Plural Chalcogens Bonded Directly To Ring Carbons Of The Five-membered Hetero Ring (e.g., Cyclic Imides, Etc.) Patents (Class 548/423)
  • Patent number: 11633881
    Abstract: A heated composite tool, useful for forming, debulking, and/or curing prepreg materials, including a composite build structure having a shape of a composite part that is to be produced, configured to receive and support prepreg materials during lay-up, and including a heating structure physically coupled to the composite build structure, and comprising at least one heating element, including a carbon nanotube structured layer defining a current path having first and second ends and first and second electrical terminals electrically coupled to the first and second ends and a first isolation ply disposed between the composite build structure and the at least one heating element, the first isolation ply forming an electrical insulating gap between the at least one heating element and the composite build structure, wherein the carbon nanotube structured layer is responsive to an electromotive force applied across the first and second electrical terminals to heat the tool.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: April 25, 2023
    Assignee: General Nano LLC
    Inventors: Larry Allen Christy, Joseph E. Sprengard, Thomas J. Sorenson, Chaminda Jayasinghe
  • Patent number: 10174043
    Abstract: A method comprising converting 2,6-naphthalene diol to produce wherein the method occurs at temperatures less than 250° C.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: January 8, 2019
    Assignee: Phillips 66 Company
    Inventors: Laura Nielsen, Kathy Woody
  • Patent number: 8404795
    Abstract: Polymers for photoresists and monomers for incorporation into those polymers are disclosed. The polymers comprise a photoacid generator (PAG) component and at least a second component that is photolytically stable and acid-stable. The polymers may also contain a third, acid-labile component. The photoacid generator is based on N-sulfoxyimides and related moieties that contain photolabile oxygen-heteroatom and oxygen-aromatic carbon bonds.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: March 26, 2013
    Assignee: The Research Foundation for the State University of New York
    Inventor: Robert L. Brainard
  • Patent number: 8334300
    Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y, Z and CKE are as defined in the description, to processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: December 18, 2012
    Assignee: Bayer Aktiengesellshaft
    Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christophe Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
  • Publication number: 20110130538
    Abstract: Polymers for photoresists and monomers for incorporation into those polymers are disclosed. The polymers comprise a photoacid generator (PAG) component and at least a second component that is photolytically stable and acid-stable. The polymers may also contain a third, acid-labile component. The photoacid generator is based on N-sulfoxyimides and related moieties that contain photolabile oxygen-heteroatom and oxygen-aromatic carbon bonds.
    Type: Application
    Filed: August 26, 2010
    Publication date: June 2, 2011
    Applicant: The Research Foundation of the State University of New York
    Inventor: Robert L. BRAINARD
  • Publication number: 20110101319
    Abstract: Provided are a hole-injecting material for an organic electroluminescent device (organic EL device) exhibiting high luminous efficiency at a low voltage and having greatly improved driving stability, and an organic EL device using the material. The hole-injecting material for an organic EL device is selected from benzenehexacarboxylic acid anhydrides, benzenehexacarboxylic acid imides, or N-substituted benzenehexacarboxylic acid imides. Further, the organic EL device has at least one light-emitting layer and at least one hole-injecting layer between an anode and a cathode arranged opposite to each other, and includes the above-mentioned hole-injecting material for an organic EL device in the hole-injecting layer. The organic EL device may contain a hole-transporting material having an ionization potential (IP) of 6.0 eV or less in the hole-injecting layer or a layer adjacent to the hole-injecting layer.
    Type: Application
    Filed: February 27, 2009
    Publication date: May 5, 2011
    Applicants: Nippon Steel Chemical Co., Ltd., Yamagata Promotional Organization for Industrial Technology
    Inventors: Takayuki Fukumatsu, Ikumi Ichihashi, Hiroshi Miyazaki, Atsushi Oda
  • Publication number: 20110006287
    Abstract: A copolymer comprising at least one donor monomer and at least one acceptor monomer is described. The polymer may optionally further comprise, consist or consist essentially of at least one additional comonomer. Various donor monomers, acceptor monomers and additional comonomers are also described. The polymer is useful in the manufacture of microelectronic devices such as optoelectronic devices.
    Type: Application
    Filed: March 18, 2010
    Publication date: January 13, 2011
    Inventors: Wei You, Shengqiang Xiao
  • Publication number: 20100331324
    Abstract: Disclosed are fused heterocyclic compounds of Formula (I) or pharmaceutically-acceptable salts or stereoisomers thereof. Also disclosed are methods of using such compounds in the treatment of at least one androgen receptor-associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
    Type: Application
    Filed: June 26, 2008
    Publication date: December 30, 2010
    Inventors: Derek J. Norris, Ashvinikumar V. Gavai, James Aaron Balog, Joel F. Austin, Weifang Shan, Yufen Zhao, Andrew James Nation, Wen-Ching Han
  • Patent number: 7829576
    Abstract: This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: November 9, 2010
    Assignee: Adolor Corporation
    Inventors: Bertrand Le Bourdonnec, Roland E. Dolle
  • Patent number: 7332487
    Abstract: The present invention is to provide an aliphatic nitrogen-containing 5-membered ring compound represented by the formula [I]: wherein symbols in the formula have the following meanings; A: —CH2— or —S—, B: CH or N, R1: H, a lower alkyl group, etc., X: a single bonding arm, —CO—, —Alk—CO—, —COCH2—, —Alk—O—, —O—CH2—, —SO2—, —S—, —COO—, —CON(R3)—, —Alk—CON(R3)—, —CON(R3)CH2—, —NHCH2—, etc., R3: hydrogen atom or a lower alkyl group, Alk: a lower alkylene group, and R2: (1) a cyclic group which may be substituted, (2) a substituted amino group, etc., provided that when X is —CO—, then B is N, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: February 19, 2008
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Kosuke Yasuda, Hiroshi Morimoto, Saburo Kawanami, Masataka Hikota, Takeshi Matsumoto, Kenji Arakawa
  • Patent number: 7132434
    Abstract: Compounds of the formula (I), useful as metal-loproteinase inhibitors, especially as inhibitors of MMP12
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: November 7, 2006
    Assignee: AstraZeneca AB
    Inventors: Anders Eriksson, Matti Lepistö, Michael Lundkvist, Magnus Munck Af Rosenschöld, Kristina Stenvall, Pavol Zlatoidsky
  • Patent number: 6967215
    Abstract: Tetrahydrocarbazoles of formula where Q is —SO2—; —O—; or —(CO)—; X is —(CH)—; or —N—; m is from 1 to 3; t is 0 or 1 and the remaining substituents are as defined herein, are useful as antimicrobial active ingredients.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: November 22, 2005
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Wolfgang Haap, Andreas Mehlin, Karin Petzold, Dietmar Ochs, Werner Hölzl
  • Patent number: 6699899
    Abstract: Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF&agr; and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)propanoate.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: March 2, 2004
    Assignee: Celgene Corporation
    Inventors: Hon-Wah Man, George W Muller, Shaei Y Huang
  • Patent number: 6162822
    Abstract: A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, or by a substituted or unsubstituted heterocylcic,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## and medicinal products containing the same are useful as anticancer agent.
    Type: Grant
    Filed: December 28, 1998
    Date of Patent: December 19, 2000
    Assignee: Adir et Compagnie
    Inventors: Gilbert Lavielle, Patrick Hautefaye, Ghanem Atassi, Alain Pierre, Laurence Kraus-Berthier, Stephane Leonce
  • Patent number: 6107345
    Abstract: A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as defined in the description,A represents ##STR2## wherein m, R.sub.1, R.sub.2 and G are as defined in the description, their isomers and addition salts thereof with a pharmaceutically-acceptable acid, and medicinal products containing the same are useful in the treatment of diseases like depression, panic attacks, obsessive compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: August 22, 2000
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Aimee Dessinges, Jean-Christophe Harmange, Mark Millan, Adrian Newman-Tancredi, Mauricette Brocco
  • Patent number: 6030967
    Abstract: A compound of the formula: whereinQ is an optionally substituted carbon atom or N(O)p wherein p is 0 or 1;Y is an optionally substituted methylene group, S(O)q wherein q is an integer of 0 to 2, or an optionally substituted imino group;Z.sup.1 is a C.sub.1-3 alkylene group which may have an oxo group or a thioxo group and may contain etherified oxygen or sulfur within the carbon chain;Z.sup.2 is an optionally substituted C.sub.1-3 alkylene group;Ar is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;one of R.sup.1 and R.sup.2 is a hydrogen atom, a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group;the other is a halogen atom, a hydroxyl group, an optionally substituted lower alkyl group, or an optionally substituted lower alkoxy group; orR.sup.1 and R.sup.2 taken together with adjacent --c.dbd.c-- form a ring; andring A is a benzene ring which may be substituted in addition to R.sup.1 and R.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: February 29, 2000
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shogo Marui, Masatoshi Hazama, Kohei Notoya, Masaki Ogino
  • Patent number: 5728709
    Abstract: Described herein is a pyrrolocarbazole derivative and a pharmaceutically acceptable salt thereof having the following formula (I): ##STR1## wherein R.sup.1 is lower alkyl or aralkyl; R.sup.2 is hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, or substituted or unsubstituted aralkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different, and are hydrogen, halogen, nitro, substituted or unsubstituted lower alkanoyl, NR.sup.9 R.sup.10, or OR.sup.11 ; R.sup.8 is hydrogen or is combined with R.sup.3 to form --CONR.sup.12 --; and when R.sup.1 is benzyl; R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are not simultaneously hydrogen. A compound of the present invention stimulates platelet production and is useful for treatment of thrombocytopenia.
    Type: Grant
    Filed: November 8, 1996
    Date of Patent: March 17, 1998
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Yoji Ikuina, Chikara Murakata, Yutaka Saitoh, Yukimasa Shiotsu, Takako Iida, Tatsuya Tamaoki, Kinya Yamashita, Shiro Akinaga
  • Patent number: 5721267
    Abstract: Compounds represented by the Formula I: ##STR1## wherein: R.sup.1 is hydrogen or lower alkyl;R.sup.2 is heteroaryl; andR.sup.3 and R.sup.4 are independently hydrogen or lower alkyl;and the pharmaceutically acceptable salts thereof, are useful as chemotherapeutic agents.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: February 24, 1998
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Chris Allen Broka
  • Patent number: 5693822
    Abstract: A method for the preparation of diaminobisimide compounds of the formula (I) which are substantially free of oligomers and are useful as curing agents in epoxy resin formulations: ##STR1## wherein Ar.sup.1 is an optionally substituted aromatic residue which provides for good conjugation between the nitrogen containing groups; and Ar is an optionally substituted aromatic residue, comprising heating an aromatic diamine of the formula H.sub.2 N--Ar.sup.1 --NH.sub.2, with an aromatic tetracarboxylic acid of the formula (HOOC).sub.2 (COOH).sub.2 or the corresponding dianhydride.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: December 2, 1997
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Jonathan Howard Hodgkin, Mervyn Benjamin Jackson, John West Loder
  • Patent number: 5674432
    Abstract: Described are novel reversible photochromic diaryl-3H-naphtho?2,1-b!pyran compounds having a substituted or unsubstituted, five or six member heterocyclic ring fused to the g, i, or l side of the naphthopyran. The heterocyclic ring contains an oxygen or nitrogen atom and is attached to the number 5, 6, 7, 8, 9, or 10 carbon atom of the naphtho portion of the naphthopyran. Also described are organic host materials containing such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(indoline)oxazine-type compounds, are also described.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 7, 1997
    Assignee: Transitions Optical, Inc.
    Inventors: David B. Knowles, Barry Van Gemert
  • Patent number: 5616666
    Abstract: The invention relates to a bismaleimide compound of the formula (I) substantially free of oligomeric, amidic and uncyclized impurities: ##STR1## wherein Ar is an optionally substituted aromatic residue; andAr' is an optionally substituted aromatic residue which provides either good conjugation between the nitrogen-containing groups shown in formula (I) or steric or other restrictions capable of moderating the reactivity of an unreacted amine moiety attached to said residue, methods for their preparation and curable compositions containing them. The curable compositions may also be used in impregnated fibre reinforced materials and advanced composite materials.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: April 1, 1997
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Trevor C. Morton, Jonathan H. Hodgkin, Robert Eibl
  • Patent number: 5523411
    Abstract: The present invention relates to the synthesis of mitomycin and analogs thereof that are useful as anticancer antibiotics. The invention further relates to analogs of mitomycin, which can be prepared according to the methods of synthesis provided. The synthetic method of the invention provides for reacting a derivitized indole with a dialkylvinylsulfonium salt to yield a tricyclic skeleton having the precursors of the fourth ring in one step, followed by an oxidation step or steps to close the fourth ring and prepare mitomycin or a related compound.
    Type: Grant
    Filed: March 14, 1994
    Date of Patent: June 4, 1996
    Assignee: Rutgers University
    Inventors: Leslie Jimenez, Zheng Wang
  • Patent number: 5514685
    Abstract: The invention concerns the compounds of formulae ##STR1## wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in particular as immunosuppressant, antiproliferative and antiinflammatory agents.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: May 7, 1996
    Assignee: Sandoz Ltd.
    Inventor: Karl Baumann
  • Patent number: 5451344
    Abstract: Described are novel reversible photochromic diaryl-3H-naphtho[2,1-b]pyran compounds having a substituted or unsubstituted, five or six member heterocyclic ring fused to the g, i, or l side of the naphthopyran. The heterocyclic ring contains an oxygen or nitrogen atom and is attached to the number 5, 6, 7, 8, 9, or 10 carbon atom of the naphtho portion of the naphthopyran. Also described are organic host materials containing such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(indoline)oxazine-type compounds, are also described.
    Type: Grant
    Filed: April 8, 1994
    Date of Patent: September 19, 1995
    Assignee: Transitions Optical, Inc.
    Inventors: David B. Knowles, Barry Van Gemert
  • Patent number: 5418232
    Abstract: A compound of formula (I) possesses excellent potassium channel opening activity and is effective on various diseases arising from contractions of blood vessels, bronchial smooth muscles, etc., for example, ischemic heart diseases exemplified by angina pectoris, asthma, pollakisuria, sequela of subarachnoid hemorrhage, peripheral arterioinfarct, and so on. The compound has potent and long-lasting antihypertensive activity, with the onset of the action being slow, excellent activity in increasing renal blood flow, and high safety, and is therefore particularly useful as an antihypertensive. ##STR1## The substituents are as defined in the specification.
    Type: Grant
    Filed: May 12, 1993
    Date of Patent: May 23, 1995
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Tetsuya Mimura, Hideo Kubo
  • Patent number: 5310909
    Abstract: Compounds of the formula I ##STR1## in which X is O, S, SO, SO.sub.2 or NR.sub.13, R.sub.13 is, for example, methyl, and R.sub.1 to R.sub.12, independently of one another, are, for example, H, C.sub.1 -C.sub.12 alkyl, C.sub.1 -C.sub.12 Alkoxy, halogen or --CN. The compounds are photosensitive and photochromic and are suitable as photosensitizers and simultaneously as color indicators, and as photoswitchable color filters.
    Type: Grant
    Filed: November 21, 1990
    Date of Patent: May 10, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Evelyn Fischer, Walter Fischer, Jurgen Finter, Kurt Meier, Martin Roth
  • Patent number: 5296610
    Abstract: An N-substituted polyamideimide essentially composed of identical or different repeating units of the formula I ##STR1## where R.sup.1 is one of the following tetravalent aromatic radicals ##STR2## and X is a bond or one of the following linkers ##STR3## where R.sup.2 and R.sup.4 are each, independently of one another, one of the following divalent aromatic radicals ##STR4## and where X has the abovementioned meanings and where R.sup.3 is hydrogen or a monovalent radical such as C.sub.1 -C.sub.6 -alkyl or phenyl, and the C.sub.1 -C.sub.6 -alkyl-, C.sub.1 -C.sub.6 -alkoxy-, aryl- or halogen-substituted derivatives thereof, and precursors (monomers) therefor, are described.
    Type: Grant
    Filed: February 4, 1993
    Date of Patent: March 22, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Wolf, Juergen Koch
  • Patent number: 5264538
    Abstract: Cyclic poly(aryl ether) oligomers and mixtures thereof, and methods for the preparation thereof in a highly dilute reaction medium under reaction conditions favorable for ring closure at low degrees of polymerization. These oligomers are represented by the general formula ##STR1## where each Y is divalent oxygen or divalent sulfur, each Ar is an aromatic diradical which comprises one or more C.sub.6 to C.sub.20 arylene groups and has at least one electron withdrawing group attached to an aromatic ring, and n is an integer from 1 to about 20 with the proviso that for integer values of n equal to 1 or 2 all linkages between independent aromatic rings comprise at least one atom.
    Type: Grant
    Filed: June 27, 1990
    Date of Patent: November 23, 1993
    Assignee: The Dow Chemical Company
    Inventors: Michael J. Mullins, Edmund P. Woo, Kimberly E. Balon, Daniel J. Murray, Cheng-Cheng C. Chen
  • Patent number: 5242551
    Abstract: A method of isomerizing an isoimide to an n-imide is described wherein an electron is supplied to the isoimide which induces the isomerization and wherein the isomerization is catalytic to the electron which remains available to initiate further isomerization. A polyimide is deposited onto a conductive substrate by providing a composition containing a polyisoimide and an electrolyte providing the substrate and a counter electrode in the composition, and providing a bias between the substrate and counter electrode to thereby supply an electron to the polyisoimide which isomerizes to deposit the insoluble polyimide on the substrate.
    Type: Grant
    Filed: October 3, 1991
    Date of Patent: September 7, 1993
    Assignee: International Business Machines Corporation
    Inventors: Ernest R. Frank, Terrence R. O'Toole, Alfred Viehbeck
  • Patent number: 5192795
    Abstract: 2-(Aminoalkyl)pyrrolealdehydes of the general formula I ##STR1## in which R: denotes hydrogen, alkyl;R.sup.1 : denotes, for example, hydrogen, alkyl, phenyl;R.sup.2 and R.sup.3 : denote, for example, hydrogen, alkyl or alkanoyl, have useful pharmacological properties.
    Type: Grant
    Filed: June 14, 1991
    Date of Patent: March 9, 1993
    Assignee: Cassella Aktiengesellschaft
    Inventors: Gerhard Zoller, Ursula Schindler
  • Patent number: 5166204
    Abstract: A novel isoindole derivative represented by general formula [1] or a salt thereof: ##STR1## which has an excellent antitumor activity and low toxicity.
    Type: Grant
    Filed: October 30, 1990
    Date of Patent: November 24, 1992
    Assignee: Toyama Chemical Co., Ltd.
    Inventors: Takashi Nagai, Isao Myoukan, Keishi Funaki, Kenji Ohta, Nobuhisa Taya, Shinji Miyabara, Masaaki Shibata, Hidetada Mikami, Takako Hori
  • Patent number: 5068243
    Abstract: Novel bicyclic tetrahydroxylated pyrrolizidines are disclosed which are inhibitors of glycosidase enzymes. A preferred inhibitor is (1S,2R,6R,7S)-1,2,6,7-tetrahydroxypyrrolizidine.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: November 26, 1991
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Patent number: 5003078
    Abstract: Imide-containing phthalonitrile monomers are prepared from a phthalonitrile and an aromatic dianhydride. The monomer and a method for preparing the monomer is disclosed. These monomers are synthesized into heat resistant polymers and copolymers with aromatic ring structure incorporating imide and ether linkages. The synthesis of the high temperature thermosetting polymers and copolymers is also disclosed.
    Type: Grant
    Filed: May 16, 1989
    Date of Patent: March 26, 1991
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Teddy M. Keller
  • Patent number: 4999369
    Abstract: The present invention relates to compounds of formula (I)ArCH.sub.2 R.sup.1 (I)or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteroatom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl;R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen;R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy;R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.
    Type: Grant
    Filed: February 15, 1990
    Date of Patent: March 12, 1991
    Assignee: Burroughs Wellcome Co.
    Inventor: Kenneth W. Bair
  • Patent number: 4992460
    Abstract: Novel bicyclic tetrahydroxylated pyrrolizidines are disclosed which are inhibitors of glycosidase enzymes. A preferred inhibitor is 1.alpha., 2.alpha., 6.alpha., 7.alpha., 7.alpha..beta.-1,2,6,7-tetrahydroxypyrrolizidine. It is synthesized from D-glycero-D-gulo-heptono-1,4-lactone.Novel Intermediate compounds prepared during this synthesis are 7-O-tert-butyldiphenylsilyl-2,3:5,6-di-O-isopropylidene-D-glycero-D-gulo-h ept ono-1,4-lactone and 1.alpha., 2.alpha., 6.alpha., 7.alpha., 7.alpha..beta.-1,2:6,7-di-O-isopropylidene-1,2,6,7-tetrahydroxypyrrolizidi ne.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: February 12, 1991
    Assignee: Monsanto Company
    Inventor: George W. J. Fleet
  • Patent number: 4977158
    Abstract: The invention relates to novel tetracyclic compounds with an anti-depressant action, without neuroleptic or sedative side effects, of the general formula I ##STR1## and also functional derivatives hereof, wherein: R.sup.1 represents one or two identical or different substituents denoting H, OH, halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;R.sup.2 represents one or two identical or different substituents having the same meaning as R.sup.1 ;R.sup.3 and R.sup.4 are two substituents which are in the cis configuration and of which one is H and the other is OH;R.sup.5 is H or C.sub.1 -C.sub.4 alkyl;X denotes O or S;n is 0 or 1.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: December 11, 1990
    Assignee: Akzo N.V.
    Inventor: Johannes H. Wieringa
  • Patent number: 4912107
    Abstract: The invention concerns new pyrrolocarbazole derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing these for the inhibition of protein kinases, such as protein kinase C, and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system as well as for the treatment of viral diseases.
    Type: Grant
    Filed: September 26, 1989
    Date of Patent: March 27, 1990
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Johannes Hartenstein, Christoph Schachtele, Claus Rudolph, David J. Dooley, Gunther Weinheimer
  • Patent number: 4874803
    Abstract: The present invention comprises reaction products resulting from the reaction of hydrazido-substituted or certain amino-substituted polymer stabilizers and cyclic dianhydrides, as well as the use of such products. The polymer stabilizers of the invention are useful for protecting a large variety of synthetic polymeric organic materials from the degradative effects of heat, light and oxygen. Some of the modifiers are flame retardants and many are metal deactivators in addition to their primary activity.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 17, 1989
    Assignee: Pennwalt Corporation
    Inventors: Arthur L. Baron, Terry N. Myers, Jerome Wicher
  • Patent number: 4585876
    Abstract: Novel xanthones and thioxanthones of the formula I ##STR1## in which A, X, Y, Z, E and E' are as defined in patent claim 1, are described. A is preferably --S-- and E and E' are preferably bonded in the ortho-position relative to one another. The compounds (I) are suitable, for example, as sensitizers for photocrosslinkable polymers or photocurable compositions, or for use in mixtures with polymers with H donor groups for image formation, in particular electrically conductive coatings and patterns, by means of electroless deposition of metals.
    Type: Grant
    Filed: November 14, 1983
    Date of Patent: April 29, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Fischer, Jurgen Finter, Hans Zweifel
  • Patent number: 4528373
    Abstract: Novel, unsaturated vinylacetylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure--CH.dbd.CH--C.tbd.C-- or--C.tbd.C--CH.dbd.CH--, hereinafter sometimes referred to as "conjugated enynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: July 9, 1985
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4520198
    Abstract: Novel, unsaturated vinylacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --CH.dbd.CH--C.tbd.C-- or --C.tbd.C--CH.dbd.CH--, hereinafter sometimes referred to as "conjugated enynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: May 28, 1985
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4517364
    Abstract: Novel, unsaturated vinylacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --CH.dbd.CH--C.tbd.C-- or --C.tbd.C--CH.dbd.CH--, hereinafter sometimes referred to as "conjugated enynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: May 14, 1985
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4517363
    Abstract: Novel, unsaturated vinylacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --CH.dbd.CH--C.tbd.C-- or --C.tbd.C--CH.dbd.CH--, hereinafter sometimes referred to as "conjugated enynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: May 14, 1985
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4435323
    Abstract: Novel, unsaturated vinylacetylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --CH.dbd.CH--C.tbd.C-- or --C.tbd.C--CH.dbd.CH--, hereinafter sometimes referred to as "conjugated enynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: March 6, 1984
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4405519
    Abstract: Novel, unsaturated diacetylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes." These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: September 20, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4405521
    Abstract: Novel, unsaturated diacteylene-terminated polyimides and processes for their preparation are disclosed herein. There new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain nonomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: September 20, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4405520
    Abstract: Novel, unsaturated diacetylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: September 20, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4405786
    Abstract: Novel, unsaturated diacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivaties of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: September 20, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4404139
    Abstract: Novel, unsaturated diacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperature to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: September 13, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus
  • Patent number: 4377673
    Abstract: Novel, unsaturated diacteylene-terminated polyimides and processes for their preparation are disclosed herein. These new polyimides are derivatives of anhydride-terminated aromatic polyimides from which they can be prepared by amidation to provide new unsaturated amide groups having a terminal group containing the structure --C.tbd.C--C.tbd.C--, hereinafter sometimes referred to as "conjugated diynes". These new compositions are more tractable than the original anhydride-terminated polyimides and can be converted at appropriate lower temperatures to crosslinked, insoluble, infusible polymers without by-product formation, thereby extending greatly the applications for which the aromatic polyimides can be employed. Moreover, these new polyimides can undergo the Diels-Alder type of addition with a large number of dienophiles. Certain monomeric materials are also described.
    Type: Grant
    Filed: March 2, 1982
    Date of Patent: March 22, 1983
    Assignee: Plastics Engineering Company
    Inventors: Gaetano F. D'Alelio, deceased, Phillip A. Waitkus