Pentacyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/382)
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Patent number: 8507549Abstract: Methods for synthesizing glycinols, glyceollins I and II, and isoflavene and chromane compounds using a Wittig reaction, compositions made therewith, and uses thereof are described.Type: GrantFiled: January 9, 2012Date of Patent: August 13, 2013Assignee: The University of ToledoInventors: Paul W. Erhardt, Rahul S. Khupse, Amarjit Luniwal
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Patent number: 8486312Abstract: The present invention relates to photochromic naphthopyrancs having a double-bridged terphenyl sub-unit, and to the use thereof in plastics of all types, particularly for ophthalmic purposes.Type: GrantFiled: April 29, 2009Date of Patent: July 16, 2013Assignee: Rodenstock GmbHInventors: Manfred Melzig, Yven Rohlfing, Udo Weigand
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Publication number: 20130171715Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: ApplicationFiled: January 16, 2013Publication date: July 4, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventor: LIFE TECHNOLOGIES CORPORATION
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Publication number: 20130065056Abstract: The present invention provides ophthalmic devices comprising at least one photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic materials. Other non-limiting embodiments relate to methods of making the ophthalmic devices comprising photochromic materials.Type: ApplicationFiled: March 12, 2012Publication date: March 14, 2013Inventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowies, Frank F. Molock, JR., Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
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Patent number: 8388872Abstract: The present invention provides a photochromic material which is an indeno-fused naphthopyran of structural formulas I or II, having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic material.Type: GrantFiled: February 21, 2012Date of Patent: March 5, 2013Assignee: Transitions Optical, Inc.Inventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowles, Frank F. Molock, Jr., Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
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Patent number: 8383841Abstract: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano, cyanato, mercaptocyanato, nitroso, nitro, azido, sulfeno, sulfinyl, and sulfino. In one embodiment, halo and/or hydroxy groups are used. Optimal dyes contain a lower C9 phenyl ring in which both ortho groups are the same and the lower ring exhibits some form a symmetry relative to an imaginary axis running from the phenyl rings point of attachment to the remainder of the xanthene dye through a point para to the point of attachment. The phenyl xanthene dyes may be activated. Furthermore, the phenyl xanthene dyes may be conjugated to one or more substances including other dyes.Type: GrantFiled: January 9, 2009Date of Patent: February 26, 2013Assignee: Applied Biosystems, LLCInventors: Joe Y. L. Lam, Steven M. Menchen, Ruiming Zou, Scott C. Benson
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Publication number: 20130041022Abstract: The present disclosure demonstrates the molecular effects of glyceollins on human prostate cancer cell LNCaP to further elucidate its potential effects on prostate cancer prevention. The glyceollins inhibited LNCaP cell growth similar to that of the soy isoflavone genistein. The growth inhibitory effects of the glyceollins appeared to be due to an inhibition on G1/S progression and correlated with an up-regulation of cyclin-dependent kinase inhibitor A1 and B1 mRNA and protein levels. By contrast, genistein only up-regulates cyclin-dependent kinase inhibitor A1. In addition, glyceollin treatments led to down-regulated mRNA levels for androgen responsive genes. In contrast to genistein, this effect of glyceollins on androgen responsive genes appeared to be mediated through modulation of an estrogen- but not androgen-mediated pathway.Type: ApplicationFiled: December 22, 2009Publication date: February 14, 2013Applicants: UNITED STATES DEPARTMENT OF AGRICULTURE, THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUNDInventors: Thomas E. Cleveland, Stephen M. Boue, Matthew E. Burow, Thomas T.Y. Wang
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Publication number: 20130035380Abstract: The present invention relates to a process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers of the type A and type B, of more than 90% purity as gallic acid equivalent which comprises the steps of removing the organic solvent from the extract to produce the free flowing oleoresin and drying of the residue under optimized conditions to produce a polyphenol and procyanidin Type A & B polymer rich solid which on subsequent extraction with water or with mixture of water and acetone or water and lower alcohol and further evaporation to a solid content of not more than 6% and subsequent chromatographic separation to obtain fractions containing procyanidin type A and B polymers free of coumarins and cinnamaldehyde. The present invention also relates to stable composition comprising cinnamon polyphenol rich powder for delivering maximum bioactivity upon oral administration.Type: ApplicationFiled: July 31, 2012Publication date: February 7, 2013Applicant: AKAY FLAVOURS & AROMATICS PVT LTD.Inventors: Krishnakumar Illathu Madhavamenon, Abin Isaac, Dineshkumar Unnikrishnan, Aswin Koshy Jacob Vaidyan, Balu Paulose Maliakel
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Publication number: 20130022542Abstract: The present application discloses a compound of formula (I) or (II): wherein X is gamma-emitting radionuclide. Also disclosed is a pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof, and a physiologically acceptable vehicle and a method of imaging a region in a patient, which includes administering to the patient a diagnostically effective amount of the pharmaceutical composition comprising the compound of formula (I), the compound of formula (II), or a mixture thereof.Type: ApplicationFiled: July 13, 2012Publication date: January 24, 2013Applicant: NORDION (CANADA) INC.Inventors: Lihui WEI, Xuxu Yan, Corinne Bensimon, Terrence David Ruddy
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Patent number: 8308995Abstract: A chromene compound represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6, m, and n are defined in the specification. The chromene compound is rarely deteriorated by exposure.Type: GrantFiled: February 9, 2012Date of Patent: November 13, 2012Assignee: Tokuyama CorporationInventors: Soko Kasai, Shinobu Izumi
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Patent number: 8308996Abstract: A photochromic chromene compound which develops a color of a neutral tint, has high color optical density, a high fading speed and high durability, and has an indeno(2,1-f)naphtho(1,2-b)pyran structure represented by the following formula as the basic skeleton, wherein a sulfur-containing substituent selected from thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group is bonded to the 6-position and/or 7-position carbon atom(s).Type: GrantFiled: August 4, 2010Date of Patent: November 13, 2012Assignee: Tokuyama CorporationInventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi
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Publication number: 20120276006Abstract: The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.Type: ApplicationFiled: June 21, 2012Publication date: November 1, 2012Applicant: Lantheus Medical Imaging, Inc.Inventors: David S. Casebier, Simon P. Robinson, Ajay Purohit, Heike S. Radeke, Michael T. Azure, Douglas D. Dischino
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Publication number: 20120244067Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.Type: ApplicationFiled: March 22, 2012Publication date: September 27, 2012Applicant: Fred Hutchinson Cancer Research CenterInventors: Mark B. Roth, Pamela A. Padilla
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Publication number: 20120183810Abstract: The present invention provides a compound represented by the Formula I: Wherein substituents R16, R17 and R17? are each independently selected from an electron withdrawing group having a Hammett ?p value of from 0.05 to 0.85, provided that one of R16 and R17 is hydrogen.Type: ApplicationFiled: October 5, 2011Publication date: July 19, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventor: Anu Chopra
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Patent number: 8222255Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.Type: GrantFiled: September 25, 2008Date of Patent: July 17, 2012Assignees: Merck Sharp & Dohme Corp., Scynexis, Inc.Inventors: James M. Balkovec, Phieng Siliphaivanh, Frances A. Bouffard, Roland A. Bouffard, legal representative, Michael R. Peel, Weiming Fan, Ahmed Mamai, Sarah Dimick Gray
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Patent number: 8217188Abstract: Described herein are C5-C6 annelated naphthopyrans that possess at least one electron-withdrawing group. The compounds possess desirable properties such as increased fading kinetics. Also described herein are new methods for synthesizing 2H-chromenes annelated at C5-C6. The methods involve less stringent reaction conditions as well as provide increased reaction yields. The methods permit the synthesis of a wide variety of substituted naphthopyrans that can be temperature sensitive, which was not possible with previous synthetic routes.Type: GrantFiled: August 4, 2009Date of Patent: July 10, 2012Assignee: Corning IncorporatedInventors: Suresh Das, Bruno Dufour, Mangalam S Nair, Kokkuvayil V Radhakrishnan
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Publication number: 20120170098Abstract: A photochromic chromene compound having an indeno(2,1-f)naphtho(1,2-b)pyran structure as its basic skeleton, an aryl group or a heteroaryl group at the 6-position carbon atom of the structure and an electron donor group having a Hammett constant ?p of not more than ?0.1 at the 7-position carbon atom.Type: ApplicationFiled: September 15, 2010Publication date: July 5, 2012Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Mitsuyoshi Sando, Kazuhiro Teranishi
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Publication number: 20120157696Abstract: The present invention relates to a method of making indeno-fused naphthol materials, that involves, with some embodiments, forming an indanone acid intermediate, which can be represented by the following general Formula V, With Formula V, m is from 0 to 4, and R1 for each m, Rg and Rh can each be independently selected from, for example, hydrogen and hydrocarbyl. The present invention also relates to a method of making an indeno-fused naphthopyran that involves an indanone acid intermediate synthetic route.Type: ApplicationFiled: December 13, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Anu Chopra, Barry Van Gemert, Wenjing Xiao, Huayun Yu
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Publication number: 20120157678Abstract: The present invention relates to methods of making fused ring compounds, such as indeno-fused naphthols, and fused ring indenopyran compounds, such as indeno-fused naphthopyrans, that each employ an unsaturated compound represented by the following Formula II. Referring to the unsaturated compound of Formula II: Ring-A can be selected from optionally substituted aryl (e.g., phenyl); m can be, for example, from 0 to 4; R1 for each m can be selected from optionally substituted hydrocarbyl (e.g., C1-C6 alkyl) optionally interrupted with at least one linking group (e.g., —O—); and R3 and R16 can each be independently selected from, for example, hydrogen or optionally substituted hydrocarbyl, such as C1-C8 alkyl. When Ring-A is a phenyl group, the unsaturated compound represented by Formula II can be referred to as an unsaturated indanone acid/ester compound, or an indenone acid/ester compound (depending on whether R16 is hydrogen, or an optionally substituted hydrocarbyl group).Type: ApplicationFiled: December 8, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL INC.Inventors: Meng He, Anil Kumar
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Publication number: 20120156508Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.Type: ApplicationFiled: December 14, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Darrin R. Dabideen, Sujit Mondal, Xiao-Man Dai, Ruisong Xu, Wenjing Xiao, Massimiliano Tomasulo, Huayun Yu, Anu Chopra, Anil Kumar
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Publication number: 20120157677Abstract: The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).Type: ApplicationFiled: December 7, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL INC.Inventors: Meng He, Darrin R. Dabideen, Ruisong Xu, Anil Kumar
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Publication number: 20120156521Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles. Also described herein are methods for preparing certain photochromic compounds, compositions, and articles.Type: ApplicationFiled: December 7, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Darrin R. Dabideen, Xiao-Man Dai, Wenjing Xiao, Ruisong Xu, Sujit Mondal, Anil Kumar, Anu Chopra
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Publication number: 20120145973Abstract: The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.Type: ApplicationFiled: December 8, 2011Publication date: June 14, 2012Applicant: TRANSITIONS OPTICAL INC.Inventors: Kevin E. Bancroft, Anu Chopra, Xiao-Man Dai, Beon-Kyu Kim, David B. Knowles, Jason R. Lewis, Victor A. Montes, Stephen D. Straight, Massimiliano Tomasulo, Barry Van Gemert, Robert W. Walters, Wenjing Xiao, Huayun Yu, Elizabeth A. Zezinka
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Publication number: 20120145975Abstract: The present invention provides a photochromic material which is an indeno-fused naphthopyran of structural formulas I or II, having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic material.Type: ApplicationFiled: February 21, 2012Publication date: June 14, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowles, Frank Molock, Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
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Publication number: 20120138876Abstract: A chromene compound represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6, m, and n are defined in the specification. The chromene compound is rarely deteriorated by exposure.Type: ApplicationFiled: February 9, 2012Publication date: June 7, 2012Inventors: Soko KASAI, Shinobu Izumi
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Publication number: 20120136148Abstract: The present invention relates to photochromic compounds that include at least two photochromic moieties that are linked together by a multivalent linking group. The multivalent linking group can be selected so as to be flexible and/or substantially prevent electronic interaction between any two photochromic moieties through the multivalent linking group. The present invention also relates to photochromic compositions and articles that include at least a photochromic amount of one or more photochromic compounds of the present invention.Type: ApplicationFiled: November 22, 2011Publication date: May 31, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Yunyi Lu, Wenjing Xiao, Robert W. Walters, Feng Wang, M. Frank Haley, Jason R. Lewis, Anu Chopra, Beon-Kyu Kim, Huayun Yu
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Publication number: 20120126185Abstract: The present invention relates to compounds represented by the following Formulas (I) and (II), Ring-A of Formulas I and II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula II.Type: ApplicationFiled: August 31, 2011Publication date: May 24, 2012Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
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Publication number: 20120121934Abstract: A photochromic chromene compound which develops a color of a neutral tint, has high color optical density, a high fading speed and high durability, and has an indeno(2,1-f)naphtho(1,2-b)pyran structure represented by the following formula as the basic skeleton, wherein a sulfur-containing substituent selected from thiol group, alkylthio group, alkoxyalkylthio group, haloalkylthio group, cycloalkylthio group, arylthio group and heteroarylthio group is bonded to the 6-position and/or 7-position carbon atom(s).Type: ApplicationFiled: August 4, 2010Publication date: May 17, 2012Inventors: Toshiaki Takahashi, Junji Takenaka, Junji Momoda, Kazuhiro Teranishi
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Publication number: 20120122822Abstract: Disclosed are a composition for reducing beta amyloid-induced neurotoxicity by inhibiting ?-secretase activity, comprising a dibenzofuran derivative, and a method for preparing the same. Further disclosed is that the combination of the dibenzofuran derivative with a ?-secretase inhibitor or an anti-inflammatory agent shows higher activity with respect to reducing beta amyloid-induced neurotoxicity.Type: ApplicationFiled: November 17, 2010Publication date: May 17, 2012Applicant: Phloronol, Inc.Inventors: Bong-Ho LEE, Seongho KIM, Hyeon-Cheol SHIN, Haengwoo LEE
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Publication number: 20120115942Abstract: Methods for synthesizing glycinols, glyceollins I and II, and isoflavene and chromane compounds using a Wittig reaction, compositions made therewith, and uses thereof are described.Type: ApplicationFiled: January 9, 2012Publication date: May 10, 2012Inventors: Paul W. Erhardt, Rahul S. Khupse, Amarjit Luniwal
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Patent number: 8153393Abstract: Spirolactam targeting compounds, related compounds, uses of such compounds, and methods of making such compounds are disclosed.Type: GrantFiled: February 29, 2008Date of Patent: April 10, 2012Assignee: University of MassachusettsInventors: Stephen C. Miller, Anjan K. Bhunia
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Patent number: 8147725Abstract: The present invention provides a photochromic material which is an indeno-fused naphthopyran having a pi-conjugation extending group bonded to the 11-position of the indeno-fused naphthopyran, the pi-conjugation extending group having at least one pendent halo-substituted group bonded thereto. The pi-conjugation extending group extends the pi-conjugation system of said indeno-fused naphthopyran. The 13-position of the indeno-fused naphthopyran is substantially free of spiro-substituents. The invention further provides photochromic materials of specified structure, photochromic compositions, photochromic articles and optical elements that include the photochromic material.Type: GrantFiled: September 1, 2010Date of Patent: April 3, 2012Assignee: Transitions Optical, IncInventors: Anu Chopra, Jun Deng, Beon-Kyu Kim, David B. Knowles, Frank Molock, Victor A. Montes, Stephen D. Straight, Wenjing Xiao, Huayun Yu
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Patent number: 8147726Abstract: A chromene compound represented by the following formula (1): wherein R1, R2, R3, R4, R5, R6, m, and n are defined in the specification. The chromene compound is rarely deteriorated by exposure.Type: GrantFiled: May 8, 2009Date of Patent: April 3, 2012Assignee: Tokuyama CorporationInventors: Soko Kasai, Shinobu Izumi
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Publication number: 20120071465Abstract: The present invention relates to the compounds useful in the prevention and/or treatment of tumours. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumours presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumour glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.Type: ApplicationFiled: May 20, 2010Publication date: March 22, 2012Inventors: Virginie Clement, Ivan Radovanovic
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Patent number: 8138358Abstract: The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol.Type: GrantFiled: September 21, 2009Date of Patent: March 20, 2012Assignee: Iowa State University Research Foundation, Inc.Inventors: George A. Kraus, Yi Yuan
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Patent number: 8134017Abstract: A compound represented by the following formula (1) or (2):Type: GrantFiled: December 2, 2010Date of Patent: March 13, 2012Assignee: RikenInventors: Shinichiro Kamino, Shuichi Enomoto
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Publication number: 20120059175Abstract: The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol.Type: ApplicationFiled: November 9, 2011Publication date: March 8, 2012Applicant: Iowa State University Research Foundation, Inc.Inventors: George A. Kraus, Yi Yuan
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Patent number: 8124746Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.Type: GrantFiled: July 29, 2010Date of Patent: February 28, 2012Assignee: Applied Biosystems, LLCInventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
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Publication number: 20120009121Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.Type: ApplicationFiled: March 19, 2010Publication date: January 12, 2012Applicant: The Johns Hopkins UniversityInventors: Martin Pomper, Ronnie Charles Mease, Ray Sangeeta, Ying Chen
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Patent number: 8084430Abstract: Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.Type: GrantFiled: January 18, 2007Date of Patent: December 27, 2011Assignees: Zhengzhou University, Furen PharmaceuticalInventors: Hongmin Liu, Wenchen Zhu, Chenggong Zhu, Qingduan Wang, Yu Ke, Zhengzhou Liu, Xuebin Yan, Zhang Jianye, Hongli Qu
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Publication number: 20110311920Abstract: A naphthalene derivative having formula (1) is provided wherein cyclic structures Ar1 and Ar2 denote a benzene or naphthalene ring, X is a single bond or C1-C10 alkylene, m is 0 or 1, and n is such a natural number as to provide a molecular weight of up to 100,000. A material comprising the naphthalene derivative or a polymer comprising the naphthalene derivative is spin coated to form a resist bottom layer having improved properties. A pattern forming process in which a resist bottom layer formed by spin coating is combined with an inorganic hard mask formed by CVD is available.Type: ApplicationFiled: June 21, 2011Publication date: December 22, 2011Applicant: SHIN-ETSU CHEMICAL CO., LTDInventors: Takeshi Kinsho, Katsuya Takemura, Daisuke Kori, Takeru Watanabe, Tsutomu Ogihara
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Publication number: 20110224289Abstract: This invention belongs to the chemical-pharmaceutical field. New compounds of pterocarpanquinone family presented in formula (I) according to this invention are capable to be activated by reduction generating alkylating species intracellularly. It presents selective cytotoxic effects particularly on mammalian human and nonhuman cells that divide constantly and are useful in treating diseases and dysfunctions related to the phenomenon of undesired cell proliferation. Such compounds are also effective for the treatment of diseases or dysfunctions related to high levels of TNF-? in human and nonhuman mammals.Type: ApplicationFiled: November 5, 2009Publication date: September 15, 2011Applicant: UNIVERSIDADE FEDERAL DO RIO DE JANEIROInventors: Alcides Jose Monteiro Da Silva, Vivian Mary Barral Dold Rumjanek, Bartira Rossi Bergmann, Eduardo Salustiano Jesus Dos Santos, Paulo Roberto Ribeiro Costa, Chaquip Daher Netto, Wallace Pacienza Lima, Eduardo Caio Torres Dos Santos, Moises Clemente Marinho Cavalcante, Sergio Henrique Seabra, Ingred Goretti Rica
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Patent number: 8013174Abstract: Specific photochromic spirodihydrophenanthropyrans and their use in synthetic resin materials of all kinds, particularly for ophthalmic purposes. The compounds of the invention are photochromic pyran compounds derived from 9,10-dihydrophenanthrene in which at least one of the two carbon atoms at positions 9 and 10 belongs to a further ring system and thus forms a spiro linkage point.Type: GrantFiled: May 9, 2008Date of Patent: September 6, 2011Assignee: Rodenstock GmbHInventors: Udo Weigand, Manfred Melzig, Yven Rohlfing
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Publication number: 20110172225Abstract: Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and/or inhibitors of (1,3)-?-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and/or preventing fungal infections and associated diseases and conditions.Type: ApplicationFiled: September 25, 2008Publication date: July 14, 2011Applicants: Merck Sharp & Dohme Corp., Scynexis, Inc.Inventors: James M. Balkovec, Phieng Siliphaivanh, Frances A. Bouffard, Roland A. Bouffard, Michael R. Peel, Weiming Fan, Ahmed Mamai, Sarah Dimick Gray
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Patent number: 7976739Abstract: A chromene compound represented by the following formula (1), wherein, “A” is an annulated ring, R1 and R2 are hydrogen atoms, hydroxyl groups or the like groups, R3, R4, R5 and R6 are substituents such as hydroxyl groups or the like groups, “a” and “b” are, respectively, integers of 0 to 4, and “c” and “d” are, respectively, integers of 0 to 5. The chromene compound is a photochromic compound developing a color of a neutral tint, and has a high color density per a unit amount.Type: GrantFiled: August 22, 2007Date of Patent: July 12, 2011Assignee: Tokuyama CorporationInventors: Shinobu Izumi, Junji Takenaka
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Publication number: 20110143141Abstract: The present invention relates to compounds represented by the following Formula I, Ring-A of the Formula I can be, for example an aryl group, and L1 is a chiral or achiral lengthening group. The compound represented by Formula I can be a photochromic compound. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula I.Type: ApplicationFiled: December 16, 2010Publication date: June 16, 2011Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Sujit Mondal, Darrin R. Dabideen, Anil Kumar, Xiao-Man Dai
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Publication number: 20110140056Abstract: The present invention relates to compounds represented by the following Formulas (I) and (II), Ring-A of Formulas I and II can be, for example, an aryl group, and Q? and Q?? can each be independently selected from groups, such as, halogen, —OH, —CN, amine groups, amide groups, carboxylic acid ester groups, carboxylic acid groups, alkenyl groups, alkynyl groups, carbonate groups, sulfide groups, and sulfonic acid ester groups. The present invention also relates to photochromic compositions and photochromic articles that include one or more photochromic compounds, such as represented by Formula II.Type: ApplicationFiled: December 16, 2010Publication date: June 16, 2011Applicant: TRANSITIONS OPTICAL, INC.Inventors: Meng He, Anil Kumar, Darrin R. Dabideen
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Publication number: 20110144195Abstract: Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.Type: ApplicationFiled: March 3, 2009Publication date: June 16, 2011Inventors: Paul W. Erhardt, Rahul Khupse, Jeffrerey G. Sarver, Thomas E. Cleveland, Stephen M. Boue, Thomas E. Wiese, Matthew E. Burow, John A. McClachlan
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Publication number: 20110129678Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles. Also described herein are methods for preparing certain photochromic compounds, compositions, and articles.Type: ApplicationFiled: December 16, 2010Publication date: June 2, 2011Applicant: Transitions Optical, Inc.Inventors: Meng He, Darrin R. Dabideen, Anil Kumar, Ruisong Xu
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Publication number: 20110104066Abstract: Disclosed is a method for the screening of a compound having an activity to selectively modulate an androgen receptor. The method comprises the steps of: contacting a substance to be tested with a prostate cancer cell and measuring the level of expression of mRNA for a prostate-specific antigen or the level of production of the prostate-specific antigen in the prostate cancer cell; and contacting the substance with an adipocyte and measuring the level of expression of mRNA for uncoupling protein-1 or the level of production of uncoupling protein-1 in the adipocyte. Also disclosed is a selective androgen receptor modulator comprising a compound represented by any one formula selected from the structural formulae (I) to (III) as an active ingredient. Further disclosed is a composition for preventing or treating lifestyle-related diseases, which comprises the selective androgen receptor modulator.Type: ApplicationFiled: May 8, 2009Publication date: May 5, 2011Applicants: ASKA Pharmaceutical Co., Ltd.Inventors: Hajime Nawata, Toshihiko Yanase, Takayoshi Nakagawa