Nitrogen Containing (e.g., Cephalins, Lecithins, Etc.) Patents (Class 554/80)
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Publication number: 20120009239Abstract: Naturally occurring lecithins and/or oleic acid stimulate the growth and lactic acid producing activity of Lactobacillus and Bifidobacterium species of probiotic bacteria, and replace polysorbate 80 for those products. They can be used in naturally occurring form, or where they are to be combined with probiotics in a carrier, or they can be treated to yield a stable powdered form of these naturally oily compounds. They can be sold as combined prebiotic/probiotic formulations in the same carrier, or sold as separate dietary supplements, e.g., in capsule or tablet form, to be used with the probiotic formulation as desired.Type: ApplicationFiled: May 31, 2011Publication date: January 12, 2012Applicant: MASTER SUPPLEMENTS, INC.Inventors: Randolph S. Porubcan, Sonja Lea Yonak
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Publication number: 20120009246Abstract: Phospholipid-analogous compounds of the general formula (I) in which a is b is where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of froth 12 to 30 carbon atoms, n is an integer from 2 to 8, R3 a can be 1,2-dihydroxypropyl or b can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n?2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y is 1 for z=1 to 5 or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.Type: ApplicationFiled: April 12, 2011Publication date: January 12, 2012Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.Inventor: Hans-Jörg EIBL
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Publication number: 20110251158Abstract: Described herein are methods for treating inflammatory disorders or for inhibiting the build-up of arterial plaque. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.Type: ApplicationFiled: September 16, 2010Publication date: October 13, 2011Applicant: Luna Innovations IncorporatedInventors: Christopher L. KEPLEY, Robert P. LENK, Darren K. MACFARLAND, Zhiguo ZHOU
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Publication number: 20110212922Abstract: The present invention discloses processes a process for the preparation of phosphatide-salt complexes, the process including the steps of: using at least one raw material lecithin as a substrate; and enzymatically processing at least one raw material lecithin with phospholipase-D, racemic or enantiomerically-pure serine, and/or amine in an aqueous carboxylate-salt-complex solution, wherein the step of processing is performed in a single-phase reaction environment, to produce phosphatide-salt complexes having a structural fatty-acid chain derived from at least one raw material lecithin. Preferably, the step of processing is performed at a pH in the range of about 4.5-8.0 at a temperature in the range of about 25-60° C. Preferably, the aqueous carboxylate-salt-complex solution is formed from an aqueous solution of a carboxylic acid with a chain length of C2-C8 and a salt in an approximately 1:2 (weight per weight) acid-to-salt ratio.Type: ApplicationFiled: February 4, 2010Publication date: September 1, 2011Applicant: LIPOGEN LTD.Inventor: David Rutenberg
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Publication number: 20110189212Abstract: Novel synthetic oxidized lipids and methods utilizing oxidized lipids for treating and preventing an inflammation associated with an endogenous oxidized lipid are provided.Type: ApplicationFiled: April 13, 2011Publication date: August 4, 2011Applicant: Vascular Biogenics Ltd.Inventors: Dror HARATS, Jacob George, Gideon Halperin, Itzhak Mendel, Niva Yacov, Eti Kovalevski-Ishai
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Publication number: 20110160471Abstract: This invention provides a process for producing a high-purity sphingomyelin and a high-purity plasmalogen-form glycerophospholipid from a biological material by simple procedures at high yields.Type: ApplicationFiled: June 19, 2009Publication date: June 30, 2011Applicants: UMEDA JIMUSHO LTD., MARUDAI FOOD CO., LTD., BOOCS MEDICAL CORPORATIONInventors: Yoshitaka Nadachi, Siro Mawatari
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Patent number: 7968737Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: GrantFiled: August 4, 2010Date of Patent: June 28, 2011Assignee: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Publication number: 20110118489Abstract: Disclosed are biomimetic membrane precursors and membranes formed therefrom. Also disclosed are methods of making biomimetic membrane precursors and membranes formed therefrom.Type: ApplicationFiled: May 22, 2009Publication date: May 19, 2011Inventors: Jacob J. Schmidt, Tae-Joon Jeon, Jason L. Poulos
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Publication number: 20110086091Abstract: The invention relates to stable crystal modifications of (R,S)-, (R)- and (5S)-DOPC, to a process for the preparation of these modifications, and to the use thereof as constituent for the preparation of medicaments.Type: ApplicationFiled: May 13, 2009Publication date: April 14, 2011Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRÄNKTER HAFTUNGInventors: Michael Platscher, Alfred Hedinger
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Patent number: 7923052Abstract: A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a permeate stream having a decreased weight percent of phospholipids compared with the weight percent of phospholipids provided in the miscella. The retentate stream can be further processed for the recovery of lecithin. The polymeric microfiltration membrane can be conditioned for the selective separation of phospholipids in the miscella. A method for conditioning a membrane for selective separation of phospholipids from vegetable oil miscella, and the resulting membrane, are provided. The membrane which can be conditioned can be characterized as having an average pore size of between about 0.1? and about 2?.Type: GrantFiled: January 13, 2009Date of Patent: April 12, 2011Assignee: Cargill, IncorporatedInventors: Bassam Jirjis, Harapanahalli S. Muralidhara, Dennis D. Otten
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Publication number: 20110067141Abstract: The present invention provides transgenic soybean event MON87769, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a sample, methods for detecting the presence of said soybean event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event in a sample, growing the seeds of such soybean event into soybean plants, and breeding to produce soybean plants comprising DNA diagnostic for the soybean event.Type: ApplicationFiled: February 12, 2009Publication date: March 17, 2011Inventors: Byron Froman, Can Duong, Jennifer Listello
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Patent number: 7893286Abstract: Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.Type: GrantFiled: May 30, 2008Date of Patent: February 22, 2011Assignee: Cellectar, Inc.Inventors: Anatoly Pinchuk, Jamey P. Weichert, Marc Longino
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Publication number: 20110016581Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-8 desaturases in plants and oleaginous yeast.Type: ApplicationFiled: October 22, 2007Publication date: January 20, 2011Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Howard Glenn Damude, Zhixiong Xue, Quinn Qun Zhu
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Publication number: 20100331281Abstract: We have discovered that phospholipids diundecanoyl (C11:0-C11:0) and dilauroyl (C12:0-C12:0) phosphatidylcholine (PC) act as agonists of the LRH-1 receptor. We have also shown that administration of these lipids to diabetic mice reduces blood glucose levels. On the basis of these discoveries, the present invention features compositions that include these lipids and structurally related lipids. Also featured are methods of treating metabolic disorders and inflammatory bowel disease, lowering blood glucose levels, and increasing LRH-1 receptor activity in a subject by administration of these lipids.Type: ApplicationFiled: November 17, 2008Publication date: December 30, 2010Applicant: Baylor College of MedicineInventors: David D. Moore, Jae Man Lee
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Publication number: 20100317622Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: ApplicationFiled: August 4, 2010Publication date: December 16, 2010Applicant: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Publication number: 20100316680Abstract: Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.Type: ApplicationFiled: August 4, 2010Publication date: December 16, 2010Applicant: AKER BIOMARINE ASAInventors: Inge Bruheim, Mikko Griinari, Sebastiano Banni, Per Christian Saebo, Erik Fuglseth
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Publication number: 20100317881Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: ApplicationFiled: August 24, 2010Publication date: December 16, 2010Applicant: Vascular Biogenics Ltd.Inventors: Gideon HALPERIN, Eti Kovalevski-Ishai
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Patent number: 7847113Abstract: The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that contain long-chain polyunsaturated fatty acids (LCPUFA) are used as a starting material, the method including a PL extracting step of extracting phospholipids (PL) from defatted cells obtained by extracting triglyceride (TG)-containing oil or fat from the lipid producing cells.Type: GrantFiled: February 28, 2005Date of Patent: December 7, 2010Assignee: Suntory Holdings LimitedInventors: Hiroshi Kawashima, Motoo Sumida, Akiko Shiraishi
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Publication number: 20100261676Abstract: Compositions comprising the peroxisome proliferator-activated receptor alpha (PPAR?)-ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC) are disclosed. These compositions may be used for the prophylaxis and treatment of PPAR?-related liver disorders including, but not necessarily limited to, fatty liver disease, to lower lipid and triglyceride levels, and to increase high density lipoprotein levels in animals. Foods modified with 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1GPC) may be used to improve the metabolism of animals.Type: ApplicationFiled: April 12, 2010Publication date: October 14, 2010Applicant: WASHINGTON UNIVERSITYInventors: Clay F. Semenkovich, Manu V. Chakravarthy, John W. Turk
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Publication number: 20100130619Abstract: The invention describes use of an injectable form of Idebenone, suitable for intravenous injection or infusion. The proposed formulation is an oil-in-water emulsion, where Idebenone is associated with the oil droplets.Type: ApplicationFiled: November 24, 2008Publication date: May 27, 2010Inventors: Joseph Schwarz, Michael Weisspapir
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Publication number: 20100099900Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) and using these delta-8 desaturases in plants.Type: ApplicationFiled: April 10, 2008Publication date: April 22, 2010Applicant: E.I. Du Pont Nemours and CompanyInventors: Howard Glenn Damude, Quinn Qun Zhu
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Publication number: 20100048928Abstract: It is intended to find novel pharmaceutical use of sphingomyelin and to provide preventive or therapeutic agents for various diseases as well as a food and drink product and feed comprising any of these agents. The present invention provides a pharmaceutical agent which contains sphingomyelin as an active ingredient and is any of the following agents: 1) a sialomucin secretion promoter, 2) an agent for preventing drunken sickness (hangover), 3) an antiallergic agent, 4) an antioxidant, 5) an agent for defending against infection, 6) a hair growth agent, 7) a therapeutic agent for demyelinating disease, 8) an anti-pigmentation agent, 9) an anti-inflammatory agent, and 10) an agent for improving learning ability. The present invention also provides a food and drink product or feed, characterized by comprising the agent. It is preferred that the sphingomyelin should be derived from milk.Type: ApplicationFiled: September 22, 2006Publication date: February 25, 2010Applicant: SNOW BRAND MILK PRODUCTS CO., LTDInventors: Ken Kato, Susumu Miura, Leo Tanaka, Hiroshi Ueno, Noriko Ueda, Yuko Haruta, Toshimitsu Yoshioka
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Publication number: 20100035990Abstract: Omega-3 lipid compounds of the general formula (I): wherein R1 and R2 are the same or different and may be selected from a group of substituents consisting of hydrogen, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride or a carboxamide; and Y is a C6 to C22 alkene with two or more double bonds, having E and/or Z configuration, are disclosed. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments in particular for the treatment of cardiovascular and metabolic diseases.Type: ApplicationFiled: November 1, 2007Publication date: February 11, 2010Inventors: Morten Bryhn, Anne Kristin Holmeide, Jenny Rosman
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Publication number: 20100009927Abstract: The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.Type: ApplicationFiled: July 14, 2009Publication date: January 14, 2010Applicant: HerbalScience Group LLCInventors: Randall S. Alberte, William P. Roschek, JR., Dan Li
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Publication number: 20090202619Abstract: A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1): wherein L, Y, W, X1, X2, X3, OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.Type: ApplicationFiled: February 17, 2006Publication date: August 13, 2009Applicants: THE UNIVERSITY OF TOKUSHIMA, NOF CORPORATIONInventors: Hiroshi Kiwada, Tatsuhiro Ishida, Chika Ito, Kazuhiro Kubo, Kenji Sakanoue, Hiroshi Kikuchi
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Publication number: 20090074942Abstract: There is disclosed a granular lecithin and the use in many applications, such as nutraceutical compositions. Also disclosed is a process for producing granular lecithins and compositions containing lecithins.Type: ApplicationFiled: May 16, 2006Publication date: March 19, 2009Applicant: CARGILL, INCORPORATEDInventors: Myong Kon Ko, Heidi Schmitt, Michael Schneider, John Van De Sype
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Patent number: 7420071Abstract: There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 to 50 carbons and optionally including an ionizable or charged group (e.g., carboxyl group or quaternary amine). Thus, there are provided surfactants having Formula I: wherein the variables are as defined herein. Further provided are methods of making thermally stable surfactants and compositions, including composites and nanocomposites, using fillers coated with the surfactants.Type: GrantFiled: May 4, 2005Date of Patent: September 2, 2008Assignee: UChicago Argonne, LLCInventor: David J. Chaiko
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Publication number: 20080085263Abstract: the present invention relates to pre-formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.Type: ApplicationFiled: June 6, 2005Publication date: April 10, 2008Inventors: Krister Thuresson, Fredrik Tiberg, Markus Johansson, Ian Harwigsson, Fredrik Joabsson
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Patent number: 7351702Abstract: This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; next to R3 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1? secretion.Type: GrantFiled: May 23, 2002Date of Patent: April 1, 2008Assignee: Vertex Pharmaceuticals IncorporatedInventors: Michael Mortimore, Andrew Miller, John Studley, Jean-Damien Charrier
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Patent number: 7303760Abstract: Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.Type: GrantFiled: November 14, 2003Date of Patent: December 4, 2007Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of JerusalemInventors: Samuel Zalipsky, Alberto Gabizon
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Patent number: 7189544Abstract: The disclosure pertains to enzymatic modification of lecithin and to hydrolyzed lecithin products obtained by such modification. One particular implementation provides methods for producing a hydrolyzed lecithin product containing hydrolyzed phospholipids, monoglycerides, and diglycerides. For example, such a method may include the steps of: (a) contacting a lecithin material, which includes a phospholipid component and a triglyceride component, in an aqueous or organic solvent medium, with a first enzyme effective to hydrolyze the phospholipid; and (b) subsequently contacting the product of step (a) with a second enzyme, effective to hydrolyze the triglyceride; under reaction conditions effective to inhibit esterification of the hydrolyzed phospholipid with released fatty acids.Type: GrantFiled: April 9, 2004Date of Patent: March 13, 2007Assignee: Cargill, IncorporatedInventors: Heidi Schmitt, Marc Heirman
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Patent number: 7078069Abstract: A sprayable cookware release composition includes an oil, a propellant, and a cookware release agent having lecithin treated with an alkali and a fatty acid at the same time or treated with a mixture of an alkali and a fatty acid. A variety of alkali and fatty acids can be used to treat the lecithin, including more than one alkali and more than one fatty acid. Suitable alkali for treating the lecithin include sodium and potassium sorbate, sodium and potassium carbonate, sodium and potassium bicarbonate, sodium and potassium acetate, sodium and potassium hydroxide, and mixtures thereof. Suitable fatty acids for treating the lecithin include oleic acid, linoleic acid, palmitic acid, stearic acid, and mixtures thereof. The cookware release agent and oil are mixed, and the mixture is dispensed from the aerosol container by the propellant.Type: GrantFiled: April 11, 2005Date of Patent: July 18, 2006Assignee: ConAgra Grocery Products CompanyInventor: Linsen Liu
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Patent number: 7037550Abstract: A sprayable cookware release composition includes a cookware release agent, a fractionated oil, such as a fractionated palm oil or a fractionated coconut oil, and a propellant. A combination of fractionated oils or a combination of a fractionated oil and a non-fractionated oil can also be utilized. The cookware release agent and the fractionated palm oil are mixed, and the mixture is dispensed from the aerosol container by the propellant. Suitable fractionated oils include fractionated coconut oil and fractionated palm oil, such as palm olein and palm super olein. Suitable cookware release agents include phospholipids, including phosphorus-containing glycerides, such as lecithin, lyso-phospholipids, phosphated monoglycerides, phosphated diglycerides, and mixtures thereof. Suitable propellants include pressurized gases, such as nitrous oxide, liquefied hydrocarbons, or mixtures thereof.Type: GrantFiled: May 28, 2003Date of Patent: May 2, 2006Assignee: ConAgra Grocery Products CompanyInventors: Linsen Liu, Barry L. Geiger
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Patent number: 7034168Abstract: A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation.Type: GrantFiled: November 3, 2003Date of Patent: April 25, 2006Assignee: Enzymotec Ltd.Inventors: Sobhi Basheer, Rassan Zuabi, Avidor Shulman, Neta Scheinman
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Patent number: 6984396Abstract: Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.Type: GrantFiled: January 25, 2002Date of Patent: January 10, 2006Assignee: Alza CorporationInventors: Samuel Zalipsky, Alberto A. Gabizon
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Patent number: 6979460Abstract: A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with target lipid membranes. The cleavable vinyl ether linkage allows the hydrophilic headgroup to be dissociated from the hydrophobic tailgroup(s) of the lipid compound to facilitate phase transitions in the lipid bilayer.Type: GrantFiled: July 17, 2000Date of Patent: December 27, 2005Assignee: Purdue Research FoundationInventors: David H. Thompson, Jeremy A. Boomer, Robert Haynes
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Patent number: 6972338Abstract: The invention relates to a series of novel alkoxylated mono alkyl glyceryl ester phosphobetaine compounds, which are exceptional surface active agents that provide outstanding foam and are very mild to the hair and skin, in addition because of the presence of the ester linkage these materials are not persistent in the aquatic environment. This lack of persistence in the aquatic environment makes these materials greener and environmentally friendly than other non-ester containing compounds. The compounds, because they contain a pendant ionizable phosphate group and a quaternary amine compound are amphoteric surfactants that is they contain both a positive and negative charge in the same molecule. This combination of properties makes these polymers ideally suited for use in personal care applications.Type: GrantFiled: September 12, 2003Date of Patent: December 6, 2005Assignee: Phoenix Research CorpInventors: John Imperante, Anthony J. O'Lenick, Jr.
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Patent number: 6949528Abstract: The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.Type: GrantFiled: March 17, 1999Date of Patent: September 27, 2005Inventors: John G. Goddard, Donald H. Picker, Samull R. Umansky, Steven Price, Jac Wijkmans, Edward Boyd, Anthony Baxter
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Patent number: 6905722Abstract: A sprayable cookware release composition includes an oil, a propellant, and a cookware release agent having lecithin treated with an alkali and a fatty acid at the same time or treated with a mixture of an alkali and a fatty acid. A variety of alkali and fatty acids can be used to treat the lecithin, including more than one alkali and more than one fatty acid. Suitable alkali for treating the lecithin include sodium and potassium sorbate, sodium and potassium carbonate, sodium and potassium bicarbonate, sodium and potassium acetate, sodium and potassium hydroxide, and mixtures thereof. Suitable fatty acids for treating the lecithin include oleic acid, linoleic acid, palmitic acid, stearic acid, and mixtures thereof. The cookware release agent and oil are mixed, and the mixture is dispensed from the aerosol container by the propellant.Type: GrantFiled: July 3, 2003Date of Patent: June 14, 2005Assignee: ConAgra Grocery Products CompanyInventor: Linsen Liu
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Patent number: 6828453Abstract: Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, hydrogen, a saturated or unsaturated acyl or alkyl radical which can optionally be branched or/and substituted, where the total of the carbon atoms in the acyl and alkyl is 16 to 44 C atoms, s is an integer from 0 to 8, c is a radical of a primary or secondary alcohol of the formula RO—, where R is a saturated or unsaturated alkyl radical, mainly with cis double bond, of from 12 to 30 carbon atoms, n is an integer from 2 to 8, R3 a can be 1,2-dihydroxypropyl or b 5 can be alkyl with 1 to 3 C atoms when z is >0 or c can be alkyl with 1 to 3 carbon atoms when n≠2 and z=0, m is 1 or 2, x is an integer from 0 to 8, y 10 is 1 for z=1 to 5 or is 1 to 4 for z=1 z is an integer from 0 to 5, are novel and are suitable as liposome constituents, solubilizers and pharmaceuticals.Type: GrantFiled: March 4, 2003Date of Patent: December 7, 2004Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.VInventor: Hans-Jörg Eibl
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Publication number: 20040219106Abstract: A compound of formula (I) or a salt thereof, wherein: R1a represents C1-3 alkyl; R1b represents C1-3 alkyl; R1c represents C1-3 alkyl; R2represents C1-5 fluoroalkyl; R3represents C1-5 fluoroalkyl; X represents —C1-6 alkylene-; Y represents —C1-6 alkylene-; with the proviso the each C1-5 fluoroalkyl contains 3 or fewer consecutive perfluorocarbon atoms, methods of preparing said compounds, pharmaceutical aerosol formulation comprising said compounds and uses thereof.Type: ApplicationFiled: January 27, 2004Publication date: November 4, 2004Inventors: Brian Edgar Looker, Christopher Lunniss, Alison Redgrave
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Patent number: 6797835Abstract: A phospholipidic composition with an L-&agr;-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-&agr;-glycerophosphatidylcholine, at least one granulation aid selected from the group consisting of a monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof.Type: GrantFiled: July 7, 2003Date of Patent: September 28, 2004Assignee: American Lecithin CompanyInventors: Peter Fussbroich, Johannes Gareiss
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Publication number: 20040161520Abstract: An improved lecithin product is provided by a process for extracting oil and/or sugar from crude lecithin. The improved lecithin product has up to about 75 wt. %, phospholipids, and an oil and sugar content of about 10 wt. % or less. The improved lecithin product may have acetone insolubles content of more than about 68, and sugar content of less than about 1.0 wt. %. The process provided involves extracting oil and/or sugar from crude lecithin using blends of ethanol and water in two extraction steps. The method includes: providing a crude lecithin material; mixing the crude lecithin material with a blend of ethanol and water in a first extraction step; collecting the residue from the first extraction step; mixing the residue from the first extraction step with a blend of ethanol and water in a second extraction step; and collecting the residue from the second extraction step as an improved lecithin product.Type: ApplicationFiled: July 23, 2003Publication date: August 19, 2004Inventor: Jonathan Maynes
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Publication number: 20040147485Abstract: Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions, such as the treatment of ischemia.Type: ApplicationFiled: January 14, 2004Publication date: July 29, 2004Applicant: D-Pharm, Ltd.Inventors: Alexander Kozak, Israel Shapiro
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Patent number: 6733814Abstract: The invention concerns a food composition, suitable for shallow frying, comprising triglycerides, wherein least 60 wt. % of triglycerides is of vegetable origin, and 0.05-3 wt. % sunflower lecithin. The invention further concerns a process for the preparation of hydrolyzed sunflower lecithin.Type: GrantFiled: December 19, 2001Date of Patent: May 11, 2004Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Cor 't Hooft, Marcelle Kommer van den, Jacobus Cornelis Segers
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Patent number: 6733754Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.Type: GrantFiled: March 13, 2003Date of Patent: May 11, 2004Assignees: Pfizer, Inc., Pfizer Products, Inc.Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
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Publication number: 20040053376Abstract: Process for preparing pure phosphatides starting from mixtures of natural phosphatides, or their single components, such as soybean or egg lecithin or animal phospholipids, or from synthetic phosphatides by reacting them both with phospholipase D derived from Streptomyces hachijoense in a completely aqueous medium in the presence of defined substates containing a primary or secondary alcoholic group, and their uses thereof.Type: ApplicationFiled: September 15, 2003Publication date: March 18, 2004Applicant: Fidia Farmaceutici S.p.A.Inventors: Guenter Kirschner, Giampaolo Menon, Susanna Vaccaro
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Patent number: 6699499Abstract: Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydrophobic moieties. All such amphiphilic molecules have a common structural motif and, in contact with water, display surface activity and self-assemble into multimolecular aggregates and liquid crystalline phases. Also disclosed are enhanced stability liposomes that incorporate such amphiphilic molecules via unique interactions, and methods of using such formulations in a variety of applications including drug delivery, nutrition, bio-diagnostics, cosmetics, blood products and related applications.Type: GrantFiled: June 11, 2001Date of Patent: March 2, 2004Assignee: Nutrimed BiotechInventor: Rajindra Aneja
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Publication number: 20040019017Abstract: The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further relates to pharmaceutical compositions comprising these compounds, which are particularly well-suited for treatment of caspase-mediated diseases, including inflammatory and degenerative diseases. This invention further relates to methods for preparing compounds of this invention.Type: ApplicationFiled: February 11, 2003Publication date: January 29, 2004Inventors: Michael Mortimore, Julian M.C. Golec
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Patent number: 6683032Abstract: The present invention relates to novel compositions and, more particularly, to a class of compounds having specific quaternized amine based upon a phosphate ester. The use of a phosphate ester based upon a fatty alcohol or fatty alcohol alkoxylate as the material used to prepare a phospholipid results in heretofore-unknown compounds. The products are very good wetting agents, have improved hydrolytic stability, are extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications. In short they are ideal surfactants for use in many personal care applications.Type: GrantFiled: May 6, 2002Date of Patent: January 27, 2004Inventors: Anthony J. O'Lenick, Jr., Kevin A. O'Lenick