Chalcogen Or Nitrogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/22)
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Patent number: 10030032Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).Type: GrantFiled: June 30, 2017Date of Patent: July 24, 2018Assignee: EISAI R&D MANAGEMENT CO., LTD.Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
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Publication number: 20150141582Abstract: Vulcanizates with desirable properties can be obtained from compounds incorporating polymers that include hydroxyl group-containing aryl functionalities. The functionalities can be incorporated by using any or all of appropriate initiators, monomers and optional terminating compounds. Such polymers exhibit excellent interactivity with both conventional and non-conventional fillers.Type: ApplicationFiled: October 26, 2014Publication date: May 21, 2015Inventors: Yuan-Yong Yan, Zengquan Qin, Xiao-Dong Pan, Dennis R. Brumbaugh
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Publication number: 20150118620Abstract: A salt represented by formula (I): wherein R1 and R2 independently in each occurrence represent a hydrogen atom, a hydroxy group or a C1-C12 hydrocarbon group where a methylene group can be replaced by an oxygen atom or a carbonyl group; Ar1 and Ar2 each independently represent a C6-C36 aromatic hydrocarbon group which can have a substituent or a C6-C36 heteroaromatic hydrocarbon group which can have a substituent; A? and A?? each independently represent an organic anion; and “m” and “n” independently each represent an integer of 1 to 2.Type: ApplicationFiled: October 21, 2014Publication date: April 30, 2015Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yukako ANRYU, Koji ICHIKAWA, Masafumi YOSHIDA
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Publication number: 20150118619Abstract: A salt represented by the formula (I): wherein R1 and R2 independently each represent a hydrogen atom, a hydroxy group or a C1-C12 hydrocarbon group where a methylene group can be replaced by an oxygen atom or a carbonyl group; Ar represents a C6-C36 aromatic hydrocarbon group which can have a substituent or a C6-C36 heteroaromatic hydrocarbon group which can have a substituent; A? represents an organic anion; and “m” and “n” independently each represent an integer of 1 or 2.Type: ApplicationFiled: October 21, 2014Publication date: April 30, 2015Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yukako ANRYU, Koji ICHIKAWA, Takahiro YASUE
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Patent number: 8809553Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.Type: GrantFiled: June 13, 2011Date of Patent: August 19, 2014Assignee: Dipharma Francis S.r.l.Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
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Publication number: 20140213725Abstract: The present invention provides a polymerizable inorganic particle dispersant that can achieve an inorganic-organic composite particle and inorganic-organic resin composite material, which have a high refractive index and a high Abbe's number, i.e., which can achieve both of a high refractive index and a high Abbe's number that is non-conventional in a composite with an inorganic particle. The present invention relates to a polymerizable inorganic particle dispersant comprising a compound which includes the following functional groups A, B and Q: A: Polymerizable functional group; B: Carboxyl group, Oxo acid group containing a phosphorous or Oxo acid group containing sulfur; and C: Sulfur-containing divalent or more aliphatic hydrocarbon group, which may contain a hetero atom other than sulfur.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: NIPPON KASEI CHEMICAL COMPANY LIMITEDInventors: Masanori YAMAZAKI, Naoko Sumitani, Ritsuko Yamauchi, Tomoko Maeda, Takako Takahashi
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Patent number: 8785475Abstract: Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.Type: GrantFiled: April 17, 2008Date of Patent: July 22, 2014Assignee: Cornerstone Pharmaceuticals, Inc.Inventors: Paul Bingham, Tom Kwok, Zuzana Zachar
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Patent number: 8785451Abstract: Disclosed are compounds of formula (IA), formula (IV) or formula (V), wherein the variables are as defined herein, and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, such as cancer. The disclosed compounds and pharmaceutical compositions are also useful for treating disorders responsive to Hsp70 induction and/or natural killer induction.Type: GrantFiled: August 20, 2007Date of Patent: July 22, 2014Assignee: Synta Pharmaceuticals Corp.Inventors: Keizo Koya, Lijun Sun, Shoujun Chen, Jun Jiang
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Publication number: 20130316906Abstract: The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, Y, Q and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as herbicides and/or pesticides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as pesticides and/or for preventing unwanted plant growth.Type: ApplicationFiled: October 28, 2011Publication date: November 28, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Alfred Angermann, Stefan Lehr, Guido Bojack, Reiner Fischer, Isolde Häuser-hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Arnd Voerste, Dieter Feucht
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Publication number: 20130296315Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.Type: ApplicationFiled: March 11, 2013Publication date: November 7, 2013Inventor: Bayer CropScience AG
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Publication number: 20130090474Abstract: The application discloses a process for the preparation of 5-deoxy-L-arabinose of formula (VI); comprising the conversion of a compound of formula (XII); wherein n is 0, 1 or 2; which can be used as intermediate for the synthesis of sapropterin.Type: ApplicationFiled: June 13, 2011Publication date: April 11, 2013Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Emanuele Attolino, Mario Michieletti, Davide Rossi, Pietro Allegrini
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Publication number: 20120287354Abstract: The present invention relates to an electro-optical light modulation element and to electro-optical displays and display systems, such as television screens and computer monitors, containing elements of this type. The light modulation elements according to the invention contain a mesogenic modulation medium which is in the isotropic phase during operation of the light modulation elements and are particularly distinguished by very short response times in addition to good contrast and low viewing-angle dependence. The mesogenic modulation media used in the electro-optical light modulation elements are likewise a subject-matter of the present invention.Type: ApplicationFiled: June 7, 2012Publication date: November 15, 2012Applicant: MERCK Patent Gesellschaft Mit Beschrankter HaftungInventors: Michael HECKMEIER, Achim Götz
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Patent number: 8101782Abstract: Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can treat, for example, a nervous system condition, a cholinergic deficiency and conditions or diseases associated with a deficiency in a pharmacologically active agent, such as acetylcholine.Type: GrantFiled: February 4, 2008Date of Patent: January 24, 2012Assignee: Colucid Pharmaceuticals, Inc.Inventors: Nadia M. J. Rupniak, James F. White, Kazumi Shiosaki, J. David Leander, Shoucheng Du, Daniel J. Coughlin
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Patent number: 8080674Abstract: R-?-Lipoic acid and its homologs are converted to their magnesium salts in the presence of a reduced form of the acid, dihydro-(+)-lipoic acid in the case of R-?-lipoic acid itself. The reduced form serves as a polymerization inhibitor, resulting in a Mg di-R-?-lipoate product of higher purity. The reduced acid retained in the product tends to convert to the starting acid, thereby avoiding the inclusion of an extraneous polymerization inhibitor in the product.Type: GrantFiled: June 12, 2009Date of Patent: December 20, 2011Assignee: Ampac Fine Chemicals LLC.Inventor: Fang-Ting Chiu
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Patent number: 7919635Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: February 6, 2009Date of Patent: April 5, 2011Assignee: UBE Industries, Ltd.Inventor: Teruo Umemoto
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Publication number: 20110076620Abstract: To provide a dithiane derivative, having a structure expressed by the following general formula 1: where R1 is —H, or —CH3, a polymer containing a monomer unit containing the dithiane derivative, a resist composition containing the polymer, and a method for manufacturing a semiconductor device using the resist composition.Type: ApplicationFiled: November 29, 2010Publication date: March 31, 2011Applicant: FUJITSU LIMITEDInventor: Koji Nozaki
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Publication number: 20110040043Abstract: Disclosed is a diurethane compound R2(SO2)m(CH2)nOCONH—R1—NHCOO(CH2)n(SO2)mR2 produced by a method allowing a diamine compound H2NR1NH2 to react with a chloroformate compound ClCOO(CH2)n(SO2)mR2 or a method allowing a diisocyanate compound OCNR1NCO to react with a hydroxyl-containing compound R2(SO2)m(CH2)nOH. The diurethane compound is compounded with multivalent amine crosslinkable group-containing acrylic rubber together with a basic vulcanization accelerator to form an acrylic rubber composition. The acrylic rubber composition including the diurethane compound as a vulcanizing agent decreases a delay in the vulcanization rate due to prevention of scorching and also allows a vulcanized article to satisfy the compression set characteristics.Type: ApplicationFiled: January 30, 2009Publication date: February 17, 2011Applicant: Unimatec Co., Ltd.Inventors: Daisuke Ito, Haruyoshi Tatsu, Keisuke Kokin, Hideyuki Ono, Yasuhiro Onoue
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Publication number: 20100317873Abstract: R-?-Lipoic acid and its homologs are converted to their magnesium salts in the presence of a reduced form of the acid, dihydro-(+)-lipoic acid in the case of R-?-lipoic acid itself. The reduced form serves as a polymerization inhibitor, resulting in a Mg di-R-?-lipoate product of higher purity. The reduced acid retained in the product tends to convert to the starting acid, thereby avoiding the inclusion of an extraneous polymerization inhibitor in the product.Type: ApplicationFiled: June 12, 2009Publication date: December 16, 2010Applicant: Ampac Fine Chemicals LLC, a California Limited Liability CompanyInventor: Fang-Ting Chiu
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Publication number: 20100220252Abstract: The present invention relates to an electro-optical light modulation element and to electro-optical displays and display systems, such as television screens and computer monitors, containing elements of this type. The light modulation elements according to the invention contain a mesogenic modulation medium which is in the isotropic phase during operation of the light modulation elements and are particularly distinguished by very short response times in addition to good contrast and low viewing-angle dependence. The mesogenic modulation media used in the electro-optical light modulation elements are likewise a subject-matter of the present invention.Type: ApplicationFiled: February 26, 2010Publication date: September 2, 2010Inventors: Michael HECKMEIER, Achim Götz
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Patent number: 7601848Abstract: The invention relates to compounds of formula (I), wherein Z represents a hydrocarbon with 2 to 28 C atoms, wherein Z can also comprise elements N, O, P, S, Si and halogen as heteroatoms, R1 and R2 are identical or different sulfur protecting groups, wherein both S atoms can also form a disulfide bridge and in said case R1 and R2 are not present; protecting group Y1 represents protecting group NH, protecting group NR4, protecting group O, CONH protecting group, protecting group OOC, protecting group S—S, —CH(protecting group O)2 or —CR5(protecting group O)2 or protecting group S; Y2 represents —OH, —NH2, —NHR3, —NR3R4, —COOH, —COCI, —COOCO—R6, —CONH2, —CONHR3, —COOR3, —SO3H, —SO3CI, —SH, —S—SR3, —CHO, —COR3, —C2H3O, halogen, —N3, —NH—NH2, —NCO, —NCS, wherein R3 represents alkyl, heteroalkyl, aryl, cycloalkyl or a protecting group, wherein R3 can be identical or different in groups Y1 and Y2, R4 is s protecting group, wherein R4 can be identical or different in groups Y1 and Y2, and wherein R4 and R3 can be idType: GrantFiled: December 21, 2002Date of Patent: October 13, 2009Assignee: Fidicula GmbHInventors: Gerhard Hartwich, Peter Frischmann, Elisenda Ferrer
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Publication number: 20090203924Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: ApplicationFiled: February 6, 2009Publication date: August 13, 2009Applicant: IM&T RESEARCH, INC.Inventor: TERUO UMEMOTO
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Publication number: 20090197865Abstract: In one embodiment the invention provides a method of combating cyanide poisoning, which comprises administering to a subject a compound capable of releasing 3-mercapto-pyruvate in vivo. In other embodiments the invention also provides pharmaceutical compositions comprising a compound capable of releasing 3-mercaptopyruvate in vivo, as well as novel compounds that are capable of releasing 3-mercaptopyruvate in vivo.Type: ApplicationFiled: June 28, 2007Publication date: August 6, 2009Inventors: Herbert T. Nagasawa, David J.W. Goon, Daune L. Crankshaw, Robert Vince
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Publication number: 20090175812Abstract: Compounds of formula I, process for making same, and cosmetic compositions and methods of skin lightening using compounds of formula I as skin lightening agents: Where each A1 and/or A2 independently is ?H or COR, CO2R, CONHR, the latter three having the following formula A: where R?C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; and each Y1 and/or Y2 independently is H; C1-C18 saturated or unsaturated hydrocarbon; or OZ, where Z=H or COR1, CO2R1, CONHR1 of formula B: and where R1?C1-C18 saturated or unsaturated, linear or branched, hydrocarbon; X is Carbon, Nitrogen, Sulfur, or Oxygen; and N is in integer between 0 and 2.Type: ApplicationFiled: March 18, 2009Publication date: July 9, 2009Applicant: CONOPCO, INC., D/B/A UNILEVERInventors: Bijan Harichian, Michael James Barratt, Carol Annette Bosko, Victor De Florio, Jose Guillermo Rosa, Michael Tallman
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Publication number: 20090131498Abstract: This invention provides a method of synthesizing enantioenriched merrilactone A and enantiopure merrilactone A, as well as an improved method of synthesizing racemic merrilactone.Type: ApplicationFiled: January 18, 2006Publication date: May 21, 2009Inventors: Samuel J. Danishefsky, Zhaoyang Meng, Vladimir Birman
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Publication number: 20080312186Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae and pharmaceutically acceptable salts, amides, esters, and ethers thereof, wherein: Ar1, Ralk, —ORO, and -Q are as defined herein: The present invention also pertains to pharmaceutical compositions comprising such compounds. The compounds inhibit osteoclast survival, formation, and/or activity, and inhibit conditions mediated by osteoclasts and/or characterised by bone resorption, and are useful in the treatment of bone disorders such as osteoporosis, rheumatoid arthritis, cancer associated bone disease, Paget's disease, aseptic loosening of prosthetic implants, and the like; and/or in the treatment of conditions associated with inflammation or activation of the immune system.Type: ApplicationFiled: August 19, 2008Publication date: December 18, 2008Applicant: The University Court of the University of AberdeenInventors: Stuart H. RALSTON, Iain R. GREIG, Aymen I. I. MOHAMED, Robert J. VAN 'T HOF
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Publication number: 20080262034Abstract: Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.Type: ApplicationFiled: April 17, 2008Publication date: October 23, 2008Inventors: PAUL BINGHAM, TOM KWOK, ZUZANA ZACHAR
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Patent number: 7385067Abstract: The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the resultant bis(alkylthio)carbenium salt is reacted with at least one compound having at least one hydroxyl group in the presence of a base, c) and subsequently, preferably in situ, the resultant dithioorthoester is subjected to oxidative fluorodesulfurisation using a fluorinating agent and an oxidant to give the compound containing at least one —CF2—O— bridge in the molecule.Type: GrantFiled: June 2, 2006Date of Patent: June 10, 2008Assignee: Merck Patent GmbHInventors: Peer Kirsch, Andreas Taugerbeck, Alexander Hahn
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Patent number: 7232915Abstract: An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.Type: GrantFiled: April 29, 2005Date of Patent: June 19, 2007Assignee: Warner-Lambert CompanyInventors: Robert Lee Bosch, Richard Joseph McCabe, Thomas Norman Nanninga, Robert Joseph Stahl
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Patent number: 7208169Abstract: The invention relates to novel biphenylcarboxamides of the formula (I) in which R1, R2, m, n, R3, Y and A are as defined in the disclosure, to a plurality of processes for preparing these substances and their use for controlling unwanted microorganisms, and to novel intermediates and their preparation.Type: GrantFiled: April 16, 2003Date of Patent: April 24, 2007Assignee: Bayer CropScience LPInventors: Ralf Dunkel, Hans-Ludwig Elbe, Heiko Rieck, Robert Markert, Ulrike Wachendorff-Neumann, Astrid Mauler-Machnik, Karl-Heinz Kuck, Martin Kugler, Thomas Jaetsch
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Patent number: 7169942Abstract: 1?-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type-2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.Type: GrantFiled: May 20, 2004Date of Patent: January 30, 2007Assignee: University of Tennessee Research FoundationInventors: Bob M. Moore, II, Antonio M. Ferreira, Mathangi Krishnamurthy
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Patent number: 7115651Abstract: The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and K—L are as defined herein, the synthesis thereof and the use of these compounds as therapeutic agents.Type: GrantFiled: August 24, 2001Date of Patent: October 3, 2006Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Robert M. Garbaccio, Daniel K. Baeschlin, Shawn J. Stachel, David Solit, Neal Rosen
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Patent number: 7091344Abstract: An infrared dye, characterized in that the dye comprises of Formulae 1 to 5Type: GrantFiled: August 10, 2001Date of Patent: August 15, 2006Assignee: Silverbrook Research Pty LtdInventors: Lachlan Everett Hall, Kia Silverbrook
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Patent number: 6900338Abstract: The present invention provides novel compounds having scavenging and anti-ROS properties and pharmaceutical composition comprising these compounds for treatment of conditions associated with oxidative stress or free radical injury. The compounds of the invention are of general formula (I).Type: GrantFiled: November 25, 1999Date of Patent: May 31, 2005Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Abdullah Haj-Yehia
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Patent number: 6787062Abstract: The invention relates to a process for the preparation of compounds having at least one —CF2O— bridge in the molecule, which comprises initially reacting a bis(alkylthio)carbenium salt with a compound containing at least one hydroxyl group in the presence of a base followed by oxidative fluorination, preferably in situ, with a fluorinating agent and an oxidizing agent to form the compound having at least one —CF2O— bridge in the molecule.Type: GrantFiled: September 3, 2002Date of Patent: September 7, 2004Assignee: Merck Patent GmbHInventors: Peer Kirsch, Andreas Taugerbeck, Detlef Pauluth, Matthias Bremer
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Patent number: 6664287Abstract: This invention comprises administering to a human or animal in need of treatment an effective amount of an antioxidant lipoic acid derivative and/or pharmaceutically acceptable salts and solvates thereof for the treatment or prevention of pathological (inflammatory, proliferative and degenerative diseases, e.g. diabetes mellitus, atherosclerosis, Alzheimer's disease and chronic viral diseases) and non-pathological (e.g. skin aging and wrinkle formation) conditions caused by oxidative damage. Methods of synthesizing novel antioxidant lipoic acid derivatives and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are described. Another aspect of this invention is the use of these antioxidant compositions for the protection of skin from damage caused by ultraviolet radiation and dessication, and to provide improved skin feel by desquamating, cleansing and clarifying the skin.Type: GrantFiled: March 14, 2001Date of Patent: December 16, 2003Assignee: Bethesda Pharmaceuticals, Inc.Inventors: Mitchell Allen Avery, Harrihar A. Pershadsingh
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Patent number: 6576596Abstract: The invention relates to 2-benzoylcyclohexane-1,3-diones of the formula I where R1, R2 are each hydrogen, nitro, halogen, cyano, thiocyanato, alkyl, haloalkyl, alkoxyalkyl, alkenyl, alkynyl, —OR5, —OCOR6, —OSO2R6, —SH, —S(O)nR7, —SO2OR5, —SO2NR5R8, —NR8SO2R6 or —NR8COR6; R3 is hydrogen, cyano, alkyl, haloalkyl, —OR7, —SR7 or —NR7R10; R4 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, —COR9, —CO2R9, —COSR9 or —CONR8R9; X is oxygen or NR8; n is 0, 1 or 2; R5 is hydrogen, alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl; R6 is alkyl or haloalkyl; R7 is alkyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl; R8 is hydrogen or alkyl; R9 is alkyl, alkenyl, alkynyl, phenyl or benzyl; R10 is alkyl, haloalkyl, alkenyl or alkynyl; Q is a cyclohexane-1,3-dione ring with or without substitution attached in position 2; and agriculturally useful salts thereoType: GrantFiled: June 23, 1999Date of Patent: June 10, 2003Assignee: BASF AktiengesellschaftInventors: Regina Luise Hill, Uwe Kardorff, Michael Rack, Ernst Baumann, Wolfgang von Deyn, Stefan Engel, Guido Mayer, Martina Otten, Joachim Rheinheimer, Matthias Witschel, Ulf Misslitz, Helmut Walter, Karl-Otto Westphalen
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Patent number: 6570025Abstract: This invention provides sulfur-containing (meth)acrylic ester compounds each of which is represented by the following formula (1); wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group or may be fused together to form a ring, R3 represents a hydrogen atom or a methyl group, X1 represents an oxygen atom or a sulfur atom, m stands for an integer of from 0 to 3, and n stands for an integer of from 1 to 4, polymerizable compositions comprising the sulfur-containing (meth)acrylic acids, and cured products and optical parts obtained by polymerizing the polymerizable compositions. The sulfur-containing (meth)acrylic ester compounds according to the present invention are very useful, as monomers for photocurable, polymerizable compositions, in applications such as optical materials and dental materials.Type: GrantFiled: January 25, 2002Date of Patent: May 27, 2003Assignee: Mitsui Chemicals, Inc.Inventors: Kenichi Fujii, Atsuo Otsuji, Masao Imai, Kenichi Sugimoto, Tadashi Okuma, Rihoko Suzuki, Keisuke Takuma
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Patent number: 6528627Abstract: The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds.Type: GrantFiled: November 28, 2000Date of Patent: March 4, 2003Assignee: NeoRx CorporationInventor: Sudhakar Kasina
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Patent number: 6512003Abstract: Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.Type: GrantFiled: October 9, 2001Date of Patent: January 28, 2003Assignee: Parker Hughes InstituteInventors: Fatih M. Uckun, Chen Mao, He Huang
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Patent number: 6472488Abstract: Polymerizable compositions from novel monomers that correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.Type: GrantFiled: September 20, 2001Date of Patent: October 29, 2002Assignee: Essilor International Compagnie Generale D'OptiqueInventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
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Patent number: 6458908Abstract: A sulfur-containing unsaturated carboxylate compound comprising a sulfur-containing substituent and at least two &agr;,&bgr;-unsaturated carboxylic acid residues, which are each attached to a secondary or tertiary carbon atom via an oxygen atom; a polymerizable composition comprising the sulfur-containing unsaturated carboxylate compound; a cured product prepared by polymerizing the polymerizable composition; an optical component consisting of the cured product; and novel intermediate compounds for preparation of the above carboxylate.Type: GrantFiled: May 31, 2000Date of Patent: October 1, 2002Assignee: Mitsui Chemicals, Inc.Inventors: Masao Imai, Kenichi Sugimoto, Kenichi Fujii, Atsuo Otsuji, Tadashi Ohkuma, Masatoshi Takagi, Rihoko Suzuki, Keisuke Takuma
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Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications
Patent number: 6379590Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solventType: GrantFiled: December 2, 1994Date of Patent: April 30, 2002Assignee: AlliedSignal Inc.Inventors: Chengjiu Wu, Jianhui Shan -
Patent number: 6342517Abstract: Novel thienopyran compounds are disclosed, useful as anti-hypertensive agents and for asthma treatment. One group of the compounds has a heterocyclic ring spiro-connected at the 7-position of the thienopyran ring structure. Use of thienopyran compounds in hair growth modulation is described.Type: GrantFiled: December 3, 1999Date of Patent: January 29, 2002Assignee: Cambridge Bioclinical LimitedInventors: Peter Esch, Franz Rovenszky, Robertson Towart, Thomas Christoph, Michael Hartmann, George Terence Evelyn Kealey
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Patent number: 6313316Abstract: The invention provides a novel polyisocyanate compound which is useful as a starting material for an optical material having a high refractive index, a low dispersion and excellent optical characteristics, and a process for producing this compound at good efficiency. The invention also provides an optical material having a high refractive index, a low dispersion, an excellent transparency without optical distortion and having good heat resistance.Type: GrantFiled: July 14, 1999Date of Patent: November 6, 2001Assignee: Hoya CorporationInventors: Yoshitaka Kitahara, Jian Jiang
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Patent number: 6307062Abstract: The novel monomers correspond to the formula: in which: Z represents H or CH3 and X represents O or S, and Y is a 5- to 8-membered heterocycle consisting of hydrogen, carbon and sulphur atoms and at least two endocyclic sulphur atoms.Type: GrantFiled: October 13, 1998Date of Patent: October 23, 2001Assignee: Essilor International Compagnie Generale d'OptiqueInventors: Florence Caye, Michèle Sindt, Daniel Paquer, Dorothée Jury, Michel Schneider, Jean-Luc Mieloszynski
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Patent number: 6288071Abstract: Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.Type: GrantFiled: December 10, 1998Date of Patent: September 11, 2001Assignee: Bayer AktiengesellschaftInventors: Henry Szczepanski, Martin Zeller, Ottmar Franz Hüter
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Patent number: 6245506Abstract: The invention is based on the discovery that the sequence of monomers in a polymeric biomolecule can be determined in a self-contained, high pressure reaction and detection apparatus, without the need for fluid flow into or out from the apparatus. The pressure is used to control the activity of enzymes that digest the polymeric biomolecule to yield the individual monomers in the sequence in which they existed in the polymer. High pressures modulate enzyme kinetics by reversibly inhibiting those enzymatic processes which result in a higher average activation volume, when compared to the ground state, and reversibly accelerating those processes which have lower activation volumes than the ground state. Modulating the pressure allows the experimenter to precisely control the activity of the enzyme. Conditions can be found, for example, where the enzyme removes only one monomer (e.g., a nucleotide or amino acid) from the biomolecule before the pressure is again raised to a prohibitive level.Type: GrantFiled: July 30, 1997Date of Patent: June 12, 2001Assignee: BBI Bioseq, Inc.Inventors: James A. Laugharn, Jr., Robert A. Hess
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Patent number: 6043361Abstract: The invention relates to compounds of the formulae: processes for their preparation, polymers, co-polymers or block co-polymers containing them or their use as monomers or co-monomers in free radical polymerisation and in the manufacture of adhesives, dental composites or optical lenses.Type: GrantFiled: August 26, 1997Date of Patent: March 28, 2000Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Richard Alexander Evans, Ezio Rizzardo, Graeme Moad
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Patent number: 6022895Abstract: Substituted amino compounds of general formula (I) ##STR1## are described, as are a method of preparing them and their use as drugs, especially as analgesics.Type: GrantFiled: March 11, 1998Date of Patent: February 8, 2000Assignee: Gruenenthal GmbHInventors: Oswald Zimmer, Wolfgang Werner Alfred Strassburger, Helmut Heinrich Buschmann, Werner Englberger, Elmar Josef Friderichs
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Patent number: 6022938Abstract: Isocyanato compounds with capped, isocyanate-reactive groups are those of the formula I ##STR1## where R.sup.1 and R.sup.2 are hydrogen, C.sub.1 -C.sub.10 -alkyl, C.sub.6 -C.sub.10 -aryl or C.sub.7 -C.sub.10 -aralkyl or together form C.sub.3 -C.sub.10 -alkanediyl,X and Y are --O--, --S-- or ##STR2## where R.sup.4 is hydrogen, C.sub.1 -C.sub.20 -alkyl which is uninterrupted or interrupted by oxygen atoms in ether function, or is C.sub.6 -C.sub.10 -aryl or C.sub.7 -C.sub.10 -aralkyl,R.sup.3 is C.sub.1 -C.sub.10 -alkanediyl which together with --X--CR.sup.1 R.sup.2 --Y-- forms a 4-7-membered ring,in which either one hydrogen in R.sup.3 or the radical R.sup.4 in ##STR3## is replaced by an allophanate group R.sup.Ia ##STR4## in which R.sup.5 is a divalent aliphatic, alicyclic, araliphatic or aromatic C.sub.2 -C.sub.20 hydrocarbon unit,R.sup.6 is a single bond or a divalent aliphatic, alicyclic, araliphatic or aromatic C.sub.1 -C.sub.20 hydrocarbon unit or a mono- or poly(C.sub.2 -C.sub.Type: GrantFiled: June 18, 1998Date of Patent: February 8, 2000Assignee: Basf AktiengesellschaftInventors: Bernd Bruchmann, Hans Renz, Gunter Mohrhardt