Ring Carbon Of The Five-membered Hetero Ring Is Bonded Directly To A Ring Carbon Of The Hetero Ring Which Is A Cyclo In The Additional Polycyclo Heterocyclic Ring System (e.g., Indigoid Dyes, Etc.) Patents (Class 548/464)
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Patent number: 11566136Abstract: The present invention relates to novel 3-oxindole derivatives, to a process for their preparation and to the use of said derivatives as dyes for manufacturing pH sensitive textiles and as indicators in titration methods. The invention also relates to a method to manufacture pH sensitive textiles and to textiles so obtained.Type: GrantFiled: August 4, 2020Date of Patent: January 31, 2023Assignee: Sanko Tekstil Isletmeleri San. Ve Tic. A.S.Inventors: Gökhan Kaplan, Gözde Öktem, Deniz Iyidogan, Olcay Bayar, Semih Kazanc, Özden Akman
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Patent number: 9893302Abstract: The invention relates to novel compounds of formula (III) that can be used as heterocyclic dyes of unique structure and properties. These compounds can be obtained in a three-step synthesis from simple substrates. The compounds according to the invention have excellent solubility in organic solvents and excellent film-forming properties. In addition, high efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when the compounds according to the invention are used in organic field effect transistors, organic photovoltaics (solar cells) and photodiodes.Type: GrantFiled: January 24, 2017Date of Patent: February 13, 2018Assignee: BASF SEInventors: Daniel T. Gryko, Marek Grzybowski
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Patent number: 9069980Abstract: Devices, methods, and computer programs are presented for managing data security. One example method includes receiving user identification information from a screen of a device that is connectable to a database of secure information. The method proceeds to authenticating of the user identification information. The authenticating includes capturing image data of a user associated with the user identification information. The method further includes providing access to the database of secure information upon authenticating the user identification information, such that while the access is provided the capturing of the image data of the user is maintained. The method includes recording data of user interactive input and viewed images displayed on the screen while the access provided. The method binds the captured image data of the user to the recorded data to produce audit data for the user when accessing the database of secure information. The method is executed by a processor.Type: GrantFiled: March 14, 2013Date of Patent: June 30, 2015Assignee: NSS Lab Works LLCInventors: Namakkal S. Sambamurthy, Parathasarathy Krishnan
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Publication number: 20150005494Abstract: Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.Type: ApplicationFiled: December 19, 2012Publication date: January 1, 2015Inventors: Naohiko Yoshikai, Ye Wei
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Publication number: 20140303207Abstract: The invention provides novel 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.Type: ApplicationFiled: April 3, 2013Publication date: October 9, 2014Applicant: NEUROVANCE, Inc.Inventors: Phil SKOLNICK, Zhengming Chen
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Publication number: 20130345420Abstract: The invention is the discovery of the use of the class of compounds represented by Formula I, as selective inhibitors of excitatory amino acid transporter (EAAT) subtype 1 (EAAT1) and its rodent ortholog L-glutamate/L-aspartate transporter (GLAST) for the study of function and distribution of EAAT1/GLAST in the central nervous system and studies of the physiological and pathological functions of the EAAT1/GLAST subtype in native tissues, cultured neurons, and/or animal models for CNS disorders.Type: ApplicationFiled: September 19, 2011Publication date: December 26, 2013Inventors: Lennart Bunch, Anders Asbjørn Jensen
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Patent number: 8268803Abstract: The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the 5,6-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.Type: GrantFiled: December 17, 2007Date of Patent: September 18, 2012Assignee: Merck Sharp & Dohme Corp.Inventors: Frank Bennett, Srikanth Venkatraman, F. George Njoroge, Kevin X. Chen, Neng-Yang Shih, Stuart B. Rosenblum, Joseph A. Kozlowski
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Publication number: 20120035361Abstract: The invention is the discovery of the use of the class of compounds represented by Formula I, as selective inhibitors of excitatory amino acid transporter (EAAT) subtype 1 (EAAT1) and its rodent ortholog L-glutamate/L-aspartate transporter (GLAST) for the study of function and distribution of EAAT1/GLAST in the central nervous system and studies of the physiological and pathological functions of the EAAT1/GLAST subtype in native tissues, cultured neurons, and/or animal models for CNS disorders.Type: ApplicationFiled: September 19, 2011Publication date: February 9, 2012Inventors: Lennart Bunch, Anders Asbjørn Jensen
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Patent number: 8093278Abstract: The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders.Type: GrantFiled: April 28, 2010Date of Patent: January 10, 2012Assignee: AstraZeneca ABInventors: Timothy Birkinshaw, Roger Bonnert, Tony Cook, Rukhsana Rasul, Hitesh Sanganee, Simon Teague
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Publication number: 20110257238Abstract: The present invention provides a compound represented by the formula: wherein the variables R1, b, R6, Y, Z, X, R and a are defined in the specification. Said compound may be used in a method for treating diseases related to unregulated tyrosine kinase signal transduction, wherein said disease is selected from the group consisting of cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, and metabolic diseases.Type: ApplicationFiled: June 1, 2011Publication date: October 20, 2011Applicant: ALLERGAN, INC.Inventors: Sougato Boral, Xialing Guo, Shimiao Wang, Julie A. Wurster, Thomas C. Malone
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Publication number: 20110098483Abstract: The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.Type: ApplicationFiled: March 27, 2009Publication date: April 28, 2011Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Nicos A. Petasis, Malgorzata Myslinska
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Patent number: 7754735Abstract: The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders.Type: GrantFiled: May 27, 2003Date of Patent: July 13, 2010Assignee: AstraZeneca ABInventors: Timothy Birkinshaw, Roger Bonnert, Tony Cook, Rukhsana Rasul, Hitesh Sanganee, Simon Teague
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Publication number: 20090247766Abstract: The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.Type: ApplicationFiled: March 27, 2009Publication date: October 1, 2009Applicant: University of Southern CaliforniaInventors: Nicos A. Petasis, Malgorzata Myslinska
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Publication number: 20080153873Abstract: The present invention is directed to dihydrobenzofuranyl derivatives of formula I: or a pharmaceutically acceptable salt thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorder, cognitive disorder, diabetic neuropathy, pain, and other diseases or disorders.Type: ApplicationFiled: December 12, 2007Publication date: June 26, 2008Applicant: WyethInventors: Puwen Zhang, Joseph Peter Sabatucci, Eugene Anthony Terefenko, Eugene John Trybulski
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Patent number: 7205316Abstract: Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X?, Y, Y?, Z, and Z? are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).Type: GrantFiled: May 6, 2005Date of Patent: April 17, 2007Assignee: Abbott LaboratoriesInventors: Robert J. Altenbach, Lawrence A. Black, Marlon D. Cowart, Huaqing Liu
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Patent number: 7060844Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: April 1, 2003Date of Patent: June 13, 2006Assignee: Allergan, Inc.Inventors: Steven W. Andrews, Xialing Guo, Zhen Zhu, Clarence E. Hull, III, Julie A. Wurster, Shimiao Wang, Edward H. Wang, Thomas Malone
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Patent number: 6787651Abstract: Disclosed are substituted indoles, pharmaceutical compositions containing such indoles, and their use in treating or preventing PPAR-&ggr; mediated diseases or conditions, such as osteopenia, osteoporosis, cancer, diabetes and atherosclerosis.Type: GrantFiled: October 9, 2001Date of Patent: September 7, 2004Assignee: SmithKline Beecham CorporationInventors: Andreas Stolle, Jacques P. Dumas, William Carley, Philip D. G. Coish, Steven R. Magnuson, Yamin Wang, Dhanapalan Nagarathnam, Derek B. Lowe, Ning Su, William H. Bullock, Ann-Marie Campbell, Ning Qi, Jeremy L. Baryza, James H. Cook
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Patent number: 6541504Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: April 3, 2002Date of Patent: April 1, 2003Assignee: Allergan Sales, LLCInventors: Steven W. Andrews, Julie A. Wurster, Clarence E. Hull, III, Edward H. Wang, Thomas Malone, Xialing Guo, Zhen Zhu
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Publication number: 20020065401Abstract: The invention relates to novel soluble pigment precursors possessing not only higher thermal stability but also improved solubility characteristics and to a process for mass coloration of high temperature polymers that utilizes these novel soluble pigment precursors.Type: ApplicationFiled: November 20, 2001Publication date: May 30, 2002Inventors: Leonhard Feiler, Zhimin Hao
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Patent number: 6313158Abstract: The present invention relates to novel 3-heteroarylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which have improved hydrosolubility and which are expected to modulate the activity of protein tyrosine kinases and therefore should be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.Type: GrantFiled: June 19, 1998Date of Patent: November 6, 2001Assignee: Sugen, Inc.Inventors: Peng Cho Tang, Li Sun, Gerald McMahon
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Patent number: 6077864Abstract: A compound of the formula ##STR1## wherein n, X, Y and Ar are as defined herein, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In addition, the compounds of the present invention may be used in combination therapy with standard non-steroidal anti-inflammatory drugs (NSAID'S) and analgesics, and in combination with cytotoxic drugs such as adriamycin, daunomycin, cis-platinum, etoposide, taxol, taxotere and other alkaloids, such as vincristine, in the treatment of cancer.Type: GrantFiled: June 17, 1999Date of Patent: June 20, 2000Assignee: Pfizer Inc.Inventors: Laurence Edward Burgess, James Patrick Rizzi
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Patent number: 5707557Abstract: Photochromic compounds with a 3H-naphthopyran structure having at least one pyrene moiety in the 3-position, a method for preparing such compounds, and the use of such compounds for producing photochromic articles from an organic synthetic material.Type: GrantFiled: December 20, 1996Date of Patent: January 13, 1998Assignee: Optische Werke G. RodenstockInventors: Manfred Melzig, Herbert Zinner
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Patent number: 5698575Abstract: A chromone derivative of the formula (I): ##STR1## wherein R.sup.11 is a pyrazolyl, pyrrolyl, triazolyl, benzotriazolyl, benzimidazolyl, indazolyl, or indolyl group, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 is independently a hydrogen or halogen atom, or a hydroxy or alkoxy group, or an alkoxy group substituted with one or more alkoxy groups, and X is an oxygen or sulfur atom, or a salt thereof is disclosed. The chromone derivative inhibits the activity of matrix metalloproteinase.Type: GrantFiled: August 9, 1996Date of Patent: December 16, 1997Assignee: Kureha Chemical Industry Co., Ltd.Inventors: Koju Watanabe, Tsuyoshi Saito, Koichi Niimura
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Patent number: 5482942Abstract: This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for treatment of peripheral vascular disease, congestive heart failure, disorders involving excessive smooth muscle contraction of the urinary tract such as incontinence or of the gastrointestinal tract such as irritable bowel syndrome, asthma, and hair loss and to pharmaceutical compositions containing an invention compound. The present invention discloses compounds represented by the formula (I): ##STR1## wherein: R.sub.1 and R.sub.2, independent from each other, are selected from the following: C.sub.1-6 perfluoroalkoxy, C.sub.1-6 perfluoroalkyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxyl, C.sub.1-6 alkoxycarbonyl, nitro, cyano, halogen, C.sub.1-6 alkylsulfonamido, C.sub.1-6 perfluoroalkylsulfonamido, amino, C.sub.1-6 acylamino, C.sub.Type: GrantFiled: June 28, 1994Date of Patent: January 9, 1996Assignee: American Home Products CorporationInventors: Richard M. Soll, Paul J. Dollings
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Patent number: 5405864Abstract: Maleimide derivatives, i.e., the compounds of Formula I: ##STR1## wherein: R.sup.1 is H, halo, alkyl, OH, alkoxy, haloalkyl, NO.sub.2, or NR.sup.5 R.sup.6 ;R.sup.2 is H or CN;R.sup.3 is aryl or heteroaryl, provided that R.sup.3 is heteroaryl when R.sup.2 is H and R.sup.4 is NR.sup.5 R.sup.6 ; andR.sup.4 is NR.sup.5 R.sup.6 or isothiourea,where R.sup.5 and R.sup.6 are independently H or lower alkyl;and the pharmaceutically acceptable salts thereof, and their use as chemotherapeutic agents.Type: GrantFiled: October 15, 1993Date of Patent: April 11, 1995Assignee: Syntex (U.S.A.) Inc.Inventor: Chris A. Broka
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Patent number: 5378713Abstract: Substituted thienopyrans and processes for preparing the thienopyrans are disclosed. The thienopyrans are useful as antihypertensive agents; antianginals are peripheral antivasoconstrictive agents.Type: GrantFiled: November 4, 1991Date of Patent: January 3, 1995Assignee: Ortho Pharmaceutical CorporationInventors: Jeffery B. Press, Pauline Sanfilippo, James J. McNally, Robert Falotico
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Patent number: 5236935Abstract: The present invention relates to novel benzopyran derivatives of formula (I) which have superior selectivity in the treatment of hypertension by lowering blood pressure with a relaxation activity on vascular smooth muscle. The present invention also relates to processes for preparing such compounds; and to a pharmaceutical compositions containing such compounds as an active ingredient. ##STR1## wherein: R.sub.1 is --CN, --NO.sub.2, --OCX.sub.1 X.sub.2 X.sub.3, --NH.sub.2, --NHSO.sub.2 R.sup.A, ##STR2## --SO.sub.2 R.sup.C or --SO.sub.2 NR.sup.C R.sup.D wherein X.sub.1, X.sub.2 and X.sub.3 are, each independently, a fluorine, chlorine or hydrogen atom; R.sup.A and R.sup.B are, each independently, an amino, C.sub.1-6 alkoxy, C.sub.1-6 alkyl group or an optionally substituted phenyl group; and R.sup.C and R.sup.D are a hydrogen atom, or a C.sub.1-6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C.sub.1-3 alkyl group;R.sub.2 is ##STR3## wherein R.sup.Type: GrantFiled: May 21, 1992Date of Patent: August 17, 1993Assignee: Korea Research Institute of Chemical TechnologyInventors: Sung-Eun Yoo, Kyu Y. Yi, Nak C. Jeong, Jee H. Suh, Seon-Ju Kim, Hwa-Sup Shin, Byung H. Lee, Kyu S. Jung
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Patent number: 5220036Abstract: This invention relates to novel di- and triarylmethane dye precursor compounds possessing a thiolactone, dithiolactone or thioether ring-closing moiety.Type: GrantFiled: December 7, 1989Date of Patent: June 15, 1993Assignee: Polaroid CorporationInventor: Patrick F. King
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Patent number: 4970309Abstract: This invention relates to a novel method of synthesizing di- and triarylmethane dye precursor compounds possessing a thiolactone ring-closing moiety, from the corresponding lactones.Type: GrantFiled: December 7, 1989Date of Patent: November 13, 1990Assignee: Polaroid CorporationInventor: Patrick F. King
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Patent number: 4435571Abstract: The present invention relates to compounds of the formula ##STR1## wherein R' is hydrogen, straight or branched chain lower alkyl having from 1 to 4 carbon atoms or benzyl, Z is hydrogen or straight chain lower alkyl having from 1 to 4 carbon atoms, Y is hydrogen or a nitrogen blocking group selected from the group consisting of tertiary alkoxycarbonyl, benzyloxycarbonyl, cycloalkoxycarbonyl and vinyloxycarbonyl, R.sub.c is hydrogen, halogen or benzyloxy and R.sub.d is hydrogen, or R.sub.c and R.sub.d are benzyloxy; or an individual diastereomer thereof. Said compounds having use as intermediates in the production of enkephalin derivatives which in turn are used as analgesic and antipsychotic agents.Type: GrantFiled: July 19, 1982Date of Patent: March 6, 1984Assignee: Richardson Merrell Inc.Inventors: Albert A. Carr, Robert A. Farr, John M. Kane