The Nitrogen Is Multiply Bonded To Acyclic Carbon Or Is Bonded To Nitrogen Of The Diazole Ring Patents (Class 548/367.7)
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Patent number: 10731038Abstract: The subject of the present invention is symmetric or dissymetric azomethine direct dyes comprising at least one pyrazolopyridine unit of formula (I), a composition comprising said dyes, a process for treating keratin fibers using said dyes, a process for preparing these compounds, synthesis intermediates and a kit. In which formula (I) X, Y1, Y2, Z1, and R1 to R5 are as defined in the description.Type: GrantFiled: June 21, 2017Date of Patent: August 4, 2020Assignee: L'OREALInventors: Stéphane Sabelle, Stéphane Blais, Aziz Fadli
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Patent number: 10245223Abstract: The invention relates to a compound chosen from dyes of azomethine type bearing a pyrazolopyridine unit of formula (I) and the leuco forms thereof of formula (II) below, and also the optical isomers and geometrical isomers thereof, the tautomers thereof, the addition salts thereof with an acid or a base, and the solvates thereof. The invention also relates to the use of these particular compounds for dyeing keratin fibers.Type: GrantFiled: December 17, 2015Date of Patent: April 2, 2019Assignee: L'OREALInventor: Aziz Fadli
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Publication number: 20140296292Abstract: Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.Type: ApplicationFiled: November 12, 2012Publication date: October 2, 2014Inventors: Lin Zhi, Keith Marschke, Virginia H. Grant, Steven L. Roach, Yixing Shen, Jason C. Pickens, Bijan Pedram, C. Arjan van Oeveren, Lino J. Valdez, Andrew R. Hudson
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Publication number: 20130116203Abstract: The present invention provides glucosinolate and isothiocyanate compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.Type: ApplicationFiled: November 7, 2011Publication date: May 9, 2013Inventors: Scott R. Rajski, Jared Rae Mays
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Patent number: 8273784Abstract: The present invention provides: dinitropyrazole derivatives of formula (I) in which: R?NO2, NH2, NF2, NHOH, OH or NHNH2 and R??H when R?NH2, NF2, NHOH, OH or NHNH2 or R??H, NH2 or a linear or branched C1-C4 alkyl group, optionally substituted by at least one hydroxy and/or one fluoro group, when R?NO2; other than 4-amino-3,5-dinitropyrazole; and also the salts of said derivatives of formula (I) in which R??H; the preparation of said derivatives and of their salts; and energetic compositions comprising at least one of said derivatives and/or at least one salt of such a derivative.Type: GrantFiled: December 16, 2008Date of Patent: September 25, 2012Assignees: Herakles, EurencoInventor: Gregoire Herve
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Patent number: 8022093Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.Type: GrantFiled: April 19, 2011Date of Patent: September 20, 2011Assignee: Pliva Hrvatska D.O.O.Inventors: Edislav Leksic, Helena Ceric, Tina Mundorfer, Irena Zrinski Antonac, Zrinka Mastelic Samardzic
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Patent number: 7892294Abstract: Provided herein is a method for dyeing keratin fibers, comprising applying to the keratin fibers, at least one composition comprising at least one compound chosen from compounds of leuco type of formula (I), dyes of azomethine type containing a pyrazolopyridine unit of formula (II) corresponding to the compounds of formula (I), mesomeric forms, isomers and tautomers thereof, and also acid-addition salts thereof and solvates thereof:Type: GrantFiled: April 28, 2010Date of Patent: February 22, 2011Assignee: L'oreal S.A.Inventors: Aziz Fadli, Stéphane Blais
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Patent number: 7887601Abstract: Disclosed herein is at least one compound chosen from compounds of leuco type of formula (I), dyes of azomethine type comprising a pyrazolopyridine unit of formula (II) corresponding to the compounds of formula (I), mesomeric forms, isomeric and tautomeric forms thereof, acid-addition salts thereof and solvates thereof:Type: GrantFiled: April 28, 2010Date of Patent: February 15, 2011Assignee: L'Oreal S.A.Inventors: Aziz Fadli, Stéphane Blais
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Publication number: 20100256212Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.Type: ApplicationFiled: April 1, 2010Publication date: October 7, 2010Applicant: PLIVA HRVATSKA D.O.O.Inventors: Edislav LEKSIC, Helena CERIC, Tina MUNDORFER, Irena Zrinski ANTONAC, Zrinka Mastelic SAMARDZIC
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Patent number: 7777052Abstract: This invention relates to a process for the preparation of 5-amino-1-phenyl-3-cyano-4-trifluoromethyl sulphinyl pyrazoles as defined by Formula-I, wherein: R1=trifluoromethyl or trifluoromethoxy, and R2, R3=individually hydrogen, chlorine or bromine, the process comprising the step of oxidizing a compound of Formula-II, wherein: R1=trifluoromethyl or trifluoromethoxy, and R2, R3=individually hydrogen, chlorine or bromine, in a medium comprising at least one oxidizing agent and trichloro acetic acid, and/or the reactions product (s) of the at least one oxidizing agent and trichloro acetic acid, and at least one melting point depressant. The preferred pyrazole is Fipronil, preferably prepared using hydrogen peroxide and dichloro acetic acid at room temperature.Type: GrantFiled: April 25, 2006Date of Patent: August 17, 2010Assignee: Gharda Chemicals LimitedInventors: Keki Hormusji Gharda, Ashokkumar Maganlal Malte, Pulinattu Cherian Joseph, Sureshkumar Dattatraya Parkar, Shekhar Vishwanath Sathe, Pragnesh Dalpatram Damania
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Publication number: 20100062464Abstract: It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R1 and R2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R3, R4, R5, R6 and R7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R3 to R7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.Type: ApplicationFiled: March 6, 2008Publication date: March 11, 2010Applicant: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Yuzuru Saito, Takako Ariga
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Patent number: 7635664Abstract: The invention relates to benzoylpyrazoles of the general formula (I), in which Q, R1, R2, R3, R4, R5, Y and Z are as defined in the disclosure, to processes and intermediates for their preparation, and to their use as herbicides.Type: GrantFiled: May 8, 2002Date of Patent: December 22, 2009Assignee: Bayer CropScience AGInventors: Hans-Georg Schwarz, Klaus-Helmut Müller, Stefan Herrmann, Dorothee Hoischen, Kristian Kather, Stefan Lehr, Otto Schallner, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
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Patent number: 7582123Abstract: The present disclosure relates to a composition for coloring keratin fibers which comprises, in an appropriate dyeing medium, at least one compound chosen from leuco compounds of formula (I), azomethine dyes with a pyrazolinone unit of formula (II), their mesomeric forms, acid addition salts and solvates thereof: and dyeing methods and multicompartment devices for use thereof.Type: GrantFiled: June 19, 2008Date of Patent: September 1, 2009Assignee: L'Oreal S.A.Inventors: Aziz Fadli, Eric Metais
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Publication number: 20090030211Abstract: This invention relates to a process for the preparation of 5-amino-1-phenyl-3-cyano-4-trifluoromethyl sulphinyl pyrazoles as defined by Formula-I, wherein: R1=trifluoromethyl or trifluoromethoxy, and R2, R3=individually hydrogen, chlorine or bromine, the process comprising the step of oxidizing a compound of Formula-II, wherein: R1=trifluoromethyl or trifluoromethoxy, and R2, R3=individually hydrogen, chlorine or bromine, in a medium comprising at least one oxidizing agent and trichloro acetic acid, and/or the reactions product (s) of the at least one oxidizing agent and trichloro acetic acid, and at least one melting point depressant. The preferred pyrazole is Fipronil, preferably prepared using hydrogen peroxide and dichloro acetic acid at room temperature.Type: ApplicationFiled: April 25, 2006Publication date: January 29, 2009Inventors: Keki Hormusji Gharda, Ashokkumar Maganlal Malte, Pulinattu Cherian Joseph, Sureshkumar Dattatraya Parkar, Shekhar Vishwanath Sathe, Pragnesh Dalpatram Damania
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Publication number: 20080312164Abstract: The present invention provides glucosinolate and isothiocyante compounds and related methods for synthesizing these compounds and analogs. In certain embodiments, these glucosinolate and isothiocyanate compounds are useful and chemopreventive and or chemotherapeutic agents.Type: ApplicationFiled: July 13, 2007Publication date: December 18, 2008Inventors: Scott R. Rajski, Jared Rae Mays
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Publication number: 20080281107Abstract: The invention relates to a process for the preparation of 5-alkylthioethylamino-1-phenyl-pyrazoles of formula (I) and the preparation of 5-methylamino-1-phenylpyrazole intermediates.Type: ApplicationFiled: April 3, 2008Publication date: November 13, 2008Inventors: Stefan Schnatterer, David Teh-Wei Chou, Uwe Doller
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Publication number: 20080249290Abstract: Disclosed is a compound of the formula and dimers thereof, wherein R, R?, X, (Y)m, and (Z)n are as defined herein. The compounds are useful as colorants, particularly in applications such as phase change inks.Type: ApplicationFiled: April 4, 2007Publication date: October 9, 2008Inventors: Jeffrey H. Banning, James D. Mayo, Rina Carlini
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Publication number: 20080139621Abstract: The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.Type: ApplicationFiled: November 30, 2007Publication date: June 12, 2008Applicant: STATegics, Inc.Inventors: Jeffrey R. Spencer, Juha Punnonen
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Patent number: 6730151Abstract: Magenta chromophore dyes which are stabilized by adding steric hindering groups to protect the imino carbons; nonlimiting examples of the steric hindering groups being phenyl, methyl, ethyl, isopropyl, fluoride, chloride, bromide and iodide groups.Type: GrantFiled: January 25, 2002Date of Patent: May 4, 2004Assignee: Hewlett-Packard Development Company, L.P.Inventor: Larrie A Deardurff
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Patent number: 6686318Abstract: The invention relates to new substituted aromatic amino compounds of the general formula (I) in which R1, R2, R3, R4 and Z have the meanings given in the description, to a process for their preparation, and to their use as herbicides.Type: GrantFiled: April 22, 2003Date of Patent: February 3, 2004Assignee: Bayer AktiengesellschaftInventors: Roland Andree, Mark Wilhelm Drewes, Kurt Findeisen, Joachim Kluth, Karl-Heinz Linker, Klaus-Helmut Müller, Otto Schallner, Markus Dollinger
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Publication number: 20030134888Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1Type: ApplicationFiled: April 26, 2002Publication date: July 17, 2003Inventor: Michael R. Hale
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Patent number: 6462044Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.Type: GrantFiled: August 30, 2001Date of Patent: October 8, 2002Assignee: NitroMed, Inc.Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
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Patent number: 6331543Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.Type: GrantFiled: September 1, 1999Date of Patent: December 18, 2001Assignee: NitroMed, Inc.Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
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Patent number: RE37495Abstract: The invention relates to new substituted 1-arylpyrazoles of the general formula (I) to a plurality of processes for their preparation, and to their use as pesticides.Type: GrantFiled: December 3, 1997Date of Patent: January 1, 2002Assignee: Bayer AktiengesellschaftInventors: Jörg Stetter, Bernd Alig, Stefan Böhm, Achim Bertsch, Pieter Ooms, Christoph Erdelen, Jürgen Hartwig, Ulrike Wachendorff-Neumann, Andreas Turberg, Norbert Mencke