Tricyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/458)
-
Publication number: 20090131300Abstract: The present invention is directed to the diastereoisomeric mixture and the individual isomeric components of the formula:Type: ApplicationFiled: November 13, 2008Publication date: May 21, 2009Inventors: Richard Boden, Paul Daniel Jones
-
Publication number: 20090131510Abstract: Disclosed herein are compounds of Formula I as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.Type: ApplicationFiled: October 24, 2008Publication date: May 21, 2009Inventors: Roger Olsson, Lene Hyldtoft, Magnus Gustafsson, Birgitte Wintherlund
-
Publication number: 20090124680Abstract: Provided is a use of a prodrug composition containing a naphthoquinone-based compound of Formula 1 for the manufacture of a medicament for treatment or prevention of metabolic syndrome diseases. wherein R1 to R10, X, m and n are as defined in the specification.Type: ApplicationFiled: October 30, 2008Publication date: May 14, 2009Applicants: Mazence Inc., KT&G CorporationInventors: Sang-Ku YOO, Sang Woo YOO, Ku Suk KANG
-
Publication number: 20090105490Abstract: An amorphous form of ramelteon is provided, as well as mixtures of amorphous and crystalline ramelteon. Also provided are methods of preparing amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, pharmaceutical compositions comprising amorphous ramelteon and mixtures of amorphous and crystalline ramelteon, and methods of treatment of insomnia using the compositions of the invention.Type: ApplicationFiled: July 14, 2008Publication date: April 23, 2009Inventors: Nurit Perlman, Michal Rafilovich, Rinat Moshkovits-Kaptsan, Elena Ben Moha-Lerman, Revital Lifshitz-Liron
-
Patent number: 7517471Abstract: The present invention relates to compounds of the formula I where X1, X2, R1, R2, A1, A2, Z1, Z2, m, n and rings B and B? are as defined in claim 1.Type: GrantFiled: April 12, 2005Date of Patent: April 14, 2009Assignee: Merck Patent GmbHInventors: Lars Lietzau, Matthias Bremer, Melanie Klasen-Memmer
-
Publication number: 20090082432Abstract: The present application describes deuterium-enriched ramelteon, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: September 19, 2008Publication date: March 26, 2009Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
-
Publication number: 20090082433Abstract: The invention provides the use of at least one plant selected from plants of the family Zingiberaceae in the preparation of a medicament for use in the treatment or prophylaxis of allergic diseases. The plant is optionally selected from the genera Siphonochilus, Kaempferia, Cienkowskia and Cienkowskiella and the species is optionally selected from Siphonochilus aethiopicus, Siphonochilus natalensis, Kaempferia aethiopica, Kaempferia natalensis, Kaempferia ethelae, Cienkowskia aethiopica and Cienkowskiella aethiopica. The allergic disease is selected from asthma and atopy.Type: ApplicationFiled: February 28, 2007Publication date: March 26, 2009Applicant: CSIRInventors: Roelof Marthinus Horak, Ebrahim Wadiwala, Gerda Fouche, Marina Mikhailovna Van Der Merwe, Vinesh Jaichand Maharaj, Louis Gabriel Jozua Ackerman
-
Publication number: 20090069581Abstract: The present invention provides processes and intermediates for the synthesis of ramelteon.Type: ApplicationFiled: June 2, 2008Publication date: March 12, 2009Inventors: Vinod Kumar KANSAL, Dhirenkumar N. MISTRY, Sanjay L. VASOYA, Michal RAFILOVICH, Elena Ben LERMAN-MOHA, Revital LIFSHITZ-LIRON
-
Publication number: 20090048325Abstract: The present invention provides a prophylactic or therapeutic agent for irritable bowel syndrome, which comprises a compound represented by formula (I): wherein, R1 represents an optionally substituted hydrocarbon group, etc., R2 represents a hydrogen atom or an optionally substituted hydrocarbon group, R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc., X represents CHR4, NR4, CO, O or S (wherein, R4 represents a hydrogen atom, an optionally substituted hydrocarbon group, etc.), Y represents C, CH or N, represents a single bond or double bond, ring A represents an optionally substituted 5- to 7-membered oxygen-containing heterocyclic ring, ring B represents an optionally substituted benzene ring, and m represents an integer of 1 to 4, or a salt thereof.Type: ApplicationFiled: March 19, 2007Publication date: February 19, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Jun Terauchi, Fumihiko Sato, Nobuhiro Inatomi
-
Publication number: 20090042977Abstract: The present invention provides a method for easily and inexpensively preparing a racemate or an optically-active 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione in high yields, 2-acetyl-2,3-dihydro-5-hydroxynaphtho[2,3-b]furan-4,9-dione which is useful as an intermediate for preparing NFD, and an anticancer agent comprising 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione as an active ingredient. Said 2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione is obtained in 4 or 5 steps by using comparatively inexpensive 5-hydroxynaphthalene-1,4-dione (also referred to as juglone) as a starting material.Type: ApplicationFiled: March 15, 2006Publication date: February 12, 2009Applicant: TAHEEBO JAPAN CO., LTD.Inventors: Harukuni Tokuda, Katsumi Nishimura
-
Publication number: 20090042861Abstract: The present invention provides a prophylactic or therapeutic agent for depression or anxiety disorders, comprising (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide.Type: ApplicationFiled: April 3, 2006Publication date: February 12, 2009Applicant: Takeda Pharmaceutical Company LimitedInventors: Keisuke Hirai, Masaomi Miyamoto
-
Publication number: 20090042866Abstract: The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for inhibiting VEGF production.Type: ApplicationFiled: November 23, 2005Publication date: February 12, 2009Inventors: William Lennox, Hongyan Qi, Duck-Hyung Lee, Soongyu Choi, Young-Choon Moon
-
Publication number: 20090018113Abstract: The present application relates to a novel cyclopenta[b]benzofuran derivatives, processes for their preparation and their use for the manufacture of medicaments, in particular for the prophylaxis and/or therapy of acute or chronic disorders characterized by elevated cellular stress, by local or systemic inflammatory processes or by hyperproliferation.Type: ApplicationFiled: May 14, 2005Publication date: January 15, 2009Applicant: Bayer HealthCare AGInventors: Nicole Diedrichs, Thomas Fahrig, Irene Gerlach, Jaques Ragot, Joachim Schuhmacher, Kai Thede, Ervin Horvath
-
Patent number: 7468447Abstract: The present invention is directed to the diastereoisomeric mixture and the individual isomeric components of the formula:Type: GrantFiled: November 19, 2007Date of Patent: December 23, 2008Assignee: International Flavors & Fragrances Inc.Inventors: Richard Boden, Paul Daniel Jones
-
Publication number: 20080300415Abstract: An object of the present invention is to provide a method for efficiently preparing (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]-furan-4,9-dione useful as a medicine at a low cost and in large amounts. According to the present invention, the desired (S)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione can be prepared with high efficiency at a low cost and in large amounts by asymmetrically reducing 2-acetyl-5-hydroxynaphtho[2,3-b]furan-4,9-dione in the presence of an asymmetric ruthenium complex and a hydrogen donor.Type: ApplicationFiled: January 29, 2008Publication date: December 4, 2008Applicant: TAHEEBO JAPAN CO., LTD.Inventors: Akira Iida, Harukuni Tokuda, Mitsuaki Yamashita
-
Publication number: 20080287692Abstract: A compound of formula (X): wherein R1, R2, equal to or different from each other are hydrogen or a linear or branched saturated or unsaturated C1-C20-alkyl, C3-C20-cycloalkyl, C6-C20-aryl, C7-C20-alkylaryl or C7-C20-arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or they can form a C4-C7 ring optionally containing O, S, N, P or Si atoms that can bear substituents; R3 is hydrogen or a linear or branched saturated or unsaturated C1-C20-alkyl, C3-C20-cycloalkyl, C6-C20-aryl, C7-C20-alkylaryl or C7-C20-arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or two adjacent R3 groups can form a C4-C7 ring optionally containing O, S, N, P or Si atoms, wherein said ring can bear substituents; and at least one of R1, R2 or R3 is different from hydrogen.Type: ApplicationFiled: June 27, 2007Publication date: November 20, 2008Applicant: Basell Polyolefine GmbHInventors: Ilya E. Nifant'ev, Igor A. Kashulin, Pavel V. Ivchenko, Peter A.A. Klusener, Frans M. Korndorffer, Kees P. de Kloe, Jos J.H. Rijsemus
-
Patent number: 7442808Abstract: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: GrantFiled: May 11, 2007Date of Patent: October 28, 2008Assignee: Merck & Co., Inc.Inventors: Min Ge, Jiafang He, Fiona Wai Yu Lau, Gui-Bai Liang, Songnian Lin, Weiguo Liu, Shawn P. Walsh, Lihu Yang
-
Publication number: 20080242877Abstract: Provided are intermediates and processes for preparation of Ramelteon.Type: ApplicationFiled: February 26, 2008Publication date: October 2, 2008Inventors: Vinod Kumar Kansal, Dhirenkumar N. Mistry, Sanjay L. Vasoya
-
Publication number: 20080177093Abstract: The present invention provides new strategies for the synthesis of compounds of the rocaglamide family and related natural products. In particular, the new biomimetic synthetic approach involves photochemical generation of an oxidopyrylium species from a 3-hydroxychromone derivative followed by 1,3-dipolar cycloaddition of the oxidopyrylium species to a dipolarophile. This approach can be used for the formation of adducts containing an aglain core structure. Methods for the conversion of aglain core structures to aglain, rocaglamide and forbaglin ring systems are also provided. The present invention also relates to the use of rocaglamide/aglain/forbaglin derivatives for the manufacture of medicaments for use in the treatment of cancer or cancerous conditions, disorders associated with cellular hyperproliferation, or NF-?B-dependent conditions.Type: ApplicationFiled: March 23, 2005Publication date: July 24, 2008Inventors: Guilford Jones ll, Baudouin Gerard, John A. Porco Jr
-
Publication number: 20080171767Abstract: Compounds of the general formula (I); wherein the substituents are as defined in claim 1, are useful as fungicides.Type: ApplicationFiled: November 29, 2005Publication date: July 17, 2008Applicants: SYNGENTA CROP PROTECTION, INC., SYNGENTA LIMITEDInventors: Roger Salmon, David Philip Bacon, Ewan James Turner Chrystal, David William Langton, Andrew Jonathan Knee, Gordon Richard Munns, Laura Quaranta, Hans-Georg Brunner, Renaud Beaudegnies, Fredrik Cederbaum, Fiona Murphy Kessabi
-
Publication number: 20080085305Abstract: Robust sustained release formulations, solid dosage forms comprising robust sustained release formulations, and methods for making and using these formulations and solid dosage forms are provided. Robustness of the sustained release formulation is related to the particle size of the hydrophilic gum. Sustained release formulations resist dose-dumping when ingested with alcohol. The formulations are useful for treating a patient suffering from a condition, e.g., pain. The formulations comprise at least one drug. In one embodiment, the drug is an opioid, e.g., oxymorphone.Type: ApplicationFiled: October 10, 2006Publication date: April 10, 2008Applicant: Penwest Pharmaceuticals Co.Inventors: Anand R. Baichwal, Kevin Fitzmaurice, Steve Labudzinski, Michelle Howard-Sparks, William Hein
-
Patent number: 7345181Abstract: The present invention provides a process for preparing benzoprostacycline derivatives of formula (1), i.e. 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives, and vinyl tin compounds of formula (III) as starting materials for the same.Type: GrantFiled: September 18, 2003Date of Patent: March 18, 2008Assignee: Yonsung Fine Chemical Co., Ltd.Inventors: Yong-Hyun Kim, Yiu-Suk Lee
-
Publication number: 20070265332Abstract: Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: ApplicationFiled: May 11, 2007Publication date: November 15, 2007Inventors: Min Ge, Jiafang He, Fiona Wai Yu Lau, Gui-Bai Liang, Songnian Lin, Weiguo Liu, Shawn P. Walsh, Lihu Yang
-
Patent number: 7255900Abstract: In the compound of the formula (I), where: R1, R2 are each independently, for example, H or a straight-chain or branched alkyl radical p, q are each independently 0 or 1, i.e. at the value zero, —H is present at the appropriate position instead of —F M1 is —CO—O—, —O—CO—, —CH2—O—, —O—CH2—, —CF2—O—, —O—CF2—, —CH?CH—, —CF?CF—, —C?C—, —CH2—CH2—CO——O—, —O—CO—CH2—CH2—, —CH2—CH2—, —CF2—CF2—, —(CH2)4—, —OC(?O)CF?CF— or a single bond A1 is, for example, 1,4-phenylene R5 has the same possible definitions as specified for R1 and R2, with the exception of —M1—A1—R5, but independently of the definition of R1 and R2 X is H, F, OF3, CF3, OCF2H with the following provisos: a) at least one of p, q has to be 1 b) R1 and R2 must not at the same time be H c) R2 and X must not at the same time be H.Type: GrantFiled: April 28, 2005Date of Patent: August 14, 2007Assignee: Merck Patent GmbHInventors: Wolfgang Schmidt, Rainer Wingen, Barbara Hornung
-
Patent number: 7253207Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.Type: GrantFiled: August 2, 2004Date of Patent: August 7, 2007Assignee: Cellgate, Inc.Inventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun
-
Patent number: 7253292Abstract: A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound.Type: GrantFiled: May 8, 2002Date of Patent: August 7, 2007Assignee: Basell Polyolefine GmbHInventors: Ilya E. Nifant'ev, Igor A Kashulin, Pavel V. Ivchenko, Peter A. A. Klusener, Frans M. Kornorffer, Kees P. De Kloe, Jos J. H. Rijsemus
-
Patent number: 7241903Abstract: A metallocene compound of formula (I): wherein M is zirconium, titanium and hafnium; X is a hydrogen atom, a halogen atom or a hydrocarbon radical; R1 is a linear C1-C20-alkyl radical; R2 is a hydrogen atom or hydrocarbon R3, R4, R5, R6, R7, and R8, are hydrogen atoms or hydrocarbon radicals, A is a sulphur (S) atom or an oxygen (O) atom; Q is a radical of formula (II), (III) or (IV) being bonded to the indenyl at the position indicated by the symbol *; (II), (III), (IV) wherein T1 is a sulphur atom, an oxygen (O) atom or a NR; R9, R10 and R11 are hydrogen atoms or hydrocarbon radicals; T2, T3, T4, T5, and T6 are carbon atoms (C) or nitrogen atoms (N); m1, m2, m3, m4 and m5 are 0 or 1; R12, R13, R14, R15 and R16 are hydrogen atoms or hydrocarbon radicals with the provisos that at least one of R12, R13, R14, R15 and R16 is different from hydrogen atoms, and that no more than two of T2, T3, T4, T5 and T6 are nitrogen atoms.Type: GrantFiled: June 20, 2002Date of Patent: July 10, 2007Assignee: Basell Polyolefine GmbHInventors: Cornelia Fritze, Luigi Resconi, Jörg Schulte, Simona Guidotti
-
Patent number: 7144885Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disordersType: GrantFiled: February 21, 2003Date of Patent: December 5, 2006Assignee: Bayer Pharmaceuticals CorporationInventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott M. Wilhelm, Qian Zhao
-
Patent number: 7109327Abstract: The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom.Type: GrantFiled: June 14, 2002Date of Patent: September 19, 2006Assignee: Centre National de la Recherche Scientifique (CNRS)Inventors: Claude Thal, Catherine Guillou, Jean-Luc Beunard, Emmanuel Gras, Pierre Potier
-
Patent number: 7018685Abstract: The invention relates to fluorinated aromatics of the formula (I) where X is CH2, C?O, CF2, O or S, Y is H or F, with the proviso that Y has to be F when X is CH2, and where the other parameters are as defined in claim 1, and also to their use in liquid-crystal mixtures, and also to liquid-crystal mixtures comprising these compounds and to liquid-crystal displays comprising these mixtures.Type: GrantFiled: January 10, 2002Date of Patent: March 28, 2006Assignee: Merck Patent GmbHInventors: Wolfgang Schmidt, Rainer Wingen, Barbara Hornung
-
Patent number: 7005527Abstract: The present invention relates to a new process for the preparation of beraprost of formula (I) using new intermediates.Type: GrantFiled: July 25, 2002Date of Patent: February 28, 2006Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Tibor Szabo, Jozsef Bodi, Gyuia Dalmadi, Zsusanna Baloghnekardos, Zoltan Szevfrenyi
-
Patent number: 6951880Abstract: This invention provides novel compounds possessing antibacterial and/or antifungal and/or antitumor activity. Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.Type: GrantFiled: May 15, 2003Date of Patent: October 4, 2005Assignee: Genelabs Technologies, Inc.Inventors: Christoher Don Roberts, Jesse Daniel Keicher, Mikail Hakan Gezginci, Mark Douglas Velligan
-
Patent number: 6943182Abstract: The invention relates to cyclopentabenzofuran derivatives, process for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-?B-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.Type: GrantFiled: May 30, 2002Date of Patent: September 13, 2005Assignee: Bayer AktiengesellschaftInventors: Walter Guarnieri, Thomas Jaetsch, Andreas Schoop, Jörg Baumgarten, Axel Kretschmer, Horst-Peter Antonicek
-
Patent number: 6852754Abstract: The subject invention provides novel compositions of biologically active linderazulene terpene compounds which can advantageously be used for treating cancer and stopping cell proliferation.Type: GrantFiled: January 22, 2004Date of Patent: February 8, 2005Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Amy E. Wright, Ross E. Longley, Srinivasa Reddy Natala, John K. Reed
-
Patent number: 6809176Abstract: Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided.Type: GrantFiled: May 6, 2002Date of Patent: October 26, 2004Assignee: SLIL Biomedical, CorporationInventors: Andrei V. Blokhin, Benjamin Frydman, Laurence J. Marton, Karen M. Neder, Jerry Shunneng Sun
-
Publication number: 20040209945Abstract: The present invention relates to a new process for the preparation of beraprost of formula (I) using new intermediates.Type: ApplicationFiled: April 1, 2004Publication date: October 21, 2004Inventors: Tibor Szabo, Jozsef Bodi, Gyuia Dalmadi, Zsusanna Baloghnekardos, Zoltan Szevfrenyi
-
Publication number: 20040138282Abstract: The present invention provides compounds and methods of administering compounds to a subject taht can reduce &bgr;APP production and that is not toxic in a wide range of dosages. The present invention also provides non-carbamate compounds and methods of administering such compounds to a subject that can reduce &bgr;APP production and that is not tocix in a wide range of dosages. It has been discovered that either the racemic or enantiomerically pure non-carbamate compounds can be used to decrease &bgr;APP production.Type: ApplicationFiled: February 6, 2004Publication date: July 15, 2004Inventors: Nigel H. Greig, Karen T. Y. Shaw, Qiang-Sheng Yu, Harold W. Holloway, Timothy T. Sencrant, Tada Utsuki, Donald K. Ingram, Arnold Brossi, Anthony Giordano, Gordon Powers, Diane Davidson, Michael Sturgess
-
Publication number: 20040124399Abstract: The invention relates to fluorinated aromatics of the formula (I) 1Type: ApplicationFiled: January 26, 2004Publication date: July 1, 2004Inventors: Wolfgang Schmidt, Rainer Wingen, Barbara Hornung
-
Patent number: 6710075Abstract: The present invention provides compounds having a cyclopentabenzofuran core and the use of such compounds in therapy as well as compositions comprising said compounds.Type: GrantFiled: November 8, 2002Date of Patent: March 23, 2004Assignee: The Government of the State of Sarawak, MalaysiaInventors: Barbara Martha Meurer-Grimes, Jin Yu, Gino Luigi Vairo
-
Publication number: 20040038977Abstract: A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders.Type: ApplicationFiled: November 22, 2002Publication date: February 26, 2004Applicant: G.D. Searle & Co.Inventors: Jeffery S. Carter, Mark G. Obukowicz, Balekudru Devadas, John J. Talley, David L. Brown, Matthew J. Graneto, Stephen R. Bertenshaw, Donald J. Rogier, Srinivasan Raj Nagarajan, Cathleen E. Hanau, Susan J. Hartmann, Cindy L. Ludwig, Suzanne Metz, Donald E. Korte
-
Patent number: 6653345Abstract: A method of inhibiting mammalian C—C chemokine production by using a mammalian C—C chemokine synthesis inhibitor containing a prostaglandin I derivative as an active component to treat a variety of circulatory diseases, inflammation, allergic diseases, and renal diseases.Type: GrantFiled: May 6, 2002Date of Patent: November 25, 2003Assignee: Toray Industries, Inc.Inventors: Hajimu Kurumatani, Rie Sasaki, Hiroki Kumagai
-
Patent number: 6605632Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the descriptionType: GrantFiled: November 10, 2000Date of Patent: August 12, 2003Assignee: Les Laboratoires ServierInventors: Daniel Lesieur, Frédérique Klupsch, Gérald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
-
Patent number: 6602903Abstract: The invention relates to compounds of formula (I): and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.Type: GrantFiled: August 28, 2001Date of Patent: August 5, 2003Assignee: Les Laboratories ServierInventors: Gérald Guillaumet, Marie-Claude Viaud, Ahmed Mamai, Isabelle Charton, Pierre Renard, Caroline Bennejean, Béatrice Guardiola, Philippe Daubos
-
Patent number: 6518274Abstract: The invention relates to the use of cycloventabenzofuran derivatives for the production of a medicament for the treatment of nuclear factor of &kgr;B-dependent diseases.Type: GrantFiled: April 18, 2001Date of Patent: February 11, 2003Assignee: Bayer AktiengesellschaftInventors: Matthias Gehling, Jörg Baumgarten, Axel Kretschmer, Horst-Peter Antonicek, Peter Proksch, Bambang Wahyu Nugroho, Frank Bohnenstengel
-
Publication number: 20030013898Abstract: The present invention offers a pericyte protective agent having a prostanoic acid derivative as the effective component. The pericyte protective agent to which the present invention relates is effective in the prevention and treatment of diabetic retinopathy, diabetic neuropathy, diabetic nephropathy and the like.Type: ApplicationFiled: June 7, 2002Publication date: January 16, 2003Applicant: Toray Industries, Inc.Inventors: Hiroshi Yamamoto, Sho-ichi Yamagishi, Hajimu Kurumatani, Koichi Hisano, Kazuo Hirano
-
Publication number: 20020193427Abstract: The present invention relates to a C—C chemokine production inhibitor containing a prostanoic acid derivative as an active component, and a method of inhibiting C—C chemokine production by using the inhibitor. Medicines of the present invention are effective to cure circulatory diseases, inflammation, allergic diseases, renal diseases, etc.Type: ApplicationFiled: May 6, 2002Publication date: December 19, 2002Applicant: Toray Industries, Inc.Inventors: Hajimu Kurumatani, Rie Sasaki, Hiroki Kumagai
-
Patent number: 6423870Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m′ are such as defined in the description; n represents an integer such that 0≦n≦3; p represents an integer such as defined in the description; B represents a group (a) or (b). The invention is useful for preparing medicines.Type: GrantFiled: July 14, 2000Date of Patent: July 23, 2002Assignee: Les Laboratoires ServierInventors: Michel Langlois, Monique Mathe-Allainmat, Carole Jellimann, Jean Andrieux, Caroline Bennejean, Pierre Renard, Philippe Delagrange
-
Patent number: 6420413Abstract: A compound selected from those of formula (I): wherein: denotes single bond or double bond, n is integer from 1 to 6 inclusive, R1, and R2 represent a group selected from hydrogen, linear or branched (C1-C6)-alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and heteroarylalkyl, X represents a group selected from —CH═CH—, oxygen, S(O)m wherein m is integer from 0 to 2 inclusive, and NR3 wherein R3 represents a group as defined in the description, Y represents CH or CH2 depending on whether denotes single bond or double bond, or may have the additional meaning of oxygen when X represents oxygen, T represents monocyclic or polycyclic (C3-C10)cycloalkyl optionally containing within the ring system oxygen, selenium, S(O)p, NR3, or SiR4R5 wherein p, R3, R4, and R5 are as defined in the description, its isomers and addition salts thereof with a pharmaceutically-accepType: GrantFiled: April 12, 2001Date of Patent: July 16, 2002Assignee: Les Laboratories ServierInventors: Jean-Louis Peglion, Aimée Dessinges, Bertrand Goument, Mark Millan, Françoise Lejeune, Mauricette Brocco
-
Patent number: 6420408Abstract: Tricyclic sulfonamide compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurysm, heart failure, left ventricular dilation, restenosis, periodontal disease, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.Type: GrantFiled: April 10, 2001Date of Patent: July 16, 2002Assignee: Warner-Lambert CompanyInventors: Patrick Michael O'Brien, Joseph Armand Picard, Drago Robert Sliskovic
-
Patent number: 6420393Abstract: The invention relates to cyclopentabenzofuran derivatives, processes for their preparation, the use of cyclopentabenzofuran derivatives for the production of a medicament for the therapy of NF-&kgr;B-dependent diseases and medicaments which contain the cyclopentabenzofuran derivatives.Type: GrantFiled: March 26, 2001Date of Patent: July 16, 2002Assignee: Bayer AktiengesellschaftInventors: Walter Guarnieri, Thomas Jaetsch, Andreas Schoop, Jörg Baumgarten, Axel Kretschmer, Horst-Peter Antonicek