Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/78)
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Publication number: 20120157373Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.Type: ApplicationFiled: February 29, 2012Publication date: June 21, 2012Applicant: MEDTRONIC, INC.Inventors: Paul Hsien-Fu Wu, Catherine E. Taylor, Linnus Cheruiyot, Jianwei Li, Terese A. Bartlett, Matt Bergan
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Publication number: 20120142934Abstract: A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.Type: ApplicationFiled: March 10, 2011Publication date: June 7, 2012Inventors: Chien-Hong CHENG, Jaganathan Karthikeyan, Pang-Chi Huang
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Patent number: 8193373Abstract: Compound having the formula below are disclosed herein: formula (I). Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: December 4, 2007Date of Patent: June 5, 2012Assignee: Allergan, Inc.Inventors: Mark Holoboski, Robert M. Burk, Mari Posner
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Publication number: 20120100486Abstract: A sulfonium salt of a naphthyltetrahydrothiophenium cation having a fluoroalkoxy chain with a specific anion is provided. The sulfonium salt is used as a photoacid generator to form a resist composition which when processed by immersion lithography, offers advantages of restrained dissolution in the immersion water and less pattern dependence or dark/bright bias.Type: ApplicationFiled: September 23, 2011Publication date: April 26, 2012Inventors: Masayoshi Sagehashi, Youichi Ohsawa, Koji Hasegawa, Takeshi Kinsho, Tomohiro Kobayashi
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Patent number: 8153667Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.Type: GrantFiled: September 14, 2007Date of Patent: April 10, 2012Assignee: Cephalon, Inc.Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Rabindranath Tripathy
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Publication number: 20120065064Abstract: Compounds of the formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: December 12, 2009Publication date: March 15, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: John Benjamin Taylor, Jeffrey Steven Wailes, Stephane André Marie Jeanmart, Mangala Govenkar
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Publication number: 20120065066Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: May 16, 2009Publication date: March 15, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Christopher John Mathews, Louisa Robinson, Stephane Andre Marie Jeanmart
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Publication number: 20120045724Abstract: A sulfonium salt of a naphthylsulfonium cation having a hydrophilic phenolic hydroxyl group or ethylene glycol chain with a specific anion is provided. The sulfonium salt is used as a photoacid generator to form a resist composition which when processed by immersion lithography, offers advantages of restrained dissolution in the immersion water and less pattern dependence or dark-bright difference.Type: ApplicationFiled: August 22, 2011Publication date: February 23, 2012Inventors: Youichi OHSAWA, Masayoshi SAGEHASHI, Tomohiro KOBAYASHI
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Publication number: 20110318690Abstract: The present invention provides a compound represented by the formula (I): wherein R1 represents a hydrogen atom or a methyl group, A1 represents a single bond or *—(CH2)m—CO—O— in which m represents an integer of 1 to 4 and * represents a binding position to —O—, B1 represents —O— or —S—, B2 represents —CH2—, —O— or —S— and W1 represents an optionally substituted aromatic ring, a resin comprising a structural unit derived from the compound and a photoresist composition comprising the resin.Type: ApplicationFiled: June 24, 2011Publication date: December 29, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Yuko YAMASHITA, Hyungjoo KIM
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Publication number: 20110275835Abstract: The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine with higher yield and lower cost by using the (S)-methylhydroxylaminopropanol compound as an intermediate.Type: ApplicationFiled: May 6, 2010Publication date: November 10, 2011Inventors: Bo-Fong Chen, Feng-Ju Lu, Jinun-Ban Yeh, Wei-chyun Wong
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Publication number: 20110201819Abstract: Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.Type: ApplicationFiled: December 11, 2008Publication date: August 18, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventor: Hideo Shimizu
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Publication number: 20110200940Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which can have one or more fluorine atoms, R3 represents a hydrogen atom or a methyl group, and Z1+ represents an organic counter cation, and a photoresist composition containing the same.Type: ApplicationFiled: February 15, 2011Publication date: August 18, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Koji ICHIKAWA, Hiromu SAKAMOTO
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Patent number: 7985767Abstract: Compounds of the formula are disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: GrantFiled: September 6, 2007Date of Patent: July 26, 2011Assignee: Allergan, Inc.Inventors: David W. Old, Robert M. Burk, Todd S. Gac
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Publication number: 20110143197Abstract: An electrode active material for a power storage device of the invention includes an organic compound having, in the molecule, a plurality of electrode reaction sites and a linker site. The electrode reaction sites are residues of a 9,10-phenanthrenequinone compound that contributes to an electrochemical redox reaction. The linker site is disposed between the plurality of electrode reaction sites, does not contain any ketone group, and does not contribute to the electrochemical redox reaction. The electrode active material for a power storage device of the present invention is inhibited from being dissolved in an electrolyte and has a high energy density. By using the electrode active material, it is possible to obtain a power storage device having a high energy density and excellent charge/discharge cycle characteristics.Type: ApplicationFiled: February 16, 2009Publication date: June 16, 2011Inventors: Yu Ohtsuka, Nobuhiko Hojo, Junichi Yoshida, Toshiki Nokami
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Publication number: 20110117494Abstract: A salt represented by the formula (X): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, L1 and L2 independently each represent a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO—, ring W1 represents a C3-C36 saturated hydrocarbon ring, R5 is independently in each occurrence a C1-C6 alkyl group or a C1-C6 alkoxy group, w represents an integer of 0 to 2, v represents 1 or 2, Z+ represents an organic counter ion, and W10 represents a group represented by the formula (X-1): wherein ring W2 represents a C3-C36 saturated hydrocarbon ring, R1 represents a C1-C12 hydrocarbon group, R2 is independently in each occurrence a C1-C6 alkyl group or a C1-C6 alkoxy group, and represents an integer of 0 to 2, or a group represented by the formula (X-2): wherein ring W3 represents a C4-C36 lactone ring, R3 is independently in each occurrence a C1-C6 alkyl group, a C1-C6 alkoxy group or a C2-C7 alkoxycarbonyl group aType: ApplicationFiled: November 16, 2010Publication date: May 19, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Koji ICHIKAWA, Mitsuyoshi OCHIAI, Masako SUGIHARA
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Publication number: 20110102970Abstract: The present invention relates to a monomer having the general formula (I) in which R1 and R2 stand, independently of one another, for hydrogen, for an optionally substituted C1-C20-alkyl group or C1-C20-oxyalkyl group, optionally interrupted by 1 to 5 oxygen atoms and/or sulfur atoms, or jointly for an optionally substituted C1-C20-dioxyalkylene group or C6-C20-dioxyarylene group, wherein the monomer has a colour in a range of a Hazen colour number determined according to test method described herein of at least 20, to a Gardner colour number determined according to test method described herein of not more than 5. The present invention also relates to a method for the manufacture of a capacitor, a capacitor obtained by this method and to the use of a monomer.Type: ApplicationFiled: September 30, 2010Publication date: May 5, 2011Applicant: H.C. Starck Clevios GmbHInventors: Udo Merker, Klaus Wussow, Knud Reuter, Andreas Elschner
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Publication number: 20110092578Abstract: The present invention provides compounds and methods of using of the compounds as anti-infective and anthelminitc agents. In a preferred embodiment, the present invention provides the following compound of Formula III: wherein: R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is OH or CH(2n+1)O, wherein n is 1-10; R2 is OH or CH(2n+1)O, where n is 1-10; W is alkyl, phenyl, halophenyl, pyridyl, piperidyl, or a substituted or unsubstituted aryl group, including unsubstituted and substituted aromatic heterocycles; and L is an optional linker or linking group selected from O, S, NH, CF2, or CH2, and x=0 or 1, i.e., if x=0, no linking group is present.Type: ApplicationFiled: December 20, 2010Publication date: April 21, 2011Inventors: Aaron P. Monte, M. Shahjahan Kabir, Marc A. Rott, William R. Schwan, James M. Cook, III, Jennifer A. Miskowski
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Publication number: 20110046147Abstract: The invention relates to 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the preparation thereof and the use thereof for the treatment and prophylaxis of hormone-related, especially estrogen-related or androgen-related, diseases.Type: ApplicationFiled: August 22, 2008Publication date: February 24, 2011Applicant: UNIVERSITAT DES SAARLANDESInventors: Rolf Hartmann, Martin Frotscher, Sandrine Oberwinkler, Emmanuel Bey
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Publication number: 20110027716Abstract: According to one embodiment, an actinic-ray- or radiation-sensitive resin composition includes any of the compounds (A) of general formula (I) below that when exposed to actinic rays or radiation, generates an acid and a resin (B) whose rate of dissolution into an alkali developer is increased by the action of an acid. (The characters used in general formula (I) have the meanings mentioned in the description.Type: ApplicationFiled: July 9, 2010Publication date: February 3, 2011Applicant: FUJIFILM CORPORATIONInventors: Shuhei YAMAGUCHI, Akinori Shibuya
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Publication number: 20110020749Abstract: The object of the present invention is to provide a chemically amplified resist composition excellent in a resolution and a mask error enhancement factor. By employing the salt represented by the formulae (A1) as an acid generator of a resist composition, the above mentioned object is achieved. wherein Z+ represents an organic cation, Q1 and Q2 each independently represent a fluorine atom or a perfluoroalkyl group, Ra2 represents a divalent alicyclic hydrocarbon group pr the like, Ra2 represents an elimination group represented by the formulae (II-1) or (II-2). In the formulae (II-1) or (II-2), Ra3 and Ra4 each independently represent a hydrogen atom or an aliphatic hydrocarbon group, Ra5 represents an aliphatic hydrocarbon group, Ra6 represents a divalent aliphatic hydrocarbon group, and Ra7 represents an aliphatic hydrocarbon group.Type: ApplicationFiled: July 27, 2010Publication date: January 27, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Koji Ichikawa, Isao Yoshida, Satoshi Yamaguchi
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Patent number: 7863319Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.Type: GrantFiled: January 16, 2007Date of Patent: January 4, 2011Assignee: Allergan, Inc.Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
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Publication number: 20100305337Abstract: The present invention relates to the preparation of compounds of the general formula II which can be obtained by 1,4 addition of 2-oxoalkanoates or 2-oxocarboxylic acids onto the appropriate ketones. The present invention also relates to the use of the PigD protein for catalysis of 1,4 additions of 2-oxoalkanoates/-carboxylic acids, for example pyruvate/pyruvic acid or 2-oxobutyrate/2-oxobutyric acid, onto aliphatic, aromatic and heterocyclic ?,?-unsaturated ketones. The 1,4 additions are effected here with CO2 elimination. The use of the PigD protein as a catalyst in the aforementioned 1,4 additions enables the synthesis of addition products with stereoactive centers these addition products being preparable with an enantiomeric excess of more than 80% ee.Type: ApplicationFiled: April 18, 2008Publication date: December 2, 2010Applicant: ALBERT-LUDWIGS-UNIVERSITAT FREIBURGInventors: Michael Müller, Carola Dresen, Michael Richter
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Publication number: 20100298140Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.Type: ApplicationFiled: September 1, 2008Publication date: November 25, 2010Applicant: SYNGENTA LIMITEDInventors: Stephane Andre Marie Jeanmart, John Benjamin Taylor, Melloney Tyte, Christopher John Mathews, Steve Smith
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Publication number: 20100279868Abstract: Pyrandione, thiopyrandione and cyclohexanetrione compounds of formula (I), which are suitable for use as herbicides.Type: ApplicationFiled: June 26, 2008Publication date: November 4, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Stephane Andre Marie Jeanmart, Christopher John Mathews, Steve Smith, John Benjamin Taylor, Mangala Govenkar
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Publication number: 20100249165Abstract: This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions.Type: ApplicationFiled: June 3, 2008Publication date: September 30, 2010Applicants: University of Copenhagen, NeuroSearch A/SInventors: Ulrik Gether, Kenneth Madsen, Thor Seneca Thorsen, Dan Peters, Tino Dyhring, Lars Christian Rønn
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Publication number: 20100240617Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.Type: ApplicationFiled: February 15, 2010Publication date: September 23, 2010Inventors: Kevin R. Lynch, Timothy L. MacDonald, Kevin Guckian, Edward Yin-shiang Lin, Bin Ma
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Publication number: 20100240722Abstract: There is provided a fluorine-containing organosulfur compound having an excellent controlling effect m represents 0 or 1; n represents 0, 1 or 2; A represents an optionally substituted 5-membered aromatic heterocyclic group; R1 and R3 are independently represent an optionally substituted C1-C4 chain hydrocarbon group, —C(=G)R5, cyano, halogen or hydrogen; R2 and R4 independently represent an optionally substituted C1-C4 chain hydrocarbon group, halogen or hydrogen; Q represents a C1-C5 haloalkyl group containing at least one fluorine, or fluorine; G represents oxygen or sulfur; and R5 represents optionally substituted C1-C4 alkyl, hydroxyl, optionally substituted C1-C4 alkoxy, optionally substituted C3-C6 alkenyloxy, optionally substituted C3-C6 alkynyloxy, amino, optionally substituted C1-C4 alkylamino, optionally substituted di(C1-C4 alkyl)amino, C2-C5 cyclic amino or hydrogen.Type: ApplicationFiled: August 28, 2008Publication date: September 23, 2010Applicant: Sumitomoo Chemical Company, LimitedInventors: Koji Kumamoto, Hiroyuki Miyazaki
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Publication number: 20100240713Abstract: This invention is directed to compounds of formula (I), wherein m, formula (II), R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.Type: ApplicationFiled: June 5, 2008Publication date: September 23, 2010Applicant: XENON PHARMACEUTICALS INC.Inventors: Jean-Jacques Cadieux, Mikhail Chafeev, Julia Fonarev, Jianmin Fu, Rajender Kamboj, Vishnumurthy Kodumuru, Serguei Sviridov, Zaihui Zhang
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Publication number: 20100196758Abstract: An electrode active material for a power storage device of the invention includes a ketone compound that includes a ring structure in a molecule, the ring structure being a five-membered or seven-membered ring composed of atoms at least three adjacent ones of which are each bonded to a ketone group. The electrode active material for a power storage device of the invention has a high weight-energy density and good reversibility of oxidation-reduction reaction. The use of the electrode active material for a power storage device of the invention can provide a power storage device having a high capacity, a high voltage, and good charge/discharge cycle characteristics.Type: ApplicationFiled: February 16, 2009Publication date: August 5, 2010Inventors: Nobuhiko Hojo, Yu Ohtsuka, Junichi Yoshida, Toshiki Nokami
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Publication number: 20100190868Abstract: Novel photochromic and electrochromic hexadiene compounds are described. The compounds are reversibly convertible between ring-open and ring-closed isomeric forms as indicated in structures I(o) and I(c) below. (See formula in original abstract of application) The conversion between the different isomeric forms may be induced by light or electricity. In one embodiment the compounds may include a charge transfer moiety including electron donor and acceptor groups. The electron donor and acceptor are linearly conjugated in the ring-open form to enable electron transfer but are electrically insulated in the ring-closed form. Methods for synthesizing the compounds from photochemically and/or electrically inert precursors are also described. For example, the photoresponsive compounds may be synthesized by reacting diene precursors with dienophiles in a condensation reaction. The compounds may be utilized in reactivity-gated photochromic or electrochromic applications.Type: ApplicationFiled: May 25, 2006Publication date: July 29, 2010Applicant: SWITCH MATERIALS INC.Inventors: Neil R. Branda, Bettina Wuestenberg, Vincent Lemieux, Michael Adams, Simon Gauthier
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Publication number: 20100173774Abstract: Cyclohexanedione compounds, and derivatives thereof, which are substituted in 5-position, are suitable for use as herbicides.Type: ApplicationFiled: March 7, 2008Publication date: July 8, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Michel Muehlebach, William Lutz, Jean Wenger, John Finney, Christopher John Matthews, Delphine Fawke
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Publication number: 20100158798Abstract: The present invention embraces compounds selected for interacting with the Fingers-Palm pocket of telomerase and use thereof for modulating the activity of telomerase and preventing or treating diseases or conditions associated with telomerase.Type: ApplicationFiled: February 8, 2010Publication date: June 24, 2010Inventor: Emmanuel Skordalakes
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Publication number: 20100121062Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T ??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.Type: ApplicationFiled: September 25, 2009Publication date: May 13, 2010Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
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Publication number: 20100111888Abstract: Disclosed are compounds having the ability to modulate, namely to improve, enhance and or modify fragrance compositions due to their ability to inhibit cytochrome P450 enzymes, e.g. CYP2A13 and CYP2B6.Type: ApplicationFiled: March 20, 2008Publication date: May 6, 2010Applicant: GIVAUDAN SAInventors: Boris Schilling, Thierry Granier, Georg Frater, Andreas Hanhart
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Publication number: 20100063041Abstract: The present invention provides a novel phenylpropionic acid derivative and a PPAR-? modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-? and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.Type: ApplicationFiled: March 7, 2008Publication date: March 11, 2010Inventors: Ho-Sang Moon, Moo-Hi Yoo, Soon-Hoe Kim, Joong-In Lim, Moon-Ho Son, Mi-Kyung Kim, Chang-Yell Shin, Jin-Kwan Kim, Sang-Kuk Park, Yu-Na Chae, Hyun-Joo Shim, Sun-Ho Jeon, Hae-Sun Kim, Gil-Tae Wie, Dong-Hwan Kim, Byung-Kyu Lee, Chan-Sun Park, Byung-Nak Ahn, Eunkyung Kim, Myung-Ho Bae, Young-Ah Shin, Youn Hur, Chun-Ho Lee, Hyun-Ho Choi, Bongtae Kim, Wonee Chong
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Publication number: 20100063303Abstract: Compound having the formula below are disclosed herein: formula (I). Therapeutic methods, compositions, and medicaments related thereto are also disclosed.Type: ApplicationFiled: December 4, 2007Publication date: March 11, 2010Applicant: ALLERGAN, INC.Inventors: Mark Holoboski, Robert M. Burk, Mari F. Posner
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Patent number: 7667050Abstract: The present invention provides a salt represented by the formula (I): wherein X represents a C3-C30 divalent group containing at least one divalent alicyclic hydrocarbon group, and at least one —CH2— in the C3-C30 divalent group may be substituted with —O— or —CO—, Y represents a C3-C30 cyclic hydrocarbon group which may be substituted with at least one group selected from a C1-C6 alkoxy group, a C1-C4 perfluoroalkyl group, a C1-C6 hydroxyalkyl group, a hydroxyl group and a cyano group, and at least one —CH2— in the C3-C30 cyclic hydrocarbon group may be substituted with —O— or —CO—, Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, and A+ represents an organic counter ion.Type: GrantFiled: August 15, 2007Date of Patent: February 23, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Junji Shigematsu, Isao Yoshida, Yukako Harada, Masumi Suetsugu
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Publication number: 20100029735Abstract: Disclosed herein is a compound of the formula. Therapeutic methods, compositions, and medicaments for the treatment of glaucoma or ocular hypertension related thereto are also disclosed.Type: ApplicationFiled: January 22, 2008Publication date: February 4, 2010Inventors: David W. Old, Vinh X. Ngo
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Patent number: 7612217Abstract: The present invention provides a sulfonium compound represented by the formula (I): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, and A+ represents an organic counter ion.Type: GrantFiled: August 10, 2007Date of Patent: November 3, 2009Assignee: Sumitomo Chemical Company, LimitedInventors: Hiromu Sakamoto, Yukako Harada
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Publication number: 20090253919Abstract: Chiral thioureas are effective catalysts for the borane reduction of prochiral ketones to optically active alcohols. A prochiral ketone may be reduced to an optically active alcohol in the presence of a substantially sub-stoichiometric amount of chiral thiourea. The asymmetric thiourea compound of the present invention may be produced according to a production method described herein.Type: ApplicationFiled: April 3, 2008Publication date: October 8, 2009Applicant: Board of RegentsInventors: Derun Li, John R. Falck
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Patent number: 7598423Abstract: This application relates to a substituted hydroxyphenyl ketone compound of formula I, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof and its use in treating migraine. This application also relates to processes for preparing a compound of formula I, and intermediate compounds useful therein.Type: GrantFiled: November 15, 2005Date of Patent: October 6, 2009Assignee: Eli Lilly and CompanyInventors: Thomas Daniel Aicher, Guillermo S. Cortez, Todd Michael Groendyke, Albert Khilevich, James Allen Knobelsdorf, Fredrik Pehr Marmsater, Jeffrey Michael Schkeryantz, Tony Pisal Tang, Nicholas Andrew Magnus
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Publication number: 20090247771Abstract: The present invention is directed to a process for the preparation of an enantiomerically enriched compound of formula II wherein, R1, R2 and R3 are each independently selected from hydrogen, halogen, substituted or unsubstituted lower alkyl or substituted or unsubstituted aryl; X is —C(?O)-Z or —Y, wherein —Y is selected from —CH2—OR4, —CH2-halogen or —CH2—NR6R7; wherein Z is selected from —NR6R7 or —OR5, wherein R5 is selected from hydrogen, substituted or unsubstituted lower alkyl or ester activating group; R4 is selected from hydrogen, hydroxyl protecting group or hydroxyl activating group; R6 and R7 are each independently selected from hydrogen, amino protecting group, amido protecting group or substituted or unsubstituted lower alkyl; or a pharmaceutically acceptable salt, complex or solvate thereof; which comprises an enantioselective addition with a thienyl zinc reagent, in the presence of a chiral ligand.Type: ApplicationFiled: February 27, 2007Publication date: October 1, 2009Inventors: Helmut Heinrich Buschmann, Antoni Torrens Jover, Matthias Lormann, Stefan Dahmen
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Publication number: 20090220886Abstract: The present invention provides a polyhydric compound represented by the formula (I): wherein R51 to R67 each independently represent a hydrogen atom etc., at least one selected from the group consisting of R1 to R5 is a group represented by the formula (II): wherein Q1 and Q2 each independently represent a fluorine atom etc., U represents a C1-C20 divalent hydrocarbon group etc., and A+ represents an organic counter ion, and the others are hydrogen atoms or groups represented by the formula (III): wherein X1 to X4 each independently represent a hydrogen atom etc., n represents an integer of 0 to 3, W represents any one of the following groups: Z1 represents a C1-C6 alkyl group etc., and ring Y represents a C3-C20 alicyclic hydrocarbon group, and a chemically amplified resist composition containing the same.Type: ApplicationFiled: February 23, 2009Publication date: September 3, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Ichiki Takemoto, Nobuo Ando
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Publication number: 20090176948Abstract: Disclosed are a transition metal complex having a high catalytic activity for the preparation of an ethylene homopolymer or a copolymer of ethylene and ?-olefin and a catalyst composition comprising the same. More specifically, there are provided a transition metal complex having, around a group IV transition metal, a cyclopentadiene derivative and at least one aryl oxide ligand with a heterocyclic aryl derivative substituted at the ortho-position thereof, with no crosslinkage between the ligands, a catalyst composition comprising the transition metal complex and an organoaluminum compound or boron compound as cocatalyst, and a method for the preparation of high molecular weight ethylene homopolymers or copolymers of ethylene and ?-olefin using the same.Type: ApplicationFiled: January 6, 2009Publication date: July 9, 2009Inventors: Dong-Cheol Shin, Ho-Seong Lee, Myung-Ahn Ok, Jong-Sok Hahn
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Patent number: 7553867Abstract: The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(?O)—N(R3)— or —N(R3)—C(?O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or aType: GrantFiled: September 4, 2003Date of Patent: June 30, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Kazumasa Hamamura, Shigekazu Sasaki, Yuichiro Amano, Junichi Sakamoto, Kohji Fukatsu
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Patent number: 7553970Abstract: The invention relates to a process for preparing enantiomer-enriched 3-heteroaryl-3-hydroxypropanoic acid derivatives and 3-heteroaryl-1-aminopropan-3-ols, and to their use.Type: GrantFiled: September 24, 2003Date of Patent: June 30, 2009Assignee: Lanxess Deutschland GmbHInventors: Frank Berendes, Markus Eckert, Nils Brinkmann, Claus Dreisbach, Ruth Meissner, Rainhard Koch
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Patent number: 7550605Abstract: The present invention provides optically pure (S)-(+)-N-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine, a compound of formula (I), and optically pure (S)-isomer of compound of formula 4, wherein R1 and R2 both are methyl or R1 is methyl and R2 is benzyl or substituted benzyl group and process for preparation thereof. Formula (I) and (IV). In another aspect the present invention provides a process for preparation of an acid addition salt of compound of formula (I).Type: GrantFiled: August 5, 2005Date of Patent: June 23, 2009Assignee: Sun Pharmaceutical Industries Ltd.Inventors: Kartik Shantilal Patel, Nischal Vinodbhai Patel, Rajeev Budhdev Rehani, Rajamannar Thennati
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Publication number: 20090137822Abstract: The present invention relates to a process for preparing a 3-substituted thiophene represented by the formula (2): wherein R represents a cyano group, a formyl group, a carboxyl group, a hydrocarbyloxycarbonyl group which may have a substituent(s) or an acyl group which may have a substituent(s), which comprises reacting a vinyl compound represented by the formula (1): RCH?CHY??(1) wherein R has the same meaning as defined above, and Y represents a leaving group, and an ?-mercaptoacetaldehyde or a multimer thereof.Type: ApplicationFiled: May 16, 2006Publication date: May 28, 2009Inventors: Akio Matsushita, Kiyotaka Yoshii, Mizuho Oda, Masayoshi Oue, Shuji Yamada
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Publication number: 20090127491Abstract: A thiophene compound having sulfonyl groups which is represented by the formula [1]. It has high heat resistance and high unsusceptibility to oxidation and can improve solubility and dispersibility in various solvents. [In the formula, R1 and R2 each independently represents hydrogen, halogeno, cyano, etc.; and R3 and R3? each independently represents C1-20 alkyl, C1-20 haloalkyl, phenyl optionally substituted by W, thienyl optionally substituted by W, etc. (W represents chlorine, etc.).Type: ApplicationFiled: July 11, 2006Publication date: May 21, 2009Applicant: Nissan Chemical Industries, Ltd.Inventors: Nobuyuki Kakiuchi, Hitoshi Furusho, Naoki Otani, Tatsuo Okauchi, Naoki Nakaie
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Publication number: 20090099250Abstract: The present invention describes non-steroidal compounds of the general formula (I) in which A is in which X1 means one or more groups on the phenyl ring and represents independently of one another a halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C3-C6)cycloalkyl-O, (C1-C14)acyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro(C1-C4)alkyl radical, —CHO or CN, and X2 means one or more groups on the phenyl ring and represents independently of one another an H, halogen, OH, (C1-C4)alkyl, (C1-C4)alkyl-O, (C1-C4)alkenyl, (C1-C4)alkynyl, perfluoro-(C1-C4)alkyl radical, —CHO or CN, as Estrogens.Type: ApplicationFiled: October 10, 2008Publication date: April 16, 2009Inventors: Ralf WYRWA, Olaf Peters, Rolf Bohlmann, Peter Droescher, Katja Prelle, Karl Heinrich Fritzemeier, Hans Peter Muhn