Chalcogen Or Nitrogen Attached Indirectly To The Tricyclo Ring System By Acyclic Nonionic Bonding Patents (Class 548/444)
-
Patent number: 8815410Abstract: It is an object of the present invention to provide a light emitting element, which is resistant to repetition of an oxidation reaction. It is another object of the invention to provide a light emitting element, which is resistant to repetition of a reduction reaction. An anthracene derivative is represented by a general formula (1). In the general formula (1), R1 represents hydrogen or an alkyl group having 1 to 4 carbon atoms, R2 represents any one of hydrogen, an alkyl group having 1 to 4 carbon atoms and an aryl group having 6 to 12 carbon atoms, R3 represents any one of hydrogen, an alkyl group having 1 to 4 carbon atoms, and an aryl group having 6 to 12 carbon atoms, Ph1 represents a phenyl group, and X1 represents an arylene group having 6 to 15 carbon atoms.Type: GrantFiled: December 26, 2005Date of Patent: August 26, 2014Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Harue Nakashima, Sachiko Kawakami, Kumi Kojima, Ryoji Nomura, Nobuharu Ohsawa
-
Publication number: 20140234238Abstract: The invention relates to specific benzodioxepin-3-one compounds, to a process for the preparation thereof and to the use thereof as dyes or as fluorescent emitters for organic electroluminescent devices (OLEDs) or for organic light-emitting electrochemical cells (OLECs), and to corresponding electronic devices.Type: ApplicationFiled: September 17, 2012Publication date: August 21, 2014Applicant: MERCK PATENT GMBHInventors: Thomas Rudolph, Philipp Buehle, Ralf Rosskopf
-
Patent number: 8808879Abstract: Methods and devices related to the treatment of diseases using phototherapy are described. Some embodiments provide an organic light-emitting diode device, such as a light-emitting device for phototherapy, comprising a compound of Formula 1. Methods of treating disease diseases with phototherapy are also described.Type: GrantFiled: July 15, 2011Date of Patent: August 19, 2014Assignee: Nitto Denko CorporationInventors: Amane Mochizuki, Sazzadur Rahman Khan, Shijun Zheng, Keisaku Okada
-
Patent number: 8808877Abstract: A method of manufacturing an organic EL element, which may be a top-emitting or a transparent organic EL element, provides an organic EL element having a low driving voltage and a high efficiency. The organic EL element includes a substrate; an anode; an organic EL layer which includes at least an emissive layer, an electron transport layer and a damage-mitigating electron injection layer; and a transparent cathode composed of a transparent conductive oxide material, the damage-mitigating electron injection layer is in contact with the transparent cathode, and the damage-mitigating electron injection layer includes a crystalline oligothiophene compound.Type: GrantFiled: August 18, 2009Date of Patent: August 19, 2014Assignee: Sharp Kabushiki KaishaInventor: Yutaka Terao
-
Publication number: 20140228409Abstract: The present invention provides a fused heterocyclic compound having an ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I?): wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N?-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.Type: ApplicationFiled: September 21, 2012Publication date: August 14, 2014Inventors: Satoshi Yamamoto, Junya Shirai, Yoshiyuki Fukase, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Kazuko Yonemori, Hideyuki Nakagawa
-
Patent number: 8791149Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.Type: GrantFiled: January 14, 2013Date of Patent: July 29, 2014Assignee: Board of Regents of the University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Patent number: 8785003Abstract: An organic EL device material includes at least a unit including 3,5-biscarbazolylphenyl group, a unit including 4-carbazolylphenyl group, and a compound including a unit including a nitrogen-containing aromatic heterocyclic ring bonding the unit including 3,5-biscarbazolylphenyl group and the unit including 4-carbazolylphenyl group.Type: GrantFiled: March 4, 2011Date of Patent: July 22, 2014Assignee: Idemtisu Kosan Co., Ltd.Inventors: Tetsuya Inoue, Kumiko Hibino, Kei Yoshida, Kazuki Nishimura, Toshihiro Iwakuma
-
Patent number: 8771844Abstract: A heterocyclic compound, an organic light-emitting diode, and a flat display device, the heterocyclic compound being represented by Formula 1, below:Type: GrantFiled: December 6, 2011Date of Patent: July 8, 2014Assignee: Samsung Display Co., Ltd.Inventors: Young-Kook Kim, Seok-Hwan Hwang, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Yoon-Hyun Kwak, Sun-Young Lee, Se-Jin Cho, Jong-Hyuk Lee, Sung-Chul Kim
-
Patent number: 8771840Abstract: Provided are a heterocyclic compound which emits blue light and is represented by General Formula (G1) below, and a light-emitting element, a light-emitting device, an electronic device and a lighting device which are formed using the heterocyclic compound represented by General Formula (G1) below. The use of the heterocyclic compound represented by General Formula (G1) makes it possible to provide a light-emitting element which has high emission efficiency, and also a light-emitting device, an electronic device and a lighting device which have reduced power consumption.Type: GrantFiled: November 9, 2010Date of Patent: July 8, 2014Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Hiroki Suzuki, Tsunenori Suzuki, Satoshi Seo
-
Patent number: 8748451Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.Type: GrantFiled: April 22, 2013Date of Patent: June 10, 2014Assignee: The Board of Trustees of The University of IllinoisInventors: Alan Kozikowski, Kyle Vincent Butler, Jay Hans Kalin
-
Patent number: 8748473Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.Type: GrantFiled: January 14, 2013Date of Patent: June 10, 2014Assignee: Board of the Regents of The University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Publication number: 20140151667Abstract: An amine derivative including a fluorine substituted aryl group is represented by compound (1) of the following Formula 1. wherein, each of Ar1 and Ar2 independently represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, L is a substituted or unsubstituted arylene group or a substituted or unsubstituted heteroarylene group, each of R1 and R2 independently represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group, a is an integer satisfying 0?a?3, and at least one of Ar1 and Ar2 is substituted with at least one fluorine atom.Type: ApplicationFiled: December 5, 2013Publication date: June 5, 2014Applicant: SAMSUNG DISPLAY CO., LTD.Inventor: Yasuo Miyata
-
Patent number: 8741446Abstract: Organic compounds and organic electroluminescent devices employing the same are provided.Type: GrantFiled: December 21, 2010Date of Patent: June 3, 2014Assignee: Industrial Technology Research InstituteInventors: Jin-Sheng Lin, Meng-Ting Lee, Heh-Lung Huang
-
Patent number: 8735440Abstract: This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.Type: GrantFiled: February 19, 2013Date of Patent: May 27, 2014Assignee: Board of Regents of The University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Publication number: 20140107174Abstract: The present invention relates to novel benzoyl derivatives of 3-aminocarbazole, to a pharmaceutical composition containing them, to a method for preparing them and to the use of such compounds for the production of a drug that is useful in the treatment or prevention of disturbances associated with the production of prostaglandin E2 (PGE2), for instance inflammatory processes, pain, fever, tumours, Alzheimer's disease and atherosclerosis.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. AC.R.A.F. S.p.A.Inventors: Maria Alessandra ALISI, Nicola CAZZOLLA, Isabella COLETTA, Patrizia DRAGONE, Guido FURLOTTI, Barbara GAROFALO, Angelo GUGLIELMOTTI, Giorgina MANGANO, Caterina MAUGERI
-
Publication number: 20140107247Abstract: The invention provides a polymerizable compound represented by formula (I), a polymerizable composition, and a polymer that have a practical low melting point, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.Type: ApplicationFiled: April 12, 2012Publication date: April 17, 2014Applicant: ZEON CORPORATIONInventors: Kei Sakamoto, Kumi Okuyama
-
Publication number: 20140094480Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death.Type: ApplicationFiled: December 9, 2013Publication date: April 3, 2014Applicant: Board of Regents of The University of Texas SystemInventors: Steven L. McKnight, Joseph M. Ready, Andrew A. Pieper, Jef K. De Brabander
-
Patent number: 8686021Abstract: Use of a benzoyl derivative of 3-aminocarbazole to produce a drug for the preventive or therapeutic treatment of a disorder selected form the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis. Method for the preventive or therapeutic treatment of a disorder selected from the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis in which a therapeutically effective quantity of a benzoyl derivative of 3-aminocarbazole according to the invention is administered to an individual.Type: GrantFiled: May 3, 2006Date of Patent: April 1, 2014Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Lorenzo Polenzani, Giorgina Mangano, Isabella Coletta, Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri
-
Patent number: 8686628Abstract: It is an object of the present invention to provide a novel material which has excellent light-emitting efficiency, a light-emitting element provided with the novel material, and a light-emitting device using the light-emitting element.Type: GrantFiled: August 30, 2006Date of Patent: April 1, 2014Assignee: Semiconductor Energy Laboratory Co., Ltd.Inventors: Sachiko Kawakami, Harue Nakashima, Kumi Kojima, Nobuharu Ohsawa, Ryoji Nomura
-
Publication number: 20140057900Abstract: Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.Type: ApplicationFiled: August 23, 2013Publication date: February 27, 2014Applicant: Board of Regents of The University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Enrique Fernandez
-
Publication number: 20140034623Abstract: A process for altering the absorption of electromagnetic radiation by one or more compounds of the general formulae (I) wherein these compounds are irradiated with electromagnetic radiation of wavelength from 300 to 750 nm. The use of compounds of the general formula (I) or (II) for marking materials, for example paper or mineral oil, and use of compounds of the general formula (I) or (II) for causing a color change. The use of compounds of the general formula (I) or (II) for laser welding, heat management, as a photoinitiator, as a free-radical scavenger or for detection of oxygen. A process for regulating the absorption or transmission of electromagnetic radiation by a material wherein one or more compounds of the general formula (I) or (II) are contacted with this material and these compounds are irradiated with electromagnetic radiation of wavelength from 300 to 750 nm. Specific compounds of the general formula (I).Type: ApplicationFiled: October 11, 2013Publication date: February 6, 2014Applicant: BASF SEInventors: Thomas GESSNER, Ruediger SENS, Sophia EBERT
-
Patent number: 8637168Abstract: The present invention relates to aromatic amines and to electronic devices in which these amines are used, in particular, as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.Type: GrantFiled: September 10, 2009Date of Patent: January 28, 2014Assignee: Merck Patent GmbHInventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard
-
Publication number: 20130331424Abstract: Described herein are antimicrobial compounds identified via a high-throughput inhibitor screen of the in vitro activity of MipZ, which is an ATPase that regulates division site placement in Caulobacter crescentus. The compounds and their analogs are active against bacterial membranes and thus represent a novel class of antimicrobial compounds. The antimicrobial compounds are effective against both actively growing bacterial cells as well as bacterial cells in the stationary phase. The antimicrobial compounds are also effective against bacteria in biofilms.Type: ApplicationFiled: June 10, 2013Publication date: December 12, 2013Inventors: Douglas Benjamin Weibel, Ye Jin Eun, Marie Hazel Foss, Katherine Ann Hurley
-
Patent number: 8604074Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.Type: GrantFiled: January 11, 2010Date of Patent: December 10, 2013Assignee: Board of Regents of The University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Patent number: 8592057Abstract: Disclosed is an organic electroluminescence element comprising an anode, a cathode and a plurality of organic compound layers between the anode and the cathode, provided that one of the organic compound layers is a light emitting layer containing a phosphorescence emitting compound, wherein at least one of the organic compound layers contains a compound represented by Formula (2): wherein, X represents O or S; three of Y1 to Y4 each are a group represented by Formula (2A), and one of Y1 to Y4 is a hydrogen atom. Formula (2A) is: Ar1L1n1* wherein, L1 represents a divalent linking group derived from an aromatic hydrocarbon ring or an aromatic heterocycle; n1 represents an integer of 0 to 3, provided that when n1 is 2 or 3, a plurality of L1s may be the same or different; “*” indicates a linking position with Formula (2).Type: GrantFiled: December 13, 2012Date of Patent: November 26, 2013Assignee: Konica Minolta Holdings, Inc.Inventors: Rie Katakura, Shuichi Sugita, Eisaku Katoh, Motoaki Sugino, Rie Fujisawa
-
Publication number: 20130309184Abstract: The invention relates to specific 1,3-dioxan-5-one compounds, to a process for the preparation thereof, and to the use thereof as dyes or as fluorescent emitters for organic electroluminescent devices (OLEDs) or for organic light-emitting electrochemical cells (OLECs), and to corresponding electronic devices.Type: ApplicationFiled: January 16, 2012Publication date: November 21, 2013Applicant: MERCK PATENT GMBHInventors: Thomas Rudolph, Philipp Buehle, Ralf Rosskopf
-
Publication number: 20130306917Abstract: The invention relates to a photovoltaic coating containing a mixture of organic N-type (acceptor) and P-type (donor) semiconductor compounds, which makes it possible, when selecting the donor/acceptor pair, to modulate the semiconductor properties of the photovoltaic coating so as to enable the use thereof within a photovoltaic device, wherein one of the organic semiconductors includes a quinone core.Type: ApplicationFiled: October 21, 2011Publication date: November 21, 2013Applicant: RHODIA OPERATIONSInventors: Floryan Decampo, Gerard Mignani, Bertrand Pavageau
-
Publication number: 20130303524Abstract: The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing's syndrome, and glaucoma.Type: ApplicationFiled: May 10, 2013Publication date: November 14, 2013Inventors: Ross Bersot, Paul Humphries
-
Publication number: 20130281484Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.Type: ApplicationFiled: April 22, 2013Publication date: October 24, 2013Inventors: Alan Kozikowski, Kyle Vincent Butler, Jay Hans Kalin
-
Patent number: 8546505Abstract: This invention relates generally to norbornene-monomer, poly(norbornene)homopolymer, and poly(norbornene)copolymer compounds containing a functionalized carbazole side chain, having desirable solution processability and host characteristics. It also relates to hole transport and/or electron blocking materials, and to organic host materials for an organic luminescence layer, an OLED device, and compositions of matter which include these compounds.Type: GrantFiled: December 19, 2008Date of Patent: October 1, 2013Assignee: Georgia Tech Research CorporationInventors: Yadong Zhang, Seth Marder, Carlos Zuniga, Stephen Barlow, Bernard Kippelen, Andreas Haldi, Benoit Domerq, Marcus Weck, Alpay Kimyonok
-
Patent number: 8524425Abstract: Compounds of the formula (I) and (II) M1, M2 and M3 independently of one another are no bond, a direct bond, CO, O, S, SO, SO2 or NR14; provided that at least one of M1, M2 or M3 is a direct bond, CO, O, S, SO, SO2 or NR14; M4 is a direct bond, CR?3R?4, CS, O, S, SO, or SO2; Y is S or NR18; R1 for example is hydrogen, C3-C8cycloalkyl, phenyl or napthyl, both of which are optionally substituted; R2 for example is C1-C20alkyl; R?2 has one of the meanings given for R2; R3 and R4 are for example hydrogen, halogen, C1-C20alkyl; R?3, R?4, R?3 and R?4 independently of one another have one of the meanings given for R3 and R4; and R5 is for example hydrogen, halogen, C1-C20alkyl; provided that in the compounds of the formula (I) at least two oxime ester groups are present and provided that at least one specified substituent R2 or R?2 is present; exhibit an unexpectedly good performance in photopolymerization reactions.Type: GrantFiled: April 28, 2008Date of Patent: September 3, 2013Assignee: BASF SEInventors: Akira Matsumoto, Junichi Tanabe, Hisatoshi Kura, Masaki Ohwa
-
Patent number: 8519154Abstract: The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients. Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2?CH3 or CHO; R3?H or OCH3; R4?H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.Type: GrantFiled: February 3, 2012Date of Patent: August 27, 2013Assignee: Council of Scientific & Industrial ResearchInventors: Sibabrata Mukhopadhyay, Mumu Chakraborty, Tulika Mukherjee, Arun Bandyopadhyay, Dipak Kar, Tanima Banerjee, Aditya Konar, Debaprasad Jana, Siddhartha Roy, Santu Bandyopadhyay, Balram Ghosh, Mabalirajan Ulaganathan, Rakesh Kamal Johri, Subhash Chander Sharma, Gurdarshan Singh, Bholanath Paul, Vasanta Madhava Sharma Gangavaram, Jhillu Singh Yadav, Radha Krishna Palakodety
-
Publication number: 20130190339Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protecting from neuron cell death.Type: ApplicationFiled: December 10, 2012Publication date: July 25, 2013Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventor: Board of Regents of the University of Texas System
-
Publication number: 20130059852Abstract: Some embodiments of this invention include methods for treating disease and methods for administering a compound of Formula (I). In some aspects of the invention, diseases can be treated by administration of compositions comprising a compound of Formula (I). Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I).Type: ApplicationFiled: April 8, 2011Publication date: March 7, 2013Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.Inventors: John O. Trent, Jason B. Meier, Kelby B. Napier
-
Publication number: 20130046072Abstract: Monomers having formula (I) and process for their synthesis which comprises the etherification reaction of a halogen-derivative (Z?Cl, Br, I) having formula (III) with the hydroxyl group of the glycerol derivative (IV), according to the following scheme:(Formula III, IV & I) (III) (IV) (I)Type: ApplicationFiled: April 29, 2011Publication date: February 21, 2013Applicant: ENI S.p.A.Inventors: Giuliana Schimperna, Riccardo Po', Andrea Pellegrino, Maria Caldararo
-
Publication number: 20130040977Abstract: This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.Type: ApplicationFiled: August 24, 2012Publication date: February 14, 2013Inventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Publication number: 20130041007Abstract: This invention provides compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and or salts thereof, pharmaceutical compositions comprising a compound of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and a pharmaceutically acceptable excipient, methods of modulating the androgen receptor, methods of treating diseases beneficially treated by an androgen receptor modulator (e.g., sarcopenia, prostate cancer, contraception, type II diabetes related disorders or diseases, anemia, depression, and renal disease) and processes for making compounds of Formula (I), (Ia), (Ib), (Ic), (II), (IIa) or (III) and intermediates useful in the preparation of same.Type: ApplicationFiled: February 4, 2011Publication date: February 14, 2013Inventor: Chris P. Miller
-
Patent number: 8367224Abstract: Disclosed is an organic electroluminescence element comprising an anode, a cathode and a plurality of organic compound layers between the anode and the cathode, provided that one of the organic compound layers is a light emitting layer containing a phosphorescence emitting compound, wherein at least one of the organic compound layers contains a compound represented by Formula (1), wherein, X represents O or S; Y1 to Y3 each represents a hydrogen atom, a substituent or a group represented by Formula (A) disclosed in the specification, provided that at least two of Y1 to Y3 are groups represented by Formula (A), not all of Y1 to Y3 are the same group, and at least one of the groups represented by Formula (A) has Ar of a carbazolyl group, or an azacarbazolyl group containing 2 to 5 nitrogen atoms.Type: GrantFiled: April 1, 2010Date of Patent: February 5, 2013Assignee: Konica Minolta Holdings, Inc.Inventors: Rie Katakura, Shuichi Sugita, Eisaku Katoh, Motoaki Sugino, Rie Fujisawa
-
Publication number: 20130026426Abstract: A carbazole derivative represented by the following General Formula (1) where at least one aromatic ring has one to three substituents each represented by the following General Formula (2): in General Formula (1), Ar1 and Ar2 each independently represent a substituted or unsubstituted aryl group which may form a ring with a benzene ring, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted arylsilyl group, or a hydrogen atom, and Ar3 represents a substituted or unsubstituted aryl group, —X—Y—Z??(2) in General Formula (2), X represents a methylene group, a carbonyloxy group, an oxycarbonyl group, a carbonyl group, an oxygen atom or a sulfur atom, Y represents a substituted or unsubstituted alkylene group, and Z represents a carboxyl group, a hydroxyl group or a thiol group.Type: ApplicationFiled: March 29, 2012Publication date: January 31, 2013Inventors: Shigeyuki HARADA, Masaomi Sasaki
-
Patent number: 8362277Abstract: This invention relates generally to stimulating neurogenesis (e.g., post-natal neurogenesis, e.g., post-natal hippocampal neurogenesis) and protection from neuron cell death.Type: GrantFiled: July 7, 2010Date of Patent: January 29, 2013Assignee: Board of Regents of The University of Texas SystemInventors: Steven L. McKnight, Andrew A. Pieper, Joseph M. Ready, Jef K. De Brabander
-
Patent number: 8357704Abstract: A compound of formula I wherein m, n, A, B, D, E, G, H, Y, R1, R2, R3, R4, R5, and R8, are described herein.Type: GrantFiled: June 10, 2010Date of Patent: January 22, 2013Assignee: Bristol-Myers Squibb CompanyInventors: James A. Johnson, John Lloyd, Alexander Kover
-
Patent number: 8344159Abstract: The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate), methods of preparing the sesquihydrate by adding phosphoric acid to a suspension of Carvedilol in water, water miscible solvents or a mixture of water and water miscible organic solvent followed by isolating the product directly or by adding solvent.Type: GrantFiled: June 11, 2007Date of Patent: January 1, 2013Assignee: Mylan Laboratories LimitedInventors: Seeta Ramanjaneyulu Gorantla, Mohan Bandari, Nageshwara Rao Karusala, Sankara Sastry Tummalapalli Uma
-
Patent number: 8338081Abstract: An alkali developable photosensitive resin composition contains (J) a photopolymerizable unsaturated compound having a structure resulting from the addition reaction of (B) a compound having a ?-diketone moiety or a compound having a ?-ketoester group to the (meth)acryloyl group of (A) a compound having at least two (meth)acryloyl groups and a hydroxyl group and subsequent esterification of the hydroxyl group of the resulting addition product with (C) a polybasic acid anhydride. The compound having a ?-diketone moiety is preferably a novel ?-diketone compound represented by general formula (I): wherein R1 is a C1-C20 alkyl group; R2 represents R11, OR11, COR11, SR11, CONR12R13, or CN; R11, R12, and R13 are each hydrogen, a C1-C20 alkyl group, etc.; a is 0 to 3; and b is 0 to 4.Type: GrantFiled: July 25, 2008Date of Patent: December 25, 2012Assignee: Adeka CorporationInventors: Takashi Yamada, Naomi Sato, Koichi Kimijima
-
Publication number: 20120309861Abstract: A specific type of carbazole photoinitiator is capable of providing radiation curable compositions that are curable by UV LEDs and do not exhibit an unstable yellowing behaviour in an image upon storage like ITX.Type: ApplicationFiled: December 6, 2010Publication date: December 6, 2012Applicant: AGFA-GEVAERT N.V.Inventor: Johan Loccufier
-
Publication number: 20120264703Abstract: The present invention provides novel methods and formulations for treating anxiety disorders, including Post Traumatic Stress Disorder, in human subjects employing coordinate treatment using ? and ? blockers alone or in combination with additional psychotherapeutic medications to treat the anxiety disorder and reduce symptomology in treated subjects.Type: ApplicationFiled: June 15, 2012Publication date: October 18, 2012Inventors: Arifulla Khan, John Frederick Reinhard, JR.
-
Publication number: 20120252740Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.Type: ApplicationFiled: July 2, 2010Publication date: October 4, 2012Inventors: Alan Kozikowski, Kyle V. Butler, Jay H. Kalin
-
Patent number: 8278450Abstract: Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.Type: GrantFiled: April 16, 2008Date of Patent: October 2, 2012Assignee: Takeda Pharmaceutical Company LimitedInventors: Jason W. Brown, Qing Dong, Bheema R. Paraselli, Nicholas Scorah, Jeffrey A. Stafford, Michael B. Wallace, Hasanthi Wijesekera
-
Patent number: 8278461Abstract: The present invention provides a novel stable amorphous form of carvedilol dihydrogen phosphate and the process for its preparation that involves reaction of carvedilol base with ortho phosphoric acid in the presence of stabilizer in a suitable solvent or mixture of solvents followed by concentration and isolation. An alternate process for preparation of amorphous form of carvedilol dihydrogen phosphate involves addition of stabiliser to the solution of stable amorphous or crystalline carvedilol dihydrogen phosphate in a suitable solvent or mixture of solvents followed by concentration and isolation. The novel stable amorphous form of carvedilol dihydrogen phosphate is highly stable.Type: GrantFiled: August 6, 2008Date of Patent: October 2, 2012Assignee: Lupin LimitedInventors: Rajesh Kumar Thaper, Manoj Devilalji Prabhavat, Yogesh Dadaji Pawar, Pritesh R. Upadhyay
-
Patent number: 8268459Abstract: A compound having the following structure as at least a part thereof: wherein FA and FA? are independently a substituted or unsubstituted hydrocarbon aromatic ring or hetero atom-containing aromatic ring, and at least one of FA and FA? is the hetero atom-containing aromatic ring.Type: GrantFiled: November 26, 2008Date of Patent: September 18, 2012Assignee: Idemitsu Kosan Co., Ltd.Inventors: Mitsunori Ito, Masahiro Kawamura
-
Publication number: 20120197016Abstract: Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADR?1 receptors, and determining based on the binding interaction of the test agent with the ADR?1 receptors whether the test agent is an effective ADR?1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADR?1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm.Type: ApplicationFiled: October 21, 2011Publication date: August 2, 2012Applicant: THE PROCTER & GAMBLE COMPANYInventors: Leo Timothy Laughlin, II, Tomohiro Hakozaki, Wenzhu Zhao, Jiazhen Wang, John Crist Bierman