Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/358)
Tricyclo ring system having the hetero ring as one of the cyclos (Class 549/359)
Bicyclo ring system having the hetero ring as one of the cyclos (Class 549/362)
  • Process for preparing hydrazinocarbonyloxylabdanes
    Patent number: 5041565
    Abstract: Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: August 20, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Gerard J. O'Malley
  • Process for preparing polyoxa tetracyclic compounds
    Patent number: 4963683
    Abstract: A process for synthesizing polyoxa tetracyclics which involves the ozonolysis of a single-ring-structure vinyl silane with resulting direct formation of the desired multiple ring matrial. The polyoxa tetracyclic compounds have the formula ##STR1## The vinyl silanes have the structure ##STR2## The vinyl silanes are new chemical compounds as are corresponding primary ozonide and dioxetane intermediates. In a preferred embodiment, this invention provides a total synthesis of the antimalarial artemisinin.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: October 16, 1990
    Assignee: SRI International
    Inventors: Mitchell A. Avery, Clive Jennings-White
  • Myo-inositol orthoformates
    Patent number: 4906761
    Abstract: This invention provides the 4-mono-anion of myo-inositol orthoformate, and describes a process for preparing this anion as well as the use of this anion in the preparation of a variety of mono- and poly-phosphate derivatives of myo-inositol.
    Type: Grant
    Filed: June 28, 1988
    Date of Patent: March 6, 1990
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventor: David C. Billington
  • Hydrazinocarbonyloxylabdanes for treating cardiac failure
    Patent number: 4883793
    Abstract: Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: November 28, 1989
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Gerard J. O'Malley
  • Nobamycin its analogs and process therefore
    Patent number: 4767847
    Abstract: The invention concerns a novel nogamycin having a heretofore unknown configuration and novel analogs which are active against various microorganisms. The invention also includes novel methods of making substituted and unsubstituted nogamycin having an essentially pure isomeric form of a preferred configuration.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: August 30, 1988
    Assignee: The Upjohn Company
    Inventors: Paul F. Wiley, David W. Elrod
  • Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure
    Patent number: 4740522
    Abstract: Novel oxolabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: August 28, 1986
    Date of Patent: April 26, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: Nicholas J. Hrib
  • Labdane compounds, pharmaceutical compositions and use
    Patent number: 4639443
    Abstract: Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: January 27, 1987
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Acidic o-nitroaromatics as photoinhibitors of polymerization in positive working films
    Patent number: 4477556
    Abstract: A photopolymerizable coating composition comprising(1) a nongaseous, ethylenically unsaturated, polymerizable compound,(2) a specified acidic o-nitroaromatic compound, and(3) an organic, radiation-sensitive, free-radical generating system which is useful for making a positive or negative polymeric image on a substrate.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 16, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Thomas E. Dueber, William J. Nebe
  • Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
    Patent number: 4474806
    Abstract: Sulfonyl or carbonyl derivatives of inositols are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These inositol derivatives are prepared by condensation of a protected inositol with a substituted sulfonic or carboxylic acid derivative followed by removal of protecting groups.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Shu S. Yang
  • Nogalamycin derivatives
    Patent number: 4439602
    Abstract: Novel N-demethyl derivatives of nogalamycin and process for preparing the same. The compounds of this invention are active against various microorganisms.
    Type: Grant
    Filed: August 20, 1981
    Date of Patent: March 27, 1984
    Assignee: The Upjohn Company
    Inventor: Paul F. Wiley