Process Of Forming The Bicyclo Ring System Directly From Reactant Which Contains Acyclic Nitrogen Bonded Directly To A Benzene Ring (e.g., Indoxyl From Phenylglycine, Etc.) Patents (Class 548/489)
  • Processes for the preparation of 4-oxo-octahydro-indole-1-carbocyclic acid methyl ester and derivatives thereof
    Patent number: 8084487
    Abstract: The present invention relates to a process for the production of carbamic acid (2-chloroethyl)(3-oxocyclohexyl)-alkyl ester enantiomers and of 1-carbalkoxy-4-ketoperhydroindole enantiomers.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: December 27, 2011
    Assignee: Novartis AG
    Inventors: Ernst Kuesters, Murat Acemoglu, Philipp Lustenberger, Gottfried Sedelmeier, Beat Schmitz, Gerhard Penn
  • 4-aryl substituted indolinones
    Patent number: 6677368
    Abstract: The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: January 13, 2004
    Assignee: Sugen, Inc.
    Inventors: Jingrong Cui, Ruofei Zhang, Hong Shen, Ji Yu Chu, Fang-Jie Zhang, Marcel Koenig, Steven Huy Do, Xiaoyuan Li, Chung Chen Wei, Peng Cho Tang
  • Preparation of carboxyalkyl derivatives as inhibitors of matrix metalloproteinases
    Patent number: 5684152
    Abstract: Carboxy-peptidyl compounds of Formula I are found to be useful inhibitors of matrix metalloendoproteinase-mediated diseases including osteoarthritis, rheumatoid arthritis, septic arthritis, tumor invasion in certain cancers, periodontal disease, corneal ulceration, proteinuria, dystrophobic epidermolysis bullosa, coronary thrombosis associated with atherosclerotic plaque rupture, and aneurysmal aortic disease. This invention relates to a process of making the carboxy-peptidyl compounds of formula I.
    Type: Grant
    Filed: September 19, 1996
    Date of Patent: November 4, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Mitree M. Ponpipom, William K. Hagmann
  • Preparation process of indoles
    Patent number: 5175308
    Abstract: A process is provided for the preparation of an indole from aniline or a derivative thereof and a polyhydric alcohol. The reaction is carried out in the presence of a catalyst composed of a carrier having a specific surface area of at least 10 m.sup.2 /g and silver supported on the carrier. The catalyst also contains as an additional component a specific amount of at least one element selected from Co, Fe and Ni. Deterioration in catalytic performance of the catalyst during the reaction and its regeneration are therefore minimized.
    Type: Grant
    Filed: November 6, 1990
    Date of Patent: December 29, 1992
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Tadatoshi Honda, Makoto Kotani
  • Process for preparing indoles
    Patent number: 4443615
    Abstract: An indole of the formula ##STR1## can be prepared by subjecting an aniline of the formula: ##STR2## and a glycol or an oxide of the formula: ##STR3## to vapor phase reaction at 250.degree. to 400.degree. C. in the presence of a solid acid catalyst having dehydrating and dehydrogenating activities.(In the above-mentioned formulae, R.sup.1 stands for hydrogen, alkyl, aryl or aralkyl, R.sup.2 stands for alkyl or alkoxy, R.sup.3 and R.sup.4 are the same or different and stands for hydrogen or alkyl, R.sup.5 and R.sup.6 are the same or different and stand for hydrogen or alkyl, and n is an integer of 0 to 4.
    Type: Grant
    Filed: November 10, 1981
    Date of Patent: April 17, 1984
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Manabu Matsuoka, Michihiro Tsuchiya, Yoshikazu Tokuda