The Spiro Includes A Hetero Ring Patents (Class 549/331)
The spiro includes a three- or four-membered hetero ring (Class 549/332)
Plural ring oxygens in a spiro hetero ring (Class 549/333)
Both rings which form the spiro are hetero rings (Class 549/343)
Bicyclo ring system having the spiro hetero ring as one of the cyclos (e.g., griseofulvin, etc.) (Class 549/345)
  • Process for preparing spiro derivatives
    Patent number: 4377689
    Abstract: The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R.sub.1 and R.sub.2 represent a hydrogen atom or an alkyl group or together form a nitrogen-containing heterocyclic ring; A is a>CH.sub.2 group or a>CO group; n is 4 or 5. These compounds can be prepared from .beta.-hydroxyacids by intramolecular rearrangement by the action of a strong acid, in order to form a .gamma.-spirolactone which is converted into an .alpha.-carboxy .gamma.-spirolactone to form the compounds of formula (I) using a Mannich reaction. As necessary, a reduction is then carried out. These compounds are useful medically, in particular, as an antidepressant, a stimulant, and a neuroleptic.
    Type: Grant
    Filed: October 23, 1981
    Date of Patent: March 22, 1983
    Assignee: Etablissements Nativelle S.A.
    Inventors: Georges Tsatsas, Evan E. Costakis, Georges V. Foscolos
  • Spiro derivatives, process for their preparation and medications containing same
    Patent number: 4371538
    Abstract: The invention relates to new derivatives of spiro compounds represented by the general formula (I) ##STR1## wherein R is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group; R.sub.1 and R.sub.2 represent a hydrogen atom or an alkyl group or together form a nitrogen-containing heterocyclic ring; A is a >CH.sub.2 group or a >CO group; n is 4 or 5. These compounds can be prepared from .beta.-hydroxyacids by intramolecular rearrangement by the action of a strong acid, in order to form a .gamma.-spirolactone which is converted into an .alpha.-carboxy .gamma.-spirolactone to form the compounds of formula (I) using a Mannich reaction. As necessary, a reduction is then carried out. These compounds are useful medically, in particular, as an antidepressant, a stimulant, and a neuroleptic.
    Type: Grant
    Filed: October 9, 1980
    Date of Patent: February 1, 1983
    Assignee: Etablissements Nativelle S.A.
    Inventors: Georges Tsatsas, Evan E. Costakis, Georges V. Foscolos
  • D-Homosteroids
    Patent number: 4361578
    Abstract: The invention is directed to 3-oxo-D-homosteroids and derivatives thereof which are useful as antiantigens.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: November 30, 1982
    Inventors: Leo Alig, Andor Furst, Peter Keller, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
  • 6(9)-Isopropyl-9(6)-methyl-6,9-ethano-2-oxaspiro[4,5]dec-7-enes
    Patent number: 4351772
    Abstract: This invention is directed to terpene derivatives. More particularly, this invention relates to a mixture of isomers of the formula ##STR1## wherein R.sub.1 and R.sub.2, which are different from each other, are each methyl or isopropyl, the preparation thereof, and perfume compositions containing them.
    Type: Grant
    Filed: November 20, 1981
    Date of Patent: September 28, 1982
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Horst Upadek, Klaus Bruns
  • 7-Dimethylamino-3-substituted-2,2'-spirobi[2H-1-benzopyrans]
    Patent number: 4342696
    Abstract: Substituted spirobi[2H-1-benzopyrans] particularly suitable for use as precursors to stable colored pyrylium salts are disclosed.
    Type: Grant
    Filed: June 25, 1981
    Date of Patent: August 3, 1982
    Assignee: Armstrong World Industries, Inc.
    Inventors: Thomas B. Garrett, John E. Herweh, Alan B. Magnusson
  • 6-Ethyl-2,10,10-trimethyl-1-oxa-spiro[4.5]deca-3,6-diene
    Patent number: 4336197
    Abstract: New spiranic compound, viz. 6-ethyl-2,10,10-trimethyl-1-oxa-spiro[4.5]deca-3,6-diene, its preparation and use of same as perfume or flavor-modifying ingredient.
    Type: Grant
    Filed: January 30, 1981
    Date of Patent: June 22, 1982
    Assignee: Firmenich SA
    Inventor: Peter Fankhauser