxamide compounds of formula (I) 1Type: ApplicationFiled: February 28, 2003Publication date: January 22, 2004Inventors: Lieven Meerpoel, Peter Walter Maria Roevens, Leo Jacobus Jozef Backx, Louis Jozef Elisabeth Van der Veken, Marcel Viellevoye
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Patent number: 6677341Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described. Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are substituted (R)-Chiral heteroaryl aminoalcohols.Type: GrantFiled: December 12, 2001Date of Patent: January 13, 2004Assignee: Pharmacia CorporationInventors: James A. Sikorski, Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Brian S. Hickory, Monica B. Norton, William F. Vernier, Deborah A. Mischke, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
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Publication number: 20030236413Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.Type: ApplicationFiled: May 31, 2002Publication date: December 25, 2003Inventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Patent number: 6638624Abstract: A filter for a display device, which comprises a dipyrazolylsquarylium dye represented by formula: wherein A and B each independently represent a substituted or unsubstituted pyrazolyl group. The filter is excellent in resistance to heat and light and gives no adverse influences on luminescence of the three primary colors, red, green and blue.Type: GrantFiled: May 22, 2001Date of Patent: October 28, 2003Assignee: Mitsubishi Chemical CorporationInventor: Tetsuo Ozawa
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Publication number: 20030199516Abstract: Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.Type: ApplicationFiled: September 12, 2002Publication date: October 23, 2003Applicant: Genesoft, Inc.Inventors: Heinz E. Moser, Eldon E. Baird, Roland W. Burli, Yigong Ge, Sarah White
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Publication number: 20030149046Abstract: Using a compound selected from compounds represented by the following formula (1) 1Type: ApplicationFiled: September 20, 2002Publication date: August 7, 2003Inventors: Junya Fujiwara, Kazuya Sakai, Kenji Kibayashi, Fumiki Shimada, Yoshio Shiga, Shiro Takagi
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Publication number: 20030149043Abstract: NHE-1 inhibitors, methods of using such NHE-1 inhibitors and pharmaceutical compositions containing such NHE-1 inhibitors. The NHE-1 inhibitors are useful for the reduction of tissue damage resulting from tissue ischemia.Type: ApplicationFiled: December 9, 2002Publication date: August 7, 2003Applicant: Pfizer Inc.Inventors: Ernest S. Hamanaka, Angel Guzman-Perez, Christian J. Mularski, Roger B. Ruggeri, Ronald T. Wester
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Publication number: 20030144280Abstract: This invention relates to a compound of the formula: 1Type: ApplicationFiled: December 31, 2002Publication date: July 31, 2003Applicant: PFIZER INC.Inventors: Kazuo Ando, Kiyoshi Kawamura
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Patent number: 6583182Abstract: This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune reponse, and in termination of pregnancy.Type: GrantFiled: November 30, 2001Date of Patent: June 24, 2003Assignee: Chelator LLCInventors: Harry S Winchell, Joseph Y Klein, Elliot D Simhon, Rosa L Cyjon, Ofer Klein, Haim Zaklad
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Publication number: 20030109709Abstract: Provided are processes and chemical intermediates useful for preparing a compound of the formula I 1Type: ApplicationFiled: September 18, 2002Publication date: June 12, 2003Inventors: M.V. Ramana Reddy, Stanley C. Bell
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Patent number: 6552051Abstract: Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.Type: GrantFiled: June 7, 2001Date of Patent: April 22, 2003Assignee: SRI InternationalInventors: Jeffrey C. Bottaro, Robert J. Schmitt, Mark A. Petrie, Paul E. Penwell
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Patent number: 6506708Abstract: 3-(Heterocyclyl)benzoylpyrazole derivatives of the formula I where: X is O, NH or N-alkyl; R1 is nitro, halogen, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfonyl or haloalkylsulfonyl; R2,R3,R4,R5 are hydrogen, alkyl or haloalkyl; R6 is halogen, nitro, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfonyl or haloalkylsulfonyl; R7 is hydroxyl, alkoxy, alkenyloxy, alkylsulfonyloxy, alkylcarbonyloxy, (alkylthio)carbonyloxy, phenylsulfonyloxy or phenylcarbonyloxy, where the phenyl radical may be substituted; R8,R9 are alkyl; R10 is hydrogen or alkyl; R11 is hydrogen or alkyl; and their agriculturally useful salts, compounds for their preparation, and the use of these compounds or of compositions comprising them for controlling undesirable plants are described.Type: GrantFiled: May 1, 2001Date of Patent: January 14, 2003Assignee: BASF AktiengesellschaftInventors: Ulf Neidlein, Norbert Götz, Ulf Misslitz, Roland Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
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Publication number: 20020170125Abstract: The new diaminopyrazole compounds are bridged 4,5-diaminopyrazole compounds or salts thereof.Type: ApplicationFiled: December 14, 2001Publication date: November 21, 2002Inventors: Otto Goettel, Aline Pirrello, Andre Hayoz, Emmanuel Morand
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Patent number: 6465658Abstract: This invention relates to the preparation of N,N′-carbonyldiazoles in a particularly advantageous manner by reacting corresponding azolide salts with phosgene in an aromatic compound or an ether as solvent. The azolide salts are preferably prepared by a novel process from an azole that is reacted with a compound of the formula M′R7 or MgR8Z′ in the presence of a solvent.Type: GrantFiled: July 17, 2001Date of Patent: October 15, 2002Assignee: Bayer AktiengesellschaftInventors: Johannes Scherer, Alexander Klausener, Robert Söllner
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Patent number: 6452017Abstract: Methods of forming a film on a substrate using chemical vapor deposition techniques and pyrazolyl complexes. The complexes and methods are particularly suitable for the preparation of semiconductor structures.Type: GrantFiled: July 14, 2000Date of Patent: September 17, 2002Assignee: Micron Technology, Inc.Inventors: Stefan Uhlenbrock, Brian A. Vaartstra
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Patent number: 6444696Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.Type: GrantFiled: July 19, 2001Date of Patent: September 3, 2002Assignee: Syntex (U.S.A.) LLCInventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
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Publication number: 20020094453Abstract: A metal coordination compound suitable as an organic material for a luminescent device is represented by the following formula (1): 1Type: ApplicationFiled: November 29, 2001Publication date: July 18, 2002Inventors: Takao Takiguchi, Shinjiro Okada, Akira Tsuboyama, Koji Noguchi, Takashi Moriyama, Jun Kamatani, Manabu Furugori
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Publication number: 20020061917Abstract: The present invention relates to the process for the preparation of the compound of Formula I: 1Type: ApplicationFiled: September 21, 2001Publication date: May 23, 2002Inventors: Hui-Yin Li, Luigi Anzalone, Fuqiang Jin, David J. Meloni, Jung-Hui Sun, Christopher A. Teleha, Jia C. Zhou, Thomas E. Smyser
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Patent number: 6380393Abstract: Compositions including at least one organic ligand including a first hetero atom and a second hetero atom directly bonded to the first hetero atom or located one carbon atom away from the first hetero atom, with at least one of the hetero atoms being nitrogen, and a transition metal moiety partially complexes by the organic ligand are provided. Such complexes have a controlled adaptable proton transfer ability and/or a hydrogen bonding ability which makes such compositions particularly useful as chemical reaction facilitators. Examples of chemical reactions facilitated by such compositions include hydrolysis reactions and carbon dioxide conversion reactions.Type: GrantFiled: March 19, 1999Date of Patent: April 30, 2002Assignee: San Diego State University FoundationInventors: Douglas Bryan Grotjahn, David Combs