The Five-membered Hetero Ring Is Unsubstituted Or Alkyl Substituted Only (e.g., Pyrrole, Etc.) Patents (Class 548/564)
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Patent number: 8912294Abstract: Polyamines A1 of formula (I) or (II). They can be easily synthesized from readily available raw materials and have no primary amino groups or only a low content of primary amino groups and thus exhibit hardly any blushing. Their viscosity is relatively low, compared with polyamine/polyepoxide adducts of the polyamine on which polyamine A1 is based. Thus epoxy resin compositions can be formulated that are free of benzyl alcohol and free of blushing.Type: GrantFiled: June 12, 2009Date of Patent: December 16, 2014Assignee: Sika Technology AGInventor: Pierre-Andre Butikofer
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Patent number: 8729277Abstract: The present invention discloses processes for producing ?-nitrocarbonyl and ?-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.Type: GrantFiled: February 28, 2012Date of Patent: May 20, 2014Assignee: Chevron Philips Chemical Company LPInventors: Hu Yang, Eduardo J. Baralt
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Publication number: 20130299391Abstract: Treatment compositions for neutralizing acidic species and reducing hydrochloride and amine salts in a fluid hydrocarbon stream are disclosed. The treatment compositions may comprise at least one amine with a salt precipitation potential index of equal to or less than about 1.0. Methods for neutralizing acidic species and reducing deposits of hydrochloride and amine salts in a hydrocarbon refining process are also disclosed. The methods may comprise providing a fluid hydrocarbon stream and adding a treatment composition to the fluid hydrocarbon stream. The treatment compositions used may have a salt precipitation potential index of equal to or less than about 1.0 and comprise either water-soluble or oil-soluble amines.Type: ApplicationFiled: May 10, 2012Publication date: November 14, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Alagarsamy Subbiah, Rebika Mayanglambam Devi, Nimeshkumar Kantilal Patel, Muthukumar Nagu, Romit Ghosh, Sathees Kesavan
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Patent number: 8362278Abstract: The present invention discloses processes for producing substituted pyrrole compounds, such as 2,5-disubstituted pyrroles. Synthetic processes which directly convert substituted furan compounds to substituted pyrrole compounds, via a reaction of the substituted furan compound with ammonia and/or an ammonium salt in the presence of a catalyst, also are described.Type: GrantFiled: October 1, 2010Date of Patent: January 29, 2013Assignee: Chevron Phillips Chemical Company LPInventors: Bruce E. Kreischer, Orson L. Sydora, Steven Hutchinson, Eduardo J. Baralt, Ron D. Knudsen
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Patent number: 8268873Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.Type: GrantFiled: August 7, 2008Date of Patent: September 18, 2012Assignee: Vertex Pharmaceuticals IncorporatedInventors: Dean Stamos, Martin Trudeau, Randy S. Bethiel, Steven M. Ronkin, Michael C. Badia, Jeffrey O. Saunders
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Patent number: 8258501Abstract: A method of using a metal complex as an n-dopant for doping an organic semiconducting matrix material in order to alter the latter's electrical characteristics is provided. In order to provide n-doped organic semiconductors with matrix materials having a low reduction potential, while achieving high conductivities, the n-dopant is a neutral electron-rich metal complex with a neutral or charged transition metal atom as a central atom and having at least 16 valence electrons. The complex can be polynuclear and can possess at least one metal-metal bond. At least one ligand can form a ? complex with the central atom, which can be a bridge ligand, or it can contain at least one carbanion-carbon atom or a divalent atom. Methods for providing the novel n-dopants are provided.Type: GrantFiled: March 3, 2005Date of Patent: September 4, 2012Assignee: Novaled AGInventors: Ansgar Werner, Olaf Kühl, Simon Gessler, Horst Hartmann, Andre Grüssing, Michael Limmert, Andrea Lux, Kentaro Harada
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Patent number: 8233830Abstract: An intermediate transfer media, such as a belt, that includes a polypyrrole associated with, attached to, and more specifically, chemically attached to a carbon black.Type: GrantFiled: January 27, 2009Date of Patent: July 31, 2012Assignee: Xerox CorporationInventor: Jin Wu
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Publication number: 20120157692Abstract: The present invention discloses processes for producing ?-nitrocarbonyl and ?-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles such as 2,5-dimethylpyrrole, and structurally similar pyrrole compounds, is also disclosed.Type: ApplicationFiled: February 28, 2012Publication date: June 21, 2012Applicant: Chevron Phillips Chemical Company LPInventors: Hu Yang, Eduardo J. Baralt
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Publication number: 20120083609Abstract: The present invention discloses processes for producing substituted pyrrole compounds, such as 2,5-disubstituted pyrroles. Synthetic processes which directly convert substituted furan compounds to substituted pyrrole compounds, via a reaction of the substituted furan compound with ammonia and/or an ammonium salt in the presence of a catalyst, also are described.Type: ApplicationFiled: October 1, 2010Publication date: April 5, 2012Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Bruce E. Kreischer, Orson L. Sydora, Steven Hutchinson, Eduardo J. Baralt, Ron D. Knudsen
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Patent number: 8148443Abstract: The present invention relates to oxonium salts having [(Ro)3O]+ cations and sulfonium salts having [(Ro)3S]+ cations, where Ro denotes straight-chain or branched alkyl groups having 1-8 C atoms or phenyl which is unsubstituted or substituted by Ro, ORo, N(Ro)2, CN or halogen, and anions selected from the group of [PFx(CyF2y+1?xHz)6?x]? anions, where 2?x?5, 1?y?8 and 0?z?2y+1, or anions selected from the group of [BFn(CN)4?n]? anions, where n=0, 1, 2 or 3, or anions selected from the group of [(Rf1SO2)2N]? anions or anions selected from the group of [BFWRf24?w]? anions, to processes for the preparation thereof, and to the use thereof, in particular for the preparation of ionic liquids.Type: GrantFiled: October 20, 2010Date of Patent: April 3, 2012Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Nikolai (Mykola) Ignatyev, German Bissky, Helge Willner
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Patent number: 8106217Abstract: The present invention relates to ionic liquids of low viscosity and high electrochemical stability, in particular for use in the area of electrochemistry and as solvents for carrying out chemical reactions.Type: GrantFiled: May 12, 2006Date of Patent: January 31, 2012Assignee: Merck Patent GmbHInventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Michael Heckmeier, German Bissky, Helge Willner
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Publication number: 20110245444Abstract: A method for processing biomass comprising heating an aqueous slurry comprising biomass, water and a phosphate catalyst in a pressure vessel at a temperature of about 150° C. to about 500° C. to produce a mixture comprising a dispersion of an organic phase and an aqueous phase.Type: ApplicationFiled: September 11, 2009Publication date: October 6, 2011Applicant: AQUAFLOW BIONOMIC CORPORATION LIMITEDInventors: Ian James Miller, Rhys Antony Batchelor
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Publication number: 20110237633Abstract: The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities thereof, or agonists or antagonists thereof, have a therapeutically useful role.Type: ApplicationFiled: December 11, 2009Publication date: September 29, 2011Inventors: Bijoy Panicker, Lambertus J.W.M. Oehlen, Itzhak G. Goldberg
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Patent number: 7994311Abstract: The present invention is a new class of fluorescent sensor with unprecedented sensitivity, selectivity and synthetic efficiency for the identification and qualitative and quantitative detection of transition metal ions. The chemosensing properties are based on an internal charge transfer mechanism or photo-induced electron transfer and are effective in vitro. The chemosensor comprises one or more electron donating dipyrrin functionalities linked to an electron withdrawing functionality. The chemosensor forms a stable transition metal complex through internal charge transfer between the electron donating functionality and the target transition metal, which results in measurable fluorescence. Specific examples for sensing zinc and copper ions are described.Type: GrantFiled: July 17, 2007Date of Patent: August 9, 2011Assignee: STC. UNMInventors: Paul A. Bentley, Yujiang Mei
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Publication number: 20110166349Abstract: Methods are provided for the catalytic hydroamination of compounds having an alkyne or allene functional group, in which the compound is contacted with ammonia or an amine in the presence of a catalytic amount of a gold complex under conditions sufficient for hydroamination to occur.Type: ApplicationFiled: May 8, 2009Publication date: July 7, 2011Applicant: The Regents of the University of CaliforniaInventors: Guy Bertrand, Vincent Lavallo, Guido D. Frey, Bruno Donnadieu, Michele Soleil-Havoup
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Patent number: 7939531Abstract: The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q and R are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.Type: GrantFiled: February 20, 2009Date of Patent: May 10, 2011Assignee: Roche Palo AltoInventors: Joe Timothy Bamberg, Mark Bartlett, Daisy Joe DuBois, Todd Richard Elworthy, Robert Than Hendricks, Johannes Cornelius Hermann, Rama K. Kondru, Remy Lemoine, Yan Lou, Timothy D. Owens, Jaehyeon Park, David Bernard Smith, Michael Soth, Hanbiao Yang, Calvin Wesley Yee
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Patent number: 7906501Abstract: Compounds which may be represented by the general formula (I) shown below and in which: R1 is a group independently selected from among: CHO, —COOH, —CH2OH R2 is hydrogen or a linear or branched C1-C6 alkyl group R3 is hydrogen or a halogen group selected from among Cl and Br R4 is a linear or branched C3-C5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.Type: GrantFiled: April 27, 2005Date of Patent: March 15, 2011Assignee: Rottapharm S.p.A.Inventors: Francesco Makovec, Roberto Artusi, Antonio Giordani, Simona Zanzola, Lucio Claudio Rovati
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Patent number: 7842804Abstract: The present invention relates to salts comprising pyrrolidinium, triazolinium, piperidinium or morpholinium cations that can have substituents thereon and alkyltrifluorophosphate anions, to processes for preparation thereof and to the use thereof, in particular for the preparation of ionic liquids.Type: GrantFiled: January 5, 2007Date of Patent: November 30, 2010Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Nikolai (Mykola) Ignatyev, German Bissky, Helge Willner
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Patent number: 7816562Abstract: The invention is amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate anion wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms, and a cationic counter ion.Type: GrantFiled: October 6, 2006Date of Patent: October 19, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Patent number: 7754744Abstract: This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.Type: GrantFiled: August 6, 2007Date of Patent: July 13, 2010Assignee: Hoffmann-La Roche Inc.Inventors: Alfred Binggeli, Andreas D. Christ, Hans P. Maerki, Rainer E. Martin
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Patent number: 7737241Abstract: The invention is a system for initiating free radical polymerization comprising: a) in one part, one or more amido-borate compounds containing one or more anionic amido-borate moieties comprising an organoborate wherein the boron atom is bonded to a nitrogen atom of ammonia or an organic compound containing one or more nitrogen atoms, such as a hydrocarbyl amine, a hydrocarbyl polyamine, or an aromatic heterocycle containing one or more nitrogen atoms and optionally containing one or more heteroatoms or heteroatom containing functional moieties, and one or more cationic counter ions and b) in a second part, a liberating compound which reacts with the nitrogen atom(s) bound to the boron atom(s) upon contact with the amido-borate to form an organoborane radical.Type: GrantFiled: October 6, 2006Date of Patent: June 15, 2010Assignee: Dow Global Technologies Inc.Inventors: Shaoguang Feng, Gary L. Jialanella, Peter Nickias, Toni Ristoski
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Patent number: 7705042Abstract: The invention relates to arylamide and hetereoarylamide compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula I, are also provided.Type: GrantFiled: October 20, 2005Date of Patent: April 27, 2010Assignee: Janssen Pharmaceutica NVInventors: Carl R. Illig, Shelley K. Ballentine, Jinsheng Chen, Sanath Meegalla, Jonathan Rudolph, Mark J. Wall, Kenneth J. Wilson, Renee DesJarlais, Carl L. Manthey, Christopher M. Flores, Christopher J. Molloy
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Publication number: 20100047603Abstract: The invention is directed to the use of a specific class of compounds in the treatment of wood, to a method of treating wood, and to the wood obtained by said method. The black insoluble polymer which forms after oxidative polymerisation of this class of compounds is able to color the wood through and through in a homogeneous fashion and cannot be rinsed off or leached with water or solvent and is stable upon UV radiation. In addition it was found that the treated wood of the present invention has a strong resistance against wood degrading fungi.Type: ApplicationFiled: December 17, 2007Publication date: February 25, 2010Applicant: Nederlandse Organisatie voor toegepast-natuurweten schappelijk onderzoek TNOInventors: Jacobus Eversdijk, Michael Fritz Sailer
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Patent number: 7655680Abstract: Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1): wherein A is any one of the following groups (i) and (ii): (i) —CO—B— wherein B is a C1-6 alkylene group and (ii) —CO—Ba— wherein Ba is a C2-6 alkenylene group, and include optical isomers and salts of the compounds.Type: GrantFiled: May 16, 2005Date of Patent: February 2, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Isao Takemura, Kenji Watanabe, Kunio Oshima, Nobuaki Ito, Junpei Haruta, Hidetaka Hiyama, Masatoshi Chihiro, Hideki Kawasome, Yoko Sakamoto, Hironobu Ishiyama, Takumi Sumida, Kazuhiko Fujita, Hideki Kitagaki
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Patent number: 7628938Abstract: The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6?-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.Type: GrantFiled: March 21, 2007Date of Patent: December 8, 2009Assignee: National University Corporation Nara Institute of Science and TechnologyInventors: Tsuyoshi Kawai, Takuya Nakajima, Shigekazu Kawai
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Publication number: 20090253670Abstract: The invention relates to novel amide derivatives that are positive allosteric modulators of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.Type: ApplicationFiled: March 26, 2009Publication date: October 8, 2009Applicant: ABBOTT LABORATORIESInventors: Michael R. Schrimpf, Kathleen H. Mortell, Diana L. Nersesian, Chih-Hung Lee, Bruce Clapham
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Patent number: 7569519Abstract: What is described are derivatives of benzoyl derivatives of the formula (I) and their use as herbicides. In this formula (I), R1, R2 and R3 are different radicals, X is a bridge atom selected from the group consisting of oxygen and sulfur and Het is a saturated heterocyclic group which comprises oxygen and carbon atoms.Type: GrantFiled: May 30, 2007Date of Patent: August 4, 2009Assignee: Bayer CropScience AGInventors: Andreas Van Almsick, Lothar Willms, Hermann Bieringer, Hubert Menne, Thomas Auler
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Publication number: 20090053826Abstract: The invention relates to an electropolymerizable monomer, intended to be polymerized in aqueous solution, comprising a single electropolymerizable unit and an electron-donating group, characterized in that it also comprises at least one arm ionizable in aqueous solution. The invention also relates to the polymerization process, to the electroactive probe thus obtained and to the method for the detection of a target ligand in a biological sample.Type: ApplicationFiled: July 7, 2006Publication date: February 26, 2009Applicants: BIOMERIEUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Aurelie Bouchet, Carole Chaix, Bernard Mandrand
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Patent number: 7411093Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.Type: GrantFiled: December 13, 2005Date of Patent: August 12, 2008Assignee: Hoffman-La Roche Inc.Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Michael Loeffler, Hans Peter Marty, Patrizio Mattei, Robert Narquizian
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Publication number: 20080006797Abstract: The present invention provides a photochromic compound that is colored when irradiated with visible light and quickly faded when set in a dark place. The photochromic compound according to the present invention is expressed by the following general formula (I): where each of A1, A2 and A3 is a five-member rings forming a 6?-electron system, the three rings being identical, partially identical or totally different from each other, and each ring may have a substituent; B1 and B2 are functional groups, each having an atomic number of five or larger, including a ring compound, and bonded to the 2-carbon of each of A2 and A3, respectively; and R1, R2 and R3 are substituents identical to or different from each other. This compound is highly colorable and durable even when it is dispersed into plastic macromolecular materials. Therefore, it is suitable as a dye material for sunglasses or similar products.Type: ApplicationFiled: March 21, 2007Publication date: January 10, 2008Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Tsuyoshi Kawai, Takuya Nakajima, Shigekazu Kawai
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Patent number: 6969744Abstract: Disclosed is a method of preparing terminally functionalized telechelic polymers using a cationic living polymer product or a terminal tert-chloride chain end of a carbocationic quasiliving polymer product, which comprises quenching the polymer product with an N-substituted pyrrole to thereby functionalize the N-substituted pyrrole at the terminal reactive polymer chain end(s). Also disclosed are the terminal functionalized polyisobuyl N-substituted pyrrole compounds where the polyisobutyl group is substituted at the 2 and 3 position of the N-substituted pyrrole.Type: GrantFiled: June 19, 2003Date of Patent: November 29, 2005Assignees: University of Southern Mississippi, Chevron Oronite Company LLCInventors: Casey D. Stokes, Robson F. Storey, James J. Harrison
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Patent number: 6852864Abstract: The present invention provides an improved method for the preparation of dipyrromethanes by reacting the pyrrole with an aldehyde in the presence of an cation exchange resin.Type: GrantFiled: March 28, 2002Date of Patent: February 8, 2005Assignee: Council of Scientific and Industrial ResearchInventors: Rajan Hiralal Naik, Padmakar Laxman Joshi
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Patent number: 6677368Abstract: The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention also relates to methods for treating protein kinase related disorders.Type: GrantFiled: December 20, 2001Date of Patent: January 13, 2004Assignee: Sugen, Inc.Inventors: Jingrong Cui, Ruofei Zhang, Hong Shen, Ji Yu Chu, Fang-Jie Zhang, Marcel Koenig, Steven Huy Do, Xiaoyuan Li, Chung Chen Wei, Peng Cho Tang
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Patent number: 6632963Abstract: Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): in which Ar1 is a radical having one of the structural formulae (a)-(c): Ar2 is a radical having one of the following formulae (d)-(h): and X is a radical having one of the following formulae (i)-(l): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.Type: GrantFiled: March 29, 1999Date of Patent: October 14, 2003Assignee: Galderma Research & Development S.N.C.Inventor: Jean-Michel Bernardon
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Patent number: 6613915Abstract: Selected olefins such as ethylene and &agr;-olefins are polymerized by nickel [II] complexes of certain monoanionic ligands. The polyolefins are useful in many applications such as molding resins, film, fibers and others. Also described are many novel nickel compounds and their precursors, as well a novel ligands.Type: GrantFiled: October 13, 1999Date of Patent: September 2, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Lynda Kaye Johnson, Alison Margaret Anne Bennett, Lin Wang, Anju Parthasarathy, Elisabeth Hauptman, Robert D. Simpson, Jerald Feldman, Edward Bryan Coughlin, Steven Dale Ittel
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Patent number: 6538139Abstract: Pyrroles of the formula (I) are prepared by dehydrogenating pyrrolidines of the formula (II) where R1 and R2, independently of one another, are hydrogen or an aliphatic radical of 1 to 6 carbon atoms, or pyridines of the formula (III) are prepared by dehydrogenating piperidines of the formula (IV) where R3, R4 and R5, independently of one another, are hydrogen or an aliphatic radical of 1 to 6 carbon atoms, in the presence of a supported noble metal catalyst, by a process in which the dehydrogenation is carried out in the presence of from 1 to 50% by weight, based on the pyrrolidine or piperidine and water, of water.Type: GrantFiled: September 5, 2002Date of Patent: March 25, 2003Assignee: BASF AktiengesellschaftInventors: Martin Schäfer, Arnd Böttcher, Andreas Kramer, Arthur Höhn, Reinhard Kaczmarek, Erhard Henkes
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Patent number: 6528647Abstract: Disclosed is a process for selectively producing aliphatic cyclic amines which comprises reacting a dihydric alcohol characterized by four to six carbons, preferably 1,5-pentane diol, with excess ammonia in presence of ZSM-5 catalyst modified with group of elements nickel, copper or cobalt-containing, at a temperature of at least 250° C., wherein said catalyst incorporates at least one metal.Type: GrantFiled: March 27, 2001Date of Patent: March 4, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Shivanand Janardan Kulkarni, Kondapuram Vijaya Raghavan, Radha Rani Vippagunta, Srinivas Nagabandi
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Patent number: 6441177Abstract: Tertiary amines of the formula wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.Type: GrantFiled: December 16, 1999Date of Patent: August 27, 2002Assignee: Hoffmann-La Roche Inc.Inventors: Johannes Aebi, Henrietta Dehmlow, Jacques Himber, Synèse Jolidon, Hans Lengsfeld, Olivier Morand, Gérard Schmid, Yu-Hua Ji
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Method of catalytically removing a protective group containing an allyl group using a reducing agent
Patent number: 6437133Abstract: A method of efficiently removing the protective group from a protected hydroxyl or amino group with an allyl derivative by one step reaction under neutral conditions. A protected hydroxyl or amino group is converted into a free hydroxyl or amino group in one-step by adding a reducing agent to an allyl derivative in the presence of nickel dichlorobis (diphenylphospino) propane.Type: GrantFiled: May 11, 2000Date of Patent: August 20, 2002Assignee: Chisso CorporationInventors: Kunio Ogasawara, Takahiko Taniguchi -
Patent number: 6432881Abstract: 2-Benzoylcyclohexane-1,3-diones of formula I : where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxy, alkenyl, alkynyl, —OR3, —OCOR3, —OSO2R3, —S(O)nR3 (n=0, 1, 2), —SO2OR3, —SO2N(R3)2, —NR3SO2R3 or —NR3COR3; R3 is hydrogen or optionally substituted alkyl, haloalkyl, alkenyl, alkynyl, phenyl or phenylalkyl; Q is optionally substituted cyclohexane-2-yl-1,3-dione; X1 is optionally substituted alkylene, propenylene, alkenylene or alkynylene; R4 is hydrogen or optionally substituted alkyl, alkenyl, alkynyl, phenyl, phenylalkyl; Het is a three- to six-membered, optionally substituted heterocyclic or heteroaromatic group; and agriculturally useful salts thereof, processes and intermediates for preparing compounds of formula I, compositions comprising them, and the use of the compounds of formula I and the compositions comprising them for controlling harmful plants are described.Type: GrantFiled: February 7, 2000Date of Patent: August 13, 2002Assignee: BASF AktiengesellschaftInventors: Stefan Engel, Joachim Rheinheimer, Ernst Baumann, Wolfgang von Deyn, Regina Luise Hill, Guido Mayer, Ulf Misslitz, Oliver Wagner, Matthias Witschel, Martina Otten, Helmut Walter, Karl-Otto Westphalen
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Patent number: 6392047Abstract: Biaryls, e,g,. biphenyls, phenylpyridines, phenylfurans, phenylpyrroles, phenylthiophenes, bipyridines, pyridylfurans or pyridylpyrroles are prepared in high yields by coupling aromatics with an aromatic boric acid or boric ester in the presence of a palladaphosphacyclobutane catalyst.Type: GrantFiled: July 13, 2000Date of Patent: May 21, 2002Assignee: Clariant GmbHInventors: Holger Geissler, Steffen Haber, Andreas Meudt, Frank Vollmueller, Stefan Scherer
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Patent number: 6384052Abstract: Trisubstituted pyrroles are useful in the control of coccidiosis in poultry.Type: GrantFiled: November 10, 2000Date of Patent: May 7, 2002Assignee: Merck & Co., Inc.Inventors: Tesfaye Bitfu, Danqing D. Feng
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Patent number: 6248765Abstract: Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.Type: GrantFiled: January 9, 1997Date of Patent: June 19, 2001Assignees: Institut National de la Sante et de la Recherche Medical, Societe Civile BioprojetInventors: Jean-Charles Schwartz, Jean-Michel Arrang, Monique Garbarg, Agnes Quemener, Jeanne-Marie Lecomte, Xavier Ligneau, Walter G. Schunack, Holger Stark, Katja Purand, Annette Huls, Reidemeister Sybille, Athmani Salah, Charon Robbin Ganellin, Nadia Pelloux-Leon, Wasyl Tertiux, Michael C. O. Krause, Sadek Bassem
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Patent number: 6166223Abstract: A process for the preparation of 2,4-dimethylpyrrole is described in which a 2,4-dimethyl-3,5-bisalkoxycarbonylpyrrole is refluxed with from 10 to 30% strength aqueous alkali metal hydroxide solution until the solid has passed into solution, the reaction mixture is neutralized with acid and the mixture is refluxed further until decarboxylation is complete. The process makes it possible to work under significantly milder, less aggressive conditions than are known from the prior art.Type: GrantFiled: December 13, 1999Date of Patent: December 26, 2000Assignee: BASF AktiengesellschaftInventors: Carsten Groning, Reinhard Kemper, Markus Frede, Klaus Ebel
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Patent number: 6162928Abstract: A process for preparing pyrroles of the formula I: ##STR1## where R.sub.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and are hydrogen atoms, alkyl groups having from 1 to 12 carbon atoms or cycloalkyl groups having from 3 to 12 carbon atoms, by dehydrogenation of pyrrolidines of the formula II: ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, in the presence of a supported noble metal catalyst is described. In this process, the dehydrogenation is carried out at from 150 to 300.degree. C. and pressures of from 0.01 to 50 bar and the noble metal catalyst comprises from 30 to 100% by weight of:a) palladium on an oxide of a rare earth or an oxide of an element of the 4.sup.th group (transition group IV) of the Periodic Table, orb) a platinum/palladium mixture on aluminum oxide, an oxide of a rare earth or an oxide of an element of the 4.sup.th groupand from 0 to 70% by weight of alkali metal oxide or alkaline earth metal oxide.Type: GrantFiled: April 20, 2000Date of Patent: December 19, 2000Assignee: BASF AktiengesellschaftInventors: Joachim Wulff-Doring, Joachim Simon, Michael Hesse, Peter Wahl
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Patent number: 6146431Abstract: A polysuccinimide composition is prepared by reacting a mixture of an alkenyl or alkylsuccinic acid derivative, an unsaturated acidic reagent copolymer, and a polyamine under reactive conditions. The alkenyl or alkyl substituent of the alkenyl or alkylsuccinic acid derivative has a Mn of from 140 to 3000. The unsaturated acidic reagent copolymer has an average degree of polymerization of from 2 to 20, and is a copolymer of an unsaturated acidic reagent and an olefin having a Mn of at least 1000. The polyamine has at least three nitrogen atoms and has from 4 to 20 carbon atoms.Type: GrantFiled: December 23, 1999Date of Patent: November 14, 2000Assignee: Chevron Chemical Company LLCInventors: James J. Harrison, William R. Ruhe, Jr.
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Patent number: 6133495Abstract: A process for producing an .alpha.-olefin oligomer, comprising subjecting an .alpha.-olefin to oligomerization in a reaction solution containing a chromium-based catalyst produced by bringing at least a chromium compound (a), a pyrrole ring-containing compound (b), an alkyl aluminum compound (c) and a halogen-containing compound (d) into contact with each other, wherein the chromium-based catalyst is a catalyst produced by bringing the pyrrole ring-containing compound (b), the alkyl aluminum compound (c) and the halogen-containing compound (d) into contact with each other in a hydrocarbon and/or halogenated hydrocarbon solvent, and then bringing the resultant mixed solution into contact with the chromium compound (a); or a catalyst produced by bringing the chromium compound (a), the pyrrole ring-containing compound (b), the alkyl aluminum compound (c) and the halogen-containing compound (d) into contact with each other in a hydrocarbon and/or halogenated hydrocarbon solvent in the absence of .alpha.Type: GrantFiled: January 2, 1998Date of Patent: October 17, 2000Assignee: Mitsubishi Chemical CorporationInventors: Hisao Urata, Takayuki Aoshima, Sugio Nishimura
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Patent number: 6022379Abstract: Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene, dye compositions containing them and the corresponding dyeing process.Type: GrantFiled: February 27, 1998Date of Patent: February 8, 2000Assignee: L'OrealInventors: Sylvie Genard, Herve Andrean, Michel Hocquaux
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Patent number: 6005113Abstract: The invention relates to fluorescent dyes that are substituted or unsubstituted derivatives of 1-(isoindolyl)methylene-isoindole that are bound through both isoindole nitrogens to a boron difluoride moiety, forming a fluorescent dibenzopyrrometheneboron difluoride compound ##STR1## that is further substituted by bathochromic substituents that are aryl or heteroaryl moieties further substituted by an additional aryl or heteroaryl, that is itself optionally further substituted by an additional aryl or heteroaryl. These aryl and heteroaryl groups are separated by a covalent bond, or by an ethenyl, butadienyl or hexatrienyl linkage. The dyes of the invention are particularly useful as labels for carriers, particularly polymeric microparticles. The resulting microparticles have a long-wavelength fluorescence emission, and possess utility for tracing flow in biological systems, particularly in tracing blood flow.Type: GrantFiled: May 14, 1997Date of Patent: December 21, 1999Assignee: Molecular Probes, Inc.Inventors: Yexin Wu, Dieter H. Klaubert, Hee Chol Kang, Yu-Zhong Zhang
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Patent number: 5916910Abstract: In accordance with the present invention, there are provided conjugates of nitric oxide scavengers (e.g., dithiocarbamates, or "DC") and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which cause a much lower incidence of side-effects due to the protective effects imparted by modifying the pharmacologically active agents as described herein. In addition, invention conjugates are more effective than unmodified pharmacologically active agents because cells and tissues contacted by the pharmacologically active agent(s) are protected from the potentially damaging effects of nitric oxide overproduction induced thereby as a result of the co-production of nitric oxide scavenger (e.g., dithiocarbamate), in addition to free pharmacologically active agent, when invention conjugate is cleaved.Type: GrantFiled: June 4, 1997Date of Patent: June 29, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai