Abstract: Thioester derived hindered phenols & thioester derived arylamines are effective antioxidant and antiwear additives for lubricants and fuels.

Abstract: The invention relates to compounds of the polyfluoroalkyl acetate, thioacetate or acetamide type, which can be denoted by the general formula: ##STR1## in which Rf denotes a perfluoroalkyl radical, m is an integer ranging from 1 to 4, Q denotes an oxygen or sulphur atom or an NH group, X.sup.- denotes an anion, R.sub.1 denotes an alkyl radical containing from 1 to 3 carbon atoms, R.sub.2 denotes the allyl radical or an alkyl radical containing from 1 to 18 carbon atoms, and R.sub.3 denotes an alkyl radical containing from 7 to 18 carbon atoms or one of the following radicals: ##STR2## wherein n is an integer from 2 to 4, R is hydrogen or methyl, and Y denotes C.sub.2 -C.sub.8 alkylene bridge optionally interrupted by an oxygen atom.These compounds can be used as surface-active agents or an monomers for developing artificial vesicles.

Abstract: Lubricants are stablized against oxidative degradation by the incorporation therein of hydroxylamines substituted with thioalkanoic acid residues of the formula ##STR1## wherein R and R.sub.1 are independently H, alkyl or aryl, X is independently OR.sub.2 SR.sub.2 or NR.sub.3 R.sub.4 wherein Rhd 2 is H, alkyl, cycloalkyl or aralkyl, and R.sub.3 and R.sub.4 are independently H, alkyl or aryl and n is 1 or 2.

Abstract: Borated glycerol hydroxyesters are effective friction reducing additives when incorporated into lubricating compositions.

Abstract: An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R.sup.1 are independently H, lower alkyl or halogen, R.sup.2 is H or lower alkyl and R.sup.3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediated for preparing antihypertensive agents, such as captopril.

Abstract: Thiester derivatives are disclosed as fat mimetic compounds for reduced calorie food compositions. These compounds have a two- to six-carbon backbone to which are attached at least one C.sub.1 to C.sub.29 fatty aliphatic, ether, ester or thioester group in ester linkage and at least one other fatty C.sub.1 to C.sub.29 group in ester or thioester linkage. Preferred compounds have three fatty substituents attached to the backbone and are partially digestible.

Abstract: New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R"--; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.

Abstract: Process for the production of 4-alkoxy-2(5H) thiophenones, which are suitable as intermediate products, i.e., for the production of highly pure thiotetronic acid.

Abstract: The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl or the radical of a natural amino acid, R.sup.2 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, amino, hydroxy, mercapto, sulphinyl, sulphonyl or the radical of a natural amino acid, and R.sup.3 represents optionally substituted hydroxy or amino, by sigmatropic rearrangement of a suitable allyl ester, halolactonisation of the resulting .gamma.,.delta.-unsaturated acid or of a suitable derivative thereof, exchange of halogen for a nitrogen-containing nucleophile, opening of the lactone ring and freeing of the amino group. Compounds of the formula I are starting materials for the preparation of renin-inhibitors which have an anti-hypertensive action.

Abstract: A phosphorous free antiwear/antifriction additive for lubricant oil is described. The additive is a fatty acid thio ester or a dialkyl disubstituted fatty acid thio amine having the formula of ##STR1## wherein R.sub.1 is a saturated or unsaturated hydrocarbon having 8 to 40 carbon atoms;R.sub.2, R.sub.3 and R.sub.4 are hydrocarbons having 1 to 4 carbon atoms; andn=1 to 4.

Abstract: The present invention provides a lipase substrate of the general formula: ##STR1## wherein A is an alkylene or alkenylene radical containing up to 16 carbon atoms, R and R.sub.1, which can be the same or different, each signify an alkyl, alkenyl or acyl radical containing up to 20 carbon atoms or an optionally alkyl-substituted aryl or aralkyl radical containing up to 8 carbon atoms in the alkyl moiety and wherein one of R and R.sub.1 can also be a hydrogen atom, X is the residue of an aromatic hydroxy or thiol compound, and each Y and Z, independently from each other, is --S-- or --O--, Z also --CH.sub.2 --.The present invention also provides a process and a reagent for the optical determination of lipase.

Abstract: N-(trans-p-hydroxy-cyclohexyl)-(2-amino-3,5-dibromo)benzylamine salts possessing mucolytic activity, and having the general formula: ##STR1## wherein R is the anion of a mono or dicarboxylic amino acid chosen from the group consisting of .alpha.-mercaptopropionylglycine, S-benzoyl-.alpha.-mercaptopropionylglycine, S-thenoyl-.alpha.-mercaptopropionylglycine, acetyl-L-cysteine, carboxymethyl-L-cysteine, thiazolidinemonocarboxylic acid and thiazolidinedicarboxylic acid, and n is 1 if said amino acid is monocarboxylic, n is 1 or 2 if said amino acid is dicarboxylic.

Abstract: This invention relates to condensation polymers of thiolactic and thioglycolic acids. These polymers, as well as thiolactic acid, 2,2'-dithobisacetic acid, and 2,2'-dithiobispropanoic acid, increase both the rate of plant growth and the concentration of chlorophyll in the plant.

Abstract: Discloses (1) reacting a 3-(hydrocarbylthio) propionaldehyde with a compound ##STR1## (2) reacting latter compound with CO and R"YH where y is O or S to make (3) hydrolyzing this compound; (4) certain new 1-acyloxy-3-methylthiopropenes and (5) the methyl ester of 2-acetoxy-4-(methylthio)thiobutanoic acid.

Abstract: Herbicidal utility for 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones and sulfur analogs is disclosed and exemplified. Many of the disclosed compounds are novel. Methods for preparing the herbicidal compounds and intermediates therefor are also disclosed.

Abstract: 5-2-chloro-4-trifluoromethylphenoxy)-2-nitro-.alpha.-substituted-acetopheno nes and oxime derivatives thereof represented by the formula ##STR1## wherein R.sup.1 and Y are as defined in the disclosure, process for the preparation thereof, herbicidal composition and method for the destruction of undesirable weeds. The herbicides comprising the above compounds are capable of selectively controlling undesirable weeds among desirable crop plants.

Abstract: Novel esters in all possible isomeric forms or a mixture thereof having the formula ##STR1## wherein Y is selected from the group consisting of hydrogen, halogen, --OAlK and ##STR2## AlK is alkyl of 1 to 6 carbon atoms, n is 0, 1 or 2, Z is selected from the group consisting of --O-- and --S--, R.sub.1 is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkylalkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --OH, --SH, --OR', --SR', ##STR3## --SO.sub.2 AlK.sub.2, --SO.sub.3 AlK.sub.3, aryl optionally substtuted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3, --SCF.sub.3 and ##STR4## R' is alkyl of 1 to 8 carbon atoms, R" and R'" are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK.sub.1, AlK.sub.2 and AlK.

Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents lower alkyl, phenyl, or phenyl lower alkyl; R.sub.2 represents lower alkyl; and R.sub.5 represents lower alkyl. These compounds are useful as intermediates in the preparation of collagenase inhibiting compounds which are useful in the treatment of arthritis and are of the formula ##STR2## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry.

Abstract: Certain novel aryl sulfonyl fluorides, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity.

Abstract: The invention relates to novel phenoxyphenylamino acid derivatives of the formula I ##STR1## wherein X is hydrogen, chlorine, fluorine or bromine,R.sup.1 is hydrogen, nitroso, or C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkylcarbonyl or C.sub.2 -C.sub.4 alkenylcarbonyl, each of which is unsubstituted or substituted by one or more halogen atoms,Q is a straight chain or branched aliphatic radical of 1 to 5 carbon atoms ##STR2## in which A', E', G', L' and M' are hydrogen or C.sub.1 -C.sub.4 alkyl, or two adjacent substituents A', E', G', L' and M' together are also a bond between the two carbon atoms to which they are attached; A, E, G, L and M are hydrogen or one or two of A, E, G, L and M are also --OR.sup.2, --SR.sup.3, --COOR.sup.4, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkyl substituted by --OR.sup.5, --SR.sup.6 or --COOR.sup.7, where R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen or C.sub.1 -C.sub.4 alkyl; a, b, c and d are 0 or 1; or R.sup.

Abstract: This invention relates to stereoisomeric forms and mixtures thereof of compounds of the formula ##STR1## having insecticidal, nematocidal, and acaricidal properties.

Abstract: As new compounds, substituted aryloxy benzoyl amino acid esters having the formula ##STR1## in which R is NO.sub.2, hydrogen or halogen; R' is H, lower alkyl having from about 1 to about 6 carbon atoms, PO.sub.3 R'2, SCC1.sub.3, or any combination thereof; R" is lower alkyl having from about 1 to about 8 carbon atoms, hydrogen, aryl, or a salt-forming cation selected from alkaline earth metals, magnesium, calcium, barium, iron, copper, zinc, and any other agriculturally acceptable salt; n is 1, 2, 3 or 4; W is oxygen, sulfur, or nitrogen; X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, hydrogen or cyano; and Z is hydrogen, chlorine, bromine, iodine, fluorine, or CH.sub.m F.sub.3-m where m is the integer 0, 1, 2 or 3. These compounds are useful as herbicides.

Abstract: Benzoylpropionic acid derivatives represented by the general formula ##STR1## (wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or a benzyl group, R.sup.2 represents a lower alkyl group or a phenyl group, X represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a phenoxy group or a halogenophenoxy group, and Y represents a hydrogen atom or a lower alkyl group). The compounds have immunomodulative function and are effective for treatment of diseases caused by abnormal immunofunction.

Abstract: 3-Benzoyl-2-mercaptopropionic acid derivatives represented by the general formula ##STR1## (wherein, X represents a hydrogen atom, a halogen atom, hydroxy group, a lower alkyl group or a lower alkoxy group, Y represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, Z represents a hydrogen atom or an acyl group, and R represents a hydrogen atom or a lower alkyl group). These compounds have immunomodulative function and are effective for the treatment of diseases caused by abnormal immunofunction.

Abstract: Optically active compounds of formula ##STR1## in which R is either a H.sub.3 C--, (CH.sub.3).sub.3 C--, (CH.sub.3).sub.3 CO--, C.sub.6 H.sub.5 CH.sub.2 O--, C.sub.6 H.sub.5 --, o-NO.sub.2 C.sub.6 H.sub.4 --, p-NO.sub.2 C.sub.6 H.sub.4 -- or a p-CH.sub.3 C.sub.6 H.sub.4 -group, or salts or lower alkyl esters thereof. The compounds are prepared by the following sequence of reaction steps:(a) there is started from a racemic mixture of a compound according to said formula in which R=a C.sub.6 H.sub.5 group,(b) cinchonidine, D(--)-2-aminobutanol-1 or a derivative thereof is added to this compound as resolving agent,(c) the D(--)-salt of the resolving agent formed is crystallized out and isolated,(d) if necessary, this salt is further purified of the L-isomer by recrystallization,(e) the pure D(--)-salt is hydrolysed in order to remove the resolving agent,(f) the D(--)-S-benzoyl-.beta.-mercaptoisobutyric acid thus liberated is won and, if necessary, purified, and(g) if desired, the C.sub.6 H.sub.