Reactant Having Halogen And -c(=x)-, Wherein X Is Chalcogen, Bonded Directly To The Same Carbon (e.g., Alpha Halo Carbonyl Compounds, Etc.) Patents (Class 558/116)
  • Novel sulfonamidomethyl phosphonate inhibitors of beta-lactamase
    Publication number: 20040059115
    Abstract: The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel &bgr;-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic &bgr;-lactamase inhibitors presently available, and which do not require a &bgr;-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
    Type: Application
    Filed: October 8, 2002
    Publication date: March 25, 2004
    Inventors: Jeffrey M. Besterman, Daniel Delorme, Jubrail Rahil
  • Phosphate derivatives as immunoregulatory agents
    Publication number: 20020091105
    Abstract: Immunoregulatory compounds are disclosed of the formula: 1
    Type: Application
    Filed: August 30, 2001
    Publication date: July 11, 2002
    Inventors: Suzanne Mandala, James Bergstrom, Richard Hajdu, Hugh Rosen, William Parsons, Deborah J. Card, Malcolm Maccoss, Rupprecht Kathleen
  • Substituted aminomethylphosphines, coordination complexes of aminomethylphosphines and their synthesis
    Patent number: 6034240
    Abstract: Novel aminomethylphosphine ligands have particular substituents on the central carbon atom. Such ligands form coordination complexes that may be catalysts for the polymerization of monomers or other catalytic induced reactions.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: March 7, 2000
    Assignee: Symyx Technologies, Inc.
    Inventor: Anne Marie La Pointe
  • Liquid crystal phase
    Patent number: 4744918
    Abstract: Liquid crystal phases containing at least one optically active compound of the formula IR.sup.1 --X.sup.1 --CHR.sup.o (CH.sub.2).sub.p X.sup.2 --R.sup.2 Iwherein X.sup.1 and X.sup.2 independently of one another are each --CO--O-- or --O--CO--, one of X.sup.1 and X.sup.2 may also be --O--, R.sup.1 and R.sup.2 independently of one another are each a group --(A.sup.1 --Z).sub.m --(A.sup.2).sub.n -Y, whereinA.sup.1 and A.sup.2 in each case independently of one another are a 1,4-phenylene, pyrimidine-2,5-diyl, pyrazine-2,5-diyl, pyridine-2,5-diyl, 1,4-cyclohexylene, 1,3-dioxane-2,5-diyl, 1,3-dithiane-2,5-diyl or 1,4-bicyclo(2,2,2)-octylene group, it also being possible for this to be monosubstituted or polysubstituted by F, Cl, Br, CN and/or alkyl groups with up to 12 C atoms, and it being possible for 1 or 2 non-adjacent CH.sub.2 groups in the alkyl groups to be replaced by O atoms,Z is --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --OCH.sub.2 --, --CH.sub.2 O--, --CH.dbd.N--, --N.dbd.CH--, --N.dbd.N--, --N(O).
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: May 17, 1988
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Gerd Heppke, Feodor Oestreicher