Plural Rings Bonded Directly To The Same Carbon In Phenolic Moiety Patents (Class 560/140)
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Patent number: 8940184Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.Type: GrantFiled: August 30, 2010Date of Patent: January 27, 2015Assignee: MERCK PATENT GmbHInventors: Andreas Taugerbeck, Achim Goetz
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Publication number: 20140346399Abstract: A liquid crystal composition and a liquid crystal display device which includes the composition are provided. The liquid crystal composition contains a specific compound having a polymerizable group as a first component, and may contain a specific compound having a large negative dielectric anisotropy and a low minimum temperature as a second component, or a specific compound having a small viscosity or a large maximum temperature as a third component. The liquid crystal composition satisfies at least one of the following characteristics: a high maximum temperature of a nematic phase, a low minimum temperature of the nematic phase, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy, a large specific resistance, a high stability to ultraviolet light and a high stability to heat. Alternatively, a liquid crystal composition having a suitable balance regarding at least two of the aforementioned characteristics is also provided.Type: ApplicationFiled: October 1, 2012Publication date: November 27, 2014Inventors: Yukihiro Fujita, Yoshimasa Furusato, Maiko Matsukuma
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Publication number: 20140303396Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20140275610Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.Type: ApplicationFiled: June 2, 2014Publication date: September 18, 2014Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Marco ARTICO, Emanuele ATTOLINO, Pietro ALLEGRINI, Gabriele RAZZETTI
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Publication number: 20140228434Abstract: The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.Type: ApplicationFiled: April 21, 2014Publication date: August 14, 2014Applicant: UCB PHARMA GMBHInventor: Claus MEESE
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Publication number: 20140221680Abstract: 4-Aralkylphenols and derivatives thereof expressed by general formulas (6) and (7) are useful for producing trisphenols.Type: ApplicationFiled: April 8, 2014Publication date: August 7, 2014Applicant: Honshu Chemical Industry Co., Ltd.Inventors: Akihiko Ojiri, Takafumi Tsujigami, Kouichi Tanba
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Patent number: 8772340Abstract: A process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having low content in impurities.Type: GrantFiled: November 14, 2011Date of Patent: July 8, 2014Assignee: Dipharma Francis S.r.l.Inventors: Marco Artico, Emanuele Attolino, Pietro Allegrini, Gabriele Razzetti
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Patent number: 8742163Abstract: The invention relates to a method for producing methacrylated benzophenones and to the uses thereof.Type: GrantFiled: November 19, 2009Date of Patent: June 3, 2014Assignee: EVONIK ROEHM GmbHInventors: Joachim Knebel, Wolfgang Klesse, Christine Maria Breiner, Gerold Schmitt
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Patent number: 8536258Abstract: The present invention provides a stabilizer containing, as a main component, a bisphenol monoester and a bisphenol-based compound, wherein the area of the bisphenol-based compound is 0.15 to 70 when the area of the bisphenol monoester is set to be 100 in a chromatograph obtained by liquid chromatography analysis of the stabilizer, a method of manufacturing the same, a thermoplastic polymer composition containing the stabilizer, as well as a stabilizer that can further improve the process stability of the thermoplastic polymer, as compared with the conventional one, by compounding the stabilizer into the thermoplastic polymer through a method of stabilizing the thermoplastic polymer using the stabilizer and a method of manufacturing the stabilizer.Type: GrantFiled: July 16, 2008Date of Patent: September 17, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Ryoji Soma, Kenji Kimura, Masatsugu Akiba
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Patent number: 8529793Abstract: The present invention provides a granular stabilizer for a polymer which is low-dusting and thus is easy to be handled. The present invention relates to a granular stabilizer for a polymer, comprising a compound shown by the formula (1): wherein R1s and R2s each independently represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or a cycloalkyl group having 5 to 8 carbon atoms; R3s each independently represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; and X represents a single bond, a sulfur atom, an oxygen atom, an alkylidene group having 1 to 8 carbon atoms or a cycloalkylidene group having 5 to 8 carbon atoms.Type: GrantFiled: July 25, 2012Date of Patent: September 10, 2013Assignee: Sumitomo Chemical Company, LimitedInventors: Kazuhiro Kitamura, Natsuko Sato, Kenji Kimura
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Patent number: 8445716Abstract: A process is described for preparing fesoterodine and/or fesoterodine fumarate comprising the esterification of (R)-feso deacyl with isobutyric acid or a precursor thereof, such as an isobutyryl halide or the isobutyric acid anhydride to give fesoterodine, in a mixture of water at alkaline pH and/or at least one organic solvent. This process allows obtaining products with high yields and purities, and in particular a product having a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-isobutyroyloxymethyl-phenyl isobutyrate less than 1% by mole and a content of (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol less than 0.05% by mole.Type: GrantFiled: May 13, 2010Date of Patent: May 21, 2013Assignee: Chemi S.p.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20130003009Abstract: To provide a liquid crystal composition satisfying at least one characteristic such as a high maximum temperature of a nematic phase, a low minimum temperature thereof, a small viscosity, a suitable optical anisotropy, a large negative dielectric anisotropy and specific resistance, a high stability to ultraviolet light and heat, or a liquid crystal composition having a suitable balance regarding at least two characteristics; an AM device having a short response time, a large voltage holding ratio and contrast ratio, a long service life and so forth; wherein the liquid crystal composition contains a specific compound having a polymerizable group as a first component, and may contain a specific compound having a large negative dielectric anisotropy and a low minimum temperature as a second component, or a specific compound having a small viscosity or a large maximum temperature as a third component, and a liquid crystal display device contains the composition.Type: ApplicationFiled: May 9, 2011Publication date: January 3, 2013Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Yoshimasa Furusato, Eriko Kurihara
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Patent number: 8318699Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.Type: GrantFiled: January 31, 2006Date of Patent: November 27, 2012Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.Inventors: Mark I Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
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Patent number: 8262954Abstract: A method of producing a granular substance comprising (i) a step of melting a compound of the formula (1): (wherein, R1 and R2 represent each independently a hydrogen atom, alkyl group having 1 to 8 carbon atoms or cycloalkyl group having 5 to 8 carbon atoms, R3 represents a hydrogen atom or alkyl group having 1 to 8 carbon atoms. X represents a single bond, sulfur atom, oxygen atom, alkylidene group having 1 to 8 carbon atoms or cycloalkylidene group having 5 to 8 carbon atoms) to obtain the melted substance, and (ii) a step of dropping the melted substance obtained in the step (i) into water and recovering the granular substance.Type: GrantFiled: May 28, 2010Date of Patent: September 11, 2012Assignee: Sumitomo Chemical Company, LimitedInventor: Kazuhiro Kitamura
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Publication number: 20120165406Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are hexafluoro-honokiol analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers. Representative hexafluoro-honokiol analogs include hexafluoro-honokiol, analogs in which one or both hydroxy groups are replaced with dichloroacetate esters, and analogs with increased fluorination. The compounds are believed to function, at least, by inhibiting angiogenesis and/or inducing apoptosis. Thus, the compounds are novel therapeutic agents for a variety of cancers.Type: ApplicationFiled: June 22, 2010Publication date: June 28, 2012Applicant: Jack L. ArbiserInventor: Jack L. Arbiser
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Publication number: 20120130117Abstract: Disclosed is a photo-acid generator having high developing properties, a cationic polymerization initiator having high curing properties, and a resist composition and a cationically polymerizable composition containing the photo-acid generator and the cationic polymerization initiator, respectively. Specifically, disclosed is an aromatic sulfonium salt compound of general formula (I) and a photo-acid generator, a cationic polymerization initiator, a resist composition, and a cationically polymerizable composition containing the compound. In formula (I), R1 to R19 are each hydrogen, halogen, hydroxyl, optionally hydroxyl-substituted C1-C18 alkyl, optionally hydroxyl-substituted C1-C18 alkoxy, optionally hydroxyl-substituted C1-C18 thioalkoxy, etc.; An? is a monovalent anion; at least one of R1 to R19 is a substituent selected from the group consisting of hydroxyl, hydroxyl-substituted C1-C12 ester group, hydroxyl-substituted C1-C18 alkoxy, and hydroxyl-substituted C1-C18 thioalkoxy.Type: ApplicationFiled: November 28, 2010Publication date: May 24, 2012Applicant: ADEKA CORPORATIONInventors: Yoshie Makabe, Yuta Okuyama
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Publication number: 20120108840Abstract: A polymer stabilizer can be molded easily by compression-molding a compound represented by formula (1): wherein, R1 and R2 represent each independently an alkyl group having 1 to 8 carbon atoms, an aryl group having 6 to 12 carbon atoms or an aralkyl group having 7 to 18 carbon atoms; R3 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and R4 represents a hydrogen atom or a methyl group. Further, the polymer stabilizer molding of the present invention is capable of further improving the processing stability of a thermoplastic polymer.Type: ApplicationFiled: September 23, 2011Publication date: May 3, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Eiko SUETSUGU
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Patent number: 8168706Abstract: A granular composition comprising an organic compound having a melting point of 30 to 100° C., and a compound represented by the formula (1): wherein R1 and R2 independently represent a hydrogen atom, a C1-8 alkyl group, or a C5-8 cycloalkyl group, R3 represents a hydrogen atom or a C1-8 alkyl group, and X represents a single bond, a sulfur atom, an oxygen atom, a C1-8 alkylidene group or a C5-8 cycloalkylidene group.Type: GrantFiled: January 29, 2009Date of Patent: May 1, 2012Assignee: Sumitomo Chemical Company, LimitedInventors: Kazuhiro Kitamura, Yoshikazu Kimura, Kenji Kimura
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Patent number: 8129446Abstract: A composition of macrocyclic oligomer with at least one (meth)acrylate polymerizable group. A method includes preparing an activated precursor of an oligomer at pseudo high-dilution conditions. A method also includes preparing an activated precursor of an oligomer by reacting the precursor with an activated coupling agent, wherein the precursor is condensable and polymerizable.Type: GrantFiled: October 27, 2010Date of Patent: March 6, 2012Assignee: DENTSPLY International Inc.Inventors: Xiaoming Jin, Paul D. Hammesfahr
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Patent number: 8115028Abstract: The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.Type: GrantFiled: June 5, 2007Date of Patent: February 14, 2012Inventors: Seth C. Ennis, Cornelia Fuchs, Ralf Kanzler, Dean A. Johnson
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Patent number: 8076402Abstract: A bisphenol monoester compound represented by the formula (1): (in the formula (1), Rs each represent independently a hydrogen atom or a methyl group, and R? represents an alkyl group of a carbon number of 1 to 6, or a hydrogen atom).Type: GrantFiled: November 26, 2008Date of Patent: December 13, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Ryoji Soma, Toyomochi Tamato, Masatsugu Akiba, Tatsumi Nuno
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Publication number: 20110294882Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.Type: ApplicationFiled: June 15, 2011Publication date: December 1, 2011Inventors: Claus Meese, Bengt Sparf
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Patent number: 8067594Abstract: The invention provides a process for producing a compound of formula (I), wherein Y is selected from the group consisting of CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX represents hydroxy or O?M+, in which M+ is a cation selected from Li+, Na+ and K+, and Y is as defined above; with trans-cinnamaldehyde (III), in the presence of a secondary amine compound; then (ii) treating the product of the preceding step with acid to afford the compound of formula (I). The above process may also be used in the production of tolterodine and fesoterodine, which are useful in the treatment of overactive bladder.Type: GrantFiled: May 21, 2007Date of Patent: November 29, 2011Assignee: Pfizer Inc.Inventors: Jens Bertil Ahman, Barry Richard Dillon, Alan John Pettman
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Patent number: 8043789Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.Type: GrantFiled: December 17, 2008Date of Patent: October 25, 2011Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
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Publication number: 20110196169Abstract: The invention relates to a method for producing methacrylated benzophenones and to the uses thereof.Type: ApplicationFiled: November 19, 2009Publication date: August 11, 2011Applicant: Evonik Roehm GmbHInventors: Joachim Knebel, Wolfgang Klesse, Christine Maria Breiner, Gerold Schmitt
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Patent number: 7989654Abstract: The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine, bromine, iodine, nitro, amino, hydroxyl, oxo, mercapto or deuterium. The C atom marked with a * (star) can be present in an (R) configuration, in an (S)-configuration or a mixture thereof. The invention is characterized in that the above-mentioned compounds are free bases with a degree of purity of more than 97 wt %. The invention also relates to a method for the production of highly pure compounds of general formula (I) and to the use thereof in the production of medicaments.Type: GrantFiled: June 18, 2008Date of Patent: August 2, 2011Assignee: UCB Pharma GmbHInventors: Armin Breitenbach, Claus Meese, Hans-Michael Wolff, Roland Drews
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Patent number: 7985873Abstract: The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.Type: GrantFiled: June 5, 2007Date of Patent: July 26, 2011Assignee: UCB Pharma GmbHInventors: Seth C. Ennis, Roland Drews, Claus Meese
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Publication number: 20110171274Abstract: Provided herein is an impurity of fesoterodine, fesoterodine dehydroxy impurity, 2-[(1R)-3-[bis(1-methylethy)amino]-1-phenylpropyl]-4-methylphenyl isobutyrate, and a process for preparing and isolating thereof. Provided further herein is a highly pure fesoterodine or a pharmaceutically acceptable salt thereof substantially free of fesoterodine dehydroxy impurity, process for the preparation thereof, and pharmaceutical compositions comprising highly pure fesoterodine or a pharmaceutically acceptable salt thereof substantially free of dehydroxy impurity. Provided also herein is a pharmaceutical composition comprising solid particles of pure fesoterodine fumarate substantially free of dehydroxy impurity, wherein 90 volume-percent of the particles (D90) have a size of less than about 200 microns.Type: ApplicationFiled: July 21, 2009Publication date: July 14, 2011Applicant: ACTAVIS GROUP PTC EHFInventors: Praveen Kumar Neela, Kishore Charugundla, Udhaya Kumar, Nitin Sharadchandra Pradhan
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Patent number: 7977418Abstract: The present invention provides a bisphenol monoester-based stabilizer composition that can improve resistance to discoloration at high temperature of a thermoplastic polymer compared with a conventional one using a bisphenol monoester-based stabilizer composition including a bisphenol monoester-based compound mainly, wherein a compound represented by the following formula: is contained in an area percentage by liquid chromatography analysis of 0.1 to 3%, a thermoplastic polymer composition and a method of manufacturing the thermoplastic polymer composition, a thermoplastic polymer molded product, and a method of stabilizing a thermoplastic polymer, as well as a thermoplastic polymer composition in which resistance to discoloration at high temperature is improved by using the stabilizer composition and a method of manufacturing the thermoplastic polymer composition, a thermoplastic polymer molded product, and a method of stabilizing a thermoplastic polymer.Type: GrantFiled: July 21, 2008Date of Patent: July 12, 2011Assignee: Sumitomo Chemical Company, LimitedInventors: Kenji Kimura, Ryoji Soma, Masatsugu Akiba, Toyomochi Tamato
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Publication number: 20110160228Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.Type: ApplicationFiled: June 4, 2009Publication date: June 30, 2011Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
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Publication number: 20110152367Abstract: Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate.Type: ApplicationFiled: December 20, 2010Publication date: June 23, 2011Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Marco ARTICO, Emanuele ATTOLINO, Pietro ALLEGRI
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Publication number: 20110124903Abstract: Provided herein are novel solid state forms of fesoterodine intermediates, (R)-4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-benzoic acid and (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-phenyl]-methanol, and processes for their preparation thereof. The solid state intermediates are useful for preparing fesoterodine or a pharmaceutically acceptable salt thereof in high purity.Type: ApplicationFiled: November 18, 2010Publication date: May 26, 2011Applicant: ACTAVIS GROUP PTC EHFInventors: Kishore CHARUGUNDLA, Udhaya KUMAR, Neela Praveen KUMAR, Nitin Sharadchandra PRADHAN
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Publication number: 20110086103Abstract: Provided herein is a novel raantlelate sail of fesoterodine, process for the preparation, pharmaceutics!! compositions, and method of treating thereof. Provided also herein are solid state forms of fesoterodine mandelate, process for the preparation, pharmaceutical compositions, and method of treating thereof. The raandelate salt of fesoterodine is useful for preparing fesoterodine free base or a pharmaceutically acceptable salt thereof; particularly fesoterodine fumaraie, in high purity.Type: ApplicationFiled: April 6, 2009Publication date: April 14, 2011Applicant: ACTAVIS GROUP PTC EHFInventors: Kishore Charugundla, Udhaya Kumar, Praveen Kumar Neela, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Publication number: 20100292502Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.Type: ApplicationFiled: May 13, 2010Publication date: November 18, 2010Applicant: CHEMI S.P.A.Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
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Publication number: 20100093904Abstract: The present invention provides a granular stabilizer for a polymer which is low-dusting and thus is easy to be handled. The present invention relates to a granular stabilizer for a polymer, comprising a compound shown by the formula (1): wherein R1s and R2s each independently represents a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or a cycloalkyl group having 5 to 8 carbon atoms; R3s each independently represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; and X represents a single bond, a sulfur atom, an oxygen atom, an alkylidene group having 1 to 8 carbon atoms or a cycloalkylidene group having 5 to 8 carbon atoms.Type: ApplicationFiled: October 5, 2009Publication date: April 15, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kazuhiro Kitamura, Natsuko Sato, Kenji Kimura
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Publication number: 20100056680Abstract: A stabilizer for polymers with suppressed powder scattering is demanded. An amorphous compound defined by the following formula (1): wherein R1 and R2 independently denote a hydrogen atom, an alkyl group, or a cycloalkyl group; R3 denotes a hydrogen atom or an alkyl group; X denotes a single bond, a sulfur atom, an oxygen atom, an alkylidene group with 1 to 8 carbon atoms, or a cycloalkylidene group: having an endothermic peak at 15 to 25° C. determined by differential scanning calorimetry (DSC) and a solution rate of 5 mg/sec or higher in cyclohexane at 25° C. in the following test system: in the test system for solution rate, the measurement is carried out by loading a container (capacity: 100 ml, outer diameter: 55 mm, height: 70 mm) containing 50 g of cyclohexane at 25° C. with 3 g of a test substance; rotating fan type stirring blades with 38 mm diameter at a rotation speed of 100 rpm; and measuring the time taken for the test substance to be dissolved.Type: ApplicationFiled: August 26, 2009Publication date: March 4, 2010Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Kenji KIMURA, Kazuhiro KITAMURA
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Publication number: 20090326160Abstract: A package is made by packing a compound of the formula (1) in a bag comprising a thermoplastic resin as a main component, wherein the film thickness of the bag is preferably from 50 to 200 ?m: wherein each of R1 and R2 is independently an alkyl group having 1 to 5 carbon atom(s); R3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atom(s); and R4 is a hydrogen atom or a methyl group. The compound is taken out of the bag and is then added to a thermoplastic resin which may be the same as or different from the thermoplastic resin as the main component of the bag to obtain a composition; and the composition is formed into a thermoplastic resin film. In this regard, no paper chip arises even if the bag containing the above-described compound is roughly opened with a cutter or the like, and thus, occurrence of fish eye gels in the film can be suppressed when the film is formed of the composition comprising the thermoplastic resin and the above-described compound.Type: ApplicationFiled: June 25, 2009Publication date: December 31, 2009Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Kenji KIMURA
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Publication number: 20090221527Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.Type: ApplicationFiled: January 31, 2006Publication date: September 3, 2009Applicants: CEPTION THERAPEUTICS, INC., TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Mark I. Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
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Publication number: 20090143517Abstract: A bisphenol monoester compound represented by the formula (1): (in the formula (1), Rs each represent independently a hydrogen atom or a methyl group, and R? represents an alkyl group of a carbon number of 1 to 6, or a hydrogen atom).Type: ApplicationFiled: November 26, 2008Publication date: June 4, 2009Inventors: Ryoji Soma, Toyomochi Tamato, Masatsugu Akiba, Tatsumi Nuno
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Patent number: 7384980Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.Type: GrantFiled: August 10, 2005Date of Patent: June 10, 2008Assignee: Schwarz Pharma AGInventors: Claus Meese, Bengt Sparf
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Patent number: 6958412Abstract: A method for synthesizing a pentafluorophenyl acrylate polymer includes bulk polymerizing a pentafluorophenyl acrylate monomer in the presence of a free radical initiator. The reactant mixture was subjected to an ultrasonication treatment, so that the mixing of the initiator and the monomer is enhanced; carried out the bulk polymerization at 25-99° C. for a period of time, and at 100-200° C. under a vacuum pressure for another period of time to complete the bulk polymerization, so that residue amounts of the initiator, unreacted monomer and oligomer of the monomer are reduced in the resulting reaction mixture.Type: GrantFiled: September 25, 2003Date of Patent: October 25, 2005Assignee: Chung-Shan Institute of Science & TechnologyInventors: Shean-Jeng Jong, Chang-Chih Lin, Yu-Sheng Lin
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Patent number: 6943194Abstract: A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phosphorylation and subsequent hydrogenolysis sequence 3b?3c?3d. Phenstatin (3b) was found to be a potent inhibitor of tubulin polymerization and the binding of colchicine to tubulin comparable to combretastatin A-4 (1b).Type: GrantFiled: January 9, 1999Date of Patent: September 13, 2005Assignee: Arizona Board of Regents, acting for and on behalf of Arizona State UniversityInventors: George R. Pettit, Brian Toki
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Patent number: 6890920Abstract: Novel quaternary ammonium compounds of the formula and any stereoisomers thereof, wherein R1, R2 and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents —H, —CH3, or —CO—R4-1, wherein R4-1 represents —(C1-C4 alkyl), —(C1-C4 alkoxy), or —NR4-2R4-3, wherein R4-2 and R4-3 independently represent —H or —(C1-C4 alkyl); R5, R6 and R7 independently represent —H, —OCH3, —OH, —CONH2, —SO2NH2, —F, —Cl, —Br, —I, —CF3, or —(C1-C4 alkyl), optionally substituted with one or two —OH, —(C1-C4 alkoxy), —COOH, or —CO—O—(C1-C3 alkyl); and X? represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.Type: GrantFiled: October 25, 2002Date of Patent: May 10, 2005Assignee: Pharmacia & Upjohn CompanyInventors: Ivan Richards, Sue K. Cammarata, Craig D. Wegner, Michael Hawley, Mark Peter Warchol, Mark Kontny, Walter Morozowich, Karen Patrice Kolbasa, Malcolm Wilson Moon, Dominique Bonafoux, Sergey Gregory Wolfson, Patrick James Lennon
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Patent number: 6875895Abstract: Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R22 each independently represent a hydrogen atom, a halogen atom, cyano group, nitro group, etc., and at least one of R1-R20 is a halogen atom, etc. The arene compound has sufficient solubility in an organic solvent and excellent reactivity.Type: GrantFiled: August 20, 2002Date of Patent: April 5, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Takahiro Ueoka, Hideyuki Ikehira, Yoshiaki Tsubata
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Patent number: 6713464Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.Type: GrantFiled: January 2, 2001Date of Patent: March 30, 2004Assignee: Schwarz Pharma AGInventors: Claus Meese, Bengt Sparf
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Patent number: 6670512Abstract: The present invention seeks to provide novel tetraarylethylene compounds which are substituted on the aryl rings ortho to the ethylenic carbon atoms and processes for the preparation for such compounds. The compounds have potential use as molecular templates.Type: GrantFiled: June 21, 2002Date of Patent: December 30, 2003Inventors: Jeffrey Mark Stryker, Udo Hendrick Verkerk, Megumi Fujita, Makoto Yasuda
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Patent number: 6537670Abstract: The present invention relates to novel bisbenzophenones and the use thereof as an ultraviolet light absorber. The presently claimed compounds are particularly useful, either alone or in combination with other additives, including other ultraviolet light absorbers, antioxidants and stabilizers, in stabilizing polymers and other materials from degradation by environmental forces such as actinic radiation (ultraviolet light), oxidation, moisture, atmospheric pollutants and combinations thereof.Type: GrantFiled: November 3, 2000Date of Patent: March 25, 2003Assignee: Cytec Technology Corp.Inventor: Thomas Patrick Sassi
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Patent number: 6492550Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.Type: GrantFiled: February 8, 2001Date of Patent: December 10, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
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Publication number: 20020183540Abstract: The present invention seeks to provide novel tetraarylethylene compounds which are substituted on the aryl rings ortho to the ethylenic carbon atoms and processes for the preparation for such compounds. The compounds have potential use as molecular templates.Type: ApplicationFiled: June 21, 2002Publication date: December 5, 2002Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: Jeffrey Mark Stryker, Udo Hendrick Verkerk, Megumi Fujita, Makoto Yasuda
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Patent number: 6465528Abstract: The present invention relates to resins obtained by reacting a compound of formula 1 with an aldehyde and alkoxylating, in any order: wherein X is —OH, Y is ortho-, meta- or para- to X and is a radical of formula 4, wherein R5 is a C1-C30-alkyl, C2-C30-alkenyl, C6-C18-aryl, or C7-C30-alkylaryl. The resin has a molecular mass from 250 to 100,000 and is useful in methods of breaking oil-water emulsions.Type: GrantFiled: April 14, 2000Date of Patent: October 15, 2002Assignee: Clariant GmbHInventors: Frank Holtrup, Elisabeth Wasmund, Wolfram Baumgärtner, Michael Feustel