Cyclopropyl In Acid Moiety Patents (Class 560/124)
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Publication number: 20110251363Abstract: The invention relates to stereoregular ROMP polymers, the monomers used to make them, and the processes used to convert the monomers to the polymers.Type: ApplicationFiled: July 17, 2007Publication date: October 13, 2011Inventors: Nicole S. Sampson, Kathlyn A. Parker
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Publication number: 20110245529Abstract: The objective of the present invention is to provide a method for obtaining an optically active vinylcyclopropanecarboxylic acid derivative with high yield and high optical purity using a safe material available at low cost. In addition, the objective of the present invention is to provide a method for safely-obtaining an optically active vinylcyclopropaneamino acid with high optical purity at low cost. The problems can be solved by a method for obtaining an optically active vinylcyclopropanecarboxylic acid derivative, which method contains the step of reacting a racemic vinylcyclopropanecarboxylic acid derivative with an optically active amine compound, to obtain a diastereomer salt of optically active vinylcyclopropanecarboxylic acid derivative-amine compound. In addition, it is possible to obtain a vinylcyclopropaneamino acid by deriving the vinylcyclopropaneamino acid from thus obtained diastereomer salt of optically active vinylcyclopropanecarboxylic acid derivative-amine compound.Type: ApplicationFiled: October 9, 2009Publication date: October 6, 2011Applicant: Kaneka CorporationInventors: Tatsuyoshi Tanaka, Kazumi Okuro
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Publication number: 20110184175Abstract: Disclosed is a method for producing a BSH derivative, which comprises a step of addition-reacting BSH with an ?,?-unsaturated nitrile compound in the presence of a base. Various BSH derivatives obtained by the method are also disclosed.Type: ApplicationFiled: July 23, 2009Publication date: July 28, 2011Applicant: STELLA PHARMA CORPORATIONInventors: Mitsunori Kirihata, Tomoyuki Asano, Kohki Uehara, Yoshihide Hattori
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Patent number: 7985872Abstract: A method for producing an olefin compound represented by the formula (2): wherein R1 and R2 are the same or different, and independently represent an alkyl group or the like, with the proviso that R1 and R2 are not hydrogen atoms at the same time, R3 represents an alkyl group or the like, which comprises contacting a palladium catalyst with an ?,?-unsaturated aldehyde compound represented by the formula (1): wherein R1, R2 and R3 are the same as defined above, in the presence of an inorganic base.Type: GrantFiled: December 12, 2006Date of Patent: July 26, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Kouji Yoshikawa
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Patent number: 7968155Abstract: An optically anisotropic material comprising at least one discotic compound having a cyclopropylcarbonyl group. The material is excellent in both the wavelength dispersion property and the refractive index anisotropy.Type: GrantFiled: March 17, 2005Date of Patent: June 28, 2011Assignee: Fujifilm CorporationInventors: Shigeki Uehira, Michitaka Matsuumi, Michio Nagai, Atsuhiro Okawa
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Patent number: 7956089Abstract: There is provided a novel cyclopropanecarboxylate compound having an excellent pest controlling effect represented by the formula (1):Type: GrantFiled: December 19, 2008Date of Patent: June 7, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Tatsuya Mori
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Publication number: 20110092601Abstract: Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer.Type: ApplicationFiled: April 14, 2008Publication date: April 21, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Patrick M. Woster, Robert A. Casero
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Publication number: 20110052513Abstract: The present patent application relates to novel surface-active cationic compounds, to their use, in particular as hair conditioning agent, to a cosmetic treatment method, in particular for the hair, employing the said compounds, and to the cosmetic or pharmaceutical compositions, in particular hair compositions, comprising the said surfactants.Type: ApplicationFiled: February 3, 2009Publication date: March 3, 2011Applicant: L' OrealInventors: Laure Ramos-Stanbury, Herve Andrean, Christian Blaise
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Publication number: 20110046406Abstract: The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)-N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-(S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.Type: ApplicationFiled: August 16, 2010Publication date: February 24, 2011Applicant: ViroBay, Inc.Inventors: Barry Hart, Jeff Dener, Michael Green, Michael Standen, Oldrich Kocian
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Patent number: 7893294Abstract: A process for production of a trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester comprising: (A) a step of obtaining a mixture containing a trans-2,2-dimethyl-3-(hydroxymethyl)cyclopropanecarboxylic acid ester, (B) a step of conducting an oxidation treatment of the mixture obtained in the step (A) to obtain a mixture containing a crude trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester, (C) a step of contacting the mixture obtained in the step (B) with an aqueous alkali metal hydrogen sulfite solution to obtain an alkali metal salt of a trans-2,2-dimethyl-3-[(hydroxy)(sulfo)methyl]cyclopropanecarboxylic acid ester, and (D) a step of contacting the alkali metal salt obtained in the above-mentioned step (C) with a base or the like to obtain a trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester.Type: GrantFiled: August 13, 2007Date of Patent: February 22, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Makoto Itagaki, Ryo Minamida, Kouji Yoshikawa
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Publication number: 20110034700Abstract: The present invention describes a heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species. The precursor comprises a chiral bisoxazoline group coupled to an inorganic substrate. The heterogeneous chiral catalyst may be capable of catalysing a chemical reaction, for example cyclopropanation, and the chemical reaction may be capable of generating a chiral product.Type: ApplicationFiled: March 8, 2005Publication date: February 10, 2011Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jackie Y. Ying, Su Seong Lee, Sukandar Hadinoto
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Publication number: 20100331408Abstract: There is provided a novel cyclopropanecarboxylate compound having an excellent pest controlling effect represented by the formula (1):Type: ApplicationFiled: December 19, 2008Publication date: December 30, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Tatsuya Mori
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Publication number: 20100305353Abstract: A method for producing a purified formylcyclopropane compound represented by the formula (1) comprising (A) a step of reacting a crude formylcyclopropane compound represented by the formula (1): wherein R1 represents an alkyl group or the like, with an alkali metal hydrogen sulfite to obtain an alkali metal hydroxymethanesulfonate represented by the formula (2): wherein R1 represents the same meaning as defined above and M represents an alkali metal, and (B) a step of reacting an acid, a base or a water-soluble aldehyde with the alkali metal hydroxymethanesulfonate represented by the formula (2) obtained in the above-mentioned step (A) to obtain a purified formylcyclopropane compound represented by the formula (1).Type: ApplicationFiled: December 12, 2006Publication date: December 2, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kouji Yoshikawa, Ryo Minamida, Makoto Itagaki
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Publication number: 20100273801Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.Type: ApplicationFiled: June 6, 2007Publication date: October 28, 2010Applicant: Valition teknillinen tutikimuskeskusInventors: Jari Yli-Kauhaluoma, Salme Koskimies, Sami Alakurtti, Taru Mäkelä, Päivi Tammela
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Patent number: 7799829Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.Type: GrantFiled: April 1, 2009Date of Patent: September 21, 2010Assignee: XenoPort, Inc.Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark A Gallop
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Patent number: 7785573Abstract: An active or functional organic compound is solubilized by an ester of an aryl alcohol, e.g., phenethyl, benzyl or substituted benzyl alcohol, and an alkyl or cycloalkyl carboxylic acid, or by a carbonate of said aryl alcohol and an alkyl or cycloalkyl carbonic acid.Type: GrantFiled: January 23, 2006Date of Patent: August 31, 2010Assignee: ISP Investments Inc.Inventors: Steven H. Bertz, Ilya Makarovsky, Donna N. Laura
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Publication number: 20100210721Abstract: Described are new insecticide compounds that are derived from 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid, also known as chrysanthemic acid, insecticidal compositions that contain the compounds, methods of synthesizing the compounds and methods of eliminating harmful insects from a substrate including bringing the substrate into contact with an effective amount of one or more such compounds.Type: ApplicationFiled: September 15, 2008Publication date: August 19, 2010Applicant: ENDURA S.P.A.Inventors: Valerio Borzatta, Greta Varchi, Elisa Capparella, Alberto Guerrini, Arturo Battaglia, Federico Trefiletti
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Publication number: 20100168463Abstract: A method of producing 6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one comprising subjecting a cyclopropane compound of the formula (1): (wherein, R1 represents an alkyl group, R2 represents an alkyl group having carbon atom(s) of 1 to 10, a haloalkyl group having carbon atom(s) of 1 to 10, or an aryl group having carbon atoms of 6 to 10 optionally substituted by an alkyl group having carbon atom(s) of 1 to 10, and when R2 represents the alkyl group, R1 and R2 are optionally the same or different each other.) to any of the following reactions a), b) and c): a) an acid treatment reaction after an alkali hydrolysis reaction b) an acid hydrolysis reaction c) an enzyme hydrolysis reaction , then, removing an aqueous layer.Type: ApplicationFiled: June 28, 2006Publication date: July 1, 2010Inventors: Norihiko Hirata, Toshitsugi Uemura
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Patent number: 7741511Abstract: There is provided a process for preparing a carboxylic acid ester of formula (3): R2COOR1??(3) wherein R1 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, and R2 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a heteroaryl which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, which process is characterized by the steps of reacting a monohydroxy compound of formula (1): R1OH??(1) wherein R1 is as defined above, with a zirconium compound of formula (6): Zr(OR8)4??(6) wherein R8 is an alkyl group or an aryl group which may be substituted and is not the same as R1, to prepare a zirconium catalyst, and reacting a carboxylic acid of formula (2):Type: GrantFiled: August 10, 2007Date of Patent: June 22, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Souda, Kazunori Iwakura
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Patent number: 7728165Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.Type: GrantFiled: June 15, 2009Date of Patent: June 1, 2010Assignee: Schering Plough CorporationInventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
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Publication number: 20100130768Abstract: The present invention relates to a hydrodehalogenation method in which a halogen atom on a carbon atom of an organic compound is removed by substituting the halogen atom with a hydrogen atom, and to a method for producing a dehalogenated compound.Type: ApplicationFiled: October 5, 2006Publication date: May 27, 2010Applicant: Daiichi Sankyo Company, LimitedInventors: Koji Sato, Makoto Imai
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Publication number: 20100120907Abstract: Provided are topical formulations comprising an Amyris alcohol and/or ester derivatives of Amyris alcohol which may be used for the treatment of diseases including herpes virus infection (e.g., HSV-1, HSV-2), epidermoid carcinoma, cold sores, and human papillomavirus. Amyris alcohols contemplated for use with the present invention include valerianol, beta-eudesmol, epi-gamma-eudesmol, elemol, alpha-eudesmol, and ester derivatives thereof.Type: ApplicationFiled: April 18, 2008Publication date: May 13, 2010Inventors: Chandra Ulagaraj Singh, Rao Jagaveerabhadra Nulu
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Patent number: 7709651Abstract: A process for producing an optically active cyclopropane compound represented by the formula (4): wherein R3, R4, R5 and R6 are the same or different, and represent a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, and so on; and R7 represents a C1-6 alkyl group; and * represents an asymmetric carbon atom, which comprises reacting a prochiral olefin represented by the formula (2): wherein R3, R4, R5, and R6 are as described above, with a diazoacetic acid ester represented by the formula (3): N2CHCO2R7??(3) wherein R7 is as defined above, in the presence of an asymmetric copper complex prepared from an optically active cycloalkylidenebisoxazoline compound represented by the formula (1): wherein R1 represents a hydrogen atom, a C1-6 alkyl group, and so on; R2 represents a C1-6 alkyl group and so on; and n represents an integer of 0 to 3; provided that, two R1s may be bonded each other together with the carbon atom to which they are bonded to form a ring; and * repType: GrantFiled: September 17, 2004Date of Patent: May 4, 2010Assignee: Sumitomo Chemical Company, LimitedInventors: Makoto Itagaki, Katsuhisa Masumoto, Ryo Minamida
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Patent number: 7700799Abstract: A method for producing a (2-formyl-1-alkenyl)cyclopropane compound represented by the formula (1): wherein R1 and R2 are the same or different, and independently represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl group or an optionally substituted aralkyl group, which comprises reacting a formylcyclopropane compound represented by the formula (3): wherein R1 is the same as defined above, with an aldehyde compound represented by the formula (4): wherein R2 is the same as defined above, in the presence of a base.Type: GrantFiled: January 22, 2009Date of Patent: April 20, 2010Assignee: Sumitomo Chemical Company, LimitedInventor: Kouji Yoshikawa
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Publication number: 20100081838Abstract: A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo reagent.Type: ApplicationFiled: September 14, 2009Publication date: April 1, 2010Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: X. Peter Zhang, Shifa Zhu
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Publication number: 20100041750Abstract: A compound represented by the formula (I): has an excellent pest controlling activity and therefore is useful for an effective ingredient of a pest control composition.Type: ApplicationFiled: March 6, 2008Publication date: February 18, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Toru Uekawa, Jun Ohshita
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Publication number: 20090314987Abstract: A process for production of a trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester comprising: (A) a step of obtaining a mixture containing a trans-2,2-dimethyl-3-(hydroxymethyl)cyclopropanecarboxylic acid ester, (B) a step of conducting an oxidation treatment of the mixture obtained in the step (A) to obtain a mixture containing a crude trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester, (C) a step of contacting the mixture obtained in the step (B) with an aqueous alkali metal hydrogen sulfite solution to obtain an alkali metal salt of a trans-2,2-dimethyl-3-[(hydroxy)(sulfo)methyl]cyclopropanecarboxylic acid ester, and (D) a step of contacting the alkali metal salt obtained in the above-mentioned step (C) with a base or the like to obtain a trans-2,2-dimethyl-3-formylcyclopropanecarboxylic acid ester.Type: ApplicationFiled: August 13, 2007Publication date: December 24, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Makoto Itagaki, Ryo Minamida, Kouji Yoshikawa
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Patent number: 7615669Abstract: The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.Type: GrantFiled: March 22, 2006Date of Patent: November 10, 2009Assignee: Tosoh F-Tech, Inc.Inventors: Norihisa Kondo, Akio Watanabe, Hiroki Kanezaki, Kosuke Kawada
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Publication number: 20090220451Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: ApplicationFiled: August 21, 2006Publication date: September 3, 2009Applicant: EMISPHERE TECHNOLOGIES, INC.Inventors: Pingwah Tang, Steven Dinh, Jongbin Lee, Puchun Liu, Gabriela Mustata
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Publication number: 20090137839Abstract: A method for producing a (2-formyl-1-alkenyl)cyclopropane compound represented by the formula (1): wherein R1 and R2 are the same or different, and independently represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl group or an optionally substituted aralkyl group, which comprises reacting a formylcyclopropane compound represented by the formula (3): wherein R1 is the same as defined above, with an aldehyde compound represented by the formula (4): wherein R2 is the same as defined above, in the presence of a base.Type: ApplicationFiled: January 22, 2009Publication date: May 28, 2009Applicant: Sumitomo Chemical Company, Ltd.Inventor: Kouji YOSHIKAWA
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Patent number: 7524885Abstract: The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.Type: GrantFiled: February 23, 2005Date of Patent: April 28, 2009Assignee: The Governors of the University of AlbertaInventors: Gary D. Lopaschuk, John C Vederas, Jason R. Dyck
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Patent number: 7498459Abstract: A method for producing a (1-alkenyl)cyclopropane compound represented by the formula (2): wherein R1 and R2 are the same or different, and independently represent a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted aryl group or an optionally substituted aralkyl group, which comprises bringing a (2-formyl-1-alkenyl)cyclopropane compound represented by the formula (1): wherein R1 and R2 are the same as defined above, into contact with a palladium catalyst.Type: GrantFiled: March 18, 2005Date of Patent: March 3, 2009Assignee: Sumitomo Chemical Company, LimitedInventor: Koji Yoshikawa
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Patent number: 7473706Abstract: The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, i and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.Type: GrantFiled: March 6, 2006Date of Patent: January 6, 2009Assignee: The Governors of the University of AlbertaInventors: Gary D. Lopaschuk, John C. Vederas, Jason R. Dyck
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Publication number: 20080249166Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.Type: ApplicationFiled: June 9, 2008Publication date: October 9, 2008Applicant: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Daniela Carmen Oniciu
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Publication number: 20080233159Abstract: The present invention provides a home-use insecticide formulated as an insect knockdown agent and insect killing agent that contains a useful pyrethroid compound having superior residual efficacy. The home-use insecticide contains (d)-2-methyl-4-oxo-3-(2-propynyl)-2-cyclopenten-1-yl (d)-trans-2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate as an active ingredient thereof.Type: ApplicationFiled: May 14, 2007Publication date: September 25, 2008Applicant: DAINIHON JOCHUGIKU CO., LTD.Inventors: Yoshio Katsuda, Toshio Takahashi
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Patent number: 7393971Abstract: A method for producing 3,3-dimethyl-2-(1-propenyl)cyclopropanecarboxylate represented by the formula (2): wherein R1 represent an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted aralkyl group, which comprises a 3,3-dimethyl-2-(2-carboxy-1-propenyl)cyclopropanecarboxylate represented by the formula (1): wherein R1 is as described above, is brought into contact with a copper compound and a nitrogen-containing aromatic compound, is provided.Type: GrantFiled: November 4, 2004Date of Patent: July 1, 2008Assignee: Sumitomo Chemical Company, LimitedInventor: Koji Hagiya
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Patent number: 7390779Abstract: Odourant compounds selected from compounds having the structure: wherein, R1 and R2 may be independently hydrogen or methyl, and n is an integer 1, 2 or 3 provided that n+ the carbon atoms in R1 and R2 is less than 5, their preparation and their use in fine fragrances and perfume components, wherein the compounds provide a musk characteristic.Type: GrantFiled: May 30, 2002Date of Patent: June 24, 2008Assignee: Givaudan SAInventors: Philip Kraft, Riccardo Cadalbert
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Patent number: 7381833Abstract: The present invention provides a for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester.Type: GrantFiled: March 31, 2005Date of Patent: June 3, 2008Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Koji Sato, Makoto Imai
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Patent number: 7365222Abstract: Bicyclic cyclopropane derivatives of the general Formula (I) in which n+m is 0 to 8; r is 1 to 4; R1 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 arylene or C7-C20 alkylenearylene radical; R2 is for r=1 a C1-C20 alkyl radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 aryl or a C7-C20 alkylaryl radical; is for r>1 an r-times substituted aliphatic C1 to C20 radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical or aliphatic-aromatic C7-C20 radical; X is absent or is —CO—O—, —CO—NH— or —O—CO—NH—, and Y is CH2, O or S which is suitable in particular for the preparation of dental materials.Type: GrantFiled: September 10, 2003Date of Patent: April 29, 2008Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Armin de Meijere, Frank Zeuner, Urs Karl Fischer
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Patent number: 7276622Abstract: It is provided that a method for producing an oxygen-containing compound, characterized in that an olefin compound having a carbon-carbon double bond which is bonded to a methyl or methylene group is reacted with an organic hydroperoxide in the presence of an ionic liquid and a selenium compound.Type: GrantFiled: March 23, 2004Date of Patent: October 2, 2007Assignee: Sumitomo Chemical Company, LimitedInventor: Koji Hagiya
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Patent number: 7262320Abstract: A process for the production of a 3,3-dimethyl-2-formylcyclopropanecarboxylic acid derivative of formula (2): wherein R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, which process comprises reacting a 3,3-dimethyl-2-(2-methyl-1-propenyl)cyclopropanecarboxylic acid compound of formula (1): wherein R is as defined above, with a periodic acid compound in the presence of a ruthenium compound.Type: GrantFiled: December 26, 2002Date of Patent: August 28, 2007Assignee: Sumitomo Chemical Company, LimitedInventor: Kouji Yoshikawa
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Patent number: 7253301Abstract: There is provided an optically active copper catalyst composition comprising (a) an optically active salicylideneaminoalcohol represented by the formula (1): wherein R1 and R2 are the same or different, and independently represent a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; X1 and X2 are the same or different, and independently represent a hydrogen atom, a lower alkoxy group, a nitro group, a lower alkoxycarbonyl group, a cyano group or a halogen atom; and * represents an asymmetric center, provided that both of X1 and X2 don't represent hydrogen atoms, (b) a monovalent or divalent copper compound, and (c-1) a lithium compound or (c-2) a compound selected from aluminum compounds having Lewis acidity, titanium compounds having Lewis acidity, boron compounds having Lewis acidity, zirconium compounds having Lewis acidity and hafnium compounds having Lewis acidity; and a process for producing an optically actType: GrantFiled: March 25, 2004Date of Patent: August 7, 2007Assignee: Sumitomo Chemical Company, LimitedInventor: Makoto Itagaki
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Patent number: 7217682Abstract: A 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 2,2-dimethyl-3-(2-cyano-3-hydrocarbyloxy-3-oxo-1-propenyl) cyclopropanecarboxylate given by the formula (1): wherein G represents C1–C4 alkyl or C3–C4 alkenyl, has excellent pests controlling effect.Type: GrantFiled: November 20, 2002Date of Patent: May 15, 2007Assignee: Sumitomo Chemical Company, LimitedInventor: Tatsuya Mori
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Patent number: 7199260Abstract: A method of producing 2-fluorocyclopropane-1-carboxylic acid ester, which comprise by allowing a compound represented by the following formula (1): wherein X represents a chlorine atom, a bromine atom or an iodine atom; and R1 represents an alkyl group having 1 to 8 carbon atoms, an aryl group having 6 to 12 carbon atoms, an alkenyl group having 2 to 8 carbon atoms, or an aralkyl group composed of an aryl group having 6 to 12 carbon atoms and an alkylene group having 1 to 6 carbon atoms; to react with a reducing agent in the presence of a phase transfer catalyst. According to the production method of the present invention, the reaction time of dehalogenation can be greatly shortened.Type: GrantFiled: January 7, 2004Date of Patent: April 3, 2007Assignee: Daiichi Pharmaceutical Co., Ltd.Inventors: Yuichiro Tani, Keiji Nakayama, Kenji Sakuratani, Koji Sato
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Patent number: 7098245Abstract: The present invention provides a polynucleotide cleavage agent switched on by photo-irradiation and a method of cleaving or decomposing a polynucleotide such as DNA or RNA using this agent switched on in this manner. More specifically, said polynucleotide cleavage agent switched on by photo-irradiation comprises cyclopropane or a 2,2-dihalogeno-cyclopropane ring between “A” unit and “B” unit, wherein said “A” unit is an aromatic group having an electron withdrawing property and is excited by photo-irradiation, and said “B” unit is a hydrophilic functional group. Said polynucleotide cleavage agent may further contain “C” unit which can recognize DNA sequences, and also a spacer molecule, if desired.Type: GrantFiled: March 5, 2003Date of Patent: August 29, 2006Assignee: Tottori UniversityInventors: Toshiyuki Itoh, Keiko Ninomiya, Masahiko Shishido
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Patent number: 7087796Abstract: The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 1 to 30 carbon atoms and containing single and/or double bonds.Type: GrantFiled: June 16, 2005Date of Patent: August 8, 2006Assignee: International Flavors & Fragrances Inc.Inventors: Anubhav P. S. Narula, Edward Mark Arruda, Franc T. Schiet
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Patent number: 7084173Abstract: The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia wherein W is C1–C6 alkyl, halogen, or aryl; Cyc is C3 or C4 cycloalkyl; p is 0–3 for Cyc being C4 cycloalkyl and p=0–2 for Cyc being C3 cycloalkyl; Y is O, S, or NR, where R?H, alkyl or aryl; X is O, S, NR, or CR3R4; Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl; R1 is H, alkyl, aryl or O; R2 is H, alkyl or aryl; R3 and R4 are, independently, H, alkyl or aryl; and n is an integer from 1 to 10; or a pharmaceutically acceptable salt, ester or prodrug thereof.Type: GrantFiled: April 1, 2002Date of Patent: August 1, 2006Assignee: The Governors of the Univerity of AlbertaInventors: Gary D. Lopaschuk, John Christopher Vederas, Jason R. Dyck
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Patent number: 7074828Abstract: The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, i and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.Type: GrantFiled: December 5, 2002Date of Patent: July 11, 2006Assignee: The Governors of the University of AlbertaInventors: Gary David Lopaschuk, John Christopher Vederas, Jason Roland Dyck
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Patent number: 7009079Abstract: There is disclosed an optically active salicylideneaminoalcohol compound of formula (1): wherein R1 represents an alkyl group or the like, R2 represents an aryl group and the like, and when X1 represents a nitro, X2 is a hydrogen atom, when X1 represents a chlorine atom, X2 is a chlorine atom, and when X1 is a hydrogen atom, X2 is a fluorine atom; and the carbon atom denoted by “*” is an asymmetric carbon atom having either an S or R configuration, and a chiral copper complex produced from the optically active salicylidenaminoalcohol compound and a copper compound.Type: GrantFiled: July 24, 2003Date of Patent: March 7, 2006Assignee: Sumitomo Chemical Company, LimitedInventors: Masashi Kamitamari, Gohfu Suzukamo, Michio Yamamoto, Koji Hagiya, Makoto Itagaki
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Patent number: 6909013Abstract: There is disclosed a process process for producing a cyclopropanecarboxylate of formula (1): which process comprises reacting cyclopropanecarboxylic acid of formula (2): with a monohydroxy compound of formula (3): R6OH??(3), in the presence of a catalyst compound comprising an element of to Group 4 of the Periodic Table of Elements.Type: GrantFiled: January 24, 2002Date of Patent: June 21, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Hiroshi Souda, Kazunori Iwakura