Plural Sulfurs Containing Patents (Class 554/102)
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Patent number: 11866385Abstract: A coating composition comprising an adduct formed by chemical reaction of a monomer containing poly-thiol with a monomer containing one or more unsaturated carbon-carbon bond; more particularly relates to coated agrochemical compositions coated with said coating composition.Type: GrantFiled: October 30, 2018Date of Patent: January 9, 2024Assignee: EVERRIS INTERNATIONAL B.V.Inventors: Evgeniy Tkalya, Ronald Petrus Johannes Gosens, Susan Tine Kathelyne Sijstermans, Michael Ernest Josephina Hendriks, Martin Anna Fransiscus Jacobus. Marx, Karina Rabe, Gerardus Jacobus Joseph Out
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Patent number: 11697712Abstract: A lacquer composition is provided, comprising 20%-79.9% by weight, based on the total weight of the composition, of a thiol compound having two or more thiol groups, 20%-79.9% by weight, based on the total weight of the composition, of a compound having two or more carbon-carbon double bonds and 0.1%-10% by weight, based on the total weight of the composition, of a separating agent having an alkyl radical having 4-20 carbon atoms, where the alkyl radical is unsubstituted or fluorine-substituted and the alkyl radical is bonded to a functional group. Also provided are the use of this lacquer composition as a protective lacquer on an optical surface of an optical element in the production of the optical element, and an optical element comprising the protective lacquer.Type: GrantFiled: May 22, 2017Date of Patent: July 11, 2023Assignee: tooz technologies GmbHInventors: Joerg Puetz, Hans-Joachim Weippert, Matthias Krieg
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Patent number: 11065335Abstract: Pharmaceutical formulations containing lipoic acid derivatives and ion pairs thereof are described. The pharmaceutical formulations are useful in the treatment of medical disorders, such as cancer.Type: GrantFiled: July 11, 2019Date of Patent: July 20, 2021Assignee: Rafael Pharmaceuticals, Inc.Inventors: Robert G. L. Shorr, Robert J. Rodriguez, Rajinder Bhasin
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Patent number: 9604912Abstract: The compositions and compounds of Formula I, Formula II, Formula III which includes a salts of polyunsaturated fatty acids in a molecular conjugate form with an amino acid L-leucine or its polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, delayed release or sustained release, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, nanoparticle, buccal administration or transdermal administration. Such compositions may be used to treatment of hyperglycemia, metabolic syndrome, diabetes, pre-diabetes, lowering triglycerides or its associated complications.Type: GrantFiled: November 11, 2015Date of Patent: March 28, 2017Inventor: Mohan Murali Alapati
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Publication number: 20140364502Abstract: Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.Type: ApplicationFiled: June 25, 2014Publication date: December 11, 2014Inventors: Paul Bingham, Tom Kwok, Zuzana Zachar
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Patent number: 8846972Abstract: The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylated salicylate derivative.Type: GrantFiled: February 26, 2010Date of Patent: September 30, 2014Assignee: Catabasis Pharmaceuticals, Inc.Inventors: Chi B. Vu, Jean E. Bemis, Michael R. Jirousek, Jill C. Milne, Jesse J. Smith
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Patent number: 8765984Abstract: The application discloses thiol ester molecules and ?-hydroxy thiol ester molecules having a thiol group located on one of the final two carbon atoms in a carbon chain or a terminal or ?-hydroxyl groups, respectively. The disclosed thiol ester molecules and or ?-hydroxyl thiol ester molecules es may be made from unsaturated ester molecules having one or more terminal alkene groups. The disclosed techniques also provide methods for making unsaturated ester molecules having one or more terminal alkene groups by the metathesis of unsaturated esters having one or more internal carbon-carbon double bonds (e.g. natural source oils). The thiol ester molecules or ?-hydroxy thiol ester molecule may be used in reactions with isocyanate monomers, epoxide monomer, or material having multiple alkene groups to make sealants, coatings, adhesives, and other products.Type: GrantFiled: May 7, 2012Date of Patent: July 1, 2014Assignee: Chevron Phillips Chemical Company LPInventor: Thomas A. Upshaw
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Patent number: 8686167Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: GrantFiled: October 1, 2010Date of Patent: April 1, 2014Assignee: Complexa, Inc.Inventor: Raymond A. Miller
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Publication number: 20130123456Abstract: The invention relates to a method for functionalizing natural fatty substances: According to said method, plant oils including at least two unsaturations and the derivatives thereof, fatty acids including at least one unsaturated compound and the derivatives thereof, and mixtures of same, are reacted with a thiol derivative of formula (I), at a temperature of between 0° C. and the temperature of total degradation of the natural fatty substance and in the presence of a thermal initiator compound or a redox initiator, or by UV radiation, or by UV radiation and in the presence of a photoinitiator. The invention also relates to the resulting functionalized fatty substances and to the use thereof for the preparation of polymers. The invention further relates to a method for preparing polymers from at least one functionalized fatty substance obtained by said functionalization method.Type: ApplicationFiled: June 30, 2011Publication date: May 16, 2013Applicants: Centre National De La Recherche Scienitique (C.N.R.S.), UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUESInventors: Sylvain Caillol, Bernard Boutevin, Myriam Desroches
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Patent number: 8410162Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.Type: GrantFiled: June 15, 2010Date of Patent: April 2, 2013Assignee: Encore Health LLCInventors: William Garner, Margaret Garner, George Minno, David Gooden
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Publication number: 20120232297Abstract: The application discloses thiol ester molecules and ?-hydroxy thiol ester molecules having a thiol group located on one of the final two carbon atoms in a carbon chain or a terminal or ?-hydroxyl groups, respectively. The disclosed thiol ester molecules and or ?-hydroxyl thiol ester molecules es may be made from unsaturated ester molecules having one or more terminal alkene groups. The disclosed techniques also provide methods for making unsaturated ester molecules having one or more terminal alkene groups by the metathesis of unsaturated esters having one or more internal carbon-carbon double bonds (e.g. natural source oils). The thiol ester molecules or ?-hydroxy thiol ester molecule may be used in reactions with isocyanate monomers, epoxide monomer, or material having multiple alkene groups to make sealants, coatings, adhesives, and other products.Type: ApplicationFiled: May 7, 2012Publication date: September 13, 2012Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventor: Thomas A. Upshaw
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Publication number: 20120178812Abstract: Pharmaceutical formulations containing lipoic acid derivatives are made.Type: ApplicationFiled: October 5, 2011Publication date: July 12, 2012Inventors: Robert G.L. Shorr, Robert J. Rodriguez, Rajinder Bhasin
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Publication number: 20100317725Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.Type: ApplicationFiled: June 15, 2010Publication date: December 16, 2010Applicant: Encore Health LLCInventors: William Garner, Margaret Garner, George Minno, Gooden David
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Publication number: 20100184730Abstract: The invention relates to fatty acid acylated salicylate derivatives; compositions comprising an effective amount of a fatty acid acylated salicylate derivative; and methods for treating or preventing an inflammatory disorder comprising the administration of an effective amount of a fatty acid acylated salicylate derivative.Type: ApplicationFiled: February 26, 2010Publication date: July 22, 2010Inventors: Chi B. Vu, Jean E. Bemis, Michael R. Jirousek, Jill C. Milne, Jesse J. Smith
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Patent number: 7713326Abstract: Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cross-linked thiol esters. The thiol ester composition can be used to produce cross-linked thiol esters, sulfonic acid-containing esters, sulfonate containing esters and thioacrylate containing esters. The thiol ester compositions can be used to produce polythiourethanes. The polythiourethanes can be used in fertilizers and fertilizer coatings.Type: GrantFiled: February 17, 2005Date of Patent: May 11, 2010Assignee: Agrium Inc.Inventors: Leslie E. Carstens, Baozhong Xing, Mitchell D. Refvik, Jim D. Byers
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Patent number: 7521401Abstract: Fuels, especially hydrocarbon fuels, and lubricants, especially lubricating oils, contain dithiocarbamyl ?-hydroxy fatty acid esters, a class of anti-corrosion, anti-wear, anti-fatigue, and extreme pressure additives that are derived from epoxidized fatty acid esters. The additives exhibit synergistic anti-wear activity in combination with phosphorus containing additives.Type: GrantFiled: November 14, 2005Date of Patent: April 21, 2009Assignee: ChemTura CorporationInventor: Robert G. Rowland
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Patent number: 7279448Abstract: A novel class of chemically-modified vegetable oils is prepared by reacting epoxidized triglyceride oils with thiols. The resultant poly(hydroxy thioether) derivatives have utility as antiwear/antifriction additives for environmentally-friendly industrial oils and automotive applications.Type: GrantFiled: July 8, 2004Date of Patent: October 9, 2007Assignees: The United States of America, as represented by the Secretary of Agriculture, The PENN State Research FoundationInventors: Sevim Z. Erhan, Atanu Adhvaryu, Brajendra K. Sharma
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Patent number: 7279563Abstract: A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds can also be used for chemically synthesizing oligonucleotides and for sequencing nucleic acid compounds.Type: GrantFiled: October 27, 2003Date of Patent: October 9, 2007Assignee: Helicos BioSciences CorporationInventor: Marek Kwiatkowski
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Patent number: 7253296Abstract: The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method of preparing said derivatives.Type: GrantFiled: February 12, 2004Date of Patent: August 7, 2007Assignee: GenfitInventors: Raphaël Darteil, Karine Caumont-Bertrand, Jamila Najib
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Patent number: 6639088Abstract: A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The hydrocarbyldithiomethyl-modified compounds can also be used for chemically synthesizing oligonucleotides and for sequencing nucleic acid compounds.Type: GrantFiled: September 12, 2001Date of Patent: October 28, 2003Assignee: Quiatech ABInventor: Marek Kwiatkowski
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Publication number: 20020128363Abstract: Organic thiol compounds are disclosed which can be utilized to plasticize and stabilize halogen-containing polymer compositions, especially poly(vinyl chloride) compositions. Compounds of the present invention are utilized in polymers normally susceptible to deterioration and color change, which typically occurs during processing of the polymer or exposure to certain environments.Type: ApplicationFiled: December 15, 2000Publication date: September 12, 2002Applicant: THE COLLEGE OF WILLIAM & MARYInventors: William Herbert Starnes, Bin Du
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Patent number: 6013815Abstract: The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.Type: GrantFiled: March 18, 1998Date of Patent: January 11, 2000Assignee: ASTA Medica AktiengesellschaftInventors: Thomas Beisswenger, Rainer Gewald, Alfred Olbrich, Horst Bethge, Frank Hubner, Klaus Huthmacher, Herbert Klenk, Roland Moller, Stephan Rautenberg, Gerhard Sator
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Patent number: 5811384Abstract: Novel nonionic gemini surfactants are extremely effective emulsifiers for oil-in-water emulsions that provide improved detergency at even low concentration levels. The surfactants are characterized by the formula: ##STR1## wherein R.sub.1 is independently H or a C.sub.1 to C.sub.22 alkyl, R.sub.2 is H or C.sub.1 to C.sub.22 alkyl and R.sub.3 is D.sub.1 --R.sub.4 --D.sub.1 or R.sub.4 --D.sub.1 --R.sub.4 wherein R.sub.4 is independently a C.sub.1 -C.sub.10 alkyl group, --C(O)--, --R.sub.5 ?O(EO).sub.a (PO).sub.b !--, --O--R.sub.5 --O--, or aryl, e.g. phenyl, and D.sub.1 is independently --O--, --S--, --S--S--, --SO.sub.2 --, --C(O)--, a polyether group ?--O(EO).sub.a (PO).sub.b --!, an amide group ?--C(O)N(R.sub.6)--!, an amino group ?--N(R.sub.6)--!, --O--R.sub.5 --O--, or aryl. (EO).sub.a (PO).sub.b is a polyether group and Z is a C.sub.1 -C.sub.Type: GrantFiled: November 26, 1997Date of Patent: September 22, 1998Assignee: Rhodia Inc.Inventors: David James Tracy, Ruoxin Li, Manilal S. Dahanayake, Jiang Yang
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Patent number: 5776973Abstract: Novel palladium complexes and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium).sub.m (lipoic acid).sub.n, wherein m and n are each independently 1 or 2. A process for preparing such complexes is also disclosed. In addition, a method of treatment of tumors and a method of treatment of psoriasis comprising administering the pharmaceutical compositions of the present invention are provided.Type: GrantFiled: October 18, 1995Date of Patent: July 7, 1998Inventor: Merrill Garnett
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Patent number: 5679697Abstract: Novel palladium complexes and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium).sub.m (lipoic acid).sub.n, wherein m and n are each independently 1 or 2. A process for preparing such complexes is also disclosed. In addition, a method of treatment of tumors and a method of treatment of psoriasis comprising administering the pharmaceutical compositions of the present invention are provided.Type: GrantFiled: October 18, 1995Date of Patent: October 21, 1997Inventor: Merrill Garnett
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Patent number: 5641735Abstract: Oil soluble compounds having the formula: ##STR1## wherein R and R.sup.1 are independently cyano, alkoxycarbonyl or together form a carbocycle or alkylcarbocycle and R.sup.2 and R.sup.3 are independently alkyl, alkenyl, hydroxyalkyl sulfurized alkyl, or alkoxycarbonylalkyl.The compound are useful as wear protectants or extreme pressure agents to enhance wear protection or extreme pressure properties in lubricating oils and greases.Type: GrantFiled: June 6, 1995Date of Patent: June 24, 1997Assignee: Chevron Chemical CompanyInventor: Andrew W. Ho
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Patent number: 5637616Abstract: A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the host is treated with an effective amount of N-acetyl ysteine or a derivative thereof, or its pharmaceutically acceptable salt, optionally in a pharmaceutically acceptable diluent or carrier for systemic or topical delivery.Type: GrantFiled: October 5, 1993Date of Patent: June 10, 1997Assignee: Arcturus Pharmaceutical CorporationInventors: Richard J. Sharpe, Maureen H. McAloon, Stephen J. Galli, Kenneth A. Arndt
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Patent number: 5463093Abstract: Novel palladium complexes and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium).sub.m (lipoic acid).sub.n, wherein m and n are each independently 1 or 2. A process for preparing such complexes is also disclosed. In addition, a method of treatment of tumors and a method of treatment of psoriasis comprising administering the pharmaceutical compositions of the present invention are provided.Type: GrantFiled: November 26, 1993Date of Patent: October 31, 1995Inventor: Merrill Garnett
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Patent number: 5342977Abstract: Salts of aminosulfonic acid derivatives of formula I ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently of the others an aliphatic hydrocarbon radical having from 7 to 21 carbon atoms,n is 0 or 1,As is the amidically bonded residue of a (D)- or (L)-amino acid or of a (D)- or (L)-amino acid derivative from the group consisting of Gly, Ala, Ser, Thr, Asp, Asp(R.sup.5), Glu, Glu(R.sup.5), Gla, Gla(R.sup.5) and Gla(R.sup.5).sub.2, andR.sup.4 and R.sup.5 are each independently of the other the amidically bonded radical of an unsubstituted or carboxy-substituted .omega.-amino-C.sub.2 -C.sub.3 alkanesulfonic acid, are described.Those salts have an immunostimulating action and can be used as medicaments.Type: GrantFiled: December 17, 1992Date of Patent: August 30, 1994Assignee: Ciba-Geigy Corp.Inventors: Gerhard Baschang, Albert Hartmann
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Patent number: 5292915Abstract: The invention relates to compounds containing carbonate groups and carbonyl groups and having the general formula ##STR1## in which R stands for a C.sub.1 -C.sub.4 -alkyl radical, an aryl radical, or a radical R.sup.1, whereR.sup.1 has the following formula ##STR2## in which R.sup.2 to R.sup.6 stand for H, alkyl, OH, O-alkyl, SH, S-alkyl, halogen, N(alkyl).sub.2, or N(alkyl)(aryl) and at least one but not more than three of the radicals R.sup.2 to R.sup.6 stand for a radical of the formula ##STR3## in which A, B and C stand for alkylene, cycloalkylene, oxaalkylene, polyoxaalkylene or arylene, k and l both stand for an integer from 1 to 80, and the end group Z stands for alkyl, aryl, alkoxycarbonyl, alkoxycarbonyloxy, or aryl.These compounds are suitable for use as emulsifiers for dispersions.Type: GrantFiled: February 4, 1992Date of Patent: March 8, 1994Assignee: BASF AktiengesellschaftInventors: Andreas Boettcher, Manfred Schwartz
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Patent number: 5281722Abstract: The pure enantiomers of alpha-lipoic acid are obtained by formation of the diastereomeric salt pairs with the optical antipodes of alpha-methylbenzylamine in solution.Type: GrantFiled: November 12, 1992Date of Patent: January 25, 1994Assignee: Degussa AGInventors: Gottfried Blaschke, Ursula Scheidemantel, Horst Bethge, Roland Moller, Thomas Beisswenger, Klaus Huthmacher
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Patent number: 5145611Abstract: Carboxylic acid derivatives of the formula ##STR1## R.sub.1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamino. R.sub.2 is optionally substituted aryl or, when B is alkylene also a hydrogen atom. A is a straight-chained or branched, saturated or unsaturated alkylene containing 3 to 10 carbon atoms which is optionally interrupted by a heteratom attached to a saturated carbon and has a chain length of at least 3 atoms. Y is S(O).sub.n group or oxygen, n being 0, 1 or 2. B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene containing 1 to 18 carbon atoms. Physiologically acceptable salts, esters and amides thereof are also included. The compounds are useful in the treatment of metabolic diseases.Type: GrantFiled: January 12, 1988Date of Patent: September 8, 1992Assignee: Boehringer Mannheim GmbHInventors: Hans P. Wolff, Ernst-Christian Witte, Hans-Frieder Kuehnle