Sulfur, Bonded Directly To A Ring, In Same Side Chain As Ester Function Patents (Class 560/17)
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Patent number: 4180394Abstract: This disclosure relates to derivatives of N-trifluoroacetyl-N-phosphonomethylglycinates wherein different moieties are attached to the phosphorus atom, to herbicidal compositions containing same and to the herbicidal use thereof.Type: GrantFiled: July 10, 1978Date of Patent: December 25, 1979Assignee: Monsanto CompanyInventors: John E. Franz, Robert J. Kaufman
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Patent number: 4180672Abstract: Organothiocyclopentanes of the formula ##STR1## wherein E represents >C.dbd.O or ##STR2## in which Z' represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group; X represents --S--, --CH.sub.2 --, --CH.dbd.; represents a single or double bond; R' represents a monovalent or divalent organic group containing 1 to 25 carbon atoms; R represents a monovalent organic group containing 1 to 25 carbon atoms; Z represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group; and when both E and Z represent a hydroxyl group or a protected hydroxyl group, X represents --S--.Also, 2-organothio-2-cyclopentenones of the formula ##STR3## wherein R and Z are as defined above. The compounds of formula (I) are prepared by reacting 2,3-epoxy-cyclopentanone or its derivatives with mercaptans in the presence of basic compounds.Type: GrantFiled: March 7, 1977Date of Patent: December 25, 1979Assignee: Teijin LimitedInventors: Seizi Kurozumi, Takeshi Toru, Makiko Kobayashi, Yoshinobu Hashimoto
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Patent number: 4175201Abstract: This invention relates to pharmacologically active compounds of the formula: ##STR1## wherein Z is trans--CH.dbd.CH, C.tbd.C; or CH.sub.2 --CH.sub.2 ;M is H or lower alkyl;n is an integer of from 2 to 5;X is alkyl;W is H or OR, wherein R is H, acyl, or alkyl;each Y is H, OH or alkoxy;and to novel intermediates and processes useful in the production thereof.Type: GrantFiled: April 18, 1977Date of Patent: November 20, 1979Assignee: University of ChicagoInventor: Josef Fried
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Patent number: 4172949Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl; R.sup.1 is hydrogen, C.sub.1 to C.sub.8 linear or branched alkyl or C.sub.1 to C.sub.8 linear or branched alkanoyl; X is oxygen or sulfur; R.sup.2 is selected from the group hydrogen, C.sub.1 to C.sub.18 linear or branched alkyl and the radicals --(CH.sub.2).sub.n --NR.sup.3 R.sup.4, --CH.sub.2 --CH(OH)--CH.sub.2 --OH or a ketal thereof formed from the aldehyde or ketone R.sup.5 R.sup.6 CO, wherein R.sup.3 and R.sup.4 are each independently C.sub.1 to C.sub.6 linear or branched alkyl or R.sup.3 and R.sup.4 taken together with the nitrogen atom of the first radical are attached to form a 5- or 6-membered heterocyclic ring, R.sup.5 and R.sup.6 are each independently hydrogen, C.sub.1 to C.sub.6 linear or branched alkyl, phenyl or benzyl or R.sup.5 and R.sup.Type: GrantFiled: June 28, 1978Date of Patent: October 30, 1979Assignee: Syntex (U.S.A.) Inc.Inventors: James P. Dunn, Peter H. Nelson, Karl G. Untch
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Patent number: 4168385Abstract: This invention discloses .alpha.-aryloxy or .alpha.-arylthio para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.Type: GrantFiled: February 17, 1977Date of Patent: September 18, 1979Assignee: American Cyanamid CompanyInventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
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Patent number: 4165310Abstract: A novel class of N-sulfenyl derivatives of di(carbamic acid esters) are described. The new compounds inhibit premature vulcanization of rubber.Type: GrantFiled: September 27, 1978Date of Patent: August 21, 1979Assignee: Monsanto CompanyInventor: Eiichi Morita
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Patent number: 4164410Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.Type: GrantFiled: May 5, 1978Date of Patent: August 14, 1979Assignee: Mobil Oil Corp.Inventor: Robert J. Theissen
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Patent number: 4164408Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.Type: GrantFiled: September 26, 1977Date of Patent: August 14, 1979Assignee: Mobil Oil Corp.Inventor: Robert J. Theissen
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Patent number: 4164409Abstract: 2-Nitro-5-(substituted-phenoxy)benzoic acids and esters, salts, amides, and acyl halides thereof comprise a class of compounds that are highly effective herbicides.Type: GrantFiled: May 5, 1978Date of Patent: August 14, 1979Assignee: Mobil Oil Corp.Inventor: Robert J. Theissen
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Patent number: 4162331Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: July 24, 1979Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4156011Abstract: The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2,Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.Type: GrantFiled: April 5, 1977Date of Patent: May 22, 1979Assignee: Societe Anonyme dite: Laboratoire L. LafonInventors: Victor Lafon, Louis Lafon
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Patent number: 4153803Abstract: Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.Type: GrantFiled: March 1, 1977Date of Patent: May 8, 1979Assignee: Siegfried AktiengesellschaftInventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
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Patent number: 4125515Abstract: Ester such as 3,6,9-trioxyundecane-1,11-bis (3-n-dodecylthiopropionate) when combined with conventional free amine antioxidants such as N,N'-diphenylparaphenylenediamine or with polymer bound antioxidants such as N-(4-anilinophenyl) methacrylamide produce improved antioxidant systems for SBR and NBR type polymers.Type: GrantFiled: March 19, 1976Date of Patent: November 14, 1978Assignee: The Goodyear Tire & Rubber CompanyInventor: Joseph A. Kuczkowski
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Patent number: 4107440Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have antibacterial activity.Type: GrantFiled: April 28, 1977Date of Patent: August 15, 1978Assignee: SmithKline CorporationInventor: John Gerald Gleason
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Patent number: 4105790Abstract: The invention concerns .alpha.-aminoacyl derivatives of phenyl-, phenoxy-, thiophenoxy- and phenylsulphinylalkanoic acids together with their amides, esters and pharmaceutically acceptable salts; processes for their preparation; and pharmaceutical compositions for therapeutic use in inhibiting the formation of thrombi and also in reducing the persistence of thrombi formed in the blood of warm blooded animals. Representative compounds of the invention are methyl 4-(aminoacetyl)phenoxyacetate, 4-(aminoacetyl)phenoxyacetic acid and methyl 4-(aminoacetyl)-thiophenoxyacetate, preferably as their hydrochlorides.Type: GrantFiled: November 9, 1976Date of Patent: August 8, 1978Assignee: Imperial Chemical Industries LimitedInventors: Clifford R. Hughes, Stephen J. Jackson, John Preston, Peter L. Walton
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Patent number: 4104043Abstract: A new series of substituted esters of 3-hydroxyindone compounds have been found to have exceptional miticidal and herbicidal activity.Type: GrantFiled: December 12, 1972Date of Patent: August 1, 1978Assignee: Union Carbide CorporationInventors: John A. Durden, Jr., Anthony A. Sousa, John F. Stephen
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Patent number: 4103027Abstract: This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in animals using the compounds of the present invention.Type: GrantFiled: August 12, 1977Date of Patent: July 25, 1978Assignee: The Dow Chemical CompanyInventors: Eugene R. Wagner, Bobbie J. Allen
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Patent number: 4098816Abstract: Pharmaceutical compositions having hypolipidaemic and/or hypoglycaemic activity, contain a substituted (4-carboxyphenoxy) phenyl alkane derivative.Type: GrantFiled: January 9, 1976Date of Patent: July 4, 1978Assignee: Beecham Group LimitedInventors: David Edward Thorne, Keith Howard Baggaley, Brian Morgan
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Patent number: 4097670Abstract: Carboxyalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, diphenyl-lower alkyl, alkali metal ion or alkaline earth metal ion; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.Type: GrantFiled: April 5, 1976Date of Patent: June 27, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Hermann Breuer, Uwe D. Treuner
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Patent number: 4094991Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment of prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: January 24, 1977Date of Patent: June 13, 1978Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Machara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4093447Abstract: New N-arylcarbamic acid esters of the formula ##STR1## in which R is lower aliphatic hydrocarbyl, optionally substituted,R.sup.1, r.sup.2 and R.sup.3, which may be identical or different, are each hydrogen, alkyl, cycloalkyl, alkoxy, haloalkyl or halogen,R.sup.4 is alkyl, alkenyl, alkynyl, cycloalkenyl, haloalkyl, haloalkenyl, haloalkynyl, alkoxyalkyl or alkylthioalkyl, acylalkyl (i.e., alkanoyloxyalkyl), alkoxycarbonylalkyl, carbalkoxyalkyl, carbalkoxyalkenyl, or an optionally substituted cycloalkyl, aryl, aralkyl, aryloxyalkyl or arylthioalkyl radical, or the grouping ##STR2## wherein R.sup.4' is hydrogen or is defined as R.sup.4 is defined above, andY and Y' are oxygen or sulfur.Are outstanding effective in regulating the growth of plants, i.e., to inhibit, stimulate or alter the growth of plants.Type: GrantFiled: November 17, 1975Date of Patent: June 6, 1978Assignee: Bayer AktiengesellschaftInventors: Carl Metzger, Gerhard Jager, Klaus Lurssen
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Patent number: 4092480Abstract: Cephalosporin compounds having a substituted phenylglycyl substituent at the 7-position and any of a variety of groups at the 3-position are prepared by acylation of a 7-aminocephalosporanic acid. The compounds have anti-bacterial activity.Type: GrantFiled: April 28, 1977Date of Patent: May 30, 1978Assignee: SmithKline CorporationInventor: John Gerald Gleason
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Patent number: 4091006Abstract: A new series of substituted esters of 3-hydroxyindone compounds have been found to have exceptional miticidal and herbicidal activity.Type: GrantFiled: October 1, 1975Date of Patent: May 23, 1978Assignee: Union Carbide CorporationInventors: John A. Durden, Jr., Anthony A. Sousa, John F. Stephen
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Patent number: 4090862Abstract: Phenoxycarboxylic acid aryloxy(thio)carbonylaminomethyl ester compound of the formula ##STR1## wherein R.sup.1 is phenyl, substituted phenyl, benzyl, substituted benzyl, naphthyl or substituted naphthyl,R.sup.2 is hydrogen or alkyl of from 1 to 4 carbon atoms,R.sup.3 is phenyl or substituted phenyl,X is oxygen or sulfur, andn is 0, 1 or 2 exhibit outstanding plant growth regulant properties.Type: GrantFiled: December 22, 1976Date of Patent: May 23, 1978Assignee: Bayer AktiengesellschaftInventors: Rudolf Thomas, Klaus Lurssen
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Patent number: 4088674Abstract: This invention concerns novel ester isocyanates derived from acyloxyalkylamine hydrochlorides. The novel compounds may contain a hetero atom in either the acid or alkanolamine moiety and may contain oxalic acid as the acyl moiety.Type: GrantFiled: May 12, 1972Date of Patent: May 9, 1978Assignee: Rohm and Haas CompanyInventors: William D. Emmons, Jerome F. Levy
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Patent number: 4083992Abstract: Novel 1-aryloxy-3-amidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess .beta.-adrenergic blocking activity and some of them additionally possess cardiac stimulant activity. Representative of the compounds disclosed is 1-phenoxy-3-.beta.-isobutyramidoethylamino-2-propanol.Type: GrantFiled: November 2, 1976Date of Patent: April 11, 1978Assignee: Imperial Chemical Industries LimitedInventor: Leslie Harold Smith
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Patent number: 4081598Abstract: This invention is directed to novel halogen-containing polythiols which impart improved flame retardancy to radiation cured thiol-ene compositions.Type: GrantFiled: May 16, 1977Date of Patent: March 28, 1978Assignee: W. R. Grace & Co.Inventors: Charles R. Morgan, David E. Kramm
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Patent number: 4080474Abstract: Allyloxy benzoic acid derivatives have hypolipidaemic activity, compositions for controlling or reducing serum lipid level in mammals, novel substituted phenoxy and phenylthio allyl compounds and administration of the compositions to mammals in need thereof.Type: GrantFiled: February 16, 1977Date of Patent: March 21, 1978Assignee: Beecham Group LimitedInventors: Richard Mark Hindley, Keith Howard Baggaley
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Patent number: 4067998Abstract: 2-((3,5-Di-tert-butylphenyl)thio) alkanoic acids and ester derivatives and pharmaceutically-acceptable salts thereof are disclosed; pharmaceutical compositions containing said compounds and methods of reducing plasma lipid levels in mammals are also provided.Type: GrantFiled: February 13, 1975Date of Patent: January 10, 1978Assignee: The Dow Chemical CompanyInventor: Eugene R. Wagner
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Patent number: 4064252Abstract: New carboxylic acid derivatives are proposed for use as agents in the treatment or prevention of arteriosclerosis. 1-(p-chlorophenoxy)-3-(N-phenyl-N-carbomethoxymethylamino)-2-propanol is a typical compound.Type: GrantFiled: June 4, 1976Date of Patent: December 20, 1977Assignee: Nippon Shinyaku Co., Ltd.Inventors: Hiromu Murai, Katsuya Ohata, Hiroshi Enomoto, Shoichi Chokai, Mitsuhiro Maehara, Katsuhide Saito, Takayuki Ozaki
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Patent number: 4062975Abstract: This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in animals using the compounds of the present invention.Type: GrantFiled: March 29, 1976Date of Patent: December 13, 1977Assignee: The Dow Chemical CompanyInventors: Eugene R. Wagner, Bobbie J. Allen
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Patent number: 4058552Abstract: This invention is concerned with esters of p-carbonylphenoxy-isobutyric acids of the general formulae: ##STR1## WHEREIN R is a phenyl group substituted by one or two halogen atoms;R' is H, CH.sub.3, C.sub.6 H.sub.5, SCH.sub.3, OCH.sub.3, or, SO.sub.2 CH.sub.3 ;R" is CH.sub.3 or C.sub.2 H.sub.5 ;Y is C.sub.1 -C.sub.4 alkoxy, phenoxy, phenoxy substituted by one or two halogen atoms, or, OCH.sub.2 O--CO--C(CH.sub.3).sub.3 ;Z is C.sub.1 -C.sub.4 alkyl, phenyl or R;Nr.sub.1 r.sub.2 is N(CH.sub.3).sub.2 N(C.sub.2 H.sub.5).sub.2, morpholino, piperidino, azepino, pyrrolidino.This invention is also concerned with acid addition salts obtained from formula Ia compounds with acids.Compounds of formulae I and Ia are useful as hypocholesterolemiant and hypolipidemiant agents.Type: GrantFiled: July 29, 1975Date of Patent: November 15, 1977Assignee: Orchimed SAInventor: Andre Mieville
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Patent number: 4057555Abstract: 1,2-Benzoisothiazole-3-on-1, 1-dioxide having the formula ##STR1## wherein X represents hydrogen, halogen, nitro, lower alkyl or lower alkoxy and Y represents hydrogen, halogen, lower alkyl, or lower alkoxy is prepared by reacting phosgene with an o-sulfobenzoic acid compound having the formula: ##STR2## or an alkali metal salt or alkaline earth metal salt thereof in the presence of dimethylformamide, thereby producing a mixture of a dichlorotolylsultone and a chlorosulfonylbenzoylchloride; (b) reacting the reaction products of step (a) with an alcohol of the formula ROH wherein R represents a lower alkyl group; and then (c) reacting the product of step (b) with ammonia.Type: GrantFiled: April 15, 1976Date of Patent: November 8, 1977Assignee: Ihara Chemical Industry Co., Ltd.Inventors: Wataro Koike, Takahiro Kimoto, Sadayoshi Matsui
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Patent number: 4056628Abstract: Novel substituted .alpha.-aryloxycarboxylic acid esters and their preparation are described. The novel compounds are useful for the control of pests.Type: GrantFiled: August 3, 1976Date of Patent: November 1, 1977Assignee: Hoffmann-La Roche Inc.Inventor: Pavol Winternitz
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Patent number: 4048218Abstract: This invention is directed to novel halogen-containing polythiols which impart improved flame retardancy to radiation cured thiol-ene compositions.Type: GrantFiled: February 24, 1975Date of Patent: September 13, 1977Assignee: W. R. Grace & Co.Inventors: Charles R. Morgan, David E. Kramm