Spiro Patents (Class 549/264)
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Patent number: 11589579Abstract: The present invention relates to polymeric particles comprising a biodegradable polymer, and at least one microorganism in a total concentration of at least 108 CFU/g dry weight that is stable for at least 35 weeks at 30° C. and optionally additional carriers and additives as well as to methods for producing polymeric particles and use thereof.Type: GrantFiled: September 24, 2018Date of Patent: February 28, 2023Assignees: BIOTENZZ GESELLSCHAFT FÜR BIOTECHNOLOGIE MBH, TECHNISCHE UNIVERSITÄT GRAZInventors: Gabriele Berg, Henry Muller
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Publication number: 20150011776Abstract: Disclosed is a compound of formula 1, as shown below, where R1, R2, R3, R4, R5, R6 and R7 are as described herein. Also, disclosed is a process for the preparation of compounds of formula 1, and intermediates used therein. The compound of formula 1 can be useful for preparation of halichondrin analogs such as Eribulin.Type: ApplicationFiled: December 24, 2012Publication date: January 8, 2015Inventors: Fabio E.S. Souza, Alena Rudolph, Ming Pan, Boris Gorin, Dino Alberico
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Publication number: 20140323559Abstract: This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.Type: ApplicationFiled: March 25, 2014Publication date: October 30, 2014Applicant: MERIAL LIMITEDInventors: Susan Mancini Cady, Baoqing Ma, Robert Clark Chapman, Chunhua Yang, Uday Jain
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Publication number: 20140256619Abstract: The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyle, (ii) X represents —CH2CH2—, or —CH?CH—, (iii) R2 is chosen from the group constituted of or —OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.Type: ApplicationFiled: October 18, 2012Publication date: September 11, 2014Inventors: Anne Lespine, Roger Prichard, Cecile Menez
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Patent number: 8822528Abstract: This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of parasitic infection in animals and humans. These compounds exhibit improved safety profiles and/or efficacies as compared to parent compounds.Type: GrantFiled: November 16, 2011Date of Patent: September 2, 2014Assignees: Merial Limited, Universite Claude Bernard Lyon 1, Centre National de la Recherche Scientifique (CNRS)Inventors: Jean Delaveau, Emile Vialle, Marc Lemaire, Stephane Pellet-Rostaing, Bruno Andrioletti
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Patent number: 8765974Abstract: Disclosed is a method for producing a tetrahydropyran compound represented by general formula (5) shown in the scheme. Accordingly, a tetrahydropyran derivative is obtained in high yield and with high selectivity without using a highly toxic reagent, and an industrially useful method for producing a tetrahydropyran derivative and an intermediate thereof can be provided. In formulae (1) to (5), R1 and R2 each independently represent a hydrogen atom, a linear, branched, or cyclic alkyl group, or an aromatic group which may have a substituent, and R1 and R2may be combined to form an alkylene group, thereby forming a ring; and R3 and R4 each independently represent a hydrogen atom or a linear, branched, or cyclic alkyl group, and R3 and R4 may be combined to form an alkylene group, thereby forming a ring.Type: GrantFiled: April 14, 2010Date of Patent: July 1, 2014Assignee: Nissan Chemical Industries, Ltd.Inventors: Hirotaka Kawanami, Kana Yamaguchi, Shota Murase
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Publication number: 20130345442Abstract: Methods and compositions are provided for the preparation of insecticidal compositions.Type: ApplicationFiled: August 21, 2013Publication date: December 26, 2013Applicant: Bayer CropScience LPInventors: Hong ZHU, Jorge JIMENEZ, Colleen TAYLOR, Magalie GUILHABERT-GOYA, Jonathan MARGOLIS
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Patent number: 8586112Abstract: The invention provides a process for the production of a substance or composition for the treatment, by therapy or prophylaxis, of parasitic infections, in particular malarial infections such as Plasmodium falciparum infections, of the human or animal body. The process comprises extracting the substance or composition from roots of the plant species Dicoma anomala, by an extraction using an organic solvent to obtain a liquid extract containing the substance or composition and removing the solvent from the liquid extract to leave a dried extract containing the substance or composition. The invention extends also to the use of the substance or composition in the manufacture of a medicament or preparation for such treatment of infections; to a substance or composition for use in such treatment of said infections; to compounds for use in such treatment of said infections; and to a method of treating said infections using such compounds.Type: GrantFiled: November 2, 2005Date of Patent: November 19, 2013Assignees: South African Medical Research Council, University of Cape TownInventors: Motlalepula Gilbert Matsabisa, William Ernest Campbell, Peter Ian Folb, Peter John Smith
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Publication number: 20130251647Abstract: The invention relates to new types of modulators of the cold menthol receptor TRPM8, to methods of modulating the TRPM8 receptor using these modulators; and in particular the use of the modulators for inducing a sensation of coldness; and also the articles and compositions produced using these modulators.Type: ApplicationFiled: September 20, 2012Publication date: September 26, 2013Applicant: BASF SEInventors: Thomas Subkowski, Claus Bollschweiler, Jens Wittenberg, Wolfgang Siegel, Ralf Pelzer
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Publication number: 20130143956Abstract: This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.Type: ApplicationFiled: November 30, 2012Publication date: June 6, 2013Applicant: Merial LimitedInventors: Susan Mancini Cady, Baoqing Ma, Robert Clark Chapman, Chunhua Yang, Uday Jain
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Patent number: 8362170Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.Type: GrantFiled: June 18, 2012Date of Patent: January 29, 2013Assignee: FUJIFILM CorporationInventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
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Patent number: 8252877Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.Type: GrantFiled: December 11, 2009Date of Patent: August 28, 2012Assignee: FUJIFILM CorporationInventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
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Publication number: 20120128722Abstract: This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of parasitic infection in animals and humans. These compounds exhibit improved safety profiles and/or efficacies as compared to parent compounds.Type: ApplicationFiled: November 16, 2011Publication date: May 24, 2012Inventors: Jean Delaveau, Emile Vialle, Marc Lemaire, Stephane Pellet-Rostaing, Bruno Andrioletti
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Publication number: 20120046476Abstract: Disclosed is a method for producing a tetrahydropyran compound represented by general formula (5) shown in the scheme. Accordingly, a tetrahydropyran derivative is obtained in high yield and with high selectivity without using a highly toxic reagent, and an industrially useful method for producing a tetrahydropyran derivative and an intermediate thereof can be provided. In formulae (1) to (5), R1 and R2 each independently represent a hydrogen atom, a linear, branched, or cyclic alkyl group, or an aromatic group which may have a substituent, and R1 and R2may be combined to form an alkylene group, thereby forming a ring; and R3 and R4 each independently represent a hydrogen atom or a linear, branched, or cyclic alkyl group, and R3 and R4 may be combined to form an alkylene group, thereby forming a ring.Type: ApplicationFiled: April 14, 2010Publication date: February 23, 2012Inventors: Hirotaka Kawanami, Kana Yamaguchi, Shota Murase
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Publication number: 20100152401Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.Type: ApplicationFiled: December 11, 2009Publication date: June 17, 2010Applicant: FUJIFILM CORPORATIONInventors: Shuji HIRANO, Kaoru IWATO, Hiroshi SAEGUSA, Yusuke IIZUKA
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Publication number: 20090304832Abstract: The invention provides a process for the production of a substance or composition for the treatment, by therapy or prophylaxis, of parasitic infections, in particular malarial infections such as Plasmodium falciparum infections, of the human or animal body. The process comprises extracting the substance or composition from roots of the plant species Dicoma anomala, by an extraction using an organic solvent to obtain a liquid extract containing the substance or composition and removing the solvent from the liquid extract to leave a dried extract containing the substance or composition. The invention extends also to the use of the substance or composition in the manufacture of a medicament or preparation for such treatment of infections; to a substance or composition for use in such treatment of said infections; to compounds for use in such treatment of said infections; and to a method of treating said infections using such compounds.Type: ApplicationFiled: November 2, 2005Publication date: December 10, 2009Inventors: Motlalepula Gilbert Matsabisa, William Ernest Campbell, Peter Ian Folb, Peter John Smith
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Patent number: 7576124Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect.Type: GrantFiled: May 11, 2007Date of Patent: August 18, 2009Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Patent number: 7576123Abstract: Compositions, methods, etc. for addressing the first-pass effect.Type: GrantFiled: April 4, 2007Date of Patent: August 18, 2009Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Publication number: 20080300134Abstract: A compound of the formula (I) wherein the bond between carbon atoms 22 and 23 indicated with a broken line is a single or double bond, n is 0, 1 or 2, R1 represents, for instance, a C1-C12alkyl group, R2 represents, for instance, R15 group, R3 represents, for instance, R2 group, R4 represents, for instance, a chemical constituent, R5 represents, for instance, hydrogen, and R6 represents, for instance, R16 group; wherein R15 represents, for instance, unsubstituted or mono- to pentasubstituted C1-C6alkyl group, and R16 represent, for instance, hydrogen, or R15; and if appropriate, an E/Z isomer and/or diastereoisomer and/or tautomer of the compound of formula (I), in each case in free form or in salt form. Such compounds have been found to have pesticidal properties.Type: ApplicationFiled: August 19, 2005Publication date: December 4, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Ottmar Franz Hueter, Thomas Pitterna, Pierre Jung, Fiona Murphy Kessabi, Laura Quaranta
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Patent number: 7378534Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.Type: GrantFiled: August 29, 2005Date of Patent: May 27, 2008Assignee: Bioavailability Systems, LLC.Inventor: James W. Harris
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Patent number: 7316884Abstract: A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): wherein R1 represents a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms, or a linear or branched alkyl group containing 1 to 6 carbon atoms which has a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms as a substituent; R2 represents a hydrogen atom, or a linear or branched alkyl group containing 1 to 6 carbon atoms; or R1 and R2 represent a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms together with the carbon atom to which they are bound, provided that the alkyl group and the bridged cyclic hydrocarbon group may have at least one substituent selected from a group consisting of a linear or branched alkyl group containing 1 to 6 carbon atoms which may be optionally substituted, a hydroxy group, a carboxy group, an acyl group containing 2 to 6 carType: GrantFiled: October 22, 2002Date of Patent: January 8, 2008Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Ryuichi Ansai, Yoshihiro Kamon, Tadayuki Fujiwara, Hideaki Kuwano, Atsushi Ootake, Hikaru Momose
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Patent number: 7314942Abstract: Alpha-methylenelactone is produced from butyrolactone and valerolactone by the addition of formaldehyde in a supercritical fluid.Type: GrantFiled: January 7, 2003Date of Patent: January 1, 2008Assignee: E. I. duPont de Nemours & Co.Inventors: Keith W. Hutchenson, Leo E. Manzer
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Patent number: 7232915Abstract: An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.Type: GrantFiled: April 29, 2005Date of Patent: June 19, 2007Assignee: Warner-Lambert CompanyInventors: Robert Lee Bosch, Richard Joseph McCabe, Thomas Norman Nanninga, Robert Joseph Stahl
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Patent number: 7230027Abstract: Compositions, methods, etc. for addressing the first-pass effect.Type: GrantFiled: March 16, 2005Date of Patent: June 12, 2007Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Patent number: 6808724Abstract: The present invention relates to a novel compound isolated from Artemisia Sylvatica, expressed by the formula 1, a method of isolation, and its use thereof, and more particularly to a novel compound isolated from Artemisia Sylvatica, a method of isolation, and its use in inhibiting farnesyl transferase activity, which is essential for activating Ras oncogene, and repressing cancer cell growth.Type: GrantFiled: January 28, 2003Date of Patent: October 26, 2004Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong-Choi Han, Jong-Han Kim, Hyun-Mi Kang, Sun Bok Jeon
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Patent number: 6716832Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl, halogeno-alkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenyl-alkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups: in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: May 2, 2002Date of Patent: April 6, 2004Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6693092Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, W and Y independently of one another each represent hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.Type: GrantFiled: May 9, 2002Date of Patent: February 17, 2004Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretshneider, Christoph Erdelen, Wolfram Andersch, Mark Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers
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Patent number: 6660766Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.Type: GrantFiled: July 30, 2001Date of Patent: December 9, 2003Assignee: Bioavailability Systems, LLCInventor: James W. Harris
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Patent number: 6605595Abstract: Avermectin derivatives represented by the general formula (I) or salts thereof: wherein —X----Y— represents —CH═CH—, —CH2—C(═O)—, —CH2—CH2—, or —CH2—CH(R13)—; for example, 1) when —X----Y— represents —CH═CH—, R1 represents (R11)(R12)C [wherein R11 represents a substituted or unsubstituted lower alkyl group; a formyl group; a lower alkoxylcarbonyl group etc.Type: GrantFiled: February 11, 2002Date of Patent: August 12, 2003Assignee: The Kitasato InstituteInventors: Satoshi Omura, Toshiaki Sunazuka, Andreas Turberg, Georg von Samson-Himmelstjerna, Olaf Hansen, Achim Harder
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Publication number: 20030139601Abstract: Compounds of formula (I) and salts thereof: 1Type: ApplicationFiled: October 22, 2002Publication date: July 24, 2003Applicant: SANKYO COMPANY, LIMITEDInventors: Akio Saito, Yoko Sugiyama, Toshimitsu Toyama, Toshihiko Nanba
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Publication number: 20030099910Abstract: The present invention relates to a photochromic spirobenzopyran compound of the formula (1) and its derivatives, a spirobenzopyran group having unsaturated terminal groups, a polymer prepared therefrom, a method for the production thereof, a composition comprising said spirobenzopyran or said spirobenzopyran group-containing polymer and a photochromic switch film using the same: 1Type: ApplicationFiled: August 24, 1999Publication date: May 29, 2003Inventors: EUN-KYOUNG KIM, YUN-KI CHOI, SAM-ROK KEUM
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Publication number: 20030027063Abstract: A three dimensional optical data storage and retrieval system that includes a three dimensional optical data storage medium and an apparatus for providing access to data stored on the medium. The data storage medium includes an optical data storage material which either a low molecular weight or polymeric glassy solid that are capable of undergoing multi-photon excitation that are energetically different in the write and read cycles. The optical data storage materials provide substantially higher storage capacities relative to conventional materials, and show high robustness in that written and stored data can undergo multiple read cycles without erasure or overwriting. An apparatus for data recording and accessing stored data on the medium includes a controllable variable energy photo-emitting excitation source and an emission photo-detector.Type: ApplicationFiled: July 12, 2002Publication date: February 6, 2003Applicant: The Trustees of Boston CollegeInventors: John T. Fourkas, Christopher E. Olson, Michael J.R. Previte
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Patent number: 6500960Abstract: Modified PKS gene clusters which produce novel polyketides in an efficient system in a host cell or in a cell free extract are described. The novel polyketides result from the incorporation of diketides of the formula wherein A is a moiety that activates the diketide, and at least one of R1 and R2 is a substituent other than that natively occurring in the diketide normally processed by the modified PKS cluster. The polyketides may also be glycosylated to provide antibiotics.Type: GrantFiled: May 14, 1999Date of Patent: December 31, 2002Assignees: Stanford University (Board of Trustees of the Leland Stanford Junior University), Brown University Research FoundationInventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao
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Patent number: 6486195Abstract: The most thermodynamically stable crystalline form of the benzoic acid salt of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b as the hemihydrate is obtained by crystallization from organic solvents containing a controlled amount of water.Type: GrantFiled: January 20, 1995Date of Patent: November 26, 2002Assignee: Merck & Co., Inc.Inventors: Raymond Cvetovich, James A. McCauley, Richard Demchak, Richard J. Varsolona
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Publication number: 20020173473Abstract: The invention relates to compounds of the general formula 1Type: ApplicationFiled: November 26, 2001Publication date: November 21, 2002Inventor: Thomas Goebel
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Patent number: 6476066Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect.Type: GrantFiled: February 27, 2001Date of Patent: November 5, 2002Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Patent number: 6410590Abstract: The present invention relates to novel derivatives of Andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of Andrographolide have the general formula (I) The andrographolide derivatives represented by general formula (I) are useful for treating cancer, HSV, HIV, psoriasis, restonosis, atherosclerosis, other cardiovascular disorders, and can be used as antiviral, antimalarial, antibacterial, hepatoprotective, and immunomodulating agents and for treatment of other metabolic disorders.Type: GrantFiled: February 1, 2001Date of Patent: June 25, 2002Assignee: Dr. Reddy's Research FoundationInventors: Srinivas Nanduri, Sriram Rajagopal, Sairam Pothukuchi, Sunilkumar Bhadramma Kochunarayana Pillai, Ranjan Chakrabarti
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Patent number: 6387948Abstract: 8-Acetylarteminolide of the formula (I) having inhibitory activities against farnesyl-protein transferase(FPTase), a progression of the cell cycle and angiogenesis may be useful for the prevention and treatment of various cancers and angiogenesis-related diseases:Type: GrantFiled: June 17, 2000Date of Patent: May 14, 2002Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Byoung-Mog Kwon, Kwang-Hee Son, Ha-Won Jeong, Seung-Ho Lee, Mi-Young Han, Hyun-Mi Kang, Hyae-Kyeong Kim, Soo-Ik Chang
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Patent number: 6388099Abstract: The heterologous expression of the OlePKS in Streptomyces lividans, produces 8,8a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with DEBS in S. lividans of the P450 monooxygenase OleP produces 8,8a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.Type: GrantFiled: January 23, 2001Date of Patent: May 14, 2002Assignee: Kosan Biosciences, Inc.Inventor: Robert McDaniel
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Patent number: 6372781Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C5) alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist, colloidal bismuth subcitrate and other antibiotics.Type: GrantFiled: June 7, 2000Date of Patent: April 16, 2002Assignee: Pfizer Inc.Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts
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Patent number: 6362168Abstract: Compounds of the formula: wherein X represents a single or a double bond; R1 is H or OH; provided that when X is a single bond, R1 is H or OH, and when X is a double bond, R1 is absent; R2 is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, alkoxy-alkyl or alkylthioalkyl containing from 1 to 6 carbon atoms in each alkyl or alkoxy group, wherein any of said alkyl, alkoxy alkenyl or alkynyl groups may be substituted by one or more halo atoms; or a C3-C8 cycloalkyl or C5-C8 cycloalkenyl group, either of which may be substituted by methylene or one or more C1-C4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may be saturated, or fully or partially unsaturated and which may be substituted by one or more C1-C4 alkyl groups or halo atoms; or a group of the formula SR5 wherein R5 is C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, phenyl or substituted phenyl wherein the substituent is C1-C4 alkyl, C1-C4 alkoxy orType: GrantFiled: June 5, 1995Date of Patent: March 26, 2002Assignee: Pfizer Inc.Inventors: Christopher J. Dutton, Stephen P. Gibson, Shih-Jen E. Lee
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Patent number: 6355441Abstract: Chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature, represented by the formulas I or II:Type: GrantFiled: July 28, 1999Date of Patent: March 12, 2002
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Patent number: 6355810Abstract: Disclosed are multibinding compounds which inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-COA reductase), the rate limiting enzyme in cholesterol biosynthesis. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to HMG-CoA reductase and the distance between ligands is at least 10 Å. The multibinding compounds of this invention are useful in the treatment and prevention of hypercholesterolemia, hyperlipidemia, atherosclerosis and the like.Type: GrantFiled: June 4, 1999Date of Patent: March 12, 2002Assignee: Advanced Medicine, Inc.Inventors: John H. Griffin, Michael R. Leadbetter, Donald E. Schmidt, Jr.
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Publication number: 20020019544Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.Type: ApplicationFiled: July 30, 2001Publication date: February 14, 2002Applicant: BIOAVAILABILITY SYSTEMS, LLCInventor: James W. Harris
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Patent number: 6309687Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for inhibiting the first pass effect.Type: GrantFiled: August 24, 2000Date of Patent: October 30, 2001Inventor: James W. Harris
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Patent number: 6281361Abstract: Dibenzonaphthyrone of formula (I) wherein A1 and A2 independently of each other are unsubstituted or mono- to tetra-substituted o-C6-C18arylene, with the proviso that formula (I) does not represent a dibenzonaphthyrone of the formula The invention further relates to processes for the preparation thereof, to the use thereof for colouring/pigmenting high-molecular-weight organic material and to substance compositions comprising dibenzonaphthyrones.Type: GrantFiled: March 29, 1999Date of Patent: August 28, 2001Assignee: Ciba Specialty Chemicals Corp.Inventors: Peter Nesvadba, Joachim Jandke
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Patent number: 6255337Abstract: First-pass effective substances derived from citrus.Type: GrantFiled: May 27, 1999Date of Patent: July 3, 2001Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Patent number: 6248776Abstract: Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect.Type: GrantFiled: February 17, 1999Date of Patent: June 19, 2001Assignee: Bioavailability Systems, L.L.C.Inventor: James W. Harris
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Patent number: 6239073Abstract: Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl-, cyclobutyl-, and cyclopentyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant growth regulating agents.Type: GrantFiled: November 4, 1999Date of Patent: May 29, 2001Assignee: Exelixis Plant Sciences, Inc.Inventors: Thomas G. Back, Richard P. Pharis, Suanne K. Nakajima
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Patent number: 6174710Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C6)alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist colloidal bismuth subcitrate and other antibiotics.Type: GrantFiled: January 16, 1997Date of Patent: January 16, 2001Assignee: Pfizer Inc.Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts