The Hetero Ring Has At Least Seven Members Patents (Class 549/9)
  • Patent number: 4261988
    Abstract: Compounds useful in the treatment of cholesterolaemia are of the general formula ##STR1## or salts thereof in which R.sup.1 and R.sup.2 independently denote radicals including hydrogen, alkyl, aryl and heterocyclic radical or together complete a carbocyclic or heterocylic ring, R.sup.3 denotes a radical ##STR2## in which R.sup.9, R.sup.10 and R.sup.11 include hydrogen, cyano, nitro, alkyl and aryl or, in pairs, complete carbocyclic rings, X denotes cyano, nitro or substituted carbonyl, sulphonyl or phosphonyl group, R.sup.4 is hydrogen or a radical defined for R.sup.1 or R.sup.3, and R.sup.5, R.sup.6, R.sup.7 and R.sup.8 include hydrogen, nitro, cyano, carboxyl, alkyl and aryl or, in pairs, complete carbocyclic rings, with the proviso that R.sup.1 and R.sup.9 are not both phenyl if X denotes CO--C.sub.6 H.sub.6. The compounds exhibit considerably higher hypocholesterolaemic activity than the known clofibrate and in addition exhibit a pronounced nutritive effect, e.g., in a medicated fodder or premix.
    Type: Grant
    Filed: March 13, 1979
    Date of Patent: April 14, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Arno Widdig, Hans-Joachim Kabbe, Martin Scheer, Rudiger Sitt
  • Patent number: 4251526
    Abstract: Novel 2-Benzothiepins, having substituents in the 1-position heretofore unknown, are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
    Type: Grant
    Filed: May 15, 1979
    Date of Patent: February 17, 1981
    Inventor: John M. McCall
  • Patent number: 4244958
    Abstract: Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.
    Type: Grant
    Filed: May 10, 1979
    Date of Patent: January 13, 1981
    Assignee: American Home Products Corporation
    Inventors: Ivo L. Jirkovsky, Dushan Dvornik, Mitchell N. Cayen
  • Patent number: 4242266
    Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=HO, alkoxy, alkanoyloxy or tert.AmR=H, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=O-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
    Type: Grant
    Filed: August 29, 1978
    Date of Patent: December 30, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Melvin H. Rosen
  • Patent number: 4226998
    Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=arylamino or N-alkyl-N-arylamino substituted by R X=HO, alkoxy, alkanoyloxy or alkyleneiminoR=alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN, or NO.sub.2n=0-2or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
    Type: Grant
    Filed: September 20, 1978
    Date of Patent: October 7, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Melvin H. Rosen
  • Patent number: 4221702
    Abstract: A compound of the formula ##STR1## is useful in protecting organic materials normally subject to oxidative degradation. Among the products benefiting from the incorporation of this phenolic antioxidant are synthetic and natural rubbers, petroleum products and plastics.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: September 9, 1980
    Assignee: Uniroyal, Inc.
    Inventors: Edward L. Wheeler, Elmar H. Jancis
  • Patent number: 4207239
    Abstract: Isochromans, isothiochromans, 2-benzoxepins, and 2-benzothiepins are described. These compounds are useful for preparing corresponding amino derivatives that possess antihypertensive and CNS activity.
    Type: Grant
    Filed: January 2, 1979
    Date of Patent: June 10, 1980
    Assignee: The Upjohn Company
    Inventor: John M. McCall
  • Patent number: 4185109
    Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: January 22, 1980
    Assignee: Ciba-Geigy Corporation
    Inventor: Melvin H. Rosen
  • Patent number: 4169202
    Abstract: Derivatives of 4,5-dihydro-4-oxofuran-2-carboxylic acid characterized by having two substituents at position 5 and in addition being optionally further substituted at position 3 with a lower alkyl group, as well as esters therefor are disclosed. The foregoing compounds are useful hypolipidemic agents in a mammal. Novel methods for the preparation of these compounds also are disclosed.
    Type: Grant
    Filed: June 5, 1978
    Date of Patent: September 25, 1979
    Assignee: American Home Products Corporation
    Inventors: Ivo L. Jirkovsky, Dushan Dvornik, Mitchell N. Cayen
  • Patent number: 4169145
    Abstract: .omega.-NOR-CYCLOALKYL-13,14-DEHYDRO-PROSTAGLANDIN COMPOUNDS, SPECIFICALLY 13,14-DEHYDRO-17-CYCLOHEXYL-20,19,18-TRINOR-PGF.sub.2.alpha. having antiulcer and luteolytic activity, are disclosed.
    Type: Grant
    Filed: September 21, 1977
    Date of Patent: September 25, 1979
    Assignee: Carlo Erba S.p.A.
    Inventors: Carmelo Gandolfi, Renato Pellegata, Roberto Ceserani, Maria M. Usardi
  • Patent number: 4166062
    Abstract: 1-Alkoxyethanol-isochromas, -isothiochromas, -2-benzoxepins, and -2-benzothiepins are described. These compounds are useful for preparing the corresponding aminoalkoxyalkyl derivatives that possess antihypertensive and CNS activity.
    Type: Grant
    Filed: July 21, 1978
    Date of Patent: August 28, 1979
    Assignee: The Upjohn Company
    Inventors: John M. McCall, Ruth E. TenBrink
  • Patent number: 4166126
    Abstract: 2,3-Dihydro-1-benzothiepin-4-carboxamides, e.g. those of the formula ##STR1## Am=NH.sub.2, mono- or di-(alkyl or HO-alkyl)-amino, alkyleneimino, cycloalkylamino, iso- or heterocyclic arylamino or N-alkyl-N-arylaminoX=ho, alkoxy, alkanoyloxy or tert. AmR=h, alkyl, alkoxy, alkylmercapto, halo, CF.sub.3, CN or NO.sub.2n=0-2Or their salts with therapeutically useful bases, exhibit anti-inflammatory effects.
    Type: Grant
    Filed: January 27, 1977
    Date of Patent: August 28, 1979
    Assignee: Ciba-Geigy Corporation
    Inventor: Melvin H. Rosen