Abstract: Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R.sup.1 and R.sup.2 independently denote radicals including hydrogen, alkyl, aryl and heterocyclic radical or together complete a carbocyclic or heterocylic ring, R.sup.3 denotes a radical ##STR2## in which R.sup.9, R.sup.10 and R.sup.11 include hydrogen, cyano, nitro, alkyl and aryl or, in pairs, complete carbocyclic rings, X denotes cyano, nitro or substituted carbonyl, sulphonyl or phosphonyl group, R.sup.4 is hydrogen or a radical defined for R.sup.1 or R.sup.3, and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 include hydrogen, nitro, cyano, carboxyl, alkyl and aryl or, in pairs, complete carbocyclic rings, with the proviso that R.sup.1 and R.sup.9 are not both phenyl if X denotes CO--C.sub.6 H.sub.6. The compounds exhibit considerably higher hypocholesterolaemic activity than the known clofibrate and in addition exhibit a pronounced nutritive effect, e.g., in a medicated fodder or premix.
Type:
Grant
Filed:
March 13, 1979
Date of Patent:
April 14, 1981
Assignee:
Bayer Aktiengesellschaft
Inventors:
Arno Widdig, Hans-Joachim Kabbe, Martin Scheer, Rudiger Sitt
Abstract: Novel 2-Benzothiepins, having substituents in the 1-position heretofore unknown, are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
Abstract: Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.
Type:
Grant
Filed:
May 10, 1979
Date of Patent:
January 13, 1981
Assignee:
American Home Products Corporation
Inventors:
Ivo L. Jirkovsky, Dushan Dvornik, Mitchell N. Cayen
Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=HO, alkoxy, alkanoyloxy or tert.AmR=H, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=O-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=arylamino or N-alkyl-N-arylamino substituted by R X=HO, alkoxy, alkanoyloxy or alkyleneiminoR=alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN, or NO.sub.2n=0-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
Abstract: A compound of the formula ##STR1## is useful in protecting organic materials normally subject to oxidative degradation. Among the products benefiting from the incorporation of this phenolic antioxidant are synthetic and natural rubbers, petroleum products and plastics.
Abstract: Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. These compounds are useful for preparing corresponding amino derivatives that possess antihypertensive and CNS activity.
Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
Abstract: Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.
Type:
Grant
Filed:
June 5, 1978
Date of Patent:
September 25, 1979
Assignee:
American Home Products Corporation
Inventors:
Ivo L. Jirkovsky, Dushan Dvornik, Mitchell N. Cayen
Abstract: .omega.-NOR-CYCLOALKYL-13,14-DEHYDRO-PROSTAGLANDIN COMPOUNDS, SPECIFICALLY 13,14-DEHYDRO-17-CYCLOHEXYL-20,19,18-TRINOR-PGF.sub.2.alpha. having antiulcer and luteolytic activity, are disclosed.
Type:
Grant
Filed:
September 21, 1977
Date of Patent:
September 25, 1979
Assignee:
Carlo Erba S.p.A.
Inventors:
Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.
Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=ho, alkoxy, alkanoyloxy or tert. AmR=h, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=0-2Or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.