Tetracyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/42)
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Publication number: 20110288306Abstract: ??-di-R-substituted fused thiophene (DCXFT4) compounds, and a method for making a compound of the formula (V): where each R is a C4 to C25 hydrocarbylene, the method including di-acylating tetra-bromo dithiophene (I); contacting the bromo-dithiophene compound (II) with a 2-mercaptoacetate to form cyclized fused thiophene (III); converting fused thiophene (III) to the corresponding diacid (IV); and decarboxylating the diacid (IV) to the fused thiophene (V), of the formulas as defined herein.Type: ApplicationFiled: May 18, 2010Publication date: November 24, 2011Inventors: Mingqian He, Jieyu Hu, James R. Matthews, Weijun Niu
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Publication number: 20110266526Abstract: Compounds comprising a triphenylene moiety and a benzo- or dibenzo-moiety are provided. In particular, the benzo- or dibenzo-moiety has a fused substituent. These compounds may be used in organic light emitting devices, particularly in combination with yellow, orange and red emitters, to provide devices with improved properties.Type: ApplicationFiled: January 11, 2011Publication date: November 3, 2011Applicant: Universal Display CorporationInventors: Bin Ma, James Fiordelsiso, Yonggang Wu, Raymond Kwong
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Publication number: 20110224445Abstract: There are provided a novel compound having a good field mobility, a method of producing of the compound, an organic semiconductor material containing the novel compound, and an organic semiconductor device. The novel compound which is represented by the following general formula (1), (2), (3) or (4) (where Z represents a sulfur atom or a selenium atom, and R represents a hydrogen atom, an alkyl group or a phenyl group in general formulae) has a structure having two benzene rings of naphthalene bonded with a thiophene ring and a selenophene ring, respectively. These compounds have a conjugate system in molecules due to an interaction between it orbitals, and show a strong molecular interaction through a sulfur atom or a selenium atom contained in a thiophene ring or a selenophene ring in each molecule, thereby having a good field mobility.Type: ApplicationFiled: October 30, 2009Publication date: September 15, 2011Inventor: Kazuo Takimiya
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Publication number: 20110204295Abstract: Disclosed are a heterocyclic compound characterized by being represented by formula (1), and a composition of the compound. Also disclosed is an organic electronic device using the compound. (In formula (1), X1, X2 and X3 each independently represents a sulfur atom or a selenium atom; and R1-R6 each independently represents an aromatic hydrocarbon group, an aliphatic hydrocarbon group, a halogen atom, a hydroxyl group, an alkoxyl group, a mercapto group, an alkylthio group, a boronic acid group, a nitro group, a substituted amino group, an amide group, an acyl group, a carboxyl group, an acyloxy group, a cyano group, a sulfo group, a sulfamoyl group, an alkylsulfamoyl group, a carbamoyl group, an alkylcarbamoyl group or a hydrogen atom, provided that all the R1-R6 are not hydrogen atoms at the same time.) The compound represented by formula (1) is suitable for use in an organic electronic device such as an organic EL element, an organic transistor element and a liquid crystal element.Type: ApplicationFiled: November 20, 2009Publication date: August 25, 2011Applicants: HIROSHIMA UNIVERSITY, NIPPON KAYAKU KABUSHIKI KAISHAInventors: Hirokazu Kuwabara, Masaaki Ikeda, Kazuo Takimiya
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Publication number: 20110178065Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.Type: ApplicationFiled: January 13, 2011Publication date: July 21, 2011Applicant: BIOMARIN PHARMACEUTICAL INC.Inventors: Daniel Chu, Bing Wang, Tao Ye
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Publication number: 20110168992Abstract: The present invention relates to a novel compound, a method for manufacturing the same, and an organic electronic device using the same, and the novel compound according to the present invention may act as a hole injection, hole transport, electron injection and transport, or light emitting material in an organic light emitting device and an organic electronic device, and the device according to the present invention shows excellent properties in terms of efficiency, a driving voltage, and stability.Type: ApplicationFiled: September 23, 2009Publication date: July 14, 2011Inventors: Jae-Soon Bae, Ji-Eun Kim, Jeung-Gon Kim, Jun-Gi Jang
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Publication number: 20110144094Abstract: This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: February 16, 2011Publication date: June 16, 2011Inventors: José Maria Cid-Núñez, Antonius Adrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez
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Publication number: 20110095270Abstract: There is provided an electroactive material having Formula I wherein: Q is the same or different at each occurrence and can be O, S, Se, Te, NR, SO, SO2, or SiR3; R is the same or different at each occurrence and can be hydrogen, alkyl, aryl, alkenyl, or alkynyl; R1 through R8 are the same or different and can be hydrogen, alkyl, aryl, halogen, hydroxyl, aryloxy, alkoxy, alkenyl, alkynyl, amino, alkylthio, phosphino, silyl, —COR, —COOR, —PO3R2, —OPO3R2, or CN.Type: ApplicationFiled: December 17, 2008Publication date: April 28, 2011Inventor: HONG MENG
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Publication number: 20110082278Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.Type: ApplicationFiled: October 15, 2010Publication date: April 7, 2011Inventor: Mingqian He
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Patent number: 7910653Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: March 22, 2011Assignee: E.I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7893191Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.Type: GrantFiled: September 17, 2009Date of Patent: February 22, 2011Assignee: Corning IncorporatedInventor: Mingqian He
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Publication number: 20110040107Abstract: A [1]benzothieno[3,2-b][1]benzothiophene compound expressed by General Formula (I): General Formula (I) where X and Y are each independently a hydrogen atom; a halogen atom; or a functional group having a straight or branched aliphatic alkyl group optionally having a halogen atom, a functional group having an alicyclic alkyl group optionally having a halogen atom, a functional group having a straight or branched aliphatic alkenyl group optionally having a halogen atom, a functional group having an alicyclic alkenyl group optionally having a halogen atom, a functional group having a carboxyl group, or a functional group having a thiol group, as a partial structure; and X and Y are the same or each independently different, provided that at least one of X and Y has a straight or branched aliphatic alkenyl group, an alicyclic alkenyl group, a carboxyl group or a thiol group, as a partial structure.Type: ApplicationFiled: April 15, 2009Publication date: February 17, 2011Inventors: Daisuke Goto, Masafumi Torii, Tamotsu Horiuchi, Tamotsu Aruga, Hiroshi Ikuno, Toshiya Sagisaka, Satoshi Yamamoto, Takeshi Orito, Masataka Mohri, Takashi Okada, Takuji Kato, Shinji Mutsumoto
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Publication number: 20110031488Abstract: A compound for an organic thin film transistor having a structure shown by the following formula (1): X1-L-Ar-L-X2 ??(1) wherein L is —C?C—, or —CH?CH— in a trans configuration, X1 and X2 are independently an alkyl group having 2 to 30 carbon atoms or a haloalkyl group having 1 to 30 carbon atoms, and Ar is a substituted or unsubstituted aromatic hydrocarbon group having 14 to 60 ring carbon atoms which is a condensed ring of three or more rings, or a substituted or unsubstituted aromatic heterocyclic group having 11 to 60 ring atoms which is a condensed ring of three or more rings.Type: ApplicationFiled: April 2, 2009Publication date: February 10, 2011Applicant: IDEMITSU KOSAN CO., LTD.Inventors: Masatoshi Saito, Yuki Nakano, Hiroaki Nakamura
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Publication number: 20110031487Abstract: A compound for an organic thin film transistor having a structure shown by the following formula (1): X1-L-Ar-L-X2??(1) wherein L is —C?C—, or —CH?CH— in a trans configuration, X1 and X2 are independently a substituted or unsubstituted aromatic heterocyclic group having 5 to 60 ring atoms, and their bonding positions to L are in heterocycles, Ar is a substituted or unsubstituted aromatic hydrocarbon group having 6 to 60 ring carbon atoms, or a substituted or unsubstituted aromatic heterocyclic group having 5 to 60 ring atoms, and at least one of X1, X2 and Ar is a bi- or higher-fused ring.Type: ApplicationFiled: April 2, 2009Publication date: February 10, 2011Applicant: Idemitsu Kosan Co., Ltd.Inventors: Masatoshi Saito, Yuki Nakano, Hiroaki Nakamura
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Publication number: 20110024731Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.Type: ApplicationFiled: October 5, 2010Publication date: February 3, 2011Applicant: National University of Corp. Hiroshima UniversityInventors: Kazuo TAKIMIYA, Yoshihito Kunugi, Yasushi Konda
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Publication number: 20110020566Abstract: A charge transporting, liquid crystal photoalignment material comprising a charge transporting moiety connected through covalent chemical bonds to a surface derivatising moiety, and a photoalignment moiety connected through covalent chemical bonds to a surface derivatising moiety.Type: ApplicationFiled: February 16, 2009Publication date: January 27, 2011Inventor: Gene Carl Koch
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Patent number: 7868086Abstract: Aromatic sulfonimide ionene polymers useful as membranes in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: January 11, 2011Assignee: E. I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Publication number: 20110003966Abstract: This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suitable photochromic or electrochromic conditions. The electrochromic conversion may be catalytic. The application also relates to ultra-high density homopolymers prepared using ring-opening methathesis polymerization (ROMP) where the central ring of the 1,2-bis(3-thienyl)-cyclopentene is incorporated directly into the polymer backbone. The monomer units may be readily functionalized to enable the synthesis of polymers with diverse structural and electronic properties.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: SWITCH MATERIALS INC.Inventors: Neil R. Branda, Andrea Peters, Anthony J. Wigglesworth
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Publication number: 20100331325Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: August 5, 2010Publication date: December 30, 2010Inventors: José Maria CID-NÚÑEZ, Antonius Adrianus Hendrikus Petrus MEGENS, Andrés Avelino TRABANCO-SUÁREZ, Mohamed KOUKNI, Georges Joseph Cornelius HOORNAERT, Frans Josef Cornelius COMPERNOLLE, Tomasz KOZLECKI, Hua MAO, Sushil Chandra JHA, Francisco Javier FERNÁNDEZ-GADEA
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Publication number: 20100305288Abstract: Fused thiophene (FT) compounds, FT polymers, FT containing articles, and methods for making and using the FT compounds and polymers thereof of the formulas, as defined herein.Type: ApplicationFiled: May 28, 2009Publication date: December 2, 2010Inventors: Mingqian He, Thomas Mark Leslie, Weijun Niu
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Patent number: 7838612Abstract: Described herein are aromatic sulfonimide compositions that can be used to prepare polymers useful as membranes in electrochemical cells.Type: GrantFiled: October 1, 2007Date of Patent: November 23, 2010Assignee: E. I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7838623Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereof.Type: GrantFiled: February 28, 2007Date of Patent: November 23, 2010Assignee: Corning IncorporatedInventor: Mingqian He
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Patent number: 7838594Abstract: Aromatic sulfonimide ionene compositions useful as monomers for polymers in electrochemical cells are prepared.Type: GrantFiled: October 1, 2007Date of Patent: November 23, 2010Assignee: E.I. du Pont de Nemours and CompanyInventor: Mark F. Teasley
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Patent number: 7834198Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.Type: GrantFiled: January 18, 2006Date of Patent: November 16, 2010Assignee: National University of Corporation Hiroshima UniversityInventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
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Patent number: 7799785Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: GrantFiled: December 6, 2005Date of Patent: September 21, 2010Assignee: Janssen Pharmaceutica NVInventors: José Maria Cid-Núñez, Antonius Andrianus Hendrikus Petrus Megens, Andrés Avelino Trabanco-Suárez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernández-Gadea
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Patent number: 7795299Abstract: Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.Type: GrantFiled: January 16, 2009Date of Patent: September 14, 2010Assignee: The University of North Carolina at Chapel HillInventors: Kuo-Hsiung Lee, Xihong Wang, Kenneth F. Bastow, Tian-Shung Wu
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Patent number: 7670512Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.Type: GrantFiled: June 28, 2006Date of Patent: March 2, 2010Assignee: National Sun Yat-Sen UniversityInventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
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Patent number: 7671141Abstract: Disclosed herein are second order nonlinear optic polyimide polymers comprising repeating units represented by the formula: wherein each of the substituents is given the definition as set forth in the Specification and Claims. Also disclosed are the preparation processes of these polymers, chromophore-forming compounds for synthesis of these polymers, and the intermediate polymers thereof. The second order nonlinear optic polyimide polymers of formula (I) may be used in the manufacture of electro-optic (EO) devices, such as electro-optic waveguide devices.Type: GrantFiled: June 28, 2006Date of Patent: March 2, 2010Assignee: National Sun Yat-Sen UniversityInventors: Tzu-Chien Hsu, Chien-Fan Chen, Shou-Shiun Wu
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Patent number: 7662313Abstract: This invention provides compositions and devices having structurally ordered nanostructures, as well as methods for producing structurally ordered nanostructures.Type: GrantFiled: September 4, 2003Date of Patent: February 16, 2010Assignee: NANOSYS, Inc.Inventors: Jeffery A. Whiteford, Mihai Buretea, Erik Scher, Steve Empedocles, Andreas Meisel
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Publication number: 20100032655Abstract: Disclosed is a field-effect transistor characterized by using a compound represented by the formula (1) below as a semiconductor material. (In the formula (1), X1 and X2 independently represent a sulfur atom, a selenium atom or a tellurium atom; and R1 and R2 independently represent an unsubstituted or halogeno-substituted C1-C36 aliphatic hydrocarbon group.Type: ApplicationFiled: October 19, 2007Publication date: February 11, 2010Inventors: Kazuo Takimiya, Hideaki Ebata, Hirokazu Kuwabara, Masaaki Ikeda, Tatsuto Yui
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Publication number: 20100010237Abstract: Described herein are compositions including heterocyclic organic compounds such as fused thiophene compounds, methods for making them, and uses thereofType: ApplicationFiled: September 17, 2009Publication date: January 14, 2010Inventor: Mingqian He
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Publication number: 20100006824Abstract: An organic nanofiber including a gelled organic semiconductor compound. Also disclosed is an organic semiconductor transistor and a method of manufacturing an organic semiconductor transistor.Type: ApplicationFiled: July 8, 2009Publication date: January 14, 2010Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Jong-in HONG, Myoung-chul UM, Jung-pyo HONG, Seong-hoon LEE
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Publication number: 20100006830Abstract: An organic semiconductor compound based on a 2,7-bis-(vinyl)[1]benzothieno[3,2-b]benzothiophene backbone, an organic semiconductor thin film, an organic thin film transistor and methods of forming the same are provided, the organic semiconductor compound including a vinyl group derived from a phosphonate derivative represented by Formula 1 and an aldehyde derivative represented by Formula 2 below:Type: ApplicationFiled: July 8, 2009Publication date: January 14, 2010Inventors: Jong-in Hong, Myoung-chul Um, Jeong-hun Kwak, Chang-hee Lee
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Publication number: 20090221687Abstract: Novel tetracyclic dibenzo(e,h)azulene compounds of formula I; their pharmacologically acceptable derivatives; process and intermediates for their preparation; pharmaceutical compositions containing them and their activity and use in the treatment of central nervous system (CNS) diseases and conditions in humans and animals.Type: ApplicationFiled: February 1, 2006Publication date: September 3, 2009Inventors: Milan Mesic, Mladen Mercep, Dijana Pesic, Renata Rupcic, Barbara Stanic
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Patent number: 7572395Abstract: The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.Type: GrantFiled: May 16, 2005Date of Patent: August 11, 2009Assignee: Nanosys, IncInventors: Jeffery A. Whiteford, Mihai A. Buretea, Erik C. Scher
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Patent number: 7572393Abstract: The present invention provides polymeric compositions that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.Type: GrantFiled: August 26, 2004Date of Patent: August 11, 2009Assignee: Nanosys Inc.Inventors: Jeffery A. Whiteford, Mihai A. Buretea, Linh Nguyen, Erik Scher
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Publication number: 20090023721Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: May 24, 2006Publication date: January 22, 2009Inventors: Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Jose Maria Cid-Nunez, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki
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Publication number: 20090001357Abstract: The object of the present invention to provide an organic semiconductor device comprising an organic semiconductor material satisfying both the requirement of high electron field-effect mobility and high on/off current ratio. The present invention provides a novel condensed polycyclic aromatic compound satisfying both the high electron field-effect mobility and high on/off current ratio required for organic semiconductor materials.Type: ApplicationFiled: January 18, 2006Publication date: January 1, 2009Applicant: National University of Corp. Hiroshima UniversityInventors: Kazuo Takimiya, Yoshihito Kunugi, Yasushi Konda
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Publication number: 20080287450Abstract: This invention concerns novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives with binding affinities towards serotonin receptors, in particular 5-HT2A and 5-HT2C receptors, and towards dopamine receptors, in particular dopamine D2 receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim 1.Type: ApplicationFiled: December 6, 2005Publication date: November 20, 2008Inventors: Jose Maria Cid-Nunez, Antonius Adrianus Hendrikus Petrus Megens, Andres Avelino Trabanco-Suarez, Mohamed Koukni, Georges Joseph Cornelius Hoornaert, Frans Josef Cornelius Compernolle, Tomasz Kozlecki, Hua Mao, Sushil Chandra Jha, Francisco Javier Fernandez-Gadea
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Patent number: 7435834Abstract: The present invention relates to compounds of 2-thia-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-?(TNF-?) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.Type: GrantFiled: April 9, 2003Date of Patent: October 14, 2008Assignee: GlaxoSmithKline Istrazivacki Center Zagreb D.O.O.Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec
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Publication number: 20080242875Abstract: A method for the degradation of polycyclic aromatic compounds is disclosed that involves dissolving ozone in a bipolar solvent comprising a non-polar solvent in which is of sufficiently non-polar character to solubilized the polycyclic aromatic compounds, and a polar-water-compatible solvent which is fully miscible with the non-polar solvent to form a single phase with the non-polar solvent. The bipolar solvent with dissolved ozone is contacted with the polycyclic aromatic compounds to solubilize the polycyclic aromatic compounds and react the dissolved polycyclic aromatic compounds with the ozone to degrade the dissolved polycyclic aromatic compounds to oxygenated intermediates. The bipolar solvent is then mixed with sufficient water to form separate non-polar and polar phases, the non-polar phase comprising the non-polar solvent and the polar phase comprising the non-polar solvent and the oxygenated intermediates.Type: ApplicationFiled: March 24, 2008Publication date: October 2, 2008Inventors: P.K. Andy Hong, David A. Wavrek, Jiun-Chi Chao, Yu Zeng
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Publication number: 20080214838Abstract: Described are oligotetracenes of formula I which may either be unsubstituted or carry one or more substituents R and R? which are selected from the group comprising halogen, CN, alkyl or alkoxy radicals containing 1 to 18 carbon atoms, aryl radicals containing up to 10 carbon atoms which may also contain one or more heteroatoms, and/or fluorinated or perfluorinated alkyl or alkoxy radicals containing 1 to 18 carbon atoms, where n is an integer from 1 to 20, preferably 1 to 6, very particularly preferably 1 or 2, and X stands for a single bond, an alklyene group containing 1 to 6 carbon atoms, a hydrocarbon chain having one or more conjugated double bonds, an aryl group, or a system composed of one or more condensed aromatic rings. In the oligotetracenes according to the invention, one or more of the condensed aromatic six-atom rings may be substituted by a five-atom ring which may also contain a heteroatom.Type: ApplicationFiled: June 21, 2006Publication date: September 4, 2008Inventors: Matthias Rehahn, Michael Roth, Heinz Von Seggern, Roland Schmechel, Marcus Ahles
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Patent number: 7420065Abstract: Provided are novel hetero-polycyclic compounds having a specific structure, color-changing material compositions comprising (A) a fluorescent coloring matter comprising at least one of the hetero-polycyclic compounds described above and (B) a binder material, color-changing films comprising the above hetero-polycyclic compounds, coloring matters comprising the above hetero-polycyclic compounds, and pigments or dyes comprising the hetero-polycyclic compounds described above, and provided are color-changing material compositions which are not deteriorated in a color-changing performance even after used for long time and which are prevented from being unusable due to deposition of coloring matters during storage and color-changing films produced by using the same, and novel hetero-polycyclic compounds, coloring matters and pigments or dyes which actualize them.Type: GrantFiled: February 12, 2004Date of Patent: September 2, 2008Assignees: Idemitsu Kosan Co., Ltd., Techno Network Shikoku Co., Ltd.Inventors: Katsuhira Yoshida, Yousuke Ooyama, Satoshi Hachiya
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Publication number: 20080142793Abstract: Organic semiconducting devices and applications exhibit high performance largely due to a treatment substrate interacting with an asymmetric linear compound. According to an example, an organic compound arrangement includes a treated substrate and an asymmetric linear compound on the treated substrate. The compound includes an acene and a thiophene unit fused to the acene and exhibits high mobility and, in some applications, a correspondingly high on/off ratio. The compound arrangement is suitable for implementation with a variety of semiconducting applications, such as thin-film applications, solar applications and transistor applications.Type: ApplicationFiled: November 13, 2007Publication date: June 19, 2008Inventors: Ming L. Tang, Zhenan Bao, Toshihiro Okamoto
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Patent number: 7384974Abstract: A 4,5-dihydronaphtho[1,2-b]thiophene derivative expressed by the formula: (wherein R1 is a C1 to C10 1-hydroxyalkyl group or a C1 to C10 acyl group, and R2 and R3 separately substitute in the 6-, 7-, 8-, or 9-positions, and are each independently a hydrogen atom, a halogen atom, a C1 to C10 alkyl group, a hydroxy group, a C1 to C10 alkoxy group, a C1 to C5 alkenyloxy group, a C1 to C5 alkynyloxy group, a benzyloxy group, or the like, provided that when R1 is an acyl group and R2 is a hydrogen atom, then R3 is neither a hydrogen atom nor an acetyl group), or a pharmaceutically acceptable salt thereof This is a novel compound that is effective in reducing triglyceride levels in the liver and reducing blood glucose levels.Type: GrantFiled: July 30, 2004Date of Patent: June 10, 2008Assignee: Taisha Pharmaceutical Co., Ltd.Inventors: Minoru Taguchi, Ryo Suzuki, Ayako Mikami
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Publication number: 20080100207Abstract: Provided are a cyclopentaphenanthrene-based compound and an organoelectroluminescent device employing the same. The cyclopentaphenanthrene-based compound is easy to prepare and excellent in solubility, color purity, color stability, and thermal stability. The cyclopentaphenanthrene-based compound is useful as a material for forming an organic layer, in particular, an emitting layer, in an organoelectroluminescent device, and as an organic dye or an electronic material such as a nonlinear optical material.Type: ApplicationFiled: July 18, 2007Publication date: May 1, 2008Inventors: Sang-Hoon Park, Yu-Jin Kim, Jhun-Mo Son
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Patent number: 7271264Abstract: The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), or —OSO2(C2-C6 alkyl); R0, R2 and R3 are each independently —H, —OH, —O(C1-C4 alkyl), —OCOC6H5, —OCO(C1-C6 alkyl), —OSO2(C2-C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl- 1-pyrrolidinyl, dimethyl-1-pyrrolidiny, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3 X is —S— or —HC?CH—; G is —O—, —S—, —SO—, SO2, or —N(R5)—, wherein R5 is —H or C1-C4 alkyl; and Y is —O—, —S—, —NH—, —NMe—, or —CH2—; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.Type: GrantFiled: July 18, 2003Date of Patent: September 18, 2007Assignee: Eli Lilly and CompanyInventors: Ronald Jay Hinklin, Owen Brendan Wallace
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Patent number: 7253292Abstract: A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound.Type: GrantFiled: May 8, 2002Date of Patent: August 7, 2007Assignee: Basell Polyolefine GmbHInventors: Ilya E. Nifant'ev, Igor A Kashulin, Pavel V. Ivchenko, Peter A. A. Klusener, Frans M. Kornorffer, Kees P. De Kloe, Jos J. H. Rijsemus
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Patent number: 7119206Abstract: The present invention provides a compound of the formula (I) wherein R1 is —H, —OH, —O(C1–C4 alkyl), —OCOC6H5, —OCO(C1–C6 alkyl), or —OSO2(C2–C6 alkyl); R0, R2 and R3 are each independently —H, —OH, —O(C1–C4 alkyl), —OCOC6H5, —OCO(C1–C6 alkyl), —OSO2(C2–C6 alkyl) or halo; R4 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino; n is 2 or 3; X is S— or —HC?CH—; and Y is O—, —S—, —NH—, —NMe—, or —CH2—; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof, optionally in combination with estrogen and progestin; methods of inhibiting a disease associated with estrogen deprivation; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogenType: GrantFiled: September 22, 2003Date of Patent: October 10, 2006Assignee: Eli Lilly and CompanyInventor: Owen Brendan Wallace
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Patent number: 6949206Abstract: The present invention provides compositions (small molecules, oligomers and polymers) that can be used to modify charge transport across a nanocrystal surface or within a nanocrystal-containing matrix, as well as methods for making and using the novel compositions.Type: GrantFiled: September 4, 2003Date of Patent: September 27, 2005Assignee: Nanosys, Inc.Inventors: Jeffery A. Whiteford, Mihai A. Buretea, Erik Scher