The Chalcogen, X, Is In A -c(=x)- Group Patents (Class 558/52)
-
Patent number: 4939303Abstract: 3,3-Dimethylhex-5-en-2-one derivatives of the formula (I) ##STR1## where A is hydrogen, halogen or C.sub.1 -C.sub.4 -haloalkyl,B is C.sub.1 -C.sub.4 -haloalkyl,X is hydrogen, or halogen andR is hydrogen, arylsulfonyl, alkylsulfonyl or haloalkylsulfonyl,are used for preparing pyrethroids.Type: GrantFiled: January 26, 1989Date of Patent: July 3, 1990Assignee: BASF AktiengesellschaftInventors: Jochen Wild, Thomas Liese-Sauer, Norbert Goetz, Hans Theobald, Bernd Wolf
-
Patent number: 4933367Abstract: This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.Type: GrantFiled: March 12, 1987Date of Patent: June 12, 1990Assignee: Boehringer Mannheim GmbHInventors: Hans P. Wolff, Ernst-Christian Witte, Hans-Frieder Kuhnle
-
Patent number: 4933510Abstract: Propanol derivatives of formula (I) wherein X is a leaving group; R.sub.1 is H or a protecting group; and R.sub.2 is H, and R.sub.3 is a group--CH.sub.2 Y wherein Y is a leaving group; or R.sub.2 and R.sub.3 together form .dbd.CH.sub.2. The propanol derivatives of the formula (I) are useful as multifunctional alkylating agents.Type: GrantFiled: March 13, 1989Date of Patent: June 12, 1990Assignee: Symbicom AktiebolagInventors: Hans G. Magnusson, Torbjorn Frejd
-
Patent number: 4931579Abstract: Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators.Type: GrantFiled: November 7, 1989Date of Patent: June 5, 1990Assignee: Miles Inc.Inventors: Holger Heidenreich, Klaus Wehling
-
Patent number: 4925874Abstract: Novel 2,2-dimethyl-cyclopropane carboxylic acid derivatives of the formula ##STR1## wherein X.sub.1 and X.sub.2 are individually halogen, R.sub.1 is selected from the group consisting of halogen, alkyl of 1 to 8 carbon atoms, optionally substituted aryl of 6 to 14 carbon atoms, perfluoroalkyl of 1 to 8 carbon atoms, --CN and ##STR2## R' is alkyl of 1 to 8 carbon atoms, Y is selected from the group consisting of --SO.sub.2 Alk.sub.1, --SO.sub.2 Ar, ##STR3## Alk.sub.1 is optionally unsaturated alkyl of 1 to 8 carbon atoms no substituted or substituted with at least one functional group, Ar is aryl of 6 to 14 carbon atoms no substituted or substituted with at least one functional group, Alk.sub.2 and Alk.sub.3 and Alk.sub.2 ' and Alk.sub.Type: GrantFiled: November 20, 1987Date of Patent: May 15, 1990Assignee: Roussel UclafInventors: Joseph Cadiergue, Jean-Pierre Demoute, Jean Tessier
-
Patent number: 4837350Abstract: Benzoin esters of aromatic sulfonic acids can be obtained in high yield from benzoin and the respective sulfonyl halide in molar amounts of a base by carrying out the reaction at low temperature in an organic solvent with the addition of water. Aqueous NaOh or KOH can be used as base in this process.Type: GrantFiled: December 7, 1987Date of Patent: June 6, 1989Assignee: Ciba-Geigy CorporationInventors: Werner Rutsch, Rinaldo Husler
-
Patent number: 4831177Abstract: Compounds of formula X ##STR1## in which R.sub.6 is aryl, R.sub.7 is hydrogen, --OH or alkyl, R.sub.8 is alkyl, R.sub.9 is hydrogen, alkyl, alkenyl, aryl, furyl or --CCl.sub.3, when n is 1, R.sub.10 is alkyl, aryl, camphoryl, --CF.sub.3 or fluoro, or when n is 2, R.sub.10 is alkylene or arylene are latent curing catalysts for acid-curable stoving varnishes. On irradiation, the active curing catalysts which lead to acid-catalysed curing of the resins are formed from the compounds of the formula x.Type: GrantFiled: May 4, 1987Date of Patent: May 16, 1989Assignee: Ciba-Geigy CorporationInventors: Rudolf Kirchmayr, Werner Rutsch
-
Patent number: 4804756Abstract: A method for preparing 5,6-dialkoxy-4-alkyl-quinazolinones is described. The 5,6-dialkoxy-4-alkyl-quinazolinones are active cardiotonic agents.Type: GrantFiled: March 28, 1988Date of Patent: February 14, 1989Assignee: Ortho Pharmaceutical CorporationInventors: Victor T. Bandurco, Robert A. Mallory, Jeffery B. Press
-
Patent number: 4797502Abstract: A sulfonic acid ester derivative represented by the general formula ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, A is a group represented by the general formula ##STR2## (wherein R.sub.2 and R.sub.3 are each alkyl having 1 to 4 carbon atoms) or by the general formula ##STR3## (wherein R.sub.4 and R.sub.5 are each alkyl having 1 to 4 carbon atoms or, when taken together with the carbon atom to which they are attached, form cycloalkyl having 4 to 6 carbon atoms), and l is an integer of from 1 to 3, and a process for preparing the derivative.Type: GrantFiled: January 20, 1987Date of Patent: January 10, 1989Assignee: Taiho Pharmaceutical Company LimitedInventors: Setsuro Fujii, Kazuo Ogawa, Toshihiro Hamakawa, Yoshiyuki Muranaka
-
Patent number: 4785089Abstract: The invention relates to novel sulfonic acid esters of formula I ##STR1## wherein R.sup.1 is C.sub.5 -C.sub.6 cycloalkyl which is unsubstituted or substituted by C.sub.1 -C.sub.7 alkyl, unsubstituted or substituted phenyl, R.sup.2 is C.sub.1 -C.sub.7 alkyl, R.sup.3 is phenyl which is substituted by halogen or nitro, and the asterisk denotes a carbon atom that is either present in the preponderant number of molecules in the S configuration or in the preponderant number of molecules in the R configuration.These compounds can be prepared by enantio-selective reduction of 4--R.sup.1 --substituted .alpha.-oxobutyric acid compounds and subsequent conversion of the resultant .alpha.-hydroxy group into the --OSO.sub.2 --R.sup.3 group. The compounds of formula I are suitable intermediates for the preparation of ACE inhibitors or precursors thereof.Type: GrantFiled: June 2, 1986Date of Patent: November 15, 1988Assignee: Ciba-Geigy CorporationInventors: Hans-Ulrich Blaser, Hans-Peter Jalett, Gottfried Sedelmeier
-
Patent number: 4758362Abstract: A phosphorus free or a low phosphorus containing lubricant composition is provided by formulating the composition with an additive of the formula ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl of 1 to about 7 carbons, aryl, aralkyl or together form an alicyclic or heteroalicyclic radical in which the ring is completed through the nitrogen; X is O or S; a is 1 or 2; R.sub.3 and R.sub.4 are independently H, alkyl or aryl; and Z is ##STR2## wherein R.sub.5 is hydrogen, alkyl, or aralkyl, and ##STR3## wherein Y is H, OH, R.sub.6 where R.sub.6 is alkyl, aryl or aralkyl, OR.sub.6, OR.sub.7 --OH, where R.sub.7 is alkylene of 1 to about 7 carbon atoms, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, alkyl, cycloaliphatic, heteroalicyclic or together form an alicyclic or heteroalicyclic radical in which the ring is completed through the nitrogen; with the proviso that when a is 1, Y is not OR.sub.6.Type: GrantFiled: March 18, 1986Date of Patent: July 19, 1988Assignee: The Lubrizol CorporationInventor: Betsy J. Butke
-
Patent number: 4751304Abstract: A method for preparing 5,6-dialkoxy-4-alkyl-quinazolinones is described. The 5,6-dialkoxy-4-alkyl-quinazolinones are active cardiotonic agents.Type: GrantFiled: September 26, 1984Date of Patent: June 14, 1988Assignee: Ortho Pharmaceutical CorporationInventors: Victor T. Bandurco, Robert A. Mallory, Jeffery B. Press
-
Patent number: 4744812Abstract: Substituted diphenyl ethers of the formula ##STR1## where Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen, halogen, nitro, cyano, carboxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylmercapto, haloalkylmercapto, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or haloalkylsulfonyl, Z.sub.4 is hydrogen, cyano, alkyl, alkoxy, acetoxy or alkylmercapto, Y is hydrogen, halogen, cyano or nitro, X is oxygen, sulfur, sulfinyl or sulfonyl, and A is hydrogen, unsubstituted or substituted alkyl ##STR2## and can also be sulfonyl ##STR3## when X is oxygen, and, when Z.sub.4 is alkoxy or alkylmercapto, can also be a methylene chain --(CH.sub.2).sub.m -- by which the radicals Z.sub.4 --CH--X-- are bonded to form a ring, R.sub.1 is hydrogen, methyl, ethyl or n-propyl, R.sub.2 is cyano, methoxy, ethoxy or ##STR4## where B is OH, ONa, O--alkyl, unsubstituted or substituted phenoxy, --NH.sub.2, --NH--alkyl or --N(alkyl).sub.2, n is 1, 2 or 3, R.sub.3 and R.sub.Type: GrantFiled: March 4, 1985Date of Patent: May 17, 1988Assignee: BASF AktiengesellschaftInventors: Adolf Parg, Bruno Wuerzer, Gerhard Hamprecht
-
Patent number: 4736055Abstract: Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR.sup.5, --COOH, COOR.sup.6, --COCl, --CH.sub.2 Hal, --SO.sub.2 Cl or --NCO group, Z is an (x+y)-valent connecting member, R.sup.1 and R.sup.2 are monovalent organic radicals, m is 0 or 1, x is 1 or 2 and y is 1 or 2, can be converted into polymers which can be thermally or photochemically dissociated to form free sulfonic acid groups. Said polymers can therefore be used as photoresists which can be developed with aqueous alkalis.Type: GrantFiled: April 11, 1986Date of Patent: April 5, 1988Assignee: Ciba-Geigy CorporationInventors: Kurt Dietliker, Werner Rutsch, Godwin Berner, Max Hunziker, Christopher G. Demmer
-
Patent number: 4683323Abstract: By hydrolyzing a sulfonic acid ester or a nitric acid ester of an optically active 4-hydroxy-2-cyclopentenone, the steric inversion of the hydroxyl group at the 4-position of the cyclopentenone mentioned above is effected.4-hydroxy-2-cyclopentenone is useful as a raw material of prostaglandins (natural substance is an (R)-substance) having stimulative action to uterine muscle and vasodilator action. For instance, 4(S)-hydroxy-2-cyclopentenone can be configurationally inverted to R-isomer. Accordingly, this method is extremely meaningful in the synthesis of prostaglandins.Type: GrantFiled: July 25, 1985Date of Patent: July 28, 1987Assignee: Sumitomo Chemical Company, LimitedInventors: Masayoshi Minai, Yuji Ueda
-
Patent number: 4675428Abstract: A sulfonic acid ester derivative represented by the general formula ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, A is a group represented by the general formula ##STR2## (wherein R.sub.2 and R.sub.3 are each alkyl having 1 to 4 carbon atoms) or by the general formula ##STR3## (wherein R.sub.4 and R.sub.5 are each alkyl having 1 to 4 carbon atoms or, when taken together with the cabon atom to which they are attached, form cycloalkyl having 4 to 6 carbon atoms), and l is an integer of from 1 to 3, and a process for preparing the derivative.Type: GrantFiled: May 7, 1986Date of Patent: June 23, 1987Assignee: Taiho Pharmaceutical Company, LimitedInventors: Setsuro Fujii, Kazuo Ogawa, Toshihiro Hamakawa, Yoshiyuki Muranaka
-
Patent number: 4661628Abstract: A new process for the optical resolution of racemic mixtures of .alpha.-naphthyl-propionic acids of formula ##STR1## This process comprises reacting a racemic mixture of a compound of formula ##STR2## with an optically active substance of formula R.sub.4 --NH.sub.2 (III), said substance being a .beta.-aminoalcohol, thus forming a pair of diastereoisomeric amides which are resolved into the single diastereoisomers by fractional crystallization. The obtained single diastereoisomeric amide is then hydrolyzed to give the desired optically active .alpha.-naphthyl-propionic acid of formula ##STR3## In the above compound I.fwdarw.III and VI, R.sub.1 is (C.sub.1-6)alkyl, R.sub.2 stands for hydrogen, halogen, mercapto, (C.sub.1-6)alkylthio, phenylthio, benzylthio, (C.sub.1-6)alkylsulfonyl, benzenesulfonyl, benzenesulfonyl substituted by halogen or (C.sub.1-4)alkyl, R.sub.3 is a reactive group and R.sub.4 is the residue of a primary or secondary alcohol.Type: GrantFiled: November 5, 1984Date of Patent: April 28, 1987Assignee: Alfa Chemicals Italiana S.p.A.Inventors: Vincenzo Cannata, Giancarlo Tamerlani
-
Patent number: 4659855Abstract: Certain novel aryl sulfonyl fluorides, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity.Type: GrantFiled: May 9, 1983Date of Patent: April 21, 1987Assignee: Georgia Tech Research CorporationInventor: James C. Powers
-
Patent number: 4639537Abstract: New laevorotatory enantiomers of phenoxy propionic acid derivatives of the formula ##STR1## in which R.sup.2 represents a radical of the formula ##STR2## wherein Y represents oxygen or the radical SO.sub.m,whereinm represents 0, 1 or 2,R.sup.2 represents hydrogen or methyl,n represents 1 or 2 andR.sup.3 and R.sup.4 independently of one another represent hydrogen, halogen, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, alkylthio with 1 to 4 carbon atoms, nitro, cyano or alkoxycarbonyl with 1 to 4 carbon atoms in the alkoxy group, and their use as intermediates for preparing herbicides.Type: GrantFiled: May 24, 1985Date of Patent: January 27, 1987Assignee: Bayer AktiengesellschaftInventors: Koichi Moriya, Uwe Priesnitz, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt
-
Patent number: 4639518Abstract: The synthesis of 5,6-dioxy substituted quinazolinediones is described. The novel quinazolinediones are useful as cardiotonic agents.Type: GrantFiled: September 24, 1984Date of Patent: January 27, 1987Assignee: Ortho Pharmaceutical CorporationInventors: Victor T. Bandurco, Stanley C. Bell, Donald W. Combs, Robert Falotico, Alfonso J. Tobia
-
Patent number: 4603017Abstract: Perfluorocarbonyl compounds of the formulae IV and V ##STR1## in which R.sub.f denotes perfluoroalkyl, R'.sub.f denotes perfluoroalkylene, R denotes F, Cl, perfluoroalkyl or --OR"' (R"'=alkyl, aryl or aralkyl) and n denotes a number from 0 to 10, are prepared, starting from compounds of the formula I ##STR2## in which R.sub.f, R'.sub.f and n have the same meaning as in the formulae IV and V and R" is F, Cl or perfluoroalkyl, by electrolysis in an electrolyte consisting of fluorosulfonic acid/alkali metal fluorosulfonate and, if necessary, esterification with R"'OH, and decomposition ##STR3## in the presence of catalytic amounts of alkali metal fluorides and/or aprotic N-bases. Most of the compounds IV and V are new; the latter are, above all, valuable heat transfer fluids, lubricating oils or intermediates for the preparation of other F-organic compounds.Type: GrantFiled: April 5, 1985Date of Patent: July 29, 1986Assignee: Hoechst AtkiengesellschaftInventors: Hans Millauer, Gunter Siegemund, Werner Schwertfeger
-
Patent number: 4578504Abstract: Polymerizable monomer compounds selected from the group having the formulae: ##STR1## wherein R is hydrogen or methyl;X is fluoro, chloro, bromo, iodo, hydroxyl, perfluoroalkylsulfonoxy of one to three carbon atoms, perfluoroacyloxy of one to three carbon atoms, benzoyloxy, or trichloroacetoxy;Y is trichloroacetyl, perfluoroacyl of the formula ##STR2## trialkylsilyl of the formula [CH.sub.3 (CH.sub.2).sub.m ].sub.3 Si-- or hydrogen,wherein n is zero to six; and m is zero to three, with the proviso that when Y in Formula I or II is hydrogen, X is selected from fluoro, chloro, bromo, iodo in Formulas I and II, and additionally from hydroxyl in Formula I, are disclosed. Polymers and copolymers of the invention are useful for preparing hydrogel processed articles such as contact lenses, and when dissolved in solvents they can be coated onto articles and then hydrolyzed to provide hydrogel coatings.Type: GrantFiled: June 3, 1983Date of Patent: March 25, 1986Assignee: Minnesota Mining and Manufacturing CompanyInventor: W. James Hammar