Copper, Silver, Or Gold Containing (cu, Ag, Or Au) Patents (Class 556/110)
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Patent number: 5420321Abstract: Tris(isonitrile)copper(I) sulfate complexes and their use in synthetic methods for making radionuclide isonitrile coordination complexes such as [.sup.99m Tc(1-isocyano-2-methoxy-2-methylpropane).sub.6 ].sup.+. The coordination complexes are useful as radiopharmaceutical imaging agents.Type: GrantFiled: August 3, 1993Date of Patent: May 30, 1995Assignee: The Du Pont Merck Pharmaceutical CompanyInventor: David S. Edwards
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Patent number: 5405601Abstract: The present invention provides new and structurally diverse compositions for diagnostic imaging comprising compounds of the general formula: ##STR1## wherein A is N or CR.sub.1, R.sub.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.6 -C.sub.10 aryl, where the alkyl or aryl group may be optionally substituted with one or more hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.6 -C.sub.10 aryl, C.sub.6 -C.sub.10 hydroxyaryl, C.sub.6 -C.sub.10 aryloxy, --CO.sub.2 R.sub.2, --CONR.sub.3 R.sub.4, or NR.sub.3 R.sub.4 ; D is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O--, or NR.sub.5 ; E is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.6 ; F is O, --O(CH.sub.2).sub.2 O--, --O(CH.sub.2).sub.3 O-- or NR.sub.7 ; R.sub.2 -R.sub.7 are as defined within; g, h, i, j, k and m may be the same or different and are an integer from one to about six; X is --CO.sub.2 H, --PO.sub.3 H.sub.2, --SO.sub.3 H or --CONHOH.Type: GrantFiled: July 2, 1993Date of Patent: April 11, 1995Assignee: Mallinckrodt Medical Inc.Inventors: T. Jeffrey Dunn, Dennis A. Moore, Muthanadar Periasamy, Milorad M. Rogic, Rebecca A. Wallace, David H. White, Steven R. Woulfe
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Patent number: 5391727Abstract: This invention provides gold(I) complexes comprising sulfur- and selenium-substituted macrocyclic polyether ligands, photographic elements containing the compounds, and emulsions containing the compounds. The compounds include monomers and dimers having the following formulas, respectively:[AuL].sup.+ X.sup.- or [AuL].sub.2.sup.2+ 2X.sup.-wherein X.sup.- is any suitable anion such as tetrafluoroborate, nitrate, etc., and wherein L is a macrocyclic ligand containing at least two thioether and/or selenoether linkages and comprising from about 12 to about 30 members in the ring. The general structural formula for the macrocyclic compounds L may be represented as follows: ##STR1## wherein Q.sub.1 and Q.sub.2 are each independently sulfur or selenium, and R.sub.1 and R.sub.Type: GrantFiled: August 13, 1993Date of Patent: February 21, 1995Assignee: Eastman Kodak CompanyInventor: Joseph C. Deaton
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Patent number: 5385724Abstract: Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize trifluoromethyl derivatives of iodinated X-ray contrast media. Typical magnetic resonance contrast media within the scope of the present invention include bis(trifluoromethyl)benzene derivatives, tris(trifluoromethyl)benzene derivatives, tetrakis(trifluoromethyl)benzene derivatives, and other related trifluoromethylated benzene derivatives.Type: GrantFiled: March 4, 1994Date of Patent: January 31, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: David H. White, Steven R. Woulfe, Youlin Lin, Mills T. Kneller
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Patent number: 5326856Abstract: This invention relates to chelating agents useful for coupling metal ions to biologically active molecules. In particular, isothiocyanate derived thiocarbonyls for chelating metals such as technetium are provided that can be conjugated to a targeting molecule such as an antibody, a peptide or a protein.Type: GrantFiled: April 9, 1992Date of Patent: July 5, 1994Assignee: Cytogen CorporationInventors: Daniel J. Coughlin, Benjamin A. Belinka, Jr.
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Patent number: 5252763Abstract: A process for preparing higher order cuprate complexes by reacting an alkyne with zirconocene chloride hydride to produce a zirconium intermediate which is reacted with an alkyllithium and a first copper reagent selected from R.sup.2 Cu(CN)Li or the mixture CuCN and R.sup.2 Li to produce a higher order cuprate complex.Type: GrantFiled: July 8, 1992Date of Patent: October 12, 1993Assignee: G. D. Searle & Co.Inventors: Kevin A. Babiak, James R. Behling, John H. Dygos, John S. Ng
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Patent number: 5248430Abstract: Ammonium salts of aromatic sulpho group-containing condensation products of at least one sulpho group-containing aromatic compound and at least one dihydroxydiphenylsulphone with formaldehyde or a formaldehyde-yielding compound or of defined starting mono- or oligosulphones which are partially metallized and compositions containing them, optionally together with UV-absorbers, are suitable as assistants in the treatment of various substrates and act in particular as improvers of the light-fastness of synthetic polyamide fibres and their dyeings, as assistants in the dyeing or tanning of leather and in the production of paper and as wood-preserving agents.Type: GrantFiled: June 14, 1990Date of Patent: September 28, 1993Assignee: Sandoz Ltd.Inventor: Hans-Peter Baumann
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Patent number: 5211886Abstract: Calcium-substituted polymeric reagents are provided. These reagents can be prepared via the oxidative addition of a soluble highly reactive calcium species to organic and inorganic polymers containing alkyl, aryl, or alkylaryl pendent groups substituted with halide atoms, cyanide molecules, 1,3-dienes, or any conjugated polyunsaturated system. Preferably, the polymer is a cross-linked p-bromopolystyrene, p-chloropolystyrene, p-fluoropolystyrene, or chloromethylated polystyrene. Preferably, the soluble highly reactive calcium species is prepared from the reduction of Ca(II) salts with an alkali metal arene, such as lithium biphenylide. These calcium-substituted polymeric reagents react with a variety of electrophiles to yield functionalized polymers. Reaction with Cu(I) salts yields calcium-substituted polymeric cuprate reagents, which can react, for example, with acid chlorides to form ketones, alkyl halides containing functionality, and undergo 1,4-conjugate addition with .alpha.,.beta.Type: GrantFiled: August 1, 1991Date of Patent: May 18, 1993Assignee: Board of Regents of the University of NebraskaInventor: Reuben D. Rieke
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Patent number: 5211889Abstract: A soluble highly reactive form of calcium, prepared from Ca(II) salts and a reducing agent in ethereal, polyethereal, or hydrocarbon solvents, is presented. This form of calcium can be used in the preparation of organocalcium reagents. The organocalcium reagents resulting from the reaction of the soluble highly reactive calcium with organic compounds containing either halide, cyanide, a 1,3-diene, or a polyunsaturated functionality, are stable, useful reagents for organic synthesis. The organocalcium halide reagents undergo Grignard-type reactions. They also undergo reactions with Cu(I) salts to form organocalcium cuprate reagents. The organocalcium cuprate reagents undergo a variety of cross-coupling reactions. The soluble highly reactive calcium reacts with 1,3-dienes to yield the corresponding 2-butene-1,4-diylcalcium complexes. These bis-organocalcium reagents can undergo dialkylation reactions with .alpha.,.omega.Type: GrantFiled: August 1, 1991Date of Patent: May 18, 1993Assignee: Board of Regents of the University of NebraskaInventor: Reuben D. Rieke
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Patent number: 5200541Abstract: The products having general formula (I) ##STR1## in which R represents a C.sub.1 -C.sub.18 alkoxyl, C.sub.1 -C.sub.18 alkylthio, C.sub.1 -C.sub.18 monoalkylamino or C.sub.2 -C.sub.36 dialkylamino group, R.sub.1 represents a hydrogen atom or a C.sub.1 -C.sub.18 alkyl group, R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom or a C.sub.1 -C.sub.18 alkoxyl group and M represents a cobalt, nickel or copper atom, process of preparation, intermediates and use of the intermediates in order to obtain a product having general formula (I).Type: GrantFiled: January 10, 1992Date of Patent: April 6, 1993Assignee: Societe Francaise HoechstInventor: Thierry Thami
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Patent number: 5189192Abstract: Addition polymerization catalysts comprising a derivative of a Group 4-8 metal compound prepared by metal center oxidation.Type: GrantFiled: January 16, 1991Date of Patent: February 23, 1993Assignee: The Dow Chemical CompanyInventors: Robert E. LaPointe, Robert K. Rosen, Peter N. Nickias
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Patent number: 5171847Abstract: Novel metallo-organic complexes of the formula (M.sub.x X.sub.z. nL)y where M is an alkaline earth metal, a transition metal(at. Nos. 21-30, 39-48 and 72-80 inclusive) or a rare earth metal (at. Nos. 57-71 inclusive), X is an anion e.g. Cl.sup.-, Br.sup.-, NO.sub.3 -, NCS.sup.- etc. and L is a Lewis base, are prepared by reacting a source of the metal M under anhydrous conditions with an anhydrous ammonium salt of the anion X in the presence of the Lewis base, and cooling the reaction mixture to precipitate the complex.Type: GrantFiled: July 5, 1990Date of Patent: December 15, 1992Assignee: The Associated Octel Company LimitedInventors: Ronald Snaith, Dominic S. Wright, Alan T. Brooker, Simon R. Drake
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Patent number: 5166381Abstract: Charge blocking materials include a complex or salt of a film forming material containing at least one nitrogen-containing compound, such as an amino, an imino or a tertiary amine group, chelated to a metal ion or atom. The charge blocking materials may be used in a charge blocking layer of an electrophotographic imaging member. The charge blocking materials may be used with transparent conductive layers, for example, comprising cuprous iodide.Type: GrantFiled: October 17, 1991Date of Patent: November 24, 1992Assignee: Xerox CorporationInventors: Leon A. Teuscher, Ronald F. Ziolo
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Patent number: 5162556Abstract: An auric compound such as a halogenoauric acid is reacted with a mercaptan of a formula: ##STR1## whereupon the proportion of the mercaptan is from 2.70 to 2.99 mols per mol of the auric compound, to prepare an organic gold compound of a formula: ##STR2## wherein X is a halogen atom, Y and Z are independently a hydrogen atom or a hydrocarbon group having from 1 to 18 carbon atoms, n is a number of from 0.01 to 0.30, m is a number of from 0.7 to 0.99, and the total of n and m is from 0.8 to 1.2. The organic gold compound has a high solubility in organic solvent such as terpineol.Type: GrantFiled: November 19, 1990Date of Patent: November 10, 1992Assignee: Nissan Chemical Industries, Ltd.Inventors: Koichi Maeda, Hideki Takamatsu, Gozyo Sakata, Takeshi Mita
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Patent number: 5149845Abstract: There are provided novel compounds useful as selective extractants of metal values from aqueous systems comprising a plurality of such ionic species. There is further provided a process for the production of the novel compounds. The invention also relates to a process of selective metal extraction by means of the novel compounds of the invention.Type: GrantFiled: November 13, 1991Date of Patent: September 22, 1992Assignee: Yeda Research and Development Co. Ltd.Inventors: Abraham Shanzer, Jacqueline Libman, Shneior Lifson
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Patent number: 5141740Abstract: Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.Type: GrantFiled: November 21, 1990Date of Patent: August 25, 1992Assignee: Mallinckrodt Medical, Inc.Inventors: Raghavan Rajagopalan, Rebecca A. Wallace, Muthunadar P. Periasamy
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Patent number: 5137711Abstract: Novel magnetic resonance imaging agents methods utilize complexes of paramagnetic ions with alkoxyalkylamide deriviatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetyraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions.The complexes are represented by the following formula: ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or ##STR2## and M.sup.+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence number, Z, of 2 or 3; R.sup.1 is --O.sup.- or R.sup.3 --N--R.sup.2, R.sup.2 is --(CH.sub.2 CH.sub.2 O).sub.n --R.sup.4, n is 1-10, R.sup.4 is alkyl or aryl, R.sup.3 is H, R.sup.2, alkyl, hydroxy, alkoxy, cycloalkyl or aryl, wherein Z of the R.sup.1 groups are --O.sup.- and the remainder of the R.sup.1 groups are R.sup.2 -N--R.sup.3 groups.Type: GrantFiled: July 13, 1989Date of Patent: August 11, 1992Assignee: Mallickrodt Medical, Inc.Inventors: Robert W. Weber, Muthunadar P. Periasamy
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Patent number: 5135737Abstract: Disclosed are amplifier molecules: various organic compounds having branched structures terminating with amine groups to which pharmacologically active groups can be chemically attached. A number of MRI contrast-enhancing agents were synthesized, each comprising plural active groups, such as stable nitroxides and complexes of trivalent metal cations. Such syntheses were successfully performed using a number of amplifiers having different branched structures, demonstrating the general utility of the pertinent chemistry in the synthesis of amplifiers having any of a wide variety of pharmacologically active groups. Amplifiers were also synthesized having linkers terminating with chemically reactive groups such as isothiocyanates, which render the amplifier bifunctional: attachable to polymers, biomacromolecules, or other biocompatible entity possessing multiple reactive sites such as terminal amines.Type: GrantFiled: September 5, 1989Date of Patent: August 4, 1992Assignee: The State of Oregon Acting by and through the State Board of Higher Education on behalf of the University of OregonInventor: John F. W. Keana
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Patent number: 5130120Abstract: Novel magnetic resonance imaging agents and methods which utilize complexes of paramagnetic ions with alkoxyalkylamide derivatives of diethylenetriaminepentaacetic acid ("DTPA") or ethylenediaminetetraacetic acid ("EDTA"). These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. The complexes are represented by the following formula: ##STR1## wherein A is --CH.sub.2 CH.sub.2 -- or ##STR2## and M.sup.+z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 or 58-70, and a valence, Z, of 2 or 3; the R groups may be the same or different and are selected from the group consisting of -O.sup..crclbar. and lower alkoxyalkylamino groups having from 2 to about 6 carbon atoms, wherein the number of R groups -O.sup..crclbar. equals Z and the remaining R groups are lower alkoxyalkylamino, equal to 4-Z when A is --CH.sub.2 CH.sub.Type: GrantFiled: July 19, 1988Date of Patent: July 14, 1992Assignee: Mallinckrodt Medical, Inc.Inventor: Robert W. Weber
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Patent number: 5118824Abstract: The invention relates to platinum hydrides, a process for their preparation and their use as components of catalytic systems. The platinum hydrides have a bridged bimetallic structure represented by the general formula: ##STR1## wherein: M is a metal of valence n, at least equal to 2,X is a halogen atom, andP P is a schematic representation of a ligand of the general formula: ##STR2## in which: R.sub.1, R.sub.2, R.sub.5, and R.sub.6, identical or different, are chosen from among aliphatic or cycloaliphatic hydrocarbon radicals with 1 to 8 carbon atoms and aromatic hydrocarbon radicals with 6 to 10 carbon atoms,R.sub.3 and R.sub.4, identical or different, are chosen from among a hydrogen atom and aliphatic hydrocarbon radicals with 1 to 8 carbon atoms, possibly functionalized and/or together forming a ring, andm is an integer higher than or equal to 4.Type: GrantFiled: February 6, 1991Date of Patent: June 2, 1992Assignee: AtochemInventors: Eric Paumard, Andre Mortreuz, Francis Petit
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Patent number: 5114688Abstract: A binuclear metal complex, comprising a metal-complexed ligand which ligand is formed by the reaction of a dialdehyde and a poly primary amine, which complex is capable of reacting reversibly with molecular oxygen.Type: GrantFiled: January 23, 1990Date of Patent: May 19, 1992Assignee: L'Air Liquide, Societe Anonyme pour l'Etude et Exploitation des Procedes Georges ClaudeInventors: Arthur E. Martell, Ramunas J. Motekaitis
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Patent number: 5107005Abstract: This invention refers to a process to obtain new mixed copper aminoacidates complexes from phenanthrolines of an aromatic type to be used as anticancerigenic agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumors such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)].+-. NO.sub.3 type in which the N-N ligand corresponds to 4, 7 - diphenyl-1, 10 phenanthroline and the N-O ligand preferably corresponds to one of the aminoacidates such as glycinate, alaninate, isoleucinate, leucinate, serinate and valinate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4, 7 - diphenyl - 1, 10 phenanthroline react with a copper complex preferably Cu NO.sub.3 5H.sub.2 O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.Type: GrantFiled: December 11, 1990Date of Patent: April 21, 1992Assignee: Universidad Nacional Autonoma de Mexico (UNAM)Inventor: Lena R. Azuara
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Patent number: 5089644Abstract: A process for making a solution of a complex of an oxamine and a polyvalent paramagnetic metal comprising contacting a solution of the oxamine with (a) the insoluble hydroxide of the polyvalent paramagnetic metal in water, or (b) an alkoxide of the metal is a non-aqueous solvent, thereby to form a solution of a complex of the oxamine and the metal. The complex, preferably ferrioxamine, is an improved NMR image enhancer compared even with ferrioxamine made conventionally, characterized by a high LD.sub.50.Type: GrantFiled: June 11, 1987Date of Patent: February 18, 1992Assignee: Salutar Inc.Inventors: Steven C. Quay, Scott M. Rocklage
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Patent number: 5087439Abstract: Complexes of a highly paramagnetic polyvalent metal, e.g., a lanthanide such as gadolinium, or of a less paramagnetic metal, e.g., iron, manganese, copper, cobalt, chromium or nickel, with a bisalkylamide of diethylenetriaminepentaacetic acid of the formula: ##STR1## wherein three groups M are hydroxyl groups and the remaining two groups M are NHR groups in which each group R is an alkyl group of the formula --(CH.sub.2).sub.n CH.sub.3 where n is zero or an integer of from 1 to 17, are disclosed. These complexes are useful as magnetic resonance imaging contrast enhancers.Type: GrantFiled: July 31, 1989Date of Patent: February 11, 1992Assignee: Salutar, Inc.Inventor: Steven C. Quay
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Patent number: 5057618Abstract: New complexes of the elements of Groups VIIA, VIIIA, and IB of the Periodic Table* with the trisodium salt of tris(m-sulfophenyl)phosphane as a complex ligand. The complexes are used as catalysts for hydrogenations for the water gas reactions, hydrocarbonyls, hydroformylations, oxidations, carbon-carbon cross-linking reactions (e.g. allene/alkine coupling), and additions of secondary amines to carbon-carbon double bonds.*according to the IUPAC version.Type: GrantFiled: November 30, 1989Date of Patent: October 15, 1991Assignee: Hoechst AktiengesellschaftInventors: Wolfgang A. Herrmann, Jurgen Kulpe, Jurgen Kellner, Herbert Riepl
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Patent number: 5039682Abstract: This invention relates to novel 1,7-disubstituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and certain esters and cation salts thereof. This invention further relates to preparation of the compounds, antibacterial compositions containing the compounds and methods of using the compounds.This invention also relates to a novel process for preparing novel N-cyclopropyl intermediates useful for preparing certain of the 1,7-disubstituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives of this invention which contain a cyclopropyl substituent at the 1 position as well as other 1,4-dihydroquinol-4-one-3-carboxylic acid derivatives so substituted with cyclopropyl.Type: GrantFiled: June 21, 1988Date of Patent: August 13, 1991Assignee: Pfizer Inc.Inventor: Paul R. McGuirk
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Patent number: 5023360Abstract: Dialkyl gold(III) .beta.-diketonates are synthesized in a two-step, one-pot process using a gold trihalide, an alkyl lithium compound and a .beta.-diketone.Type: GrantFiled: May 1, 1990Date of Patent: June 11, 1991Assignee: International Business Machines CorporationInventors: Thomas H. Baum, Phillip J. Brock, Daniel J. Dawson
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Patent number: 5021187Abstract: Bleach activators are herein disclosed having the stoichiometric formula:[Cu(R.sub.1 R.sub.2 CHR.sub.5 (CH.sub.2).sub.n R.sub.6 CHNR.sub.3 R.sub.4)X.sub.m ] (I)wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each a radical selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, arylalkyl, phenyl, benzyl and mixtures thereof,or R.sub.5 and R.sub.6 together form a hydrogen carbon ring,n is an integer from 0 to 1,m is an integer from 1 to 2, andX is selected from mono- and polyvalent anions.These bleach activators are combined with a peroxygen compound capable of releasing hydrogen perioxide in an aqueous solution. The combination is especially effective in the removal of hydrophobic stains from fabrics.Type: GrantFiled: April 4, 1989Date of Patent: June 4, 1991Assignee: Lever Brothers Company, Division of Conopco, Inc.Inventors: Sharon M. Harriott, Van Au, Wayne M. Rees
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Patent number: 5011958Abstract: This invention encompasses a process for preparing higher order cuprate complexes which contain a carbanion for the formation of carbon to carbon bonds in reactions such as epoxide addition. The complex is formed by reacting a first cuprate complex with a stannane such that the carbanion to be used to form carbon to carbon bonds is transferred from the stannane to the first cuprate complex to form a different higher order cuprate complex. This process permits the in situ preparation of a higher order cuprate complex having the carbanion desired to be used in a synthetic reaction. Higher order cuprate complexes derived from the reaction of a cuprate complex with 1,2-bis-tri-n-butylstannyl ethylene are particularly useful for the addition to epoxides to form vinyl tin intermediates useful for preparing omega side chains of prostaglandins.Type: GrantFiled: October 25, 1989Date of Patent: April 30, 1991Assignee: G. D. Searle & Co.Inventors: Arthur L. Campbell, James R. Behling, John S. Ng, Kevin A. Babiak
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Patent number: 5008418Abstract: Tris(isonitrile)copper(I) complex salts with anions selected from BF.sub.4, PF.sub.6, ClO.sub.4, I, Br, Cl and CF.sub.3 COO are useful in preparing radionuclide complexes rapidly at room temperature. Preferred isonitrile ligands are ether isonitriles. The tris(isonitrile)copper(I) adducts enable technetium complexes, such as those of Tc99m, to be prepared easily just prior to their use as imaging agents.Type: GrantFiled: August 23, 1989Date of Patent: April 16, 1991Assignee: E. I. du Pont de Nemours and CompanyInventors: Tahir Iqbal, John H. Cain, Jr., Jack J. Slosky
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Patent number: 4999443Abstract: Transition metal complexes of the general formula I[A].sup.x- [Q].sup.+.sub.x Iwhere Q is one equivalent of a cation, x is from 0 to 2 and A is a transition metal complex of the general formula ##STR1## where n is from 1 to 3, M is positively charged cobalt, rhodium, iridium or ruthenium, the ligands B are phosphonic, arsonic, phosphinic and/or arsinic acid ligands which are esterified with identical or different alcohols, one or more of these alcohol components carrying a functional group, L is ##STR2## the radicals R.sup.5 are identical or different radicals from the group consisting of C.sub.1 -C.sub.4 -alkyl and phenyl, p is an integer from 0 to 6, q is an integer from 0 to 5, and R.sup.1 is fluorine, chlorine, bromine, iodine, cyanide, isocyanide, cyanate, isocyanate, thiocyanate, isothiocyanate, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.Type: GrantFiled: June 2, 1989Date of Patent: March 12, 1991Assignee: BASF AktiengesellschaftInventors: Werner Bertleff, Dieter Koeffer, Wolfgang Klaeui, Choong-Eui Song
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Patent number: 4965384Abstract: This invention relates to the production of copper catalysts for the oxidative coupling of 2,6-dialkylphenols to produce mixtures of 3,3',5,5'-tetra-alkyl-4,4'-dihydroxybiphenyls and corresponding diphenoquinones.Type: GrantFiled: May 5, 1989Date of Patent: October 23, 1990Assignee: Amoco CorporationInventors: Michael D. Cliffton, Stephen J. Carter
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Patent number: 4952289Abstract: Methods and apparatus for electrochemical extraction of a ligand such as molecular oxygen from a first fluid environment and for release of a ligand such as molecular oxygen, as well as ligand carrier compounds therefor comprising macrocyclic amines having the general formulas: ##STR1## where: A, B, C, D, E, and F are each nitrogen, oxygen, sulfur, or phosphorous;m, n, o, p, q, and r are each typically 2, 3, 4, 5, or 6;the R substituents are each generally H or short chain (linear or branched) alkyl, although R.sub.2 may represent ketyl (.dbd.o); andM is a suitable transition metal ion.Type: GrantFiled: May 9, 1988Date of Patent: August 28, 1990Assignee: Aquanautics CorporationInventors: Joseph P. Ciccone, Emory S. DeCastro, John B. Kerr
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Patent number: 4948594Abstract: In solid form, copper complex salts of the formula: ##STR1## wherein "n" is from 1 to 5, and "Z" is an anion and "y" is the number required to electrostatically balance the set.Type: GrantFiled: August 22, 1989Date of Patent: August 14, 1990Assignee: Zinpro CorporationInventors: Mahmoud M. Abdel-Monem, Michael D. Anderson
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Patent number: 4933204Abstract: A gold(III) acetate is formed by dissolving gold(III) hydroxide in glacial acetic acid. This solution containing gold(III) acetate can be used to form a gold-containing film by heating it above about 60.degree. C. and then casting it to form a film. Gold can be deposited from the film by heating it to about 175.degree. C. to decompose the film. In this manner, a line or pattern of conductive gold can be formed by heating selected portions of the film with a laser.Type: GrantFiled: September 23, 1988Date of Patent: June 12, 1990Assignee: Rockwell International CorporationInventors: Leslie F. Warren, Jr., Patricia H. Cunningham
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Patent number: 4921847Abstract: There is described a novel class of aminegold(III) complexes in which the nitrogen-containing ligand is an alkylamine, an arylamine or a heterocyclic amine. Said complexes are useful in the treatment of tumors in mammals.Type: GrantFiled: February 27, 1989Date of Patent: May 1, 1990Assignee: Engelhard CorporationInventors: Alan R. Amundsen, Eric W. Stern
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Patent number: 4900561Abstract: In solid form copper complex salts of the formula: ##STR1## wherein "n" is from 1 to 5, and "Z" is an anion and "y" is the number required to electrostatically balance the set.Type: GrantFiled: January 3, 1989Date of Patent: February 13, 1990Assignee: Zinpro CorporationInventors: Mahmoud M. Abdel-Monem, Michael D. Anderson
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Patent number: 4888032Abstract: Salts containing cations of the formula: ##STR1## (in which M is Co, Fe, Cr or Mn, X, Y, R.sub.1,The Government has rights in this invention pursuant to Contract Number CHE-75-14837 awarded by the National Science Foundation.Type: GrantFiled: January 18, 1984Date of Patent: December 19, 1989Assignee: The Ohio State University Research FoundationInventor: Daryle H. Busch
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Patent number: 4885368Abstract: Novel radical ion salts of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently of one another are each hydrogen, methyl, ethyl, phenyl, methoxy, ethoxy, fluorine, chlorine or bromine, or R.sup.1 or R.sup.1 and R.sup.3 may furthermore be tert-butyl and/or R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together may in each case form a radical of the formula ##STR2## where z is 0, 1, 2 or 3, and the fused aromatic rings are unsubstituted or monosubstituted or disubstituted by chlorine, bromine, methyl and/or methoxy, M.sup.m.sym. is an m-valent alkali metal, alkaline earth metal, transition metal, tin, lead, thallium, ammonium, phosphonium, arsonium or stibonium ion, k is from 1 to 5, l is from 0.1 to 4, m is from 1 to 3, n is from 0.1 to 4, x is from 0 to 2 and y is from 0 to 6, and k, l, n, x and y may furthermore be non-integral numbers and (l+x)=n.m, are electrically conductive in the crystalline state. A number of the salts are stable at 300.degree. C. and above.Type: GrantFiled: November 23, 1987Date of Patent: December 5, 1989Assignee: BASF AktiengesellschaftInventors: Siegfried Huenig, Alexander Aumueller, Peter Erk
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Patent number: 4885100Abstract: Tris(isonitrile)copper(I) complex salts with anions selected from BF.sub.4, PF.sub.6, ClO.sub.4, I, Br, Cl and CF.sub.3 COO are useful in preparing radionuclide complexes rapidly at room temperature. Preferred isonitrile ligands are ether isonitriles. The tris(isonitrile)copper(I) adducts enable technetium complexes, such as those of Tc99m, to be prepared easily just prior to their use as imaging agents.Type: GrantFiled: September 11, 1987Date of Patent: December 5, 1989Assignee: E. I. Du Pont de Nemours and CompanyInventors: Tahir Iqbal, John H. Cain, Jr., Jack J. Slosky
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Patent number: 4859451Abstract: In the NMR imaging of a subject comprising administering to such subject a composition containing an image-modifying effective amount of an image enhancer, permitting the enhancer to move through the subject, and after a time interval taking an NMR image of the subject, the improvement which comprises employing as said enhancer a complex of a paramagnetic polyvalent metal and a partial amide and/or ester of diethylenetriaminepentaacetic acid. The complexes are new.Type: GrantFiled: April 24, 1986Date of Patent: August 22, 1989Assignee: Salutar, Inc.Inventors: Steven C. Quay, Dilip M. Worah
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Patent number: 4851557Abstract: Copper-amine complexes comprised of a water-soluble copper salt and a polyamide-amine can be used as fungicides without the addition of ammonia, and they form firmly adhering coatings on leaf surfaces.Type: GrantFiled: June 18, 1986Date of Patent: July 25, 1989Assignee: Benckiser-Knapsack GmbHInventors: Stephan G. Kleemann, Guenter Claus
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Patent number: 4816038Abstract: Metal complexes of hydroxyl- and/or thiol-containing Mannich are prepared by reacting a transition metal-containing agent with an aromatic Mannich. The Mannich is prepared from a substituted hydroxyl- and/or thiol-containing aromatic, an aldehyde or ketone, and a hydroxyl- and/or thiol-containing amine compound. A Schiff base is then reacted therewith. The products are useful in reducing soot ignition temperatures in diesel particulate traps.Type: GrantFiled: February 23, 1988Date of Patent: March 28, 1989Assignee: The Lubrizol CorporationInventors: Frederick W. Koch, Gail A. Evans, Casper J. Dorer, Jr., Alan A. Del Paggio
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Patent number: 4788151Abstract: Acetylenic complexes are disclosed that are useful as environmental indicating materials whereby exposure thereof to environmental stimuli induces a color change. These complexes contain at least one effective complexing metal and at least one acetylenic compound of the general formula:[R--(C"C).sub.a --(CH.sub.2).sub.b --(C"C).sub.c ].sub.2.dHXWherein a is 1 or 2, b is about 0-5; c is 0 or 1; with the proviso that when a is 1, b and c are 0, when a is 2, b is about 0-5 and c is 0 or 1; and R is --(CH.sub.2).sub.n -NHC(O)NHR'; wherein n is an integer of about 1 to 10; and R' is selected from the group consisting of: (a) hydrogen; (b) cycloalkyl; (c) alkenyl; (d) cycloalkenyl; (e) alkyl; (f) phenyl; (g) alkoxy; (h) alkoxy alkyl; and (i) alkoxycarbonylalkyl.Type: GrantFiled: September 29, 1986Date of Patent: November 29, 1988Assignee: LifeLines Technology, Inc.Inventors: Anthony F. Preziosi, Thaddeus Prusik
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Patent number: 4778612Abstract: Compounds of formula I ##STR1## wherein R and R.sup.1 are identical or different and are a radical of the formula ##STR2## where R.sup.2, R.sup.3 and R.sup.4 are each independently C.sub.1 -C.sub.18 alkyl and together contain not more than 22 carbon atoms, and R.sup.3 and R.sup.4 are also hydrogen, or wherein R and R.sup.1 are C.sub.5 -C.sub.6 cycloalkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted phenyl, or naphthyl, C.sub.7 -C.sub.14 aralyl, furfuryl or thienyl, and wherein Y is --S--, --O--, --NH--, --N(C.sub.1 -C.sub.12 alkyl)--, --CH.sub.2 --, --CH(C.sub.1 -C.sub.12 alkyl)-- or --C(C.sub.1 -C.sub.12 alkyl).sub.2 -- and X.sup..sym. is 1 equivalent of a metallic cation selected from the group consisting of Li.sup..sym., Na.sup..sym., K.sup..sym., Mg.sup.2.sym., Ca.sup.2.sym., Ba.sup.2.sym., Zn.sup.2.sym., Mn.sup.2.sym., Ni.sup.2.sym., Fe.sup.3.sym., Fe.sup.2.sym., Co.sup.2.sym., Cu.sup.2.sym., Al.sup.3.sym., Cr.sup.3.sym., VO.sup. 3.sym., ZrO.sup.2.sym., MoO.sub.2.sup.2.sym. and TiO.sup.2.sym.Type: GrantFiled: October 22, 1986Date of Patent: October 18, 1988Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Rolf Schumacher, Klaus Muller
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Patent number: 4758682Abstract: A complex of a tetradentate tetraanionic ligand L of the formula: ##STR1## and a metal, preferably a transition metal, is described where Z is an anionic oxidation reistant metal complexing group, Ch is an oxidation resistant chelate group containing 1 to 4 chain atoms and Y is hydrogen. The chelate and ring Z-Ch-M-Z functional groups Z, such as N or O, are resistant to oxidation and the ring contains 4 to 7 preferably 5 to 6 chain atoms. An osmium complex containing two pyridine ligands is an oxidation catalyst. Further activation by anodic oxidation and heating to a temperature exceeding 30.degree. C. greatly increases catalytic activity.Type: GrantFiled: November 1, 1985Date of Patent: July 19, 1988Assignee: California Institute of TechnologyInventors: Terrence J. Collins, Fred C. Anson, Stephen L. Gipson, Terry E. Krafft
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Patent number: 4731460Abstract: Acylcyanamides are disclosed having the formula ##STR1## in which the symbol R represents a straight-chain or branched chain alkyl or alkenyl group having from about 5 to about 21 carbon atoms, which group may be substituted by OH--, O--CH.sub.2 --CH.sub.2 --OH-- and/or O--R'-- groups, where the symbol R' represents an alkyl group having from 1 to about 4 carbon atoms and wherein M is a manganese, iron, cobalt, nickel, zinc, cadmium, copper and/or lead.The compounds of the invention are useful as heat stabilizers for chlorine-containing polymers.Type: GrantFiled: June 24, 1986Date of Patent: March 15, 1988Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Christian Hase, Bernd Wegemund, Werner Erwied, Dieter Krampitz
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Patent number: 4673687Abstract: A chemotherapeutic composition for the control of plant diseases caused by mycoplasma-like organisms, rickettsia-like organisms, or seed-borne legume viruses. The composition is composed essentially of the tannate complex of picro ammonium formate combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate. The preparation and use of the composition are disclosed. Also disclosed is a related chemotherapeutic composition for the control of plant diseases caused by plant pathogenic fungi and bacteria and composed essentially of a tannate complex of picro cupric ammonium formate in aqueous solution combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, along with its method of preparation and manner of use.Type: GrantFiled: September 5, 1985Date of Patent: June 16, 1987Assignee: Source Technology Biologicals, Inc.Inventors: Mandayam J. Thirumalachar, Mandayam J. Narasimhan, Mandayam J. K. Thirumalachar
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Patent number: 4668810Abstract: Methods for preparing copper(I)-diamine-phenoxide complexes within solution, such as the polymerization medium of polyphenylene oxides, are described which utilize a copper-diamine-halide complex, an alkali metal hydroxide and a monohydroxy aromatic compound to generate effective catalysts without the scrupulous exclusion of moisture and air.Type: GrantFiled: January 14, 1986Date of Patent: May 26, 1987Assignee: General Electric CompanyInventor: Deborah A. Haitko
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Patent number: H1170Abstract: The invention relates to volatile mixed metal alkoxides of the formula M'.sub.x M.sub.y Cu.sub.z (OR).sub.x+2(y+z) wherein M is selected from the group consisting of Ba, Sr, and Ca, M' is an alkali metal, x=0-6, y=0-4 and z=1 to 6, and x and y are not 0 at the same time, and R is selected from the group consisting of CMe.sub.3, CMe.sub.2 Et, CMeEt.sub.2, CMe.sub.2 Pr, CMeEtPr, CEt.sub.3 or combinations of these substituents. Volatile alkoxides of Y and Cu are known. These volatile alkoxides can be used in a CVD process where stoichiometric quantities of the material are sublimated, transported to a substrate and decomposed to an oxide with or without the presence of oxygen. The oxides are then treated in a known manner to produce the superconducting film.Type: GrantFiled: July 31, 1989Date of Patent: April 6, 1993Assignee: United States of AmericaInventor: Andrew Purdy