Abstract: The present specification provides novel antimicrobial analogs of spectinomycin and intermediates and processes for their preparation. Particularly described are novel 3'-diazo-secospectinomycin derivatives useful in the preparation of a variety of 3'-substituted spectinomycin analogs.
Abstract: New antibacterial compounds, DC--45--A.sub.1 and DC--45--A.sub.2 are produced by fermentation of a microorganism belonging to the genus Streptomyces. The antibiotics are accumulated in the culture liquor and are isolated therefrom. These compounds are also prepared by acid hydrolysis of known compounds, DC--45--A or DC--45--B.sub.2. DC--45--A.sub.2 is also prepared by acid hydrolysis of DC--45--A.sub.1.
Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
Type:
Grant
Filed:
June 20, 1983
Date of Patent:
June 26, 1984
Assignee:
Bristol-Myers Company
Inventors:
Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
Abstract: The present specification provides novel analogs of khellin. These analogs are all useful as antiatherosclerotic agents. Particularly, the present specification provides 4-methoxy, 9-methoxy, or 4,9-dimethoxy-6,7-dihydro-7,7-disubstituted-5H-furo[3,2-g][1]benzopyran-5- ones.
Abstract: Novel 3-hydroxyiminoscirpen-4.beta., 15-diol esters and derivatives thereof are provided for use as antitumor agents. Also provided are processes for producing the above compounds and methods for using them to inhibit malignant tumors in mammals.
Type:
Grant
Filed:
December 28, 1981
Date of Patent:
February 21, 1984
Assignee:
Bristol-Myers Company
Inventors:
Takushi Kaneko, John M. Essery, Henry Schmitz, Terrence W. Doyle
Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
Type:
Grant
Filed:
January 15, 1982
Date of Patent:
November 1, 1983
Assignee:
Bristol-Myers Company
Inventors:
Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle
Abstract: Chemical compounds having a substituted oxepane ring and methods of preparing such compounds are described. The compounds are active as utero-evacuant agents.
Type:
Grant
Filed:
January 12, 1981
Date of Patent:
October 4, 1983
Assignee:
Ortho Pharmaceutical Corporation
Inventors:
Ramesh M. Kanojia, Michael P. Wachter, Robert H. K. Chen
Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; trifluoromethyl; alkyl of 1 to 11 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; hydroxyl; alkoxy of 1 to 6 carbon atoms; mercapto; (alkyl of 1 to 6 carbon atoms)-mercapto; phenyl-(alkyl of 1 to 3 carbon atoms); phenyl; or mono-, di- or tri-substituted phenyl, where the substituents, which may be identical to or different from each other, are each halogen, alkyl of 1 to 4 carbon atoms, (alkyl of 1 to 6 carbon atoms)-sulfinyl, hydroxyl, alkoxy of 1 to 6 carbon atoms, mercapto or (alkyl of 1 to 6 carbon atoms)-mercapto;R.sub.2 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms or phenyl-(alkyl of 1 to 3 carbon atoms); andR.sub.3 is alkyl of 1 to 6 carbon atoms; optically active antipodes thereof; and non-toxic, pharmaceutically acceptable acid addition salts of said compounds or of said optically active antiposed. The compounds are useful as cardiotonics and antithrombotics.
Type:
Grant
Filed:
May 1, 1981
Date of Patent:
November 30, 1982
Assignee:
Dr. Karl Thomae Gesellschaft mit Beschrankter Haftung
Inventors:
Volkhard Austel, Joachim Heider, Wolfgang Eberlein, Willi Diederen, Walter Haarmann
Abstract: A novel series of 3,8-dihydroxy-scirpen-4.beta.,15-diol esters is provided for use as antitumor agents. The compounds are also useful as intermediates in the preparation of other trichothecene antitumor agents.
Abstract: A synthesis of periplanone-B, a female sex pheromone of the American cockroach, P. americana, is described. Novel compounds which are useful as intermediates in the synthesis of periplanone-B are described including the precursor alcohol, periplanol-B.
Abstract: Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.
Type:
Grant
Filed:
March 4, 1981
Date of Patent:
June 1, 1982
Assignee:
Bristol-Myers Company
Inventors:
Henry Schmitz, Takushi Kaneko, John M. Essery, Terrence W. Doyle