Abstract: The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Abstract: In order to provide a method of safely, efficiently, and industrially manufacturing fluoroaryl magnesium halide containing no impurities, such as coloring components, by a relatively gradual reaction compared with the conventional reactions, and a method of readily and efficiently manufacturing a highly-pure fluoroaryl borane derivative, fluoroaryl magnesium halide expressed by General Formula (1): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at least three of R1-R5 are fluorine atoms, and Xa represents Cl, Br, or I; is manufactured by reacting, in a solvent containing a chain ether solvent, hydrocarbon magnesium halide expressed by General Formula (2): R6MgXa  (2) where R6 represents a hydrocarbon group, and Xa represents Cl, Br, or I; with fluoroaryl halide expressed by General Formula (3): where each of R1-R5 independently represents H, F, a hydrocarbon group, or an alkoxy group, provided that at

Abstract: Sulfur-containing boroester compounds useful as antiwear additives for oleaginous compositions including alicyclic borate thioesters having the general formula (I): ##STR1## wherein R.sub.1 is a hydrocarbyl radical having 4 to 12 carbon atoms, R.sub.2 and R.sub.3 are independently selected from --(OR.sub.4).sub.n SR.sub.1 and --(OR.sub.4).sub.n SR.sub.1 OH; R.sub.4 is a hydrocarbyl radical having 1 to 6 carbon atoms; n is an integer of from 1 to 4; and l and m are independently 0, 1 or 2; thioalkyl-substituted cyclic meta borate esters having the general formula (II): ##STR2## wherein n, R.sub.1 and R.sub.4 are defined as in formula (I); and mixtures of the alicyclic compounds of formula (I) and the cyclic compounds of formula (II).

Abstract: Sulfur-containing boroester compounds useful as antiwear additives for oleaginous compositions including alicyclic borate thioesters having the general formula (I): ##STR1## wherein R.sub.1 is a hydrocarbyl radical having 4 to 12 carbon atoms, R.sub.2 and R.sub.3 are independently selected from --(OR.sub.4).sub.n SR.sub.1 and --(OR.sub.4).sub.n SR.sub.1 OH; R.sub.4 is a hydrocarbyl radical having 1 to 6 carbon atoms; n is an integer of from 1 to 4; and l and m are independently 0, 1 or 2; thioalkyl-substituted cyclic meta borate esters having the general formula (II): ##STR2## wherein n, R.sub.1 and R.sub.4 are defined as in formula (I); and mixtures of the alicyclic compounds of formula (I) and the cyclic compounds of formula (II).

Abstract: A borate ester having the formula ##STR1## wherein Y is N, S or O, X is O or S, R.sup.1 and R.sup.2 are, independent of one another, selected from the group consisting of H, (C.sub.1 -C.sub.40)hydrocarbon residues and (C.sub.3 -C.sub.50)cycloalkyl, aryl and aralkyl, each of which may further contain N, O or S, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are independent of one another, selected from the group consisting of H and (C.sub.1 -C.sub.8)hydrocarbon residues, n is 0 to 4. An anti-wear/anti-oxidant/anti-friction/anti-rust additive comprises the borate ester of the invention when added to a lubricating oil.

Abstract: Novel borane adducts of hydroxydialkylsulfide borate esters represented by formula ##STR1## wherein R is straight or branched chain alkyl or alkoxy having from 2 to 5 carbon atoms and n is 1 to 3 inclusive. The compound are new hydroboration agents.

Abstract: A method for the removal of ester protecting groups from .alpha.-amino boronic acid is disclosed for the preparation of compounds of formula (II) belowR.sup.1 -X.sub.n -NHCH (R.sup.2)-B(OH).sub.

Abstract: Borated dihydrocarbyl dithiocarbamate reaction products have been found to be effective antioxidant/antiwear multifunctional additives for lubricants.

Abstract: Borated hydroxyalkyl esters of alkyl- or alkenylsuccinimide-derived dithiocarbamic acids, have been found to be effective multifunctional additives in lubricant and fuel applications.

Abstract: Borated or partially borated, amine-contained hindered phenols provide effective antioxidant properties to compositions comprising lubricants and liquid fuels.

Abstract: Disclosed are polyamino alkenyl or alkyl succinimides which have been modified by treatment with a lactone to yield polyamino alkenyl or alkyl succinimides wherein one or more of the basic nitrogens of the polyamino moiety is substituted with a hydrocarbylcarbonylalkylene group. The additives so disclosed are useful as dispersants in lubricating oils, gasolines, marine crankcase oils and hydraulic oils.

Abstract: Disclosed are polyaminoalkenyl or alkyl succinimides which have been modified by treatment with a compound of the formula: ##STR1## wherein W is oxygen or sulfur; X is oxygen or sulfur; R.sub.4 is an alkylene group of from 2 to 3 carbon atoms or an alkylene group of from 2 to 3 carbon atoms substituted with from 1 to 3 alkyl groups of from 1 to 2 carbon atoms each; and R.sub.5 is hydrogen or alkyl of from 1 to 20 carbon atoms. The modified polyamino alkenyl or alkyl succinimides of this invention have been found to possess dispersancy and detergency in lubricating oils. These modified succinimides are also useful as dispersants and detergents in fuels.

Abstract: Disclosed are additives which are useful as dispersants in lubricating oils, gasolines, marine crankcase oils and hydraulic oils. In particular, disclosed are polyamino alkenyl or alkyl succinimides which contain carbamate functionalities.

Abstract: A boron-containing heterocyclic compound prepared by reacting a primary amine or ammonia with an alkylene oxide or epoxide and then reacting concurrently or subsequently this reaction intermediate with a boric acid. This boron-containing heterocyclic compound may further be reacted with a metal, metaloid or other metal compound and even further contain sulfur, such as a sulfide group.The boron-containing heterocyclic compound provides extreme pressure anti-wear properties when provided in a lubricating composition. The lubricating composition may also comprise anti-oxidants, copper corrosion inhibitors, and lead corrosion inhibitors. The anti-wear properties of a lubricating composition can be enhanced using the borates of the present invention in conjunction with a copper compound.The boron-containing heterocyclic compound may be used in automatic transmission fluids alone, further reacted with an ester of a polyhydric alcohol or mixed with said ester.Automatic transmission fluid compositions are provided.

Abstract: Disclosed herein are additives which are useful as dispersants and detergents in lubricating oils and fuels.

Abstract: Borated adducts of alkyl diamines and alkoxides impart effective multifunctional friction reducing and high temperature stabilizing characteristics to compositions comprising hydrocarbyl lubricants and fuels.