Two Of The Cyclos Share At Least Three Ring Members Or Ring Carbon Is Shared By The Three Cyclos (e.g., Bridged Or Peri Compounds, Etc.) Patents (Class 549/386)
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Patent number: 9334257Abstract: The invention provides methods of purifying and quantifying procyanidin oligomers from cocoa-containing sources. The methods advantageously provide ways to isolate commercially useful quantities of a range of procyanidin oligomers.Type: GrantFiled: November 10, 2014Date of Patent: May 10, 2016Assignee: The Hershey CompanyInventors: Jan Glinski, W. Jeffrey Hurst
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Publication number: 20150073145Abstract: A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.Type: ApplicationFiled: November 14, 2014Publication date: March 12, 2015Inventors: Igor Alabugin, Philip M. Byers
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Patent number: 8927594Abstract: The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.Type: GrantFiled: March 15, 2011Date of Patent: January 6, 2015Assignees: National Sun Yat-Sen University, National Museum of Marine Biology & AquariumInventors: Jyh-Horng Sheu, Wei-Hsien Wang, Zhi-Hong Wen, Bo-Wei Chen, Ping-Jyun Sung
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Publication number: 20140255853Abstract: A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, including a base component (A) which exhibits changed solubility in a developing solution under action of acid, the base component (A) including a polymeric compound (A1) containing a structural unit (a0) represented by general formula (a0-1) shown below. In the formula, W1 represents a group which is formed by polymerization reaction of a group containing a polymerizable group; Y1 and Y2 each independently represents a divalent linking group; Y3 represents a carbonyl group or an alkylene group; R2 and R3 each independently represents a fluorine atom or a fluorinated alkyl group; Mm+ represents an organic cation having a valency of m; and m represents an integer of 1 or more.Type: ApplicationFiled: March 4, 2014Publication date: September 11, 2014Applicant: Tokyo Ohka Kogyo Co., Ltd.Inventors: Daichi Takaki, Yoshiyuki Utsumi
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Publication number: 20140194499Abstract: Two novel polyprenylated benzoylphloroglucinol derivatives, garciesculentones A and C, are disclosed in the present invention. Garciesculentones A and C exhibit cytotoxicity and/or antimigration effect against various cancer cell lines. The experimental results of the present invention suggest that Garciesculentones A and C are useful for developing into anticancer drugs.Type: ApplicationFiled: January 9, 2014Publication date: July 10, 2014Applicant: Hong Kong Baptist UniversityInventors: Hongxi XU, Hong ZHANG, Yuanzhi LAO, Dandan ZHANG, Kaixian CHEN, Zhaoxiang BIAN, Chengyuan LIN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
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Publication number: 20140057950Abstract: The present invention relates to compounds of the general formula (I) which show a specific activity against cancer cell lines, the use of these compounds for prophylaxis and treatment of cancer as well as to pharmaceutical compositions containing at least one compound of general formula (I).Type: ApplicationFiled: December 22, 2011Publication date: February 27, 2014Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DE WISSENSCHAFTEN E.V.Inventors: Mathias Christmann, Lea Radtke, Herbert Waldmann, Matthieu Willot, Slava Ziegler, Hongyan Sun
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Publication number: 20130237711Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.Type: ApplicationFiled: April 23, 2013Publication date: September 12, 2013Applicant: Eisai R&D Management Co., Ltd.Inventors: Farid BENAYOUD, Trevor Lee Calkins, Charles E. Chase, William Christ, Francis G. Fang
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Patent number: 8471043Abstract: The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia-zoketone derivative.Type: GrantFiled: March 31, 2009Date of Patent: June 25, 2013Assignee: SNU R&DB FoundationInventors: Eun Lee, Ki Po Jang, Chan Hyuk Kim, Seong Wook Na, Dong Seok Jang
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Patent number: 8461359Abstract: The invention relates to a method for preparing 1,6:2,3-dianhydro-?-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound B, where R is an activating agent, in the presence of a base selected from among ammonium hydroxides and mineral bases.Type: GrantFiled: September 15, 2009Date of Patent: June 11, 2013Assignee: SanofiInventors: Laurent Bouvenot, Paul Cruciani, Denis Largeau, Jean-Claude Rovera
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Publication number: 20130095085Abstract: An expanding agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful as a therapy for various hematopoietic diseases and useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy is provided. A method of producing hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises expanding hematopoietic stem cells by culturing hematopoietic stem cells ex vivo in the presence of a compound represented by the formula following (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof (wherein R1 to R6 are as defined in the description).Type: ApplicationFiled: June 13, 2011Publication date: April 18, 2013Applicants: NATIONAL UNIVERSITY OF CORPORATION CHIBA UNIVERSITY, Nissan Chemical Industries, Ltd.Inventors: Taito Nishino, Atsushi Iwama
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Patent number: 8410292Abstract: Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2?-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.Type: GrantFiled: December 30, 2008Date of Patent: April 2, 2013Assignee: The United States of America, as represented by the Secretary, Department of Health and Human ServicesInventors: John A. Beutler, Ranjala Ratnayake, David Covell, Tanya R. Johnson
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Patent number: 8404088Abstract: The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-?B-dependent conditions.Type: GrantFiled: March 19, 2012Date of Patent: March 26, 2013Assignee: Trustees of Boston UniversityInventors: John A. Porco, Jr., Baudouin Gerard
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Publication number: 20120238766Abstract: The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-?B-dependent conditions.Type: ApplicationFiled: March 19, 2012Publication date: September 20, 2012Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: John A. Porco, JR., Baudouin Gerard
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Patent number: 8183200Abstract: The present invention is directed to novel fragrance compounds and their unexpected advantageous use in improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: wherein R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen and C1-C5 alkyl.Type: GrantFiled: December 16, 2010Date of Patent: May 22, 2012Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Richard M. Boden, James A. Lasome
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Publication number: 20120123129Abstract: The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R3, R9, R10, R11, R12 and G have the meanings given above as insecticides and/or acaricides and/or fungicides.Type: ApplicationFiled: April 28, 2010Publication date: May 17, 2012Applicant: Bayer CropScience AGInventor: Alfred ANGERMANN
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Patent number: 8178485Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel hexahydro ethanochromene and related hexahydro ethanochromane compounds of the present invention are represented by formula: wherein R1 is hydrogen or methyl; R2 and R2? are identical and are hydrogen or methyl; R3 and R3? are identical and are hydrogen or methyl; R4 and R5 are independently hydrogen or methyl; R6 is methyl, ethyl, or isopropyl, with the proviso that when R1 is H, R2 and R3? form an alkylene bridge containing 1 or 2 carbon atoms, and wherein the broken line represents a single or double bond.Type: GrantFiled: August 12, 2010Date of Patent: May 15, 2012Assignee: International Flavors & Fragrances Inc.Inventors: Feng Geng, Richard M. Boden
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Publication number: 20120095242Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.Type: ApplicationFiled: December 22, 2011Publication date: April 19, 2012Applicant: Eisai R&D Management Co., Ltd.Inventors: Charles Chase, Atsushi Endo, Francis G. Fang, Jing Li
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Patent number: 8137509Abstract: The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by an enantioselective 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile in the presence of a TADDOL derivative. This approach can be used for the formation of adducts containing an aglain core structure. Methods of the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-?B-dependent conditions.Type: GrantFiled: May 21, 2007Date of Patent: March 20, 2012Assignee: Trustees of Boston UniversityInventors: John A. Porco, Jr., Baudouin Gerard
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Publication number: 20120041214Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel hexahydro ethanochromene and related hexahydro ethanochromane compounds of the present invention are represented by formula: wherein R1 is hydrogen or methyl; R2 and R2? are identical and are hydrogen or methyl; R3 and R3? are identical and are hydrogen or methyl; R4 and R5 are independently hydrogen or methyl; R6 is methyl, ethyl, or isopropyl, with the proviso that when R1 is H, R2 and R3? form an alkylene bridge containing 1 or 2 carbon atoms, and wherein the broken line represents a single or double bond.Type: ApplicationFiled: August 12, 2010Publication date: February 16, 2012Inventors: Feng Geng, Richard M. Boden
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Patent number: 8093410Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.Type: GrantFiled: October 3, 2008Date of Patent: January 10, 2012Assignee: Eisai R&D Management Co., Ltd.Inventors: Charles Chase, Atsushi Endo, Frances G. Fang, Jing Li
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Publication number: 20110224446Abstract: The invention relates to a method for preparing 1,6:2,3-dianhydro-?-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound B, where R is an activating agent, in the presence of a base selected from among ammonium hydroxides and mineral bases.Type: ApplicationFiled: September 15, 2009Publication date: September 15, 2011Applicant: SANOFI-AVENTISInventors: Laurent Bouvenot, Paul Cruciani, Denis Largeau, Jean-Claude Rovera
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Publication number: 20110028741Abstract: The present invention relates to novel platensimycin derivatives, their intermediates and preparing methods of the same. Platensimycin is known as an effective antibiotic material having a broad antimicrobial spectrum and its derivatives are also expected to be effective antibiotic candidates. The present invention also relates to a novel preparing method of platensimycin. The intermediates used for the production of platensimycin and its derivatives of the present invention are tricyclo ketone derivatives and tetracyclo derivatives. Tetracyclo derivatives are prepared from tricyclo ketone derivatives prepared by carbonyl ylide [3+2] cycloaddition of dia-zoketone derivative.Type: ApplicationFiled: March 31, 2009Publication date: February 3, 2011Applicant: SNU R&DB FOUNDATIONInventors: Eun Lee, Ki Po Jang, Chan Hyuk Kim, Seong Wook Na, Dong Seok Jang
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Patent number: 7700584Abstract: The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof: wherein, Y is selected from the group consisting of ?CHR2, —CH2R2, ?O, ?—OH or —OR1;R1 is selected from H, R, RCO or HO3S; and R is selected from the group consisting of H; saturated or unsaturated linear C1-10 hydrocarbon group and the like; R2 is selected from the group consisting of F; Cl; Br; I; H; —OH; —OR; —HSO3 and the like; with the proviso that both R1 and R2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmaceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.Type: GrantFiled: May 26, 2005Date of Patent: April 20, 2010Assignee: Hangzhou Minsheng Pharmaceuticals Co., Ltd.Inventors: Shulong Wang, Dianwu Guo, Zhaoke Meng
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Patent number: 7649014Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.Type: GrantFiled: September 29, 2005Date of Patent: January 19, 2010Assignees: Beth Israel Deaconess Medical Center, Inc., Trustees of Boston UniversityInventors: Chen-Yu Zhang, Bradford B. Lowell, John A Porco, Jr., Ruichao Shen, Cheng T. Lin, Stefan Krauss
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Publication number: 20090247524Abstract: Compounds represented by formula (1) shown below, pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising such compounds are provided.Type: ApplicationFiled: May 25, 2007Publication date: October 1, 2009Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Takuo Tsukuda, Ken-ichi Kawasaki, Susumu Komiyama, Yoshiaki Isshiki, Yasuhiko Shiratori, Kiyoshi Hasegawa, Takaaki Fukami, Takaaki Miura, Naomi Ono, Toshikazu Yamazaki, Young-Jun Na, Dong-Oh Yoon, Sung-Jin Kim
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Publication number: 20090198074Abstract: Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.Type: ApplicationFiled: October 3, 2008Publication date: August 6, 2009Applicant: EISAI CO., LTD.Inventors: Charles CHASE, Atsushi ENDO, Francis G. FANG, Jing LI
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Publication number: 20080319042Abstract: The present invention comprises compositions and methods for the treatment of liver disease, particularly treatments for infection by HCV and/or HBV. The present invention comprises antiviral compositions comprising lamiridosin, derivatives of lamiridosin or iridoids that are effective in inhibiting one or more steps in the infection of cells by HCV or HBV. Methods for treating subjects, particularly humans, infected with HCV or HBV are provided.Type: ApplicationFiled: February 13, 2008Publication date: December 25, 2008Inventor: Harry Fong
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Patent number: 7446080Abstract: The compounds 6-oxabicylco[3.2.1]octane, 5-methyl-1-(1,2,2-trimethylbicyclo [3.1.0]hex-3-yl)- and 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo [3,1,0]hex-3yl)-, and their uses in fragrance applications.Type: GrantFiled: November 29, 2007Date of Patent: November 4, 2008Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda
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Patent number: 7432232Abstract: The compound 2-oxabicyclo[2,2,2]octane, 1-methyl-4-(1,2,2-trimethylbicyclo[3,1,0]hex-3-yl)— and its uses in fragrance applications.Type: GrantFiled: December 8, 2006Date of Patent: October 7, 2008Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda
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Publication number: 20080177094Abstract: 7-ethynyl-2,4,9-trithiaadamantane and related methods are presented. Manufacturing 7-ethynyl-2,4,9-trithiaadamantane includes the steps of: (1) reducing alkyl 2,4,9-trithiaadamantane-7-carboxylate to produce 7-hydroxymethyl-2,4,9-trithiaadamantane; (2) oxidizing 7-hydroxymethyl-2,4,9-trithiaadamantane to produces 7M carbonyl-2,4,9-trithiaadamantane; and (3) reacting 7-carbonyl-2,4,9-trithiaadamantane with Ohira-Bestmann reagent to produces 7-ethynyl-2,4,9-trithiaadamantane. Molecular wires having 2,4,9-trithiaadamantane surface anchors are also disclosed.Type: ApplicationFiled: July 1, 2004Publication date: July 24, 2008Inventor: Jun Hu
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Patent number: 6962768Abstract: Provided are a variety of monomers suitable of producing photosensitive polymers, that are in turn, useful in photoresist compositions, through radical (cationic) polymerization including at least one multi-ring alkenyl ethers and one ?-fluorinated acrylate. The resulting photoresist compositions exhibit both acceptable resistance to dry etching processing and light transmittance suitable for use with various light sources such as KrF excimer lasers, ArF excimer lasers or F2 excimer lasers, in a photolithography process to produce fine photoresist patterns. In addition to the multi-ring alkenyl ethers and ?-fluorinated acrylates, additional monomers comprising one or more cyclic aliphatic and heterocyclic compounds, both unsubstituted and substituted, in particular dihydropyrans, may be incorporated into the photosensitive polymers.Type: GrantFiled: March 12, 2004Date of Patent: November 8, 2005Assignee: Samsung Electronics Co., Ltd.Inventors: Hyun-Woo Kim, Sang-Gyun Woo
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Patent number: 6894073Abstract: The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exisanin A, which would be effective for the treatment inflammation, immune disease or cancer by inhibiting the production of nitric oxide, prostaglandin, and TNF-a1 through the suppression of NF-k B activity.Type: GrantFiled: December 12, 2001Date of Patent: May 17, 2005Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jung-Joon Lee, Jeong-Hyung Lee, Hang-Sub Kim, Young-Soo Hong, Bang-Yeon Hwang
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Patent number: 6872840Abstract: The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, R1 is a phenyl group, and R2 and R3 is a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.Type: GrantFiled: April 14, 2004Date of Patent: March 29, 2005Assignee: Korea Institute of Science And TechnologyInventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
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Patent number: 6849746Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.Type: GrantFiled: January 31, 2003Date of Patent: February 1, 2005Assignee: Mars, Inc.Inventors: Leo J. Romanczyk, Jr., Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
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Publication number: 20040170919Abstract: Provided are a variety of monomers suitable of producing photosensitive polymers, that are in turn, useful in photoresist compositions, through radical (cationic) polymerization including at least one multi-ring alkenyl ethers and one &agr;-fluorinated acrylate. The resulting photoresist compositions exhibit both acceptable resistance to dry etching processing and light transmittance suitable for use with various light sources such as KrF excimer lasers, ArF excimer lasers or F2 excimer lasers, in a photolithography process to produce fine photoresist patterns. In addition to the multi-ring alkenyl ethers and &agr;-fluorinated acrylates, additional monomers comprising one or more cyclic aliphatic and heterocyclic compounds, both unsubstituted and substituted, in particular dihydropyrans, may be incorporated into the photosensitive polymers.Type: ApplicationFiled: March 12, 2004Publication date: September 2, 2004Inventors: Hyun-Woo Kim, Sang-Gyun Woo
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Patent number: 6750364Abstract: This invention provides compounds of the formula: wherein X is (CH2)n, O, S, SO, SO2 or CR1R2; n is 1 or 2; R1 and R2 are H, halogen, hydroxy, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, or R1 and R2, taken together form cycloalkyl of 3 to 6 carbon atoms, an alkylidene of up to 6 carbon atoms or a carbonyl; R3, R4 and R5 are H or alkyl of 1 to 6 carbon atoms; Z is H, alkyl of 1 to 6 carbon atoms, alkanoyl of 1 to 6 carbon atoms or alkoxycarbonyl of 2 to 7 carbon atoms; or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods for their use in treating or preventing characterized by glutamate hypofunction, including schizophrenia, schizoaffective disorder and schizophreniform disorder, and for the treatment of cognitive deficits due to aging, stroke, Alzheimer's disease or other neurodegenerative diseases.Type: GrantFiled: June 27, 2002Date of Patent: June 15, 2004Assignee: WyethInventors: Gary Paul Stack, John Dunlop, Alexander Alexei Greenfield, Jonathan Laird Gross
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Patent number: 6713228Abstract: Provided are alkenyl ether-based monomers having multi-ring structure, and photosensitive polymers and resist compositions obtained from the same. The photosensitive polymer includes a monomer unit represented by the following formula: wherein R4 and R5 are independently -H or -CH3, and R4 are independently -H, -OH or a alkyl group having 1-20 carbon atoms.Type: GrantFiled: April 24, 2002Date of Patent: March 30, 2004Assignee: Samsung Electronics Co., Ltd.Inventors: Hyun-Woo Kim, Sang-Gyun Woo, Sung-Ho Lee
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Patent number: 6599553Abstract: A dry drink mix which is rich in cocoa polyphenols such as catechin, epicatechin, and cocoa procyanidins contains a cocoa polyphenol rich cocoa powder, an alkalized cocoa powder, and a sweetener. The dry mix contains other conventional ingredients such as vanillin an emulsifier. A chocolate flavored drink can be prepared from the dry drink mix by adding milk, for example a low fat milk. The cocoa polyphenol rich cocoa powder is prepared from non-roasted cocoa beans or blends thereof having a fermentation factor of 275 less, i.e., slaty and/or purple cocoa beans. The alkalized cocoa powder is prepared from roasted cocoa beans.Type: GrantFiled: November 5, 2001Date of Patent: July 29, 2003Assignee: Mars IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Jr., Hans M. Geyer, Mary E. Myers, Eric J. Whitacre, John F. Hammerstone, Jr., Harold H. Schmitz
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Patent number: 6517841Abstract: Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa polyphenols or procyanidins and methods for treating patients employing the compositions. Additionally disclosed and claimed is a kit for treating a patient in need of treatment with an antineoplastic agent containing cocoa polyphenols or procyanidins as well as a lyophilized antineoplastic composition containing cocoa polyphenols or procyanidins. Further, disclosed and claimed is the use of the invention in antioxidant, preservative and topiosomerase-inhibiting compositions and methods.Type: GrantFiled: October 11, 2001Date of Patent: February 11, 2003Assignee: Mars IncorporatedInventors: Leo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck
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Publication number: 20020160303Abstract: Provided are alkenyl ether-based monomers having multi-ring structure, and photosensitive polymers and resist compositions obtained from the same.Type: ApplicationFiled: April 24, 2002Publication date: October 31, 2002Applicant: Samsung Electronics Co., Ltd.Inventors: Hyun-Woo Kim, Sang-Gyun Woo, Sung-Ho Lee
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Patent number: 6420334Abstract: 2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-indeno[5,6-b]furans are valuable novel woody fragrances for the preparation of perfume oils.Type: GrantFiled: June 30, 2000Date of Patent: July 16, 2002Assignee: Haarmann & Reimer GmbHInventors: Horst Surburg, Peter Wörner
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Patent number: 6399139Abstract: The invention provides food products, including confectioneries and chocolates, having conserved concentrations of polyphenols, and in particular cocoa polyphenols. The method of this invention avoids the significant and detrimental losses of polyphenols that occur during conventional manufacture by controlling the handling of ingredients in batching processing to provide a product having a significant amount of the cocoa polyphenol concentration present in the raw materials conserved in the finished product. Additionally, the production steps of milling/refining and conching may also be controlled and modified to provide the confectioneries of the present invention having conserved concentrations of cocoa polyphenols relative to the concentration of the polyphenols present in the starting ingredients. The cocoa polyphenol ingredient may be a cocoa ingredient, an extract of a cocoa ingredient (beans, liquor, or powder, etc.Type: GrantFiled: January 17, 2001Date of Patent: June 4, 2002Assignee: Mars IncorporatedInventors: Mary E. Myers, Chigozie V. Nwosu, Eric J. Whitacre, John F. Hammerstone, Jr.
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Patent number: 6399653Abstract: The invention relates to compounds of the formula I in which the radicals R1, R2, R3 and A have the meaning mentioned in the description. The invention further relates to a process for the preparation of the compounds of the formula I by means of solid-phase synthesis, and use thereof as pharmaceuticals.Type: GrantFiled: June 30, 2000Date of Patent: June 4, 2002Assignee: Hoechst AktiengesellschaftInventor: Stephan Henke
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Patent number: 6312753Abstract: Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.Type: GrantFiled: August 9, 1999Date of Patent: November 6, 2001Assignee: Mars, IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Jr., Hans M. Geyer, Mary E. Myers, Eric J. Whitacre, John F. Hammerstone, Jr., Harold H. Schmitz
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Patent number: 6258838Abstract: The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.Type: GrantFiled: December 26, 2000Date of Patent: July 10, 2001Assignee: AstraZeneca ABInventors: Andrew Baxter, Thomas McInally, Michael Mortimore, David Cladingboel
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Publication number: 20010003121Abstract: The invention provides adamantane derivatives, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.Type: ApplicationFiled: December 26, 2000Publication date: June 7, 2001Applicant: AstraZeneca UK LimitedInventors: Andrew Baxter, Thomas Mcinally, Michael Mortimore, David Cladingooel
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Patent number: 6194020Abstract: The invention provides food products, including confectioneries and chocolates, having conserved concentrations of polyphenols, and in particular cocoa polyphenols. The method of this invention avoids the significant and detrimental losses of polyphenols that occur during conventional manufacture by controlling the handling of ingredients in batching processing to provide a product having a significant amount of the cocoa polyphenol concentration present in the raw materials conserved in the finished product. Additionally, the production steps of milling/refining and conching may also be controlled and modified to provide the confectioneries of the present invention having conserved concentrations of cocoa polyphenols relative to the concentration of the polyphenols present in the starting ingredients. The cocoa polyphenol ingredient may be a cocoa ingredient, an extract of a cocoa ingredient (beans, liquor, or powder, etc.Type: GrantFiled: March 12, 1998Date of Patent: February 27, 2001Assignee: Mars IncorporatedInventors: Mary E. Myers, Chigozie V. Nwosu, Eric J. Whitacre, John F. Hammerstone, Jr.
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Patent number: 6127415Abstract: The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especially androgen-independent prostate cancer, skin cancer, pancreatic carcinomas, colon cancer, melanoma, ovarian cancer, liver cancer, small cell lung carcinoma, non-small cell lung carcinoma, cervical carcinoma, brain cancer, bladder cancer, breast cancer, neuroblastoma/glioblastoma, and leukemia. Also, the invention relates to novel adamantyl or adamantyl group derivative compounds which are useful as active agents for the treatment or prevention of keratinization disorders and other dermatological conditions, and other diseases.Type: GrantFiled: April 14, 1999Date of Patent: October 3, 2000Assignee: Galderma Research & Development, S.N.C.Inventors: Magnus Pfahl, Xian-Ping Lu, Darryl Rideout, Hongyue Zhang
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Patent number: 6015913Abstract: The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing products. Additionally, the inventive method also provides cocoa compositions comprising at least one active polyphenol, wherein the concentration of the polyphenol(s) with respect to the nonfat solids is conserved with respect to the concentration of the active polyphenol(s) in the bean from which the compositions are derived.Type: GrantFiled: September 6, 1996Date of Patent: January 18, 2000Assignee: Mars, IncorporatedInventors: Kirk S. Kealey, Rodney M. Snyder, Leo J. Romanczyk, Jr., John F. Hammerstone, Jr., Margaret M. Buck, Giovanni G. Cipolla
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Patent number: 5990104Abstract: Polycyclic alkaloids of formula (I), wherein R.sub.1 is H, C.sub.1-6 alkyl, or C.sub.6-12 aryl optionally substituted with polar groups; R.sub.2 and R.sub.3 are independently H, OH, C.sub.1-6 alkyl, --C(NH)--NH.sub.2, a positively charged group, or C.sub.7-13 aralkyl optionally substituted with NH.sub.2, OH, C.sub.1-6 alkyl, or halogen; or R.sub.2 and R.sub.3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R.sub.4 is H, C.sub.1-6 alkyl, OR.sub.6, SR.sub.6, or N(R.sub.6).sub.2, wherein each R.sub.6 is independently H, C.sub.1-3 alkyl; X ix O, S, SO, SO.sub.2, or N--R.sub.5, wherein each R.sub.5 is independently H, C.sub.1-6 alkyl, or C.sub.7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; and m is an integer from 0 to 3. These compounds act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor.Type: GrantFiled: March 25, 1998Date of Patent: November 23, 1999Assignee: Biochem Pharma, Inc.Inventors: John Dimaio, Dilip M. Dixit