The Additional Polycyclo Ring System Includes A Five-membered Nitrogen Containing Hetero Ring Patents (Class 548/455)
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Publication number: 20130309184Abstract: The invention relates to specific 1,3-dioxan-5-one compounds, to a process for the preparation thereof, and to the use thereof as dyes or as fluorescent emitters for organic electroluminescent devices (OLEDs) or for organic light-emitting electrochemical cells (OLECs), and to corresponding electronic devices.Type: ApplicationFiled: January 16, 2012Publication date: November 21, 2013Applicant: MERCK PATENT GMBHInventors: Thomas Rudolph, Philipp Buehle, Ralf Rosskopf
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Publication number: 20130289042Abstract: Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes.Type: ApplicationFiled: June 25, 2013Publication date: October 31, 2013Inventors: Stephen M. CONDON, Matthew G. LaPORTE, Yijun DENG, Susan R. RIPPEN
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Publication number: 20130287689Abstract: The present invention is directed to compounds, compositions, methods, and kits for detecting reactive oxygen species (ROS) by conventional fluorescence microscopy, fluorescence spectroscopy, flow cytometry, and/or high content imaging. The compounds disclosed herein are novel reduced dyes, including Cy-based hydrocyanine dyes and Cy-based deuterocyanine dyes, which dyes are probes for detecting ROS and measuring oxidative stress in cells either in vitro and/or in vivo. Also described herein are processes for preparing novel reduced dyes, i.e., ROS probes, for use in the disclosed compositions, methods and kits.Type: ApplicationFiled: November 1, 2011Publication date: October 31, 2013Applicant: Life Technologies CorporationInventors: Hee Chol Kang, Kyle Gee, Bhaskar Mandavilli, Lai-Qiang Ying, Bruce Branchaud
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Publication number: 20130280172Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: ApplicationFiled: March 15, 2013Publication date: October 24, 2013Inventor: LI-COR, INC.
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Publication number: 20130281450Abstract: The present invention provides for compounds of formula (I) wherein A, Y, J, R1, R2, and R3 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, diabetes, obesity, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or more compounds of formula I.Type: ApplicationFiled: March 12, 2013Publication date: October 24, 2013Inventors: John K. Pratt, Dachun Liu, Chang H. Park, George S. Sheppard, Lisa A. Hasvold, Le Wang
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Publication number: 20130251637Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.Type: ApplicationFiled: December 20, 2011Publication date: September 26, 2013Applicants: DYOMICS GMBH, PIERCE BIOTECHNOLOGY, INC.Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann
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Publication number: 20130231373Abstract: The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of use compounds of Formula (I) in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.Type: ApplicationFiled: August 27, 2010Publication date: September 5, 2013Applicant: Novartis AGInventors: Clinton Alan Brooks, Christine Hiu-Tung Chen, Young Shin Cho, Lei Jiang, Gang Liu, Michael David Schultz
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Publication number: 20130230466Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.Type: ApplicationFiled: February 28, 2013Publication date: September 5, 2013Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa R. Dworecki, Frank G. Lehmann, Marie Christine Nlend
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Publication number: 20130231604Abstract: Halo-organic heterocyclic compounds are described, in which at least two halogen atoms are bound to a nitrogen-containing heterocyclic terminal moiety of the compound, with at least one of such halogen atoms being iodine or bromine. Also described are polymethine dyes based on these heterocyclic compounds, and dendrimeric compounds and conjugates of such polymethine dyes. The polymethine dyes are characterized by enhanced properties, e.g., brightness, photostability, sensitivity and/or selective affinity that make them useful to target cancer cells, pathogenic microorganisms, and/or other biological materials, in applications such as photodynamic therapy, photodynamic antimicrobial chemotherapy (PACT), cancer treatment, selective removal or attachment of biological materials, antimicrobial coating materials, and other diagnostic, theranostic, spectrum shifting, deposition/growth, and analytic applications.Type: ApplicationFiled: March 3, 2012Publication date: September 5, 2013Applicant: NANOQUANTUM SCIENCES, INC.Inventors: Gary W. Jones, Anatoliy L. Tatarets, Leonid D. Patsenker
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Publication number: 20130224115Abstract: Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.Type: ApplicationFiled: April 1, 2011Publication date: August 29, 2013Applicant: Baylor College of MedicineInventors: Wei Wang, Jason Shohet, Michel Mawad, Shi Ke
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Publication number: 20130217679Abstract: Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.Type: ApplicationFiled: March 23, 2011Publication date: August 22, 2013Applicants: THE SCRIPPS RESEARCH INSTITUTE, THE JOHNS HOPKINS UNIVERSITYInventors: Donald J. Zack, Thomas Bannister, Tomas Vojkovsky, Zhiyong Yang, Cynthia Berlinicke
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Publication number: 20130210706Abstract: Novel peptide compounds and pharmaceutical compositions thereof are disclosed that have a formula represented by the following formula (I) wherein L1, L2, L3, Z, R1, R2, R4 and R5 are as described herein. The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provided by standard antibiotics.Type: ApplicationFiled: August 26, 2011Publication date: August 15, 2013Inventors: Neville Robert Kallenbach, Filbert Totsingan
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Patent number: 8507677Abstract: A compound represented by the following general formula (I): [wherein R1 and R2 represent a C1-6 alkyl group; R3, R4 and R5 represent hydrogen atom, a C1-6 alkyl group, or an aryl group; Y1 and Y2 represent —O—, —S—, —Se—, —CH?CH—, —C(R6)(R7)—, or —N(R8)— (wherein R6, R7 and R8 represent hydrogen atom or a C1-6 alkyl group); A represents a C1-3 alkylene group; n and n? represent 0, 1 or 2; Z1 and Z2 represent a nonmetallic atom group required to form a benzo-condensed ring or a naphtho-condensed ring; L1 to L7 represent a methine group; and M? represents a counter ion in a number required for neutralizing electrical charge], which is useful as a fluorescent probe of which optical characteristics change depending on pH change.Type: GrantFiled: February 15, 2008Date of Patent: August 13, 2013Assignee: The University of TokyoInventors: Tetsuo Nagano, Hirotatsu Kojima, Kazuki Kiyose
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Publication number: 20130196968Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein Q and Z are defined herein.Type: ApplicationFiled: March 13, 2013Publication date: August 1, 2013Applicant: Janssen Pharmaceutica, NVInventor: Janssen Pharmaceutica, NV
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Publication number: 20130186468Abstract: The photoelectric conversion device described herein includes a working electrode having a dye-supported metal oxide electrode in which a dye is supported on a metal oxide layer. The dye includes a structure represented by general formula (I) wherein A is a structure having a maximum absorption wavelength ?max of 350 to 500 nm in a methanol solution; B is a cyanine skeleton having a maximum absorption wavelength ?max of 500 to 700 nm in a methanol solution; Z1 is any one divalent linking group selected from —CONR—, —NRCO—, —SO2NR—, and —NRSO2—; R in Z1 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or an arylalkyl group having 7 to 20 carbon atoms; Y1 and Y2 are each independently an alkylene group having 1 to 8 carbon atoms, or a single bond, and may be the same or different; r is 1 or 2; m and n are each independently an integer of 0 to 2; and (m+n) is 1 or more.Type: ApplicationFiled: September 27, 2011Publication date: July 25, 2013Applicants: ADEKA CORPORATION, TDK CORPORATIONInventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Yohei Aoyama, Kensaku Akimoto, Tatsuya Ishida, Toru Yano
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Publication number: 20130183247Abstract: The invention relates to fluorescent derivatives of cyanines conjugated with a polyamine group, having formula (I), or a pharmaceutically acceptable salt thereof. The invention also relates to the method for preparing said derivatives, diagnostic compositions containing same and the use thereof as a diagnostic probe for the detection of cancer tumours, in particular in vivo.Type: ApplicationFiled: November 24, 2011Publication date: July 18, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), PIERRE FABRE MEDICAMENTInventors: Yves Guminski, Thierry Imbert, Sabrina Pesnel, Arnaud Pillon, Alain Le Pape, Stephanie Lerondel
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Publication number: 20130175507Abstract: Novel heterocyclic materials are disclosed. The materials contain a fused tetracyclic structure that can improve the properties of OLED devices when the novel heterocyclic materials are incorporated into such devices.Type: ApplicationFiled: January 10, 2012Publication date: July 11, 2013Applicant: Universal Display CorporationInventor: Bin Ma
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Patent number: 8481752Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting of: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: GrantFiled: June 21, 2010Date of Patent: July 9, 2013Assignee: Li-Cor, Inc.Inventors: Xinshe Xu, Daniel R. Draney
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Patent number: 8476462Abstract: Fluorescent cyanine and squaraine dyes are described that can be conjugated to analyte molecules of interest such as peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers and small molecules via a sulfonyl or sulfonamide substituent. The new dyes are made via a novel cyanine dye activation procedure that converts the normally stable, water solubilizing sulfonate substituents into a reactive sulfonyl halides. The sulfonyl halides may be directly conjugated to analytes or can be further converted to more stable reactive sulfonamide handles or to water soluble sulfonamides. The general structure of the new dyes is given below where the central linker is an unsaturated carbon chain or an unsaturated chain containing a squaraine moiety.Type: GrantFiled: August 14, 2008Date of Patent: July 2, 2013Assignee: Combinix, Inc.Inventor: Nicholas Cairns
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Patent number: 8470959Abstract: A novel polyimide compound which has a low linear expansion coefficient and permits film formation by a spin coating method or the like, a preparation method for the polyimide compound, and an optical film and an optical waveguide produced by employing the compound. The polyimide compound has a structural unit represented by the following general formula (1): wherein X is a covalent single bond, —CH2—, —C(CF3)2— or —CR(R?)— (wherein R and R?, which may be the same or different, are each a C1 to C6 alkyl group or an aryl group); A and B, which may be the same or different, are substituents each selected from a hydroxyl group, a halogen group and a C1 to C4 alkyl group; a and b, which are the numbers of the substituents A and B, respectively, are each an integer of 0 to 2; and o, p and q are each an integer of 1 to 5.Type: GrantFiled: May 28, 2010Date of Patent: June 25, 2013Assignee: Nitto Denko CorporationInventors: Tomoyuki Hirayama, Junichi Fujisawa
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Patent number: 8465985Abstract: A fluorescent probe comprising a compound represented as (Fluorophore A)-S-(Fluorophore B) (Fluorophore A and Fluorophore B are fluorophores which emit fluorescence when they are irradiated with an excitation light of a wavelength of 600 to 950 nm, Fluorophore A has a property that it shows change of fluorescence characteristic before and after a specific reaction with an substance to be measured, and S represents a spacer which connects Fluorophore A and Fluorophore B), which compound shows substantial change in efficiency of fluorescence resonance energy transfer between Fluorophore A and Fluorophore B before and after the specific reaction with the objective substance, wherein Fluorophore A is represented by the following formula (AI): which uses and shows an excitation light wavelength/fluorescence wavelength in the near infrared region, lights of which region show superior biological tissue permeability, and enables measurement of an substance to be measured by the ratio method.Type: GrantFiled: February 29, 2008Date of Patent: June 18, 2013Assignee: The University of TokyoInventors: Tetsuo Nagano, Hirotatsu Kojima, Sakiko Aizawa, Kazuki Kiyose
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Publication number: 20130150254Abstract: The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.Type: ApplicationFiled: December 6, 2011Publication date: June 13, 2013Inventors: John J. Naleway, Ying Jiang, Ryan Link-Cole
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Patent number: 8455516Abstract: A new series of HIV-1 fusion inhibitors and methods of use are disclosed. The compounds are based on a substituted indole, benzimidazole, indoline or isoindoline fragment. The compounds find use in inhibiting or preventing HIV fusion from occurring, thus inhibiting or preventing entry of viral RNA into host cells. The compounds may be useful towards other biological targets involving protein-protein interactions.Type: GrantFiled: January 14, 2011Date of Patent: June 4, 2013Assignee: Touro UniversityInventors: Miriam Gochin, Guangyan Zhou
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Publication number: 20130137873Abstract: The invention relates to a family of fluorescent compounds that comprise a bridged polycyclo moiety. The compounds can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications, and are particularly useful for the in vivo imaging of regions of interest within a mammal.Type: ApplicationFiled: July 13, 2012Publication date: May 30, 2013Inventor: Nara Narayanan
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Publication number: 20130129812Abstract: Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.Type: ApplicationFiled: October 26, 2012Publication date: May 23, 2013Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventor: Board of Regents, The University of Texas System
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Patent number: 8445697Abstract: The present invention relates to squarylium dyes including an anchoring group, to a method of synthesis of such dye, to an electronic device comprising such dye, and to uses of such dye.Type: GrantFiled: October 27, 2008Date of Patent: May 21, 2013Assignee: Sony CorporationInventors: Gerda Fuhrmann, Gabriele Nelles, Ameneh Bamedi Zilai, Akio Yasuda
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Publication number: 20130121926Abstract: The present invention relates to sulfonated optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.Type: ApplicationFiled: June 29, 2011Publication date: May 16, 2013Applicant: GE HEALTHCARE ASInventors: Radha Achanath, Srinath Balaji, John Henrik Johansen
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Patent number: 8440840Abstract: A dye including an anchoring group in its molecular structure, said anchoring group allowing a covalent coupling of said dye to a surface, for example a surface of a nanoporous semiconductor layer, said anchoring group being represented by formula 1 wherein attachment of said anchoring group within said molecular structure of said dye is at the terminal carbon marked with an asterisk in above formula, wherein G is selected from —COOH, —SO3H, —PO3H2, —BO2H2, —SH, —OH, —NH2, preferably —COOH, wherein A is selected from the group comprising H, —CN, —NO2, —COOR, —COSR, —COR, —CSR, —NCS, —CF3, —CONR2-OCF3, C6H5-mFm, wherein m=1-5, R being H or any straight or branched alkyl chain of general formula —CnH2n+I, n=O-12, preferably 0-4, or any substituted or non-substituted phenyl or biphenyl.Type: GrantFiled: October 27, 2008Date of Patent: May 14, 2013Assignee: Sony CorporationInventors: Gerda Fuhrmann, Gabriele Nelles, Ameneh Bamedi Zilai, Akio Yasuda
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Publication number: 20130112946Abstract: A heterocyclic compound represented by Formula 1 below and an organic light-emitting device including the heterocyclic compound: wherein X1 and X2, X1 and R1 to R10 are defined as in the specification.Type: ApplicationFiled: February 29, 2012Publication date: May 9, 2013Applicant: SAMSUNG MOBILE DISPLAY CO., LTD.Inventors: Bum-Woo Park, Yoon-Hyun Kwak, Sun-Young Lee, Chang-Ho Lee, Se-Jin Cho
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Patent number: 8436153Abstract: The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.Type: GrantFiled: January 5, 2010Date of Patent: May 7, 2013Assignee: Biosearch Technologies, Inc.Inventors: Tim Carter, Mark Reddington
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Publication number: 20130102756Abstract: A curable resin comprising a compound having the structure (I): wherein each carbon 2, together with either its carbon 1 or carbon 3, arc members of a fused cycloaliphatic ring, and when carbon 1 is a member of the ring so is N, and wherein each of the aliphatic or aromatic ring-member carbons may either be members of further fused cycloaliphatic rings or be bonded to a group selected from H or linear or branched C1 to C5 alkyl.Type: ApplicationFiled: March 21, 2011Publication date: April 25, 2013Applicant: HEXCEL COMPOSITES LIMITEDInventor: John Cawse
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Publication number: 20130101517Abstract: A compound of structural formula (I): The values and alternative values are as defined herein. The invention also includes biosensors comprising nanoparticles functionalized with a compound of structural formula (I). Also described is a method for labeling a biomolecule using a compound of structural formula (I) and a method of detecting a target biomolecule using a compound of structural formula (I) or a biosensor of the invention.Type: ApplicationFiled: September 24, 2012Publication date: April 25, 2013Applicants: Agency for Science, Technology and Research, National University of SingaporeInventors: National University of Singapore, Agency for Science, Technology and Research
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Publication number: 20130095040Abstract: The present invention relates to sulfonated unsymmetrical pentamethine optical dye compositions, especially dyes suitable for biological applications in vitro, and for in vivo imaging. Improved dye compositions and intermediates are provided, which enable the suppression of undesirable newly-identified impurities. Also provided is the use of the improved dye compositions in the preparation of conjugates with biological targeting molecules.Type: ApplicationFiled: June 29, 2011Publication date: April 18, 2013Applicant: GE HEALTHCARE ASInventor: Umamaheshwar P. Mokkapati
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Publication number: 20130052138Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.Type: ApplicationFiled: March 27, 2012Publication date: February 28, 2013Applicant: Vanderbilt UniversityInventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
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Patent number: 8378120Abstract: Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays.Type: GrantFiled: July 10, 2009Date of Patent: February 19, 2013Assignee: GE Healthcare UK LimitedInventors: Richard Martin West, Rahman Aziz Ismail
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Patent number: 8377981Abstract: A unique class of N-acyl O-amino phenol prodrugs of CBI-TMI and CBI-indole2 were synthesized and shown to be prodrugs, subject to reductive activation by nucleophilic cleavage of a weak N—O bond, effectively releasing the free drug in functional cellular assays for cytotoxic activity approaching or matching the activity of the free drug, yet remain essentially stable to ex vivo DNA alkylation conditions. Most impressively, assessment of the in vivo antitumor activity of a representative O-(acylamino) prodrug, 8, indicate that they approach the potency and exceed the efficacy of the free drug itself (CBI-indole2), indicating that the inactive prodrugs not only effectively release the free drug in vivo, but that they offer additional advantages related to a controlled or targeted release in vivo.Type: GrantFiled: November 13, 2008Date of Patent: February 19, 2013Assignee: The Scripps Research InstituteInventor: Dale Boger
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Publication number: 20130039860Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula I are presented: wherein Q is a portion of a polymethine bridge: Also included are bioconjugates of the compounds of Formula I, methods of labeling biomolecules with the compounds, and methods of imaging.Type: ApplicationFiled: August 31, 2012Publication date: February 14, 2013Applicant: LI-COR, INC.Inventor: Lael Cheung
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Publication number: 20130039854Abstract: A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.Type: ApplicationFiled: July 26, 2012Publication date: February 14, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Jean C. SHIH, Leland CHUNG, Haiyen E. ZHAU, Boyang Jason WU, Bogdan Z. OLENYUK
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Patent number: 8367358Abstract: The present disclosure discloses a reagent for differentiating and counting leukocytes which includes: (1) cationic cyanine compounds selected from those having the following general formulae I and II; (2) cationic surfactants selected from those having the following general formulae III, IV and/or V; (3) at least one nonionic surfactant; and (4) optionally, at least one anionic compound selected from those having one or more carboxyl or sulphonyl groups; and optionally includes alcohol compounds. Also disclosed is a kit comprising the reagent for differentiating and counting leukocytes. Further disclosed is a method for differentiating and counting leukocytes using the reagent and kit. Use of the reagent, kit and method disclosed enables the identification of leukocytes in blood samples into five subtypes in a very short time, or at least achieves the differentiation and counting of four leukocyte groupings. Moreover, immature and abnormal cells can be identified.Type: GrantFiled: September 28, 2009Date of Patent: February 5, 2013Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Lei Ting, Xu Bing, Kuang Yuji, Zhang Baohua, Shao Jianhui
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Publication number: 20130028872Abstract: Described are methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a cell or population of cells characteristic of the definitive endoderm, the method comprising incubating the cell or population of cells with a GSK-3 inhibitor. Also described are methods for inducing differentiation of a cell or population of cells, characteristic of the definitive endoderm, towards a hepatocyte-like cell or a population of hepatocyte-like cells, and methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a hepatocyte-like cell or a population of hepatocyte-like cells. Further described are cells obtained by the methods and uses thereof in therapy and toxicity screening.Type: ApplicationFiled: November 26, 2010Publication date: January 31, 2013Inventors: Heather K. Bone, David Tosh, Melanie J. Welham
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Patent number: 8350015Abstract: An objective of this invention is to extend the range of choosing organic dye compounds as radiation-absorbing agents in a variety of fields by providing a novel organic dye compound which absorbs short-wavelength visible radiation and exhibits a superior in optical resistance, solubility in solvents, and heat characteristics required in a novel field in which the organic dye compound is applied: The objective is attainable by providing a cyanine dye which has a specific structure and exhibits a major adsorption maximum at a wavelength longer than 400 nm in a solution.Type: GrantFiled: February 24, 2005Date of Patent: January 8, 2013Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Yasushi Aizawa, Yoshinori Koyama, Ayashi Noguchi
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Publication number: 20130005963Abstract: An organic photoelectric conversion material for use in an organic thin-film photoelectric conversion device, containing a compound represented by formula 1; and an organic thin-film photoelectric conversion device having a photoelectric conversion layer which containing the organic photoelectric conversion material: wherein D represents an electron-donating aromatic substituent whose bonding site atom is a sp2 carbon atom; and a plurality of D may be the same or different from each other.Type: ApplicationFiled: September 7, 2012Publication date: January 3, 2013Applicant: FUJIFILM CORPORATIONInventor: Tetsu KITAMURA
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Patent number: 8344158Abstract: The invention encompasses fluorescent cyanine dyes and methods of using such dyes. In particular, the invention encompasses near infrared polymethine cyanine dyes.Type: GrantFiled: August 15, 2008Date of Patent: January 1, 2013Assignee: Washington UniversityInventors: Samuel Achilefu, Hyeran Lee, John Christian Mason, Hyeran Lee, legal representative
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Patent number: 8337728Abstract: An optical filter containing at least a clay mineral complex (A). The clay mineral complex (A) comprises a layered clay mineral (B) intercalated with a dye cation (C), and an organic cation (D).Type: GrantFiled: April 9, 2012Date of Patent: December 25, 2012Assignee: Adeka CorporationInventors: Tatsuya Ishida, Koichi Shigeno
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Patent number: 8338473Abstract: Derivatives of psammaplin A responding to formula (I), a method for their synthesis and their use for the preparation of a medicament for preventing and for treating a tumor or a cancer. Formula (I).Type: GrantFiled: February 28, 2008Date of Patent: December 25, 2012Assignees: Centre National de la Recherche Scientifique, Universite de Strasbourg, Institut National de la Sante et de la Recherche Medicale (Inserm), Universidade de Vito, Seconda Universita Degli Studi di Napoli, Radboud University NijmegenInventors: Hinrich Gronemeyer, Lucia Altucci, Angel De Lera, Hendrik Gerard Stunnenberg
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Publication number: 20120318348Abstract: Photoactive layers for use in a photovoltaic cell are described. The photoactive layers comprise at least one photoactive ion paired with another ion. This photoactive ion pair can be in the form of an ionic liquid, hydrogen bonded ion pair, cocrystal, or complex to allow for greater flexibility and portability. Also described are photovoltaic cells that contain the described photoactive layers sandwiched between two electrodes.Type: ApplicationFiled: June 18, 2012Publication date: December 20, 2012Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMAInventors: Rachel M. Frazier, Daniel T. Daly, Scott K. Spear, Robin D. Rogers, Whitney Hough
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Patent number: 8334109Abstract: A reagent for blood analysis includes: (1) a compound having the general formula I; and (2) at least one surfactant selected from cationic surfactants and nonionic surfactants. In another aspect a method for differentiating and counting blood cells is provided, the method includes the following steps: (a) mixing a blood sample with the reagent for blood analysis according to the present disclosure to form a cell suspension; (b) detecting scattered light signals and fluorescence signals of cells in the blood sample; and (c) differentiating and counting the cells in the blood sample based upon the scattered light signals and fluorescence signals. The reagent for blood analysis may be effective for identifying and counting erythroblasts and/or basophils in a blood sample to be detected, and meanwhile counting leukocytes therein.Type: GrantFiled: December 8, 2009Date of Patent: December 18, 2012Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Zhang Baohua, Xu Bing, Kuang Yuji, Lei Ting, Shao Jianhui, Bao Dequan
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Publication number: 20120305074Abstract: A photoelectric conversion element includes a working electrode having a dye-supported metal oxide electrode in which a dye is supported on a metal oxide layer, a compound having a structure represented by the following general formula (1): is used as the dye. wherein R1 to R4 are each independently a linear alkyl group having 4 to 20 carbon atoms and may be the same or different; A1 and A2 are each any one selected from the following aromatic ring group A (a pyrrole ring in the formula (1) is represented by an arc a to show a condensation position with the pyrrole ring), may be the same or different, and may have a substituent in an aromatic ring; Anp- is a p-valent anion; p is 1 or 2; and q is a coefficient for keeping a charge of the entire dye neutral.Type: ApplicationFiled: December 27, 2010Publication date: December 6, 2012Applicants: ADEKA CORPORATION, TDK CORPORATIONInventors: Junji Tanabe, Atsushi Monden, Masahiro Shinkai, Yohei Aoyama, Kensaku Akimoto, Toru Yano
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Patent number: 8323536Abstract: A near-infrared absorbing dye has an anion of formula (1) wherein A1 is H or CF3, R0 is OH or —OC(?O)—R?, and R? is a monovalent hydrocarbon group. The dye has excellent solvent solubility as well as good optical properties and heat resistance, offering the advantages of easy coating and effective working during film formation. The dye free of heavy metal in its structure is advantageously used in the process of fabricating semiconductor devices.Type: GrantFiled: May 16, 2011Date of Patent: December 4, 2012Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Masaki Ohashi, Takeshi Kinsho, Kazumi Noda, Seiichiro Tachibana
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Publication number: 20120294807Abstract: Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.Type: ApplicationFiled: December 20, 2011Publication date: November 22, 2012Applicants: DYOMICS GMBH, PIERCE BIOTECHNOLOGY, INC.Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa Dworecki, Frank G. Lehmann