Halogen Attached Directly Or Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/504)
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Patent number: 8956799Abstract: A photoacid generator includes those of formula (I): wherein each Ra in formula 1 is independently H, F, a C1-10 nonfluorinated organic group, C1-10 fluorinated organic group, or a combination comprising at least one of the foregoing, provided at least one Ra is F or a C1-10 fluorinated organic group, the C1-10 fluorinated and nonfluorinated organic groups each optionally comprising O, S, N, or a combination comprising at least one of the foregoing heteroatoms; L1 is a linking group comprising a heteroatom comprising O, S, N, F, or a combination comprising at least one of the foregoing; G+ is an onium salt of the formula (II): wherein in formula (II), X is S or I, each R0 is independently C1-30 alkyl group; a polycyclic or monocyclic C3-30 cycloalkyl group; a polycyclic or monocyclic C4-30 aryl group; or a combination comprising at least one of the foregoing, provided at least one R0 is substituted where each R0 is a C6 monocyclic aryl group, and wherein when X is I, a is 2, and where X is S, a is 3,Type: GrantFiled: December 12, 2012Date of Patent: February 17, 2015Assignee: Rohm and Haas Electronic Materials LLCInventors: Emad Aqad, Cheng-Bai Xu, Mingqi Li, William Williams, III
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Publication number: 20150024267Abstract: The present invention relates to an electrolyte having improved high-rate charge and discharge property, and a capacitor comprising the same, and more particularly to an electrolyte having improved high-rate charge and discharge property comprising an aromatic compound, which comprises at least one compound of the following Chemical Formula 1 to Chemical Formula 11 that can induce resonance effect of electron movement, and which is a substituted organic compound in which a functional group is present at a location that can structurally prevent local polarization effect, and the boiling point of which is 80° C. or higher, wherein R in the Chemical Formula 1 to Chemical Formula 11 is at least one functional group selected from the alkyl group consisting of methyl, ethyl, propyl and butyl, and a capacitor comprising the same.Type: ApplicationFiled: September 30, 2014Publication date: January 22, 2015Inventor: Cheol Soo JUNG
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Patent number: 8933251Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.Type: GrantFiled: March 20, 2013Date of Patent: January 13, 2015Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
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Publication number: 20140275539Abstract: Provided herein are stabilized radioiodinated and astatinated compounds, and to methods for their preparation.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Ground Fluor Pharmaceuticals, Inc.Inventor: Stephen G. DiMagno
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Patent number: 8685274Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: GrantFiled: June 10, 2011Date of Patent: April 1, 2014Assignees: JNC Corporation, JNC Petrochemical CorporationInventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
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Publication number: 20140018414Abstract: The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water solubility of the anesthetic. The invention further provides methods for modulating the selectivity of an anesthetic for an anesthetic-sensitive receptor by altering or modifying the anesthetic to have higher or lower water solubility. The invention further provides methods of inducing anesthesia in a subject by administering via the respiratory pathways (e.g., via inhalational or pulmonary delivery) an effective amount of an anesthetic compound identified according to the present methods.Type: ApplicationFiled: March 14, 2013Publication date: January 16, 2014Inventor: Robert J. Brosnan
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Publication number: 20110309300Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: ApplicationFiled: June 10, 2011Publication date: December 22, 2011Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
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Patent number: 7989440Abstract: A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.Type: GrantFiled: December 30, 2008Date of Patent: August 2, 2011Assignee: Synthonics, Inc.Inventor: Thomas Piccariello
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Patent number: 7977344Abstract: The present invention includes novel compounds useful in the treatment of various disorders in particular infectious diseases, cancer, and allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, and as vaccine adjuvants.Type: GrantFiled: February 15, 2008Date of Patent: July 12, 2011Assignee: GlaxoSmithKline LLCInventors: Linos Lazarides, Stephen Allan Smith, Richard Stocker, Colin Jack Theobald
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Publication number: 20100261772Abstract: The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.Type: ApplicationFiled: May 24, 2010Publication date: October 14, 2010Inventors: Jing Fang, Dennis Heyer, Subba Reddy Katamreddy, Kenneth William Batchelor, Richard Dana Caldwell
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Patent number: 7759502Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.Type: GrantFiled: October 29, 2007Date of Patent: July 20, 2010Assignee: The Trustees of the University of PennsylvaniaInventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang
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Patent number: 7745483Abstract: Novel 2-halofuryl/thienyl-3-carboxamides of the formula (I) in which A, Hal, R, M and Z are as defined in the description, a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.Type: GrantFiled: January 22, 2005Date of Patent: June 29, 2010Assignee: Bayer CropScience AGInventors: Ralf Dunkel, Hans-Ludwig Elbe, Jörg Nico Greul, Benoit Hartmann, Peter Dahmen, Karl-Heinz Kuck, Ulrike Wachendorff-Neumann
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Patent number: 7678299Abstract: The present invention provides stock solutions for production of nonlinear-optical materials using a wet coating method. In particular, the invention provides a stock solution containing a nonlinear-optically active organic compound, which is a push-pull ?-conjugated compound having a particular chemical structure, having one or more cross-linkable functional groups. In addition, the invention provides a stock solution comprising a nonlinear-optically active organic compound having at least a certain chemical structure and a matrix-forming compound having one or more cross-linkable functional groups. Further, the invention provides a nonlinear-optical material and a nonlinear-optical device, both prepared by using the stock solutions.Type: GrantFiled: June 15, 2004Date of Patent: March 16, 2010Assignee: Fuji Xerox Co., Ltd.Inventors: Yasuhiro Yamaguchi, Tomozumi Uesaka, Hokuto Takada, Yasunari Nishikata
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Patent number: 7638256Abstract: Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing the pattern collapse by swelling, exhibit improved resistance to the etching used in the pattern transfer to an organic film, and are thus suited for use in resist compositions for the bilayer process.Type: GrantFiled: July 6, 2006Date of Patent: December 29, 2009Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeshi Kinsho, Takeru Watanabe, Mutsuo Nakashima, Yoshitaka Hamada
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Patent number: 7582780Abstract: The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.Type: GrantFiled: February 2, 2005Date of Patent: September 1, 2009Assignee: H. Lundbeck A/SInventor: Lars Ole Lyngso
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Patent number: 7531289Abstract: Cyclic structure-bearing fluorinated monomers having formula (1) wherein Z is a divalent organic group containing a polymerizable unsaturated group are useful to produce polymers for the manufacture of radiation-sensitive resist compositions which are fully transparent to radiation having a wavelength of up to 300 nm and have improved development properties.Type: GrantFiled: October 27, 2005Date of Patent: May 12, 2009Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeshi Kinsho, Takeru Watanabe, Masaki Ohashi, Koji Hasegawa, Seiichiro Tachibana
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Patent number: 7507840Abstract: Acceptor compounds useful for making hyperpolarizable organic chromophores having a ?-donor conjugated to a ?-acceptor through a ?-bridge.Type: GrantFiled: March 11, 2005Date of Patent: March 24, 2009Assignee: University of WashingtonInventors: Larry R. Dalton, Kwan-Yue Jen, Timothy Londergan, William Brenden Carlson, Gregory Phelan, Diyun Huang, Daniel Casmier, Todd Ewy, Nicholas Buker
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Publication number: 20080275253Abstract: A practical and efficient method for halogenation of activated carbon atoms using readily available N-haloimides and a Lewis acid catalyst has been disclosed. This methodology is applicable to a range of compounds and any halogen atom can be directly introduced to the substrate. The mild reaction conditions, easy workup procedure and simple operation make this method valuable from both an environmental and preparative point of view.Type: ApplicationFiled: February 29, 2008Publication date: November 6, 2008Inventors: Yanhua Zhang, Hisashi Yamamoto, Kazutaka Shibatomi
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Patent number: 7442815Abstract: A pellicle which is excellent in transmittance and durability against short wavelength light, and which can be used for photolithography by using e.g. a KrF excimer laser, is provided. A pellicle for exposure to a light having a wavelength of at most 200 nm, which comprises a frame and a pellicle membrane bonded to the frame by means of an adhesive, wherein the pellicle membrane and/or the adhesive comprises a polymer containing repeating units represented by the following formula (1): wherein Q represents a C1-3 polyfluoroalkylene group having a linear structure, or a group having at least one atom selected from hydrogen atoms and fluorine atoms in such a polyfluoroalkylene group substituted by a substituent comprising a polyfluoroalkyl group which may contain an ethereal oxygen atom, or the like, and X represents a hydrogen atom, a fluorine atom or a C1-3 polyfluoroalkyl group which may contain an ethereal oxygen atom.Type: GrantFiled: February 22, 2005Date of Patent: October 28, 2008Assignee: Asahi Glass Company, LimitedInventors: Ikuo Matsukura, Hidekazu Okamoto, Eisuke Murotani, Kazuya Oharu
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Patent number: 7091051Abstract: A chemiluminescence method characterized in that when a 1,2-dioxetane derivative of the formula 1: wherein each of R1, R2, R3, R4 and R5 which are independent of one another, is a hydrogen atom, an alkyl group or an aryl group, or each pair of R2 and R3, and R4 and R5, which are independent of each other, may form together a cyclic alkyl group, R6 is a hydroxyl group, an alkoxyl group, an aralkyloxy group, a group represented by —OSi(R8R9R10) (provided that each of R8, R9 and R10 which are independent of one another, is an alkyl group or an aryl group), a phosphate group or a group represented by S(C?O)R11 (provided that R11 is an alkyl group or an aryl group), and R7 is a hydrogen atom, a halogen atom, an alkyl group or an alkoxyl group, is let generate chemiluminescence by means of an activator selected from the group consisting of a base, an acid, a salt, a fluorine compound, an enzyme, a catalyst and an amine compound, a cationic surfactant and a fluorescent material are made to coexist.Type: GrantFiled: August 25, 2004Date of Patent: August 15, 2006Assignee: Tosoh CorporationInventors: Kenji Kitaoka, Masashi Yamada, Seiji Kawaguchi
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Patent number: 7078542Abstract: Nonlinear optically active compounds, methods for making nonlinear optically active compounds, compounds useful for making nonlinear optically active compounds, methods for making compounds useful for making nonlinear optically active compounds, macrostructures that include nonlinear optically active components, and devices including the nonlinear optically active compounds and the macrostructures.Type: GrantFiled: September 3, 2004Date of Patent: July 18, 2006Assignee: University of WashingtonInventors: Kwan-Yue Jen, Hong Ma, Sen Liu, Larry R Dalton
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Patent number: 7038068Abstract: A liquid/liquid extraction method is used for separating a perfluorinated polyether (PFPE) into two molecular-weight distributions using an alcohol or cyclic ether as one solvent and a fluorinated solvent as the other solvent. The more polar alcohol or cyclic ether solvent extracts the lower molecular weight PFPE and the less polar fluorinated solvent extracts the higher molecular weight PFPE. In addition, when the PFPE is a mixture of PFPEs with different end groups, such as a mixture of predominantly Z-Tetraol but with other PFPEs with Z-Dol end groups, there is an enrichment of the Z-Tetraol in the more polar solvent. The preferred PFPE is a mixture of PFPEs in as-purchased Z-Tetraol and the preferred solvents are methanol or trifluoroethanol as one solvent and a perfluorinated hydrocarbon, such as perfluorohexane, as the other solvent.Type: GrantFiled: March 16, 2004Date of Patent: May 2, 2006Assignee: Hitachi Global Storage Technologies Netherlands B.V.Inventor: John M. Burns
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Patent number: 6974658Abstract: Disclosed is a polymer compound for photoresist characterized in that the polymer compound is formed of a polymer compound having at least one skeleton represented by the following general formula (1), general formula (2A), general formula (2B) or general formula (2C):Type: GrantFiled: April 30, 2003Date of Patent: December 13, 2005Assignee: Kabushiki Kaisha ToshibaInventors: Naomi Shida, Toru Ushirogouchi, Takuya Naito
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Patent number: 6840965Abstract: The object of the invention are p-aminophenol derivatives of general formula (I) or physiologically tolerated, water-soluble salts thereof and oxidative coloring preparations based on a developer-coupler combination containing at least one p-aminophenol derivative of formula (I).Type: GrantFiled: March 9, 2001Date of Patent: January 11, 2005Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
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Patent number: 6624316Abstract: The present invention refers to a new procedure for obtaining and purifying 2-bromo-5-(2-bromo-2-nitrovinyl)-furan in one reaction step starting with 2-nitrovinylfuran, and maintains high indexes of purity and an appropriate yield. The process involves the direct bromination of 2-nitrovinylfuran using charcoal from the beginning of the reaction, followed by the neutralization and dehydrobromination using pyridine, and finally crystallizing and purifying the product obtained with ethanol and charcoal. With the new procedure it is possible to reduce the time of obtaining the final product, the reaction becomes endothermic instead of exothermic, which facilitates the work of the operators and allows for the scaling up of the reaction to superior levels. The process significantly decreases the amount of chemicals in the reaction, some of them with toxic properties.Type: GrantFiled: November 4, 2002Date of Patent: September 23, 2003Assignee: Centro de Bioactivos QuimicosInventors: Nilo R. Castañedo Cancio, Teófilo Exiquio Gaitan Placeres
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Publication number: 20030149272Abstract: The invention concerns a method for preparing a polyaromatic compound comprising at least a chain formation of two aromatic cycles. The method for preparing a polycyclic aromatic compound comprising at least a chain formation of two aromatic cycles is characterised in that it consists in reacting an aromatic compound bearing a leaving group and an alkaline organometallic compound, in the presence of an efficient amount of a nickel catalyst, said element being optionally complexed with at least a co-ordination agent or ligand.Type: ApplicationFiled: November 4, 2002Publication date: August 7, 2003Inventors: Henri-Jean Cristau, Corinne Bouchitte, Marc Taillefer, Jean-Francis Spindler, Thierry Schlama
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Publication number: 20030059710Abstract: A monomer containing an electron-withdrawing group of the present invention is represented by following Formula (a), (b) or (c): 1Type: ApplicationFiled: July 23, 2002Publication date: March 27, 2003Inventor: Keizo Inoue
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Publication number: 20030060571Abstract: Monofunctional polyfluorooxetane oligomers and polymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. The fluorooxetane oligomers or polymers can be copolymerized with generally cyclic ethers. Alternatively, the polyfluorooxetane oligomer or polymer having a single hydroxyl end group can be functionalized with a variety of compounds so as to yield a functional end group such as an acrylate, a methacrylate, an allylic, an amine, etc., with the functionalized oligomer or polymer being suitable for use in radiation curable or thermal curable coating compositions. These functionalized polymers can be copolymerized and cured to provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils.Type: ApplicationFiled: March 28, 2002Publication date: March 27, 2003Applicant: OMNOVA Solutions Inc.Inventors: Raymond J. Weinert, Guillermina C. Garcia, Aslam Malik, Roland Carlson, Robert E. Medsker
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Publication number: 20020183471Abstract: Perfluoro-4-alkyl-1,3-dioxoles having the general formula 1Type: ApplicationFiled: June 15, 2001Publication date: December 5, 2002Applicant: AUSIMONT S.P.AInventors: Antonio Russo, Walter Navarrini
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Publication number: 20020156200Abstract: Monofunctional polyfluorooxetane oligomers and polymers Zare prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. The fluorooxetane oligomers or polymers can be copolymerized with generally cyclic ethers. Alternatively, the poly-fluorooxetane oligomer or polymer having a single hydroxyl end group can be functionalized with a variety of compounds so as to yield a functional end group such as an acrylate, a methacrylate, an allylic, an amine, etc., with the functionalized oligomer or polymer being suitable for use in radiation curable or thermal curable coating compositions. These functionalized polymers can be copolymerized and cured to provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils.Type: ApplicationFiled: March 28, 2002Publication date: October 24, 2002Applicant: OMNOVA Solutions Inc.Inventors: Raymond J. Weinert, Guillermina C. Garcia, Aslam Malik, Roland Carlson, Robert E. Medsker
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Publication number: 20020143112Abstract: Monofunctional polyfluorooxetane oligomers and polymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. The fluorooxetane oligomers or polymers can be copolymerized with generally cyclic ethers. Alternatively, the polyfluorooxetane oligomer or polymer having a single hydroxyl end group can be functionalized with a variety of compounds so as to yield a functional end group such as an acrylate, a methacrylate, an allylic, an amine, etc., with the functionalized oligomer or polymer being suitable for use in radiation curable or thermal curable coating compositions. These functionalized polymers can be copolymerized and cured to provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils.Type: ApplicationFiled: March 28, 2002Publication date: October 3, 2002Applicant: OMNOVA Solutions Inc.Inventors: Raymond J. Weinert, Guillermina C. Garcia, Aslam Malik, Roland Carlson, Robert E. Medsker
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Publication number: 20020137853Abstract: Monofunctional polyfluorooxetane oligomers and polymers are prepared by the cationic polymerization of fluorooxetane monomers with a monoalcohol. The fluorooxetane oligomers or polymers can be copolymerized with generally cyclic ethers. Alternatively, the polyfluorooxetane oligomer or polymer having a single hydroxyl end group can be functionalized with a variety of compounds so as to yield a functional end group such as an acrylate, a methacrylate, an allylic, an amine, etc., with the functionalized oligomer or polymer being suitable for use in radiation curable or thermal curable coating compositions. These functionalized polymers can be copolymerized and cured to provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils.Type: ApplicationFiled: March 27, 2002Publication date: September 26, 2002Applicant: OMNOVA Solutions Inc.Inventors: Raymond J. Weinert, Guillermina C. Garcia, Aslam Malik, Roland Carlson, Robert E. Medsker
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Publication number: 20020132365Abstract: A 1,2-dioxetane derivative of the formula (I): 1Type: ApplicationFiled: March 7, 2002Publication date: September 19, 2002Applicant: TOSOH CORPORATIONInventors: Masakatsu Matsumoto, Nobuko Watanabe, Masashi Yamada
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Patent number: 6369102Abstract: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.Type: GrantFiled: March 6, 2001Date of Patent: April 9, 2002Assignee: Alcon Manufacturing, Ltd.Inventor: Robert D. Selliah
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Patent number: 6197812Abstract: Substituted tetrahydrofuran analogs of prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.Type: GrantFiled: November 15, 1999Date of Patent: March 6, 2001Assignee: Alcon Laboratories, Inc.Inventors: Robert D. Selliah, Mark R. Hellberg, Peter G. Klimko, Verney L. Sallee, Paul W. Zinke
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Patent number: 6127554Abstract: Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.Type: GrantFiled: May 14, 1999Date of Patent: October 3, 2000Assignees: The University of North Carolina at Chapel Hill, Georgia State UniversityInventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, Iris Francesconi
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Patent number: 6124484Abstract: The present invention provides a method for the preparation of triarylmethyl protecting group reagents. The reagents are prepared from reaction effluent from the cleavage step of oligonucleotide synthetic regimes.Type: GrantFiled: July 17, 1998Date of Patent: September 26, 2000Assignee: Isis Pharmaceuticals, Inc.Inventors: Yogesh S. Sanghvi, Zhiqiang Guo
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Patent number: 6066766Abstract: 4-Chlorobiphenyls are prepared by reacting a haloaromatic with an aryl Grignard compound, where halogen is chlorine, bromine or iodine, in the presence of a palladium catalyst of the formula (IV) ##STR1##Type: GrantFiled: August 3, 1999Date of Patent: May 23, 2000Assignee: Clariant GmbHInventors: Steffen Haber, Stefan Scherer, Andreas Meudt, Antje Noerenberg
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Patent number: 6063928Abstract: Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar.sup.1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, indolyl, indazolyl and benzimidazolyl, which is bonded to X.sup.1 through a ring nitrogen atom, and which may be optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino, C.sub.1-4 alkyl and the like; X.sup.1 is a direct bond or C.sub.1-4 alkylene; Ar.sup.2 is phenylene optionally substituted with halo, hydroxy, cyano, amino and the like; X.sup.2 is --A--X-- or --X--A-- wherein A is a direct bond or C.sub.1-4 alkylene and X is oxy, thio, sulfinyl or sulfonyl; Ar.sup.3 is phenylene, pyridylene, thienylene, furylene, oxazolylene or thiazolylene optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino, C.sub.1-4 alkyl and the like; R.sup.1 and R.Type: GrantFiled: December 8, 1998Date of Patent: May 16, 2000Assignee: Pfizer IncInventors: Rodney W. Stevens, Takashi Mano, Kazunari Nakao, Yoshiyuki Okumura
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Patent number: 6025392Abstract: Substituted tetrahydrofuran analogs of F-series prostaglandins and methods of their use in treating glaucoma and ocular hypertension are disclosed.Type: GrantFiled: July 2, 1998Date of Patent: February 15, 2000Assignee: Alcon Laboratories, Inc.Inventors: Robert D. Selliah, Mark R. Hellberg, Peter G. Klimko, Verney L. Sallee, Paul W. Zinke
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Patent number: 6008247Abstract: Compounds according to the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are each independently selected from the group consisting of H, loweralkyl, aryl, alkylaryl, aminoalkyl, aminoaryl, halogen, oxyalkyl, oxyaryl, or oxyarylalkyl; R.sub.3 and R.sub.4 are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkylaryl, aryl, oxyaryl, aminoalkyl, aminoaryl, or halogen; and X and Y are located in the para or meta positions and are each selected from the group consisting of H, loweralkyl, oxyalkyl, and ##STR2## wherein: each R.sub.5 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R.sub.5 groups together represent C.sub.2 to C.sub.10 alkyl, hydroxyalkyl, or alkylene; and R.sub.Type: GrantFiled: February 27, 1998Date of Patent: December 28, 1999Assignees: The University of North Carolina at Chapel Hill, Georgia State UniversityInventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, Iris Francesconi
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Patent number: 5994397Abstract: Substituted tetrahydrofuran analogs of prostagladins and methods of their use in treating glaucoma and ocular hypertension are disclosed.Type: GrantFiled: April 4, 1997Date of Patent: November 30, 1999Assignee: Alcon Laboratories, Inc.Inventors: Robert D. Selliah, Peter G. Klimko
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Patent number: 5886167Abstract: 2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.- and -.beta.-D-ribofuranosyl bromides. Further, according to this invention, 2'-deoxy-2'-epi-2'-fluorocoformycin and 2'-deoxy-8,2'-diepi-2'-fluorocoformycin are synthesized by a multi-stage process starting from 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.-D-arabinofuranosyl bromide. These four 2'-fluoro derivatives of coformycin are novel compounds and have high enzyme-inhibitory activities against adenosine deaminase. In particular, these novel compounds are useful substances which exhibit therapeutic effects on acute lymphocytic leukemias due to their high enzyme-inhibitory activities above-mentioned. In addition, a variety of intermediates are obtained as novel compounds which are useful for the synthesis of the aforesaid novel 2'-fluoro derivatives of coformycin.Type: GrantFiled: December 15, 1997Date of Patent: March 23, 1999Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Sumio Umezawa, Tsutomu Tsuchiya, Yoshiaki Takahashi
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Patent number: 5883106Abstract: Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar.sup.1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, indolyl, indazolyl and benzimidazolyl, which is bonded to X.sup.1 through a ring nitrogen atom, and which may be optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino, and C.sub.1-4 alkyl; X.sup.1 is a direct bond or C.sub.1-4 alkylene; Ar.sup.2 is phenylene optionally substituted with halo, hydroxy, cyano, and amino X.sup.2 is --A--X-- or --X--A-- wherein A is a direct bond or C.sub.1-4 alkylene and X is oxy, thio, sulfinyl or sulfonyl; Ar.sup.3 is phenylene, pyridylene, thienylene, furylene, oxazolylene or thiazolylene optionally substituted with one or two substituents selected from halo, hydroxy, cyano, amino and C.sub.1-4 alkyl; R.sup.1 and R.sup.2 are each C.sub.Type: GrantFiled: February 6, 1998Date of Patent: March 16, 1999Assignee: Pfizer Inc.Inventors: Rodney W. Stevens, Takashi Mano, Kazunari Nakao, Yoshiyuki Okumura
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Patent number: 5877333Abstract: A compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are each independently a hydrogen atom, an alkyl group or an aryl group, or wherein R.sup.2 and R.sup.3 together and R.sup.4 and R.sup.5 together are joined as a cycloalkyl group; wherein R.sup.6 is a hydroxyl group, an alkoxyl group, an aralkyloxy group, or --OSi (R.sup.8 R.sup.9 R.sup.10) in which R.sup.8, R.sup.9 and R.sup.10 are each independently an alkyl group or a phosphate salt group and R.sup.7 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxyl group.Type: GrantFiled: November 5, 1997Date of Patent: March 2, 1999Assignee: Fujirebio Inc.Inventors: Masakatsu Matsumoto, Nobuko Watanabe, Hisako Kobayashi, Hiroshi Ikawa
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Patent number: 5831103Abstract: Halogen magnesium aluminum hydridohalides of the general formula?Mg.sub.2 X.sub.3 (ether).sub.y !.sup.+ ?AlH.sub.4-n X.sub.n !.sup.-wherein X is chlorine, bromine or iodine, y is a number from 0 to 6, n is a number from 1 to 3 and ether is an aliphatic or cylcoaliphatic ether with 2 to 30 carbon atoms, with the exception of t-butyl ether, with a dipole moment>0.5 Debye and a melting point of<0.degree. C. are prepared. The invention furthermore relates to a method for the synthesis of these compounds and to a method of reducing functional organic compounds utilizing the inventive compounds.Type: GrantFiled: February 2, 1996Date of Patent: November 3, 1998Assignee: Th. Goldschmidt AGInventor: Wilfried Knott
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Patent number: 5773607Abstract: 2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.- and -.beta.-D-ribofuranosyl bromides. Further, according to this invention, 2'-deoxy-2'-epi-2'-fluorocoformycin and 2'-deoxy-8,2'-diepi-2'-fluorocoformycin are synthesized by a multi-stage process starting from 3,5-di-O-benzoyl-2-deoxy-2-fluoro-.alpha.-D-arabinofuranosyl bromide. These four 2'-fluoro derivatives of coformycin are novel compounds and have high enzyme-inhibitory activities against adenosine deaminase. In particular, these novel compounds are useful substances which exhibit therapeutic effects on acute lymphocytic leukemias due to their high enzyme-inhibitory activities above-mentioned. In addition, a variety of intermediates are obtained as novel compounds which are useful for the synthesis of the aforesaid novel 2'-fluoro derivatives of coformycin.Type: GrantFiled: March 22, 1996Date of Patent: June 30, 1998Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Tomio Takeuchi, Sumio Umezawa, Tsutomu Tsuchiya, Yoshiaki Takahashi
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Patent number: 5753776Abstract: This invention pertains to a method for liquid phase fluorination for perfluorination of a wide variety of hydrogen-containing compounds.Type: GrantFiled: June 6, 1995Date of Patent: May 19, 1998Assignee: Exfluor Research CorporationInventors: Thomas R. Bierschenk, Timothy J. Juhlke, Hajimu Kawa, Richard J. Lagow
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Patent number: 5710289Abstract: Disclosed is a process for the preparation of 3,4-dichlorotetrahydrofuran, 3,4-dibromotetrahydrofuran, 2,3-dichlorotetrahydrofuran, and 2,3-dibromotetrahydrofuran by the reaction of 2,5- or 2,3-dihydrofuran with chlorine or bromine in the presence of a quaternary onium halide compound. The reaction preferably is carried out by the addition of the dihydrofuran and chlorine or bromine to an organic, halogenation solvent containing chlorine or bromine and the quaternary onium halide compound.Type: GrantFiled: January 7, 1997Date of Patent: January 20, 1998Assignee: Eastman Chemical CompanyInventors: Stephen N. Falling, Patricia Lopez
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Patent number: 5674949Abstract: This invention pertains to a method for liquid-phase fluorination for perfluorination of a wide variety of hydrogen-containing compounds.Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: Exfluor Research CorporationInventors: Thomas R. Bierschenk, Timothy Juhlke, Hajimu Kawa, Richard J. Lagow