Abstract: The present disclosure provides a compound for releasing nitric oxide; the compound has the structure of formula (I): The present disclosure also provides a pharmaceutical composition containing the compound of formula (I). The present disclosure further provides a method of releasing nitric oxide, the method includes: administrating the compound of formula (I). The present disclosure also provides a method of treating disease in a patient, the method includes administrating a therapeutically effective amount of the compound of formula (I). The present disclosure also provides the method for synthesizing the compound of formula (I).

Abstract: The invention discloses a method for the continuous preparation of n-butyl nitrite with a low content of n-butanol comprising the reaction of n-butanol, an acid and NaNO2 in a continuous way, in which the n-butanol, an acid and NaNO2 are mixed in a mixing device which provides for a pressure drop of at least 1 bar; the acid is selected from the group consisting of HCI, H2SO4, formic acid, methanesulfonic acid, and mixtures thereof; and the amount of HCI is at least 1.02 molar equivalent based on the molar amount of n-butanol.

Abstract: Methods of forming a nitrate ester include combining at least one nitrate salt and sulfuric acid to form a nitrating solution and adding an aliphatic polyol to the nitrating solution. Nitrate esters formed by this method may be, for example, triethylene glycol dinitrate (TEGDN), pentaerythritol tetranitrate (PETN), diglycerol tetranitrate (DGTN), 1,1,1-tris(methylol)ethane trinitrate (TMETN), 1,2,4-butanetriol trinitrate (BTTN), nitroglycerin (NG), diethylene glycol dinitrate (DEGDN), ethylene glycol dinitrate (EGDN), metriol trinitrate (MTN), nitrocellulose (NC), or 1,2-propanediol dinitrate (PDDN).

Abstract: Methods for the separation of targeted components from gun propellant formulations. In particular, the methods separate targeted components in a usable/useful form. Preferred methods are directed to the separation of nitrocellulose, nitroguanidine and/or nitroglycerine from a formulation containing one or more of these components.

Abstract: A mixture of isolated or synthetic affinity molecules in a liquid carrier is disclosed. The mixture comprises at least two different affinity molecules, each with affinity for a predetermined analyte, for use in a single or multi flow cell piezoelectric crystal micro balance apparatus. Each isolated or synthetic affinity molecule forms together with the predetermined analyte an interaction pair selected from the group consisting of anion-cation, antibody-antigen, receptor-ligand, enzyme-substrate, oligonucleotide-oligonucleotide with complementary sequence, oligonucleotide-protein, oligonucleotide-cell, and peptide nucleic acid (PNA) oligomer-polynucleotide, wherein the polynucleotide may be selected from the group consisting of RNA, DNA and PNA polymers complementary to PNA oligomer. Use of the mixture for introduction into the liquid flow of a single or multi flow cell piezoelectric crystal micro balance apparatus is also described, as well as a kit containing the mixture.

Abstract: The invention concerns a method for preparing alkyl nitrites of formula (I) R ONO (I) ONO wherein R represents a C1-C20, advantageously C2-C10 linear or branched alkyl group. The invention is characterised in that it consists in gradually and continuously adding in an aqueous medium, an alcohol of formula (II) R OH, R being as defined above, a nitrite of formula (III) M NO2, wherein M represents a metal cation, and a strong acid, so as to form continuously said alkyl nitrite, and in continuously drawing off said alkyl nitrite thus formed from the reaction medium.

Abstract: An efficient method for preparing nitrated glycerol glycol ether useful as a high energy plasticizer, by using as nitrator feed, the reaction products of an alkali metal bisulfate-catalyzed reaction of ethylene oxide and a stoichiometric excess of glycerol.

Abstract: The invention relates to a nitroglycerin pump spray containing 0.2 to 3.5% by wt. of nitroglycerin and up to 3% by wt. of customary additives such as flavoring agent or antioxidants and a liquid phase consisting of aliphatic C.sub.2 to C.sub.4 alcohols and a vehicle and is characterized in that the liquid phase consists of 10 to 40% by wt. of ethyl alcohol and 90 to 60% by wt. of a neutral oil.

Abstract: The process of the present invention provides a method of obtaining a high yield of water or acid soluble nitrate esters without the use of organic solvents in the nitration reaction or the production of unstable products or by-products. The process involves the nitration of an organic hydroxy-containing compound with a suitable nitrating agent such as nitric acid in the absence of organic solvents in the nitration reaction. The reaction mixture is neutralized, causing the nitrate esters to precipitate or separate from the neutralized nitrate solution. The nitrate ester is then recovered, and any dissolved nitrate salts can be removed therefrom by gentle washing with water or a dilute halide solution. As provided by the process of the present invention, no organic solvents are used in the nitration reaction and average yields range from about 80% to about 95%.

Abstract: The invention relates to pharmaceutical compositions containing novel nitrate esters, of which it was found that they are useful for the treatment of ischemiatic heart diseases, decompensatio cordis, myocardial infarction and hypertension.

Abstract: A process for preparing an energetic mixture of 1,2,4-butanetroil trinitr and nitroglycerin by forming a polyol mixture of 1,2,4-butanetriol and glycerin, and then nitrating the polyol mixture with a mixture of nitric and sulfuric acids.