The Two Cyclos Share At Least Three Ring Members (i.e., Bridged) Patents (Class 549/397)
-
Patent number: 6599861Abstract: Compounds of formula I wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/N-oxides/isomers/enantiomers of these compounds, are eminently suitable for use as herbicides.Type: GrantFiled: June 21, 2001Date of Patent: July 29, 2003Assignee: Syngenta Participations AGInventors: Jürgen Schaetzer, Alain De Mesmaeker, Shy-Fuh Lee
-
Publication number: 20030069269Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: ApplicationFiled: March 13, 2002Publication date: April 10, 2003Inventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
-
Patent number: 6504037Abstract: The present invention relates to an improved process for preparing 4-substituted resorcinol derivatives, and intermediate compounds useful in the preparation of such resorcinol derivatives.Type: GrantFiled: March 8, 2001Date of Patent: January 7, 2003Assignee: Warner-Lambert CompanyInventors: Stuart Edward Bradley, John Kitchin, Graham Michael Wynne
-
Patent number: 6420334Abstract: 2-Alkoxydecahydro-2,3a,4,4,7-pentamethyl-3,7a-methano-7aH-indeno[5,6-b]furans are valuable novel woody fragrances for the preparation of perfume oils.Type: GrantFiled: June 30, 2000Date of Patent: July 16, 2002Assignee: Haarmann & Reimer GmbHInventors: Horst Surburg, Peter Wörner
-
Patent number: 6417221Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: GrantFiled: September 27, 2000Date of Patent: July 9, 2002Assignees: Organix, Inc., President and Fellows of Harvard CollegeInventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
-
Patent number: 6376532Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.Type: GrantFiled: January 25, 2001Date of Patent: April 23, 2002Assignee: Georgetown UniversityInventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi
-
Patent number: 6344463Abstract: Compounds of the formula where R1 and R2, independently are alkyl groups having 2 to 8 carbons; R3 is hydrogen or lower alkyl; X is S, O or N—R4 where R4 is hydrogen or lower alkyl; Y is phenyl or pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, and pyrazinyl; A is (CH2)n where n is 0-5, or lower branched chain alkyl, alkenyl having 2 to 6 carbons and 1 or 2 double bonds, alkynyl having 2 to 6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a salt thereof, COOR5, CONR6R7, —CH2OH, CH2OR8, CH2OCOR8, CHO, CH(OR9)2, CHOR10O, —COR11, CR11(OR9)2, or CR11OR10O, where R5 is alkyl of 1 to 10 carbons, or cycloalkyl of 5 to 10 carbons, or R5 is phenyl or lower alkylphenyl, R6 and R7 independently are hydrogen, alkyl of 1 to 10 carbons, or cycloalkyl of 5 to 10 carbons, or phenyl or lower alkylphenyl, R8 is alkyl of 1 to 10 carbons, phenyl or lower alkylphenyl, R9 is lower alkyl, R10 is divalent alkyl radical of 2-5 carbons and R11 is alkyl, cycloalkyl or alkenyl containing 1Type: GrantFiled: July 7, 2000Date of Patent: February 5, 2002Assignee: Allergan Sales, Inc.Inventor: Roshantha A. S. Chandraratna
-
Publication number: 20020010207Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: ApplicationFiled: June 6, 2001Publication date: January 24, 2002Inventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
-
Patent number: 6291512Abstract: New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7- substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxy-tryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.Type: GrantFiled: September 27, 2000Date of Patent: September 18, 2001Assignees: Organix, Inc., President and Fellows of Harvard CollegeInventors: Peter C. Meltzer, Bertha K. Madras, Paul Blundell, Zhengming Chen
-
Patent number: 6288246Abstract: The present invention relates to a process for preparing hydroxamic acids from hydroxylic acid intermediates wherein the carboxylic acid intermediate does not possess reactive substituents such as hydroxy or amino groups.Type: GrantFiled: April 7, 1999Date of Patent: September 11, 2001Assignee: Pfizer IncInventor: Joel M. Hawkins
-
Patent number: 6229025Abstract: The present invention relates to a process for alkylating hindered sulfonamides by Michael addition to propiolates, and to novel intermediates prepared in said process. The products of these reactions can be converted into pharmaceutical compounds useful in the treatment of disease states mediated by matrix metalloproteinase enzymes. Novel intermediates prepared according to the present invention include compounds of the formula wherein R1 is (C1-C6)alkyl or optionally substituted benzyl; R2 and R3 are independently (C1-C6)alkyl or R2 and R3 are taken together to form a three to seven membered cycloalkyl, pyran-4-yl ring or a bicyclo ring of the formula wherein the asterisk indicates the carbon atom common to R2 and R3; and group Q is as herein described.Type: GrantFiled: April 9, 1999Date of Patent: May 8, 2001Assignee: Pfizer IncInventor: Joel Michael Hawkins
-
Patent number: 6114568Abstract: The present invention relates to a process for alkylating hindered sulfonamides useful as intermediates in the preparation of matrix metalloproteinase inhibitors.Type: GrantFiled: April 9, 1999Date of Patent: September 5, 2000Assignee: Pfizer Inc.Inventors: Brian Michael Andresen, Phillip Dietrich Hammen, Joel Michael Hawkins
-
Patent number: 6110964Abstract: A compound of the formula ##STR1## wherein Z and Q are as defined in the specification, to pharmaceutical compositions containing them and to their medicinal use.Type: GrantFiled: September 30, 1999Date of Patent: August 29, 2000Assignee: Pfizer Inc.Inventor: Ralph Pelton Robinson
-
Patent number: 5962703Abstract: Functionalized bicyclic (meth)acrylates with norbornenyl or norbornadienyl groups are described, which may be cured with radicals at room temperature and are particularly suitable as an adhesion-promoting component of dental adhesives.Type: GrantFiled: February 21, 1997Date of Patent: October 5, 1999Assignee: Ivoclar AGInventors: Norbert Moszner, Volker Rheinberger, Karin Vogel, Frank Zeuner
-
Patent number: 5744010Abstract: The invention relates to a process for the preparation of acesulfam salts by reaction of salts of amidosulfonic acid with diketene to give a salt of acetoacetamidosulfonic acid (I), ring closure by the action of at least about an equivalent amount of SO.sub.3, at least this ring closure reaction being carried out in the presence of a halogenated, aliphatic hydrocarbon as an inert solvent, treatment of the cyclization product with water and conversion of the resulting acesulfam-H (II) into the form of a non-toxic salt, which comprises, in the work-up by distillation of the resulting crude solvent, after removal of water and low-boilers and recovery of solvent sufficiently pure for reuse in the preparation of compounds (I) and/or (II), directly returning :he remaining, solvent-containing distillation residue, without further purification, into the system downstream of the reaction vessel for carrying out the ring closure reaction.Type: GrantFiled: June 19, 1995Date of Patent: April 28, 1998Assignee: Hoechst AktiengesellschaftInventors: Gunter Roscher, Heinz Litterer, Axel Engelmann, Wolf-Dietmar Kaufmann, Bernd Laugwitz, Hans-Dietmar Schnabel
-
Patent number: 5700762Abstract: Substituted aryl or heteroaryl in particular benzoyl bicycloalkanediones and related compounds, intermediates therefor, synthesis thereof, and the use of said diones for the control of weeds.Type: GrantFiled: May 23, 1995Date of Patent: December 23, 1997Assignee: Sandoz Ltd.Inventors: Shy-Fuh Lee, Takashi Nishizaka, Kenichi Komatsubara
-
Patent number: 5661166Abstract: A Saishin N derivative represented by the following general formula: ##STR1## wherein X represents a carbonyl group or a >CH--ORx group, or X bonds to a carbon atom in Y or Z to represent a >C(ORx)--O-- group; Y and Z may be the same or different and each represents a carbonyl group or a >CH--ORy group, or each bonds to an oxygen atom in X to represent a >CH-- group; the broken line represents an optional bond; and Rx and Ry may be the same or different and each represents a hydrogen atom or an alkyl, alkenyl, aralkenyl, aralkyl, heterocyclic-alkyl or acyl group, is provided which is therapeutically usable as an antiulcer agent.Type: GrantFiled: March 13, 1995Date of Patent: August 26, 1997Assignee: Tokyo Tanabe Co. Ltd.Inventors: Susumu Yokura, Kiyokazu Murakami, Nobuo Takoi, Hiroyuki Iizuka, Eiji Ohtubo
-
Patent number: 5625067Abstract: The invention relates to cyclopentane ether derivatives of Formula I ##STR1## their salts with physiologically compatible bases, as well as the .alpha.-, .beta.- or .gamma.-cyclodextrin clathrates, and also the liposome-encapsulated compounds of Formula I, processes for their production, and their pharmaceutical usage.Type: GrantFiled: December 14, 1994Date of Patent: April 29, 1997Assignee: Schering AktiengesellschaftInventors: Hartmut Rehwinkel, Ulrich Klar, Helmut Vorbruggen, Karl-Heinz Thierauch, Peter Verhallen
-
Patent number: 5491152Abstract: The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.Type: GrantFiled: March 23, 1994Date of Patent: February 13, 1996Assignee: The Du Pont Merck Pharmaceutical CompanyInventors: Richard G. Wilde, Soo S. Ko, Jeffrey T. Billheimer
-
Patent number: 5360815Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.Type: GrantFiled: June 23, 1993Date of Patent: November 1, 1994Assignee: Merck Frosst Canada, Inc.Inventors: Rejean Fortin, Yves Girard, Erich Grimm, John Hutchinson, John Scheigetz
-
Patent number: 5276211Abstract: Described are aryl oxabicyclooctane derivatives and phenyl norbornane derivatives defined according to the structures: ##STR1## wherein N is an integer selected from the group consisting of 1 and 2, processes for preparing same, perfumery uses thereof and intermediates used in said processes which intermediates are defined according to the structures: ##STR2## wherein M is 0, 1 or 2 and X is chloro or bromo. Also described are the by-products having the structure: ##STR3## wherein P is 1 or 2 and uses thereof in perfumery.Type: GrantFiled: March 11, 1993Date of Patent: January 4, 1994Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, John J. De Virgilio
-
Patent number: 5252599Abstract: Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.Type: GrantFiled: August 27, 1992Date of Patent: October 12, 1993Assignee: Merck Frosst Canada, Inc.Inventors: Yves Girard, Rejean Fortin, Daniel Delorme, Daniel Dube, Pierre Hamel, Yves Ducharme, John W. Gillard
-
Patent number: 5240907Abstract: Described are substituted cyclopentyl oxabicyclooctanes, cyclopentyl vinyl pyrans, cyclopentylformylcyclohexenes and cyclopentylhydroxymethyl cyclohexenes having the generic structures: ##STR1## wherein R.sub.1, R.sub.2, R', R", R.sub.1 ', R.sub.2 ', R.sub.1 " and R.sub.2 " represent hydrogen or methyl with the provisos that:(i) R.sub.1 and R.sub.2 are not both methyl;(ii) R' and R" are not both methyl;(iii) when R.sub.1 ' is methyl, R.sub.2 ' is hydrogen; and(iv) when R.sub.2 " is methyl, then R.sub.1 " is hydrogen,processes for preparing same and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, e.g., solid or liquid, anionic, cationic, nonionic or zwitterionic detergents, cosmetic preparations, fabric softener compositions, fabric softener articles, hair preparations and perfumed polymers.Type: GrantFiled: October 23, 1992Date of Patent: August 31, 1993Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, John J. De Virgilio, Franc T. Schiet, Charles E. J. Beck, Charles J. Vinals, Marie R. Hanna
-
Patent number: 5225436Abstract: Certain aryl substituted naphthalene, benzoxepine, benzazepine and henzocycloheptene derivatives are disclosed. The compounds are useful in treating hyperproliferative skin disease, allergic reactions and inflammation.Type: GrantFiled: October 15, 1991Date of Patent: July 6, 1993Assignee: Schering CorporationInventors: Neng-Yang Shih, Pietro Mangiaracina, Michael J. Green, Ashit K. Ganguly
-
Patent number: 5206393Abstract: Novel oxydiketones having the general structure: ##STR1## with R being alkyl groups of up to 12 carbons atoms and derivatives thereof having utility in the manufacture of various polymers and a process for their preparation are described.Type: GrantFiled: June 11, 1992Date of Patent: April 27, 1993Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Ronald S. Newman, St. Clair W. Greenidge
-
Patent number: 5179104Abstract: An asymmetric process for the preparation of enantiomerically pure .beta.-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of the nucleosides. The anti-viral activity of the compounds is surprising in light of the generally accepted theory that moieties in the endo conformation, including these dioxolanes, are not effective antiviral agents. The toxicity of the enantiomerically pure dioxolane nucleosides is lower that that of the racemic mixture of the nucleosides, because the nonnaturally occurring .alpha.-isomer is not included.The product can be used as a research tool to study the inhibition of HIV in vitro or can be administered in a pharmaceutical composition to inhibit the growth of HIV in vivo.Type: GrantFiled: December 5, 1990Date of Patent: January 12, 1993Assignee: University of Georgia Research Foundation, Inc.Inventors: Chung K. Chu, Raymond F. Schinazi
-
Patent number: 5145973Abstract: Novel oxydiketones having the general structure: ##STR1## with R being alkyl groups of up to 12 carbon atoms and derivatives thereof having utility in the manufacture of various polymers and a process for their preparation are described.Type: GrantFiled: September 30, 1991Date of Patent: September 8, 1992Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Ronald S. Newman, St. Clair W. Greenidge
-
Patent number: 5137579Abstract: Menthyl pyran compounds are provided repesented by the formula 1: ##STR1## wherein R is H or lower acyl or 1-3 carbon atoms; R' is H, hydroxyl, or C.sub.1-3 acyloxy, and the dotted line represents an optional double bond.Use of the compounds provides a menthol note upon pyrolysis or hydrolysis. Smoking compositions containing a compound of formula 1 are also included.Type: GrantFiled: March 31, 1989Date of Patent: August 11, 1992Assignee: BASF K&F CorporationInventors: Philip Christenson, Robert Eilerman
-
Patent number: 5128317Abstract: Described are camphonyl spirocyclooxaoctane-containing compositions having the generic structures: ##STR1## and mixtures of same with substituted cyclopentenyl-oxabicyclooctanes defined according to the generic structures: ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 ' and R.sub.3 " each represents hydrogen or methyl and R.sub.4 ' represents hydrogen or C.sub.1 -C.sub.5 alkyl, processes for preparing same and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, e.g., solid or liquid anionic, cationic, nonionic or zwitterionic detergents, cosmetic preparations, fabric softener compositions, fabric softener articles, hair preparations and perfumed polymers.Type: GrantFiled: July 25, 1991Date of Patent: July 7, 1992Assignee: International Flavors and Fragrances Inc.Inventors: Anubhav P. S. Narula, John J. De Virgilio, Carlos Benaim, Anton Van Ouwerkerk, Olivier Gillotin
-
Patent number: 5125954Abstract: The present invention relates to novel bicyclo ether derivatives, to compositions containing them, and to their method of use especially to control the growth of undesired vegetation in rice.Type: GrantFiled: November 2, 1990Date of Patent: June 30, 1992Assignee: E.I. Du Pont de Nemours and CompanyInventors: James E. Powell, Richard B. Phillips
-
Patent number: 5057508Abstract: Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo[2,2,3]-nonanes having 2 or 3 ring hetero atoms selected from O, S and N, substituted at the 1-position by a 4-alkynylphenyl group and at the 4-position and optionally at the 3 and/or 5-position are valuable pesticides, particularly insecticides and acaracides. The compounds may be prepared by reacting an alkyne with the corresponding 4-iodophenyl substituted compound or by debromination of the corresponding 4-dibromomethylphenyl substituted compound.Type: GrantFiled: February 20, 1990Date of Patent: October 15, 1991Assignee: The Regents of the University of CaliforniaInventors: John E. Casida, Christopher J. Palmer, John P. Larkin, Ian H. Smith
-
Patent number: 5043415Abstract: The application describes nitrogen-containing an oxacalixarene or calixarene derivative of formula I: ##STR1## wherein m'+m"=0-8n=0-8m'.gtoreq.1/2(m'+M")3.ltoreq.m'+m"+n.ltoreq.8if n=0, m'+m".gtoreq.4R.sup.3 is H, halogen, or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof and R.sup.3 may be the same or different on each aryl group;R.sup.1 and R.sup.15 which may be the same or different are H or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof;R.sup.2 is selected from:R.sup.4 which is H, or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof, ##STR2## wherein R.sup.5 and R.sup.6 which may be the same or different are H, or hydrocarbyl, aryl, hydrocarbylaryl, or a substituted derivative thereof,-OR.sup.1, wherein R.sup.1 is as defined aboveand R.sup.17 which is a residue of a hydrocarbyl, aryl, or hydrocarbylaryl group or of a substituted derivative thereof providing a bond to another oxacalixarene or calixarene derivative of formula I wherein R.Type: GrantFiled: September 23, 1988Date of Patent: August 27, 1991Assignee: Loctite (Ireland) Ltd.Inventors: Stephen J. Harris, Maureen G. MacManus, John Guthrie
-
Patent number: 5041566Abstract: Levoglucosenone is prepared by reaction sequence using 1,6-anhydro-.beta.-D-galactopyranose as a starting material. First, the starting material is reacted with ortho formate, obtaining an ortho ester of said starting material. Then, the ortho ester is placed under the conditions for a reductive elimination reaction of the ortho formate part of said ortho ester, thereby converting said ortho ester to a 1,6-anhydro-3,4-dideoxy derivative. The dideoxy derivative is placed under the conditions for oxidation of the hydroxy group of said dideoxy derivative, thereby forming levoglucosenone.Type: GrantFiled: September 6, 1990Date of Patent: August 20, 1991Assignee: Japan Tobacco Inc.Inventors: Makoto Shibagaki, Kyoko Takahashi, Hideyuki Kuno, Ichiro Honda, Masataka Mori, Hajime Matsushita
-
Patent number: 5026554Abstract: This invention relates to a method of inhibiting fungal growth by employing an antifungal amount of a compound of formula (I): ##STR1##Type: GrantFiled: September 13, 1990Date of Patent: June 25, 1991Assignee: Merck & Co., Inc.Inventors: Kenneth F. Bartizal, Janet C. Onishi
-
Patent number: 4999439Abstract: Described are alkyl-substituted tetra- or hexahydrobenzopyran derivatives defined according to one of the generic structures: ##STR1## wherein Z is a moiety in the alternative either ##STR2## wherein in the moiety having the structure: ##STR3## R' is methyl or ethyl and in the moiety having the structure: ##STR4## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds; wherein R.sub.1 and R.sub.2 taken separately represent hydrogen or C.sub.1 -C.sub.3 lower alkyl (with the proviso that R.sub.1 and R.sub.2 are not both hydrogen) or R.sub.1 and R.sub.2 taken together complete a C.sub.5 or C.sub.Type: GrantFiled: March 22, 1990Date of Patent: March 12, 1991Assignee: International Flavors & Fragrances Inc.Inventors: Mark A. Sprecker, Robert P. Belko, Marie R. Hanna, Charles E. J. Beck, Salvatore M. Brucato
-
Patent number: 4994585Abstract: A method of preparing (S)-.gamma.-hydroxymethyl-.alpha.,.beta.-butenolide includes the step of oxidizing a levoglucosenone with a peracid in an organic solvent. Peracetic acid, metha-chloroperbenzoic acid or magnesium monoperoxyphthalate hexahydrate can be used as the peracid. According to this method, an (S)-.gamma.-hydroxymethyl-.alpha.,.beta.-butenolide having high optical purity can be easily prepared from a levoglucosenone as a starting material at a high yield.Type: GrantFiled: July 10, 1990Date of Patent: February 19, 1991Assignees: Japan Tabacco Inc., Yuki Gosei Kogyo Co., Ltd.Inventors: Koshi Koseki, Takashi Ebata, Hiroshi Kawakami, Hajime Matsushita, Kazuo Itoh, Yoshitake Naoi
-
Patent number: 4868318Abstract: The present invention relates to novel perfluoro chemicals (PFC), particularly perfluorocyclic ethers and polyfluorinated compounds containing a few chlorine atoms and to a method for the preparation thereof.Type: GrantFiled: March 9, 1987Date of Patent: September 19, 1989Assignee: The Green Cross CorporationInventors: Kirby V. Scherer, Jr., Taizo Ono, Kouichi Yamanouchi, Kazumasa Yokoyama
-
Patent number: 4861913Abstract: Bicyclic sulfonamido derivatives represented by the formula: ##STR1## wherein R.sub.1 is a hydrogen or lower alkyl; R.sub.2 is an alkyl, substituted or unsubstituted aryl, aralkyl or heterocycle; R.sub.3 is a hydrogen or methyl; X is an alkylene or alkenylene which may be substituted by a fluorine atom or atoms an may contain an oxygen, sulfur and/or phenylene in the chain; Y is straight or branched alkylene or alkenylene, oxygen, or sulfur; m is 0 or 1; and n is 0, 1 or 2, or their salt, said derivatives being useful as antithrombotic, anti-vasoconstricting, and anti-bronchoconstricting drugs.Type: GrantFiled: November 5, 1986Date of Patent: August 29, 1989Assignee: Shionogi & Co., Ltd.Inventors: Masayuki Narisada, Mitsuaki Ohtani, Fumihiko Watanabe, Sanji Hagishita, Kaoru Seno, Susumu Kamata, Nobuhiro Haga, Tatsuo Tsuri, Tadahiko Tsushima, Kenji Kawada
-
Patent number: 4857660Abstract: 1-Phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula ##STR1## in which R.sub.1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up to and including 18, preferably up to and including 12, carbon atoms, R.sub.2 represents hydrogen, lower alkyl, sulpho or acyl, R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents hydrogen, lower alkyl, phenyl or phenyl substituted by --N(R.sub.2)(R.sub.3), and salts of these compounds, have valuable pharmacological properties, are effective as aromatase inhibitors and can therefore be used for the treatment of hormone-dependent diseases, especially mammary carcinoma.Type: GrantFiled: April 22, 1988Date of Patent: August 15, 1989Assignee: Ciba-Geigy CorporationInventors: Alex Alder, Jaroslav Stanek, Daniel Bellus
-
Patent number: 4855461Abstract: Oxacalixarenes of general formula I: ##STR1## wherein m=0-7 and n=1-8 with the proviso that m+n.ltoreq.8;R is hydrogen, halogen, or hydrocarbyl, aryl, hydrocarbylaryl or a substituted derivative thereof, and R may be the same or different on each aryl group; andR' is hydrocarbyl, aryl, hydrocarbylaryl, hydrocarbyloxy, aryloxy or hydrocarbylaryloxy or a substituted derivative thereof.The invention also provides a method of preparing oxacalixarenes of formula I, and cyanoacrylate adhesive compositions including as accelerator an oxacalixarene of formula I.Type: GrantFiled: January 20, 1988Date of Patent: August 8, 1989Assignee: Loctite (Ireland) Ltd.Inventor: Stephen J. Harris
-
Patent number: 4831163Abstract: A method is provided for preparing cineole in an improved yield and with increased 1,4- isomer content, by reaction of terpin hydrate or terpineol with an acid, such as phosphoric acid, with distillation of the cineole from the reaction mixture as the cineole is formed.Type: GrantFiled: July 24, 1987Date of Patent: May 16, 1989Assignee: Union Camp CorporationInventor: Peter W. D. Mitchell
-
Patent number: 4739082Abstract: Enantiomerically pure mono acetal-protected diols of the formula ##STR1## wherein A, B, C and D are hydrogen or a methyl group in any combination, M and N are aliphatic or araliphatic hydrocarbons, m and n are the numbers 0, 1 or 2, whereby the total of m plus n must be the number 1 or 2, their preparation and use for the syntheses of the pheromones (1R-exo)-Brevicomin, (1S-exo)-Brevicomin, (1R-endo)-Brevicomin and (1S-endo)-Brevicomin.Type: GrantFiled: March 29, 1985Date of Patent: April 19, 1988Assignee: Chemie Linz AktiengesellschaftInventors: Christian R. Noe, Max Knollmuller
-
Patent number: 4670041Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2, or 3; the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides.Type: GrantFiled: September 13, 1982Date of Patent: June 2, 1987Assignee: E. I. du Pont de Nemours and CompanyInventors: George B. Payne, Samuel B. Soloway, James E. Powell, Steven A. Roman, Willy D. Kollmeyer
-
Patent number: 4609743Abstract: A process for the production of the beetle aggregation pheromone brevicomin comprising reacting acrolein dimer sequentially with ethyllithium, a methylating agent and aqueous protonic acid. In a modification of the process the acrolein dimer is reacted with ethyl Grignard reagent prior to reaction with an alkyllithium compound. The process includes distributing the brevicomin product to areas to be controlled for beetles.Type: GrantFiled: April 17, 1984Date of Patent: September 2, 1986Assignee: University of PittsburghInventors: Theodore Cohen, Mahadevan Bhupathy
-
Patent number: 4606753Abstract: Novel oxabicycloalkane ether of the formula ##STR1## wherein X is a single bond or --C(CH.sub.3).sub.2 -- and Y is a single bond or --CH.sub.2 -- with the proviso that both X and Y are not a single bond; R is H or --C(O)R.sup.3 in which R.sup.3 is H or certain hydrocarbyl groups; R.sup.1 is certain hydrocarbyl groups, or certain derivatives thereof, such as esters or carbamoyl compounds; and R.sup.2 is cyano or certain unsaturated, aromatic, heterocyclic, cycloalkyl, cycloalkenyl or secondary alkyl group, are useful as herbicides or plant growth regulators.Type: GrantFiled: June 15, 1984Date of Patent: August 19, 1986Assignee: Shell Oil CompanyInventor: James E. Powell
-
Patent number: 4602933Abstract: Novel compounds of the formula ##STR1## wherein D is hydrogen, halogen, (halo)alkyl or (halo)alkoxy; R is hydrogen, alkyl or alkoxy and R.sup.1 is the hydrocarbyl residue of a saturated oxygen-heterocyclic alcohol, are useful as herbicides.Type: GrantFiled: November 13, 1984Date of Patent: July 29, 1986Assignee: Shell Oil CompanyInventor: Kurt H. Pilgram
-
Patent number: 4602934Abstract: Novel compounds of the formula ##STR1## wherein D is hydrogen, halogen, (halo)alkyl or (halo)alkoxy; R is alkyl or is cycloalkyl optionally 1-substituted by alkyl or halogen and R.sup.1 is the hydrocarbyl residue of a saturated oxygen-heterocyclic alcohol, are useful as herbicides.Type: GrantFiled: November 13, 1984Date of Patent: July 29, 1986Assignee: Shell Oil CompanyInventor: Kurt H. Pilgram
-
Patent number: 4588821Abstract: Compound of the formula ##STR1## wherein X is --C(O)Hal, --CN, or --C(O)Y in which Y is OR.sup.1 or NR.sup.1 R.sup.2 in which R.sup.1 and R.sup.2 are H or hydrocarbyl or the like and R are certain optionally substituted hydrocarbyl and heterocyclic groups, are useful as herbicides and plant growth regulators or intermediates thereto. The intermediate 6-hydroxy and 6-oxo-2-oxabicyclo[2.2.1]heptane-4-carbonitriles are also new.Type: GrantFiled: June 15, 1984Date of Patent: May 13, 1986Assignee: Shell Oil CompanyInventor: James E. Powell
-
Patent number: 4548929Abstract: Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.Type: GrantFiled: April 18, 1983Date of Patent: October 22, 1985Assignee: SDS Biotech CorporationInventors: Thomas A. Magee, Robert D. Battershell, Lawrence E. Limpel, Andrew W. Ho, Arthur W. Friedman, H. Glenn Corkins, William W. Brand, Russell Buchman, Louis Storace, Edmond R. Osgood
-
Patent number: 4525203Abstract: Compounds of the formula ##STR1## wherein X is a single bond or --C(CH.sub.3).sub.2 ; Y is a single bond or --CH.sub.2 -with the proviso that both X and Y are not a single bond, and Z is H or alkyl; each R is H, hydroxy, oxo, methylene, alkyl or alkoxy, or one pair of adjacent R groups form a carbon-carbon bond; and R.sup.1 is H or alkyl, are useful as herbicides or plant growth regulators.Type: GrantFiled: June 15, 1984Date of Patent: June 25, 1985Assignee: Shell Oil CompanyInventors: George B. Payne, James E. Powell