Abstract: An o-sulfobenzimide having the formula: ##STR1## is prepared by reacting phosgene with a methylbenzoate-o-sulfonate having the formula: ##STR2## WHEREIN M represents potassium or calcium, n is 1 when M is K and n is 2 when M is Ca, in an inert organic solvent in the presence of dimethylformamide; and then reacting ammonia with the reaction product.
Abstract: A derivative of coniferous tree barks is produced by reacting at elevated temperatures an alkaline polyphenolic solution of a coniferous bark extract in the proportion of from 0.1, and preferably from 0.5 to 8.0 moles of a carbonyl-activated halocompound per mole of monomeric unit in the polyphenol of the formula ##STR1## or with a cyano-activated halocompound of the formula ##STR2## wherein R' is H, HC.dbd.O or R--C .dbd.O where R is alkyl or aryl; X is halogen and R" is alkyl, OH, oxyalkyl, aryl or OM in which M is a metal. The starting materials are the alkaline extracts resulting from the digestion of coniferous tree barks with an alkaline aqueous solution or preferably the sulfonated acid extracts of such barks. The reaction products are etherified polyphenolic compounds which are water-soluble and possess chelating characteristics.
Type:
Grant
Filed:
April 5, 1976
Date of Patent:
December 20, 1977
Assignee:
International Telephone and Telegraph Corporation
Inventors:
Karl David Sears, Ronald Leroy Casebier
Abstract: The present invention relates to cyclopentane derivatives similar to prostaglandins. Due to their antiprostaglandin effect they have valuable properties as medicaments.
Type:
Grant
Filed:
October 28, 1976
Date of Patent:
December 6, 1977
Assignee:
Hoechst Aktiengesellschaft
Inventors:
Wilhelm Bartmann, Rudolf Kunstmann, Ulrich Lerch, Bernward Scholkens
Abstract: 1,2-Benzoisothiazole-3-on-1, 1-dioxide having the formula ##STR1## wherein X represents hydrogen, halogen, nitro, lower alkyl or lower alkoxy and Y represents hydrogen, halogen, lower alkyl, or lower alkoxy is prepared by reacting phosgene with an o-sulfobenzoic acid compound having the formula: ##STR2## or an alkali metal salt or alkaline earth metal salt thereof in the presence of dimethylformamide, thereby producing a mixture of a dichlorotolylsultone and a chlorosulfonylbenzoylchloride; (b) reacting the reaction products of step (a) with an alcohol of the formula ROH wherein R represents a lower alkyl group; and then (c) reacting the product of step (b) with ammonia.
Abstract: Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.
Type:
Grant
Filed:
September 14, 1973
Date of Patent:
October 4, 1977
Assignee:
The Boots Company Limited
Inventors:
Stewart S. Adams, Bernard J. Armitage, John S. Nicholson
Abstract: Water soluble sulfonated polyesters made by polycondensation of an aromatic diacid or its anhydride or diester and an unsaturated aliphatic diacid or its anhydride or diester with a saturated glycol and sulfonating.