Abstract: N-(1-allyl-2-pyrrolidinyl-methyl)2-methoxy-4-amino-5-methylsulfamoyl benzde and derivatives thereof, which are useful in the treatment of anomalies in cerebral hemodynamics of patients subject to migraines.
Type:
Grant
Filed:
August 25, 1981
Date of Patent:
September 20, 1983
Assignee:
Societe d'Etudes Scientifiques et Industrielles de l'Ile-de France
Abstract: 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, converting the ether formed to a salt of Mannich base by reacting it with a salt of a secondary amine in the presence of formaldehyde or paraformaldehyde and treating the Mannich salt with a weak base to deaminate the same and form the final product.