Abstract: The present invention discloses a method for preparing a prostaglandin E-type compound, in which prostaglandin F-type compound is used as an initiator to generate novel derivative of prostaglandin F-type compound through a silylation reaction, and eventually a prostaglandin E-type compound is obtained through an oxidation and a desilylation reaction.
Type:
Grant
Filed:
February 26, 2001
Date of Patent:
June 11, 2002
Assignee:
Everlight USA, Inc.
Inventors:
Chi-Hsiang Yao, Rung-Tian Suen, Yu-Liang Liu
Abstract: Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, 3-t-butyldimethylsilyl triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epistereoisomeric mixture.
Type:
Grant
Filed:
September 30, 1994
Date of Patent:
November 5, 1996
Assignee:
Korea Institute of Science and Technology
Inventors:
Hokoon Park, Sun Ho Jung, Yong Sup Lee, Ki Hong Nam