And Chalcogen Bonded Directly To A Ring Carbon Of The Five Membered Hetero Ring Which Is Not Adjacent To The Ring Nitrogen (e.g., 2,4 Pyrrolidinediones, Etc.) Patents (Class 548/544)
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Publication number: 20030216260Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols of the formula (I) 1Type: ApplicationFiled: December 16, 2002Publication date: November 20, 2003Inventors: Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Rainer Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
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Publication number: 20030207935Abstract: The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic and neurodegenerative disease such as cerebral ischemia, Alzheimer disease and vascular dementia.Type: ApplicationFiled: March 26, 2002Publication date: November 6, 2003Applicant: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCESInventors: Juntian Zhang, Liang Huang, Kemei Wu, Shiming Chen
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Patent number: 6642180Abstract: The present invention relates to novel biphenyl-substituted cyclic ketoenols of the formula (I) in which W represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, halogenoalkyl or halogenoalkoxy, CKE represents one of the groups in which A, B, D, L, M, Q1, Q2, Q3, Q4, Q5 and Q6 are as defined in the description, to preparation and to their use as pesticides and herbicides.Type: GrantFiled: January 25, 2002Date of Patent: November 4, 2003Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht
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Patent number: 6642267Abstract: A substituted 1,5-dihydropyrrol-2-one compound of formula I: and methods for preparing the compounds. Also disclosed are pharmarceutical compositions comprising the compounds and methods of using the compounds for the treatment or prophylaxis of pain, inflammatory and allergic reactions, depressions, drug abuse and various other diseases or conditions.Type: GrantFiled: February 6, 2002Date of Patent: November 4, 2003Assignee: Gruenenthal GmbHInventors: Michael Przewosny, Hans-Dietrich Stachel, Hermann Poschen-Rieder
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Publication number: 20030199569Abstract: The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.Type: ApplicationFiled: February 25, 2003Publication date: October 23, 2003Inventors: Johannes Aebi, Daniel Bur, Alexander Chucholowski, Henrietta Dehmlow, Eric Argirios Kitas, Ulrike Obst, Hans Peter Wessel
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Publication number: 20030187057Abstract: The present invention relates to a compound of formula (I) 1Type: ApplicationFiled: November 8, 2002Publication date: October 2, 2003Applicant: Aventis Pharma Deutschland GmbHInventors: Matthias Schiell, Martin Knauf, Luigi Toti, Astrid Markus-Erb
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Publication number: 20030171599Abstract: Lactams, libraries of lactams, and an efficient method of synthesizing a lactam, including a &ggr;-lactam, in which an &agr;-diazoacetamide of the general structure (I) is reacted under conditions promoting intramolecular C—H insertion, for example in the presence of a rhodiurn salt such as Rh2(OAc)4, 1Type: ApplicationFiled: December 18, 2002Publication date: September 11, 2003Inventors: Kyung Woon Jung, Cheol Hwan Yoon
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Publication number: 20030171219Abstract: The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) 1Type: ApplicationFiled: September 19, 2002Publication date: September 11, 2003Inventors: Folker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Alan Graff, Norbert Mencke, Andreas Turberg, Peter Dahmen
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Publication number: 20030166707Abstract: One of the aspects of the present invention is directed to tetramic acid derivatives useful in treating or preventing bacterial diseases, especially diseases caused by gram-positive pathogens resistant to antibiotics of the prior art. Within the scope of the present invention are pharmaceutical compositions containing at least one of the tetramic acid derivatives of the invention as the active ingredient, methods of treating and/or preventing a bacterial disease by administering at least one of the tetramic acid derivatives of the invention, and the use of the tetramic acid derivatives of the invention in the treatment and/or prevention of a bacterial disease. Preferably, the tetramic acid derivative of the invention is a compound of formula IV shown below.Type: ApplicationFiled: October 17, 2002Publication date: September 4, 2003Inventors: Chao-Mei Yu, Stephen W. Ayer, Ronald G. Micetich, Sameeh M. Salama, Rakhshandeh Fathi-Afshar, Jonathan M. Curtis, Jeffrey Lawson Cameron Wright
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Publication number: 20030149081Abstract: The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.Type: ApplicationFiled: September 26, 2002Publication date: August 7, 2003Inventors: Dong Zou, Olivier Dasse, Janelle Evans, Paul Higgins, Jeremy Kintigh, Rama Kondru, Eric Schwartz, Laurent Knerr, Hai-Xiao Zhai
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Publication number: 20030144504Abstract: The present invention relates to new compounds of the formula (I) 1Type: ApplicationFiled: July 18, 2002Publication date: July 31, 2003Inventors: Reiner Fischer, Thomas Bretschneider, Hermann Hagemann, Folker Lieb, Michael Ruther, Arno Widdig, Peter Dahmen, Markus Dollinger, Christoph Erdelen, Hans-Joachim Santel, Ulrike Wachendorff-Neumann, Alan Graff, Wolfram Andersch
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Patent number: 6583297Abstract: Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.Type: GrantFiled: September 4, 2001Date of Patent: June 24, 2003Assignee: Board of Trustees operating Michigan State UniversityInventor: Rawle I. Hollingsworth
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Patent number: 6576632Abstract: The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.Type: GrantFiled: April 13, 2000Date of Patent: June 10, 2003Assignee: Pfizer IncInventors: Steven W. Goldstein, Kelly P. Longo, James F. Blake, Mohamed M. A. Awad, Kenneth P. Raiche, Kevin W. Kramer
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Publication number: 20030073851Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) 1Type: ApplicationFiled: May 9, 2002Publication date: April 17, 2003Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretshneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Publication number: 20030045432Abstract: The present invention relates to new compounds of the formula (I) 1Type: ApplicationFiled: December 11, 2001Publication date: March 6, 2003Inventors: Reiner Fischer, Thomas Bretschneider, Hermann Hagemann, Folker Lieb, Norbert Lui, Michael Ruther, Arno Widdig, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Peter Dahmen, Norbert Mencke, Andreas Turberg
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Patent number: 6518437Abstract: Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.Type: GrantFiled: September 4, 2001Date of Patent: February 11, 2003Assignee: Board of Trustees of Michigan State UniversityInventor: Rawle I. Hollingsworth
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Patent number: 6498004Abstract: This invention provides a photographic element comprising at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of the formula (a): &Dgr;−(t)m−XY′ (a) XY′−(t)m−&Dgr; (b) &Dgr;−(t)m−XY′−(t)m−&Dgr; (c) wherein &Dgr; is protective group that is eliminated during development of the photographic element, t is a timing group, m is an integer from 0 to 3, and XY′ is a fragmentable electron donor moiety in which X is an electron donor group and Y′ is a leaving proton H or a leaving group Y, with the proviso that if Y′ is a proton, a base, &bgr;−, is present in the emulsion or is covalently linked directly or indirectly to X, and wherein: 1) X—Y′ has an oxidation potential between 0 and about 1.Type: GrantFiled: December 28, 2000Date of Patent: December 24, 2002Assignee: Eastman Kodak CompanyInventors: Jerome R. Lenhard, Annabel A. Muenter, Stephen A. Godleski, Paul A. Zielinski, Deepak Shukla, Donald R. Diehl
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Publication number: 20020188136Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) 1Type: ApplicationFiled: May 2, 2002Publication date: December 12, 2002Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6486169Abstract: The present invention related to safe botanical drug for treatment and prevention of Alzheimer's disease. Specifically, this invention proves a safe botanical drug, Huperzine (HUE) and Clausenamide (CLE) and their preparation. HUE has the following pharmaceutical functions: inhibiting acetylcholinesterase (CAT), increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion. CLE has the following pharmaceutical functions: increasing memory, decreasing Alzheimer amyloid protein, increasing RNA and protein synthesis of brain, increasing calcium in brain, decreasing superoxide anion, increasing long-term potentiation and increasing dopanmine (DA). It is important that HUE combined with CLE have stronger function as mentioned above.Type: GrantFiled: February 19, 2002Date of Patent: November 26, 2002Inventor: Yaguang Liu
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Patent number: 6482947Abstract: Compounds of the formula I and their salts, as defined in claim 1, are suitable as safeners for protecting crop plants against the phytotoxic side-effects of herbicides.Type: GrantFiled: January 29, 1998Date of Patent: November 19, 2002Assignee: Hoechst AktiengesellschaftInventors: Xenia Holdgrün, Lothar Willms, Klaus Bauer, Klaus Trinks, Hermann Bieringer
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Patent number: 6476062Abstract: Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Chaetomium globosum Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.Type: GrantFiled: March 23, 2001Date of Patent: November 5, 2002Assignee: Schering CorporationInventors: Min Chu, Ronald A. Mierzwa, Joseph Terracciano, Mahesh G. Patel
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Patent number: 6472419Abstract: The present invention relates to new 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) in which A, B, G, X, Y and Z have the meanings given in the description, to processes for their preparation, and to intermediates therefor. The compounds of the formula (I) are used as pesticides.Type: GrantFiled: November 5, 1997Date of Patent: October 29, 2002Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Krüger, Michael Ruther, Christoph Erdelen, Ulrike Wachendorff-Neumann
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Patent number: 6458965Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketonols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, W and Y independently of one another each represent hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: January 2, 2001Date of Patent: October 1, 2002Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretshneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6451843Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols, their preparation and the use of such ketoenols as pesticides and/or herbicides. The novel arylphenyl-substituted cyclic ketoenols are of the formula (I) in which CKE refers to the cyclic ketoenol and W, X, Y and Z are as defined in the specification.Type: GrantFiled: January 2, 2001Date of Patent: September 17, 2002Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Dieter Feucht, Rolf Pontzen, Randy Allen Myers
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Patent number: 6437009Abstract: This invention provides water-based compositions, particularly coating, ink, fountain solution, adhesive, agricultural and electronics cleaning compositions, manifesting reduced equilibrium surface tension by the incorporation of a surface tension reducing amount of an N-alkylimide of tartaric acid and/or an N-alkylimide of malic acid of the following structures, respectively: where R1 is a C5 to C10 alkyl group.Type: GrantFiled: March 29, 2001Date of Patent: August 20, 2002Assignee: Air Products and Chemicals, Inc.Inventors: Ingrid Kristine Meier, Kevin Rodney Lassila, Caroline Sassano Slone
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Patent number: 6420415Abstract: Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1s are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, acyl, etc.; X1 represents a bond, optionally substituted divalent aliphatic hydrocarbyl, etc.; X2 represents a bond, optionally substituted divalent aliphatic hydrocarbyl, —O—, etc.; Ys are the same or different represents hydrogen, optionally substituted hydrocarbyl, oxo, etc.; m is 0 or 1; n is an integer of 1 to 3; q1 is an integer of 1 to 2n+4; and q2 is an integer of 0 to 2n+3, provided that q1+q2 is 2n+4.Type: GrantFiled: March 20, 2001Date of Patent: July 16, 2002Assignee: Takeda Chemical Industries, Ltd.Inventors: Toshiro Yamashita, Hiroshi Nara, Masayuki Takizawa, Koji Yoshimura
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Patent number: 6417370Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogeno-alkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenyl-alkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their use as pesticides and herbicides.Type: GrantFiled: October 23, 2000Date of Patent: July 9, 2002Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6384052Abstract: Trisubstituted pyrroles are useful in the control of coccidiosis in poultry.Type: GrantFiled: November 10, 2000Date of Patent: May 7, 2002Assignee: Merck & Co., Inc.Inventors: Tesfaye Bitfu, Danqing D. Feng
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Patent number: 6380241Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.Type: GrantFiled: November 17, 2000Date of Patent: April 30, 2002Assignee: Abbott LaboratoriesInventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
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Patent number: 6350761Abstract: This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R1, R2, R3, R4, R5 and R6 are defined herein. These compounds are useful as anti-coagulants.Type: GrantFiled: July 24, 2000Date of Patent: February 26, 2002Assignee: Berlex Laboratories, Inc.Inventors: William J. Guilford, Steven T. Sakata, Kenneth J. Shaw, Shung Wu, Wei Xu, Zuchun Zhao
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Patent number: 6348629Abstract: An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either be an N-hydroxylamine or an N-nitrosonamine, the hydrophilic tail can be a polyhydric alcohol tail and the inhibitor can be a concentrate in a liquid medium such as water, alcohol and mixture thereof.Type: GrantFiled: August 9, 2001Date of Patent: February 19, 2002Assignee: Sun Drilling Products Corp.Inventor: Robert Albright
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Patent number: 6271392Abstract: The present invention pertains to novel 3-substituted-4-thiopyrrole intermediates for the preparation of 1-arylpyrrole compounds that are useful for the control of insects, acarids and nematodes. The compounds, including their isomers, e.g., diastereomers and optical isomers, are compounds of a general formula (I) wherein the structural variables are as defined in the description.Type: GrantFiled: July 12, 1995Date of Patent: August 7, 2001Assignee: Rhone-Poulenc Inc.Inventors: Alain Chene, Scot Kevin Huber
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Patent number: 6262222Abstract: Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be obtained. In addition, ultrafine circuits can be formed and an exceptional improvement in PED stability can be accomplished by use of the photoresist.Type: GrantFiled: October 8, 1998Date of Patent: July 17, 2001Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Jin Baek Kim, Min Ho Jung, Jong Ho Cheong
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Patent number: 6255479Abstract: A method for preparing an &agr;-oxolactam comprising, reacting a corresponding &agr;-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding &agr;-oxolactam.Type: GrantFiled: December 29, 1998Date of Patent: July 3, 2001Assignee: Research Corporation Technologies, Inc.Inventors: John D. Buynak, Akireddy Srinivasa Rao
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Patent number: 6252089Abstract: 4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.Type: GrantFiled: October 20, 2000Date of Patent: June 26, 2001Assignee: Daicel Chemical Industries, Ltd.Inventor: Masahiro Nishikawa
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Publication number: 20010004629Abstract: The present invention relates to novel compounds of the formula (I) 1Type: ApplicationFiled: April 14, 2000Publication date: June 21, 2001Inventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
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Patent number: 6174989Abstract: The present invention relates to rubber compounds containing polymeric bis-succinimide polysulfides of the formula: wherein R is selected from the group consisting of phenylene and xylylene; R1 is selected from the group consisting hydrogen and alkyls having from 1 to 18 carbon atoms; x is an integer of from 2 to 8 and y is an integer of from 2 to 10.Type: GrantFiled: June 25, 1999Date of Patent: January 16, 2001Assignee: The Goodyear Tire & Rubber CompanyInventors: Richard Michael D'Sidocky, Lawson Gibson Wideman
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Patent number: 6153766Abstract: 4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.Type: GrantFiled: November 25, 1997Date of Patent: November 28, 2000Assignee: Daicel Chemical Industries, Ltd.Inventor: Masahiro Nishikawa
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Patent number: 6140358Abstract: The present invention relates to novel compounds of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, V, W, X, Y and Z are as defined in the description,processes and intermediates for their preparation, and to their use as pesticides and herbicides.Type: GrantFiled: September 29, 1998Date of Patent: October 31, 2000Assignee: Bayer AktiengesellschaftInventors: Volker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Alan Graff, Udo Schneider
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Patent number: 6136983Abstract: Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR.sup.3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining substituents, are defined in the description, are useful for controlling arthropod, nematodes, helminth or protozoan pests.Type: GrantFiled: June 16, 1998Date of Patent: October 24, 2000Assignee: Rhone-Poulenc AgrochimieInventors: Patrick Doyle Lowder, David Treadway Manning, Jennifer Lantz Phillips, Michael Thomas Pilato, Tai-Teh Wu
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Patent number: 6124435Abstract: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.Type: GrantFiled: December 22, 1998Date of Patent: September 26, 2000Assignee: Genetech, Inc.Inventors: Avi J. Ashkenazi, Steven M. Chamow, Timothy P. Kogan
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Patent number: 6114374Abstract: The invention relates to novel phenyl-substituted cyclic ketoenols of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, X and Z are each as defined in the description, to a plurality of processes and intermediates for their preparation, and to their use as pesticides.Type: GrantFiled: January 28, 1999Date of Patent: September 5, 2000Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Thomas Bretschneider, Michael Ruther, Alan Graff, Udo Schneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Wolfram Andersch, Andreas Turberg
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Patent number: 6060502Abstract: Pyrazole, pyrrole and imidazole derivatives having formula (I) or (II): ##STR1## wherein .dbd.X is .dbd.NR.sup.3, .dbd.O or an electron pair and Q comprises certain pyrazole, pyrrole and imidazole structures which, together with the remaining substituents, are defined in the description, are useful for controlling arthropod, nematodes, helminth or protozoan pests.Type: GrantFiled: March 22, 1999Date of Patent: May 9, 2000Assignee: Rhone-Poulenc AgrochimieInventors: Patrick Doyle Lowder, David Treadway Manning, Jennifer Lantz Phillips, Michael Thomas Pilato, Tai-Teh Wu
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Patent number: 6054622Abstract: A method for the preparation of aromatic hydroxythiols including oxidizing an aromatic aminothiol to form an aminodisulfide compound; forming a bis-diazonium salt of the aminodisulfide compound; and reacting the bis-diazonium salt with water to form an aromatic hydroxyldisulfide compound, which is then reduced to the hydroxythiol. New bis-diazonium aromatic disulfide compounds are also disclosed.Type: GrantFiled: December 18, 1998Date of Patent: April 25, 2000Assignee: AlliedSignal IncInventors: Mingbao Zhang, David Ryckman, Eric MacMillan
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Patent number: 6051678Abstract: Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be obtained. In addition, ultrafine circuits can be formed and an exceptional improvement in PED stability can be accomplished by use of the photoresist.Type: GrantFiled: March 13, 1997Date of Patent: April 18, 2000Assignee: Hyundai Electronics Industries Co., Ltd.Inventors: Jin Baek Kim, Min Ho Jung, Jong Ho Cheong
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Patent number: 6048840Abstract: This invention relates to novel insulin-potentiating hypoglycaemic compounds.Type: GrantFiled: April 1, 1994Date of Patent: April 11, 2000Assignee: Monash UniversityInventors: Milton Thomas William Hearn, Frank Man-Woon Ng, Victoria Marie Jane Robson, Michael Francis O'Donoghue, Ian David Rae
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Patent number: 6046213Abstract: This invention relates to compounds of formula (I), or pharmaceutically acceptable acid addition salts thereof, wherein: (a) R.sup.2 and R.sup.5 are taken separately and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1 -C.sub.6) alkyl, halo, CF.sub.3, OH or OR.sup.7 and R.sup.5 is methyl or ethyl; or (b) R.sup.2 and R.sup.5 are taken together, forming a chroman-4-ol ring, and R.sup.1, R.sup.3 and R.sup.4 are each independently hydrogen, (C.sub.1 -C.sub.6) alkyl, halo, CF.sub.3, OH or OR.sup.7 ; and R.sup.6 is a substituted piperidinyl, pyrrolidinyl or 8-azabicyclo(3.2.1)octanyl derivative; provided that (a) when R.sup.2 and R.sup.5 are taken separately, at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is not hydrogen; and (b) when R.sup.2 and R.sup.5 are taken together, at least one of R.sup.1, R.sup.3 and R.sup.Type: GrantFiled: February 13, 1997Date of Patent: April 4, 2000Assignee: Pfizer Inc.Inventors: Bertrand L. Chenard, Todd W. Butler
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Patent number: 6031113Abstract: 4-Hydroxy-2-pyrrolidinone which is useful as a raw material of drugs can be produced rapidly and highly selectively in a high yield from an optically active or recemic 4-amino-3-hydroxybutylic acid derivative or a 4-azido-3-hydroxybutyric acid derivative by adding a base catalyst to the reaction system. 4-Hydroxy-2-pyrrolidinone having a high optical purity can be obtained by carrying out recrystallization of optically active 4-hydroxy-2-pyrrolidinone without using a poor solvent.Type: GrantFiled: May 25, 1999Date of Patent: February 29, 2000Assignee: Daicel Chemical Industries, Ltd.Inventor: Masahiro Nishikawa
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Patent number: 6015569Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.Type: GrantFiled: November 17, 1997Date of Patent: January 18, 2000Assignee: Centre International de Recherches Dermatologiques GaldermaInventor: Jean-Michel Bernardon
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Patent number: 5994274Abstract: The present invention relates to new compounds of the formula (I) ##STR1## in which X represents alkyl,Y represents halogen or alkyl andZ represents halogen or alkyl,with the proviso that one of the radicals Y and Z always represents halogen and the other alkyl,Het represents one of the groups ##STR2## in which A, B, D and G have the meanings given in the description,a plurality of processes for their preparation and their use as pesticides and herbicides.Type: GrantFiled: December 23, 1997Date of Patent: November 30, 1999Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Thomas Bretschneider, Hermann Hagemann, Folker Lieb, Michael Ruther, Arno Widdig, Peter Dahmen, Markus Dollinger, Christoph Erdelen, Hans-Joachim Santel, Ulrike Wachendorff-Neumann, Alan Graff, Wolfram Andersch