The Tetracyclo Ring System Consists Of Four Six-membered Cyclos Patents (Class 549/384)
-
Publication number: 20100051826Abstract: Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.Type: ApplicationFiled: July 19, 2007Publication date: March 4, 2010Inventors: Robert M. Strongin, Isiah M. Warner, Youjun Yang, Mark Lowry, Sayo O. Fakayode, Jorge O. Escobedo Cordova, Xiangyang Xu
-
Publication number: 20100047859Abstract: A composition including the reaction product of: an organic silane of Formula SiR1mX14-m; a fluorescent dye-silane compound of Formula D-L?-(CH2)n—SiX23; water; and a hydrolysis catalyst; where R1 is a C1-C6 alkyl that is unsubstituted or substituted with one or more halogens or hydroxyl group, C2-C6 alkenyl that is unsubstituted or substituted with one or more halogens or hydroxyl group, or an aryl group that is unsubstituted or substituted with one or more halogens or hydroxyl group, m is 0 or 1; n is 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12, D is a radical having a fluorophore; L1 is a bond, O, S, C(O)O, C(O)NR2, SO2O, C(O)S, C(S), or S2; R2 is hydrogen, a C1-C12 alkyl that is unsubstituted or is substituted with hydroxyl; each X1 and X2 are independently a hydrolyzable substituent; and the reaction product is a silica-based fluorescent nanoparticle.Type: ApplicationFiled: August 22, 2008Publication date: February 25, 2010Inventor: Jin-Kyu Lee
-
Publication number: 20100034762Abstract: Improved methods to prepare aqueous extracts of gallic acid esters including 1-O-galloyl-?-D-glucose (?-glucogallin) and other mucic acid gallates from the fruits of Emblica officinalis, wherein enrichment of gallic acid esters is achieved by Supercritical Fluid Extraction (SCFE) procedure, are disclosed. The use of such standardized extracts of gallic acid esters (greater than 40% w/w of gallic acid esters) in the manufacture of medicaments with diverse health benefits, is also disclosed.Type: ApplicationFiled: September 10, 2008Publication date: February 11, 2010Inventors: Muhammed Majeed, Atul Namdevrao Jadhav, Jyotish Shanker Srivastava, Subbalakshmi Prakash, Kalyanam Nagabhushanam, Beena Bhat
-
Publication number: 20100010240Abstract: The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol.Type: ApplicationFiled: September 21, 2009Publication date: January 14, 2010Applicant: Iowa State University Research Foundation, Inc.Inventors: George A. Kraus, Yi Yuan
-
Patent number: 7615649Abstract: A method for preparing A-type procyanidins is provided by reacting flavylium salts with catechins and analogs thereof, under anhydrous conditions in alcohol.Type: GrantFiled: January 26, 2006Date of Patent: November 10, 2009Assignee: Iowa State University Research Foundation, Inc,Inventors: George A. Kraus, Yi Yuan
-
Publication number: 20090093646Abstract: The present invention relates to novel compound of stemphones obtained by culturing microorganism belonging to genus Aspergillus and having ability to produce compound of stemphones selected from the group consisting of stemphone D substance, stemphone E substance, stemphone E1 substance, stemphone E2 substance, stemphone E3 substance and stemphone F substance, accumulating the compound of stemphones in the cultured mass, and isolating the compound of stemphones from the cultured mass. Since the obtained compound has enhancing activity for imipenem and activity for reducing cytotoxicity, it can be expected to be useful as lead compounds for combination remedy for methicillin resistant Staphylococcus aureus (MRSA) infection.Type: ApplicationFiled: March 15, 2006Publication date: April 9, 2009Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuda
-
Publication number: 20090001353Abstract: A thin layer of organic semiconductor material comprising a comprising an organic semiconductor thin film material is disclosed in which the thin film material substantially comprises a heteropyrene compound or derivative. In one embodiment, a thin film transistor comprises a layer of the organic semiconductor material. Further disclosed is a process for fabricating an organic thin-film transistor device, preferably by relative low-temperature sublimation or solution-phase deposition onto a substrate.Type: ApplicationFiled: June 26, 2007Publication date: January 1, 2009Inventors: Deepak Shukla, Thomas R. Welter, Ann L. Carroll-Lee, Wendy G. Ahearn, Douglas R. Robello
-
Publication number: 20080306139Abstract: Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).Type: ApplicationFiled: July 20, 2004Publication date: December 11, 2008Inventors: Angela Basilio, Olga Genilloud, Pilar Hernandez, Sheo Bux Singh, Jose Rueben Tormo, Jun Wang
-
Patent number: 7459555Abstract: The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which a further ring system is bonded to the f side of the naphthopyran. The inventive photochromic dyes generally have the general formula (I) wherein n, R1, R2, R3, X, B and B? are defined as in claim 1. The inventive compounds are distinguished by good darkening and decolorizing properties and a very good service life.Type: GrantFiled: December 13, 2001Date of Patent: December 2, 2008Assignee: Rodenstock GmbHInventors: Manfred Melzig, Claudia Mann, Udo Weigand
-
Publication number: 20080268462Abstract: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.Type: ApplicationFiled: November 1, 2007Publication date: October 30, 2008Inventors: Jerome W. Kosmeder, Mark Lefever, Donald Johnson, Michael Farrell, Zhanna Zhilina, Christopher Bieniarz
-
Publication number: 20080177073Abstract: The present teachings provide compounds of formulae I and II: where Q, Ra, R1, W, and n are as defined herein. The present teachings also provide methods of preparing compounds of formulae I and II, including methods of preparing compounds of formula II from compounds of formula I. The compounds disclosed herein can be used to prepare semiconductor materials and related composites and electronic devices.Type: ApplicationFiled: January 7, 2008Publication date: July 24, 2008Inventors: Antonio Facchetti, Tobin J. Marks, He Yan
-
Publication number: 20080160587Abstract: The present invention relates to novel stemphones having enhancing effect of ?-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE BP-83, accumulating the stemphones in the cultured mass, and isolating the stemphones from the cultured mass. Since the obtained stemphones have an action enhancing activity of ?-lactam antibiotic used as an antibacterial agent by combining with ?-lactam antibiotic, the stemphones are expected to be useful as the therapeutic agent for MRSA infection and infectious diseases caused by multi-drug resistant microorganisms including ?-lactam antibiotic resistance.Type: ApplicationFiled: October 3, 2005Publication date: July 3, 2008Applicant: THE KITASATO INSTITUTEInventors: Satoshi Omura, Hiroshi Tomoda, Rokuro Masuma
-
Patent number: 7365113Abstract: Flavan-based and spirodichroman compound-based phosphate esters prepared by reacting flavans and spirodichroman compounds with phosphorus oxychloride, monophenyl dichlorophosphate, or diphenyl chlorophosphate compounds are described. The flavans and spirodichroman compounds can be synthesized by the reaction of resorcinol with aliphatic acetone. Such phosphate esters can be used as flame retardants.Type: GrantFiled: September 21, 2005Date of Patent: April 29, 2008Inventors: Raj B. Durairaj, Gary A. Jesionowski
-
Patent number: 7332260Abstract: The present invention relates to novel compounds of the naphthopyran type which have an annelated carbocycle in position 5,6. These compounds are of formula (I) given below: in which A is an alicyclic ring which is optionally annelated with an aromatic ring and in which two adjacent R3 can together form at least one ring, for example a benzo group. These compounds (I) possess interesting photochromic properties. The invention also relates to the method of preparing these compounds (I), as well as their applications as photochromes and compositions and (co)polymer matrices comprising them.Type: GrantFiled: July 16, 2002Date of Patent: February 19, 2008Assignee: Corning IncorporatedInventors: Olivier Breyne, You-Ping Chan, Patrick Jean
-
Patent number: 7326696Abstract: Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.Type: GrantFiled: December 15, 2003Date of Patent: February 5, 2008Assignee: Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Haregewein Assefa, Joel Berniac, Beena Bhatia, Todd Bowser, Jackson Chen, Laura Honeyman, Mohamed Y. Ismail, Oak Kim, Rachid Mechiche, N. Laxma Reddy, Atul K. Verma, Peter Viski, Tadeusz Warchol, Ivan Yanachkov
-
Patent number: 7250120Abstract: Disclosed are novel benzo-, naphtho- and phenanthrochromenes substituted by carbamated or ureated phenyls having the following general formula (I): wherein R1 represents a group their preparation, photochromic compositions and articles containing them. This family of compounds have interesting and useful photochromic properties, especially in terms of absorption band and discoloration speed.Type: GrantFiled: June 14, 2004Date of Patent: July 31, 2007Assignee: Corning Inc.Inventors: You-Ping Chan, Olivier Breyne
-
Patent number: 7229576Abstract: The present invention relates to specific photochromic phenanthropyrans as well as to their use in synthetic resin materials of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic compounds derived from 2H-phenanthro[2,1-b]pyrans and 3H-phenanthro[3,4-b]pyrans, which in the open form have especially long wavelength absorption maxima, but in the unexcited state are still colorless.Type: GrantFiled: March 17, 2006Date of Patent: June 12, 2007Assignee: Rodenstock GmbHInventors: Claudia Mann, Manfred Melzig, Udo Weigand
-
Patent number: 7157492Abstract: This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification.Type: GrantFiled: February 23, 2005Date of Patent: January 2, 2007Assignee: WyethInventors: Richard Eric Mewshaw, Richard James Edsall, Jr.
-
Patent number: 7138428Abstract: Disclosed herein are an acetone-extracted product obtained from gamboge resin and compounds further purified from said acetone-extracted product, including a new compound called formoxanthone A. The acetone-extracted product and the further purified compounds have been demonstrated to have activities in inhibiting the growth of tumor/cancer cells. Also disclosed are the processes for obtaining said further purified compounds, and the uses of the acetone-extracted product and the further purified compounds in the preparation of pharmaceutical composition for inhibiting the growth of tumor/cancer cells.Type: GrantFiled: October 6, 2004Date of Patent: November 21, 2006Assignee: Taiwan Sunpan Biotechnology Development Company, Ltd.Inventors: Sen-Bin Lee, Chiu-Ming Chen
-
Patent number: 7074943Abstract: This invention relates to novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the i, j, or k side of the naphthopyran ring, having certain substituents at the 2, 5, and 6 positions of the naphthopyran ring. These naphthopyrans may have the formula (I) presented below: These compounds (I) have interesting photochromic properties. Also related to this invention are host materials that contain such naphthopyran compounds, and articles such as ophthalmic lenses or other plastic transparencies that incorporate the naphthopyran compounds.Type: GrantFiled: October 3, 2005Date of Patent: July 11, 2006Assignee: Vision-Ease LensInventor: Xuzhi Qin
-
Patent number: 6963003Abstract: This invention relates to novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the i, j, or k side of the naphthopyran ring, having certain substituents at the 2, 5, and 6 positions of the naphthopyran ring. These naphthopyrans may have the formula (I) presented below: These compounds (I) have interesting photochromic properties. Also related to this invention are host materials that contain such naphthopyran compounds, and articles such as ophthalmic lenses or other plastic transparencies that incorporate the naphthopyran compounds.Type: GrantFiled: October 27, 2003Date of Patent: November 8, 2005Assignee: Vision-Ease LaneInventor: Xuzhi Qin
-
Patent number: 6936725Abstract: A photochromic compound suitable for use as a single substance for photochromic tinting of a transparent plastic article so that the tinted article has a neutral gray or brown color in the excited state, is made by fusing at least two non-identical photochromic sections to an aromatic structure. The photochromic sections are selected so that the different absorption wavelengths of the excited photochromic sections give rise to a neutral gray or brown color in the plastic material and are selected from the group consisting of oxazines and pyrans. At least one of the photochromic sections is not an indolino spiropyran. The aromatic structure to which the photochromic sections are fused is selected from the group consisting of benzene, biphenyl, naphthalene, anthracene and phenanthrene. The positions of fusion of the photochromic sections on the aromatic structure are directly adjacent to the oxygen atom of the pyran or the oxygen or nitrogen atom of the oxazine.Type: GrantFiled: March 29, 2001Date of Patent: August 30, 2005Assignee: Rodenstock GmbHInventors: Manfred Melzig, Herbert Zinner
-
Publication number: 20040224928Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: May 24, 2004Publication date: November 11, 2004Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
-
Publication number: 20040214801Abstract: The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: May 4, 2004Publication date: October 28, 2004Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts CollegeInventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
-
Publication number: 20040176334Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.Type: ApplicationFiled: February 24, 2004Publication date: September 9, 2004Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts CollegeInventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd E. Bowser, Mohamed Y. Ismail
-
Patent number: 6781001Abstract: Extended rhodamine compounds exhibiting favorable fluorescence characteristics having the structure are disclosed. In addition, novel intermediates for synthesis of these dyes are disclosed, such intermediates having the structure In addition, methods of making and using the dyes as fluorescent labels are disclosed.Type: GrantFiled: February 9, 2001Date of Patent: August 24, 2004Assignee: Applera CorporationInventors: Joe Y. L. Lam, Scott C. Benson, Steven M. Menchen
-
Publication number: 20040138183Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: December 16, 2003Publication date: July 15, 2004Applicant: Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tadeusz Warchol, Paul Sheahan
-
Patent number: 6727277Abstract: A class of novel compounds is described for use in affecting lymphatic absorption of cholesterol. Compounds of particular interest are defined by Formula I: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 12, 2002Date of Patent: April 27, 2004Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Sung I. Koo, Sang K. Noh
-
Patent number: 6723747Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: April 20, 2004Assignee: WyethInventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
-
Publication number: 20030176491Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1Type: ApplicationFiled: December 11, 2002Publication date: September 18, 2003Applicant: WyethInventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
-
Patent number: 6608216Abstract: The present invention relates to the preparation of chiral glucocorticoid receptor agents via biaryl atropisomers.Type: GrantFiled: June 28, 2002Date of Patent: August 19, 2003Assignee: Abbott LaboratoriesInventors: Yi-Yin Ku, Tim Grieme, Howard E. Morton, Steven A. King
-
Patent number: 6608215Abstract: Novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the f, i, j, or k side of the naphthopyran ring. These naphthopyrans may have the formula (I) presented below: These compounds (I) have interesting photochromic properties. Various organic host materials that contain such compounds are described. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations are enabled.Type: GrantFiled: September 20, 2001Date of Patent: August 19, 2003Assignee: Vision-Ease Lens, Inc.Inventor: Xuzhi Qin
-
Publication number: 20030109721Abstract: The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17&bgr;-hydroxy-17&agr;-methyl-5&agr;-androst-1-en-3-one; (b) hydroxylating the 17&bgr;-hydroxy-17&agr;-methyl-5&agr;-androst-1-en-3-one to form 1&agr;,2&agr;,17&bgr;-trihydroxy-17&agr;-methylandrostan-3-one; (c) cleaving the 1&agr;,2&agr;,17&bgr;-trihydroxy-17&agr;-methylandrostan-3-one to form 17&bgr;-hydroxy-17&agr;-methyl-1-oxo-1,2,-seco-A-nor-5&agr;-androstan-2-oic acid; and (d) reducing the 17&bgr;-hydroxy-17&agr;-methyl-1-oxo-1,2,-seco-A-nor-5&agr;-androstan-2-oic acid to form oxandrolone.Type: ApplicationFiled: December 11, 2001Publication date: June 12, 2003Inventors: Shaileshkumar Ramanlal Desai, David Wayne Ray, Yousry A. Sayed
-
Publication number: 20030055025Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: June 29, 2001Publication date: March 20, 2003Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
-
Patent number: 6503552Abstract: The present invention relates to use of natural flavidin compound (2,7-dihydroxy 9,10-dihydrophenanthro-4,5 bcd-pyran) as an antioxidant in compositions comprising flavidin and other additives.Type: GrantFiled: January 26, 2000Date of Patent: January 7, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Lingamallu Jagan Mohan Rao, Guddadarangavvanahally Krishnareddy Jayaprakasha, Kunnumpurath Kurian Sakariah
-
Patent number: 6500936Abstract: The invention relates to a compound of formula (I) wherein R1 is a sugar; R2 is —CH2—O—(R7)m, R7 representing a sugar, or is —COOH; R3 is an epoxide-comprising group, or is C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH; R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; R4R6, R8 and R10 independently of one another are H; C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, —X2H, or —X2R12, or R4 and R6 together and/or R8 and R10 together are =X2; X2 is O, NH, N—C1-C6-alkyl, N—C2-C6-alkenyl, N-C2-C6-alkynyl or S; R12 is C1-C6-alkyl, C2-C6—alkenyl, C2-C6-alkynyl, aryl or acyl; and m and n are 1 or 2; in any of its stereochemical forms and mixtures of these forms in any ratio, and a physiologically acceptable salt or derivative thereof. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation.Type: GrantFiled: February 16, 2001Date of Patent: December 31, 2002Assignee: Aventis Pharma Deutschland GmbHInventors: Laszlo Vertesy, Klaus Ehrlich, Martin Knauf, Joachim Wink, Francis P. Barbone, Elaine A. Powers, Elizabeth A. Cashman
-
Publication number: 20020193354Abstract: The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: ApplicationFiled: June 29, 2001Publication date: December 19, 2002Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Laura McIntyre, Beena Bhatia, Paul Hawkins, Laxma Reddy, Karen Stapleton, Tad Warchol, Paul Sheahan
-
Patent number: 6398987Abstract: The present invention relates to novel compounds of the naphthopyran type which have a perfluoroalkyl group (X) in position 5. These compounds are of formula (I) given below: These compounds (I) possess interesting photochromic properties. The invention also relates to their preparation, their applications as photochromes as well as the compositions and matrices containing them.Type: GrantFiled: November 3, 2000Date of Patent: June 4, 2002Assignee: Corning S.A.Inventors: Olivier Breyne, You-Ping Chan, Patrick Jean
-
Patent number: 6384045Abstract: This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxypyrone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.Type: GrantFiled: June 24, 1999Date of Patent: May 7, 2002Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Jean-Pierre Perchellet
-
Patent number: 6346536Abstract: Poly(ADP-ribose) polymerase (“PARP”) inhibitors and methods for treating neurodegenerative diseases, neural tissue damage related to cerebral ischemia and reperfusion injury, and cardiovascular in an animal.Type: GrantFiled: September 3, 1997Date of Patent: February 12, 2002Assignee: Guilford Pharmaceuticals Inc.Inventors: Jia-He Li, Paul F. Jackson, Keith M. Maclin, Jie Zhang
-
Patent number: 6342459Abstract: The present invention relates to photochromic 2H-naphtho[1,2-b]pyrans as well as their use in synthetic resins of all types, especially for ophthalmic purposes. In particular, the present invention relates to photochromic naphthopyran compounds, for which a further ring system is bonded to the f side of the naphthopyran. The inventive photochromic dyes generally have the general formula (I) wherein n, R1, R2, R3, X, B and B′ are defined as in claim 1. The inventive compounds are distinguished by good darkening and decolorizing properties and a very good service life.Type: GrantFiled: May 18, 2000Date of Patent: January 29, 2002Assignee: Optische Werke G. RodenstockInventors: Manfred Melzig, Claudia Mann, Udo Weigand
-
Patent number: 6166066Abstract: Disclosed are novel cannabinoids which are selective for the CB2 receptor. The novel cannabinoids comprise a substituted or unsubstituted tricyclic cannabinoid core and a substituted or unsubstituted C5-C8 carbocyclic ring, five to eight-membered heterocyclic ring or a seven to ten membered bicyclic ring system fused to the monhydroxylated phenyl ring of the cannabinoid core. Also disclosed are methods of suppressing the immune system in a subject by administering to the subject a (e.g. immunosuppressive amount) effective amount of a novel cannabinoid described above.Type: GrantFiled: May 4, 1999Date of Patent: December 26, 2000Assignee: The University of ConnecticutInventors: Alexandros Makriyannis, Atmaram Khanolkar, Dai Lu
-
Patent number: 6133288Abstract: The present invention provides compounds of formula I and II: ##STR1## wherein X is --O--, --S--, or --NR.sup.5 --;Y is --O--, --S--, --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, or --NR.sup.5 --;B is --CH.sup.2 -- or --CO--;R.sup.1, R.sup.2, and R.sup.3 are each independently --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl), --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl), --OSO.sub.2 CF.sub.3, Cl, or F;n is 1 or 2;W is CH.sub.2 or C.dbd.O;R.sup.4 is 1-piperidinyl, 2-oxo-1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 2-oxo-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino;R.sup.5 is C.sub.1 -C.sub.3 alkyl, --COC.sub.6 H.sub.5, --CO(C.sub.1 -C.sub.6 alkyl), --C(O)OC.sub.6 H.sub.5, --C(O)O(C.sub.1 -C.sub.6 alkyl), --SO.sub.2 (C.sub.1 -C.sub.6 alkyl), --SO.sub.2 C.sub.6 H.sub.5, or --SO.sub.2 CF.sub.3 ;or a pharmaceutically acceptable salt or solvate thereof.Type: GrantFiled: November 9, 1999Date of Patent: October 17, 2000Assignee: Eli Lilly and CompanyInventor: Timothy Alan Grese
-
Patent number: 6106744Abstract: Described are novel photochromic pyrano-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted "S" pyran ring, the 3,4 positions of which are fused to the f side of the naphtho portion of the naphthopyran, and certain substituents at the 2-position of the "T" pyran ring. Certain substituents may also be present at the number 5, 7, 8, 9, 10, 11 or 12 carbon atoms of the compounds. These compounds may be represented by the following graphic formula: ##STR1## Also described are polymeric organic host materials that contain or that are coated with such compounds or combinations thereof with complementary photochromic compounds, e.g., certain other naphthopyrans, benzopyrans, and spiro(indoline)type compounds.Type: GrantFiled: December 3, 1997Date of Patent: August 22, 2000Assignee: PPG Industries Ohio, Inc.Inventors: Barry Van Gemert, Christopher D. Selvig
-
Patent number: 6087347Abstract: Estratriene derivatives of the following formula have a powerful inhibitory effect on estrone sulfatase and are hence useful for the prophylaxis or treatment of diseases caused by estrogens, such as breast cancer, uterine cancer, ovarian cancer, endometriosis, adenomyosis uteri and mastopathy. ##STR1## wherein one of A and B represents C.dbd.O or CH.sub.2 and the other represents O or NH; and R represents --SO.sub.2 NR.sup.1 R.sup.2 or --PO(OM).sub.2 in which R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a lower alkyl group and M represents a hydrogen atom or an alkali metal; provided that, when one of A and B represents NH, the other represents C.dbd.O.Type: GrantFiled: March 12, 1999Date of Patent: July 11, 2000Assignee: Teikoku Hormone Mfg. Co., Ltd.Inventors: Naoyuki Koizumi, Shigehiro Takegawa, Shigeki Iwashita, Tomoko Kawachi, Mamoru Mieda, Tomohito Fujii
-
Patent number: 5958970Abstract: This invention provides cancer-active tricyclic and tetracyclic oxypyrones and a method of synthesizing these compounds. Preferred compounds have aryl groups at the 3-position of the oxypyrone ring. The tricyclic oxyprone synthetic method is a simple condensation reaction of pyrones with cyclohexenecarboxaldehydes, providing high yields and using few steps. The tetracyclic oxypyrone synthetic method is a simple condensation reaction of carvones with pyrones.Type: GrantFiled: July 29, 1997Date of Patent: September 28, 1999Assignee: Kansas State University Research FoundationInventors: Duy H. Hua, Jean-Pierre Perchellet
-
Patent number: 5912362Abstract: High-purity isochroman compounds can be obtained in high yields according to a simple and economical process for preparing isochroman compounds, comprising the step of adding an aquesous solution of formaldehyde having a concentration of 40 to 70 wt. % to a complex of an arylalkanol represented by the following general formula (II) with a Friedel-Crafts catalyst to cyclize the arylalkanol: ##STR1## wherein R.sub.1 and R.sub.2 each stands for a hydrogen atom, a lower alkyl group or a lower alkoxyl group, or alternatively R.sub.1 and R.sub.2 are respectively bonded to adjacent carbon atoms with mutual bonding of R.sub.1 and R.sub.2 together with the carbon atoms respectively bonded to R.sub.1 and R.sub.2 to form a benzene ring, a naphthalene ring, or a C.sub.5 or C.sub.6 cycloalkane or cycloalkene which may have 1 to 6 lower alkyl groups; and R.sub.3 stands for a hydrogen atom or a lower alkyl group.Type: GrantFiled: November 10, 1997Date of Patent: June 15, 1999Assignee: Kao CorporationInventors: Shigeyoshi Tanaka, Masayuki Oku, Junji Koshino
-
Patent number: 5888432Abstract: The present invention has for subjects, novel benzopyran derivatives, substituted in position 2 with an adamantyl group as well as the compositions and (co)polymer matrices containing such derivatives. Said derivatives possess interesting photochromic properties.Type: GrantFiled: December 3, 1997Date of Patent: March 30, 1999Assignee: Corning IncorporatedInventor: You-Ping Chan
-
Patent number: 5847168Abstract: A photochromic article that includes a host material and a photochromic amount of a naphthopyran compound, the naphthopyran compound represented by the formula: ##STR1## wherein R.sub.1 ', R.sub.2 ', R.sub.3 ', R.sub.4 ', R.sub.5 ', R.sub.6 ', R.sub.7 ', R.sub.8 ', R.sub.9 ', R.sub.10 ', R.sub.1 ", R.sub.2 ", R.sub.3 ", R.sub.4 ", R.sub.5 ", R.sub.6 ", R.sub.7 ", R.sub.8 ", R.sub.9 ", and R.sub.10 " are each selected from the following group: a stable organic radical, a heterocyclic group, halogen, a nitrogen-substituted group, and a nitrogen-substituted ring compound.Type: GrantFiled: December 1, 1997Date of Patent: December 8, 1998Assignee: Vision-Ease Lens, Inc.Inventor: Frank J. Hughes
-
Patent number: 5840926Abstract: A photochromic article that includes a host material and a photochromic amount of a naphthopyran compound, the naphthopyran compound represented by the formula: ##STR1## wherein R.sub.1 ', R.sub.2 ', R.sub.3 ', R.sub.4 ', R.sub.5 ', R.sub.6 ', R.sub.7 ', R.sub.8 ', R.sub.9 ', R.sub.10 ', R.sub.1 ", R.sub.2 ", R.sub.3 ", R.sub.4 ", R.sub.5 ", R.sub.6 ", R.sub.7 ", R.sub.8 ", R.sub.9 ", and R.sub.10 " are each selected from the following group: a stable organic radical, a heterocyclic group, halogen, a nitrogen-substituted group, and a nitrogen-substituted ring compound.Type: GrantFiled: July 17, 1997Date of Patent: November 24, 1998Assignee: Vision-Ease Lens, Inc.Inventor: Frank J. Hughes