Polyoxy Acid Moiety Patents (Class 560/186)
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Patent number: 11884633Abstract: A compound represented by Formula (I), or a salt or N-oxide compound thereof is provided. In Formula (I), A1 to A4 each independently represents a carbon atom or nitrogen atom, X1 represents a C1-6 alkyl group or the like, n represents the number of X1 groups, R1 represents a C1-6 alkylthio group or the like, and D is a group represented by Formula (D-1) or (D-2), and in Formula (D-1) and (D-2), * represents a binding position, Q represents a C1-6 alkyl group or the like, B1 and B2 each independently represents a nitrogen atom or the like, R2 represents a C1-6 alkyl group or the like that is bound to one of the nitrogen atoms in Formula (D-1), B3 and B4 each independently represents a nitrogen atom or carbon atom, R4 represents a C1-6 alkyl group or the like, and m represents the number of R4 groups.Type: GrantFiled: September 28, 2021Date of Patent: January 30, 2024Assignee: Nippon Soda Co., Ltd.Inventors: Isami Hamamoto, Hikaru Aoyama, Keita Sakanishi, Takao Iwasa, Tomomi Kobayashi
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Patent number: 11717848Abstract: A method of applying a closed cell spray foam insulation may include spraying a first layer of a closed cell spray foam insulation into a wall cavity. A B-side mixture of the closed cell spray foam insulation may include a polyol blend having a polyester polyol having a functionality of at least about 3.0 and a polyether polyol. The method may include spraying at least one additional layer of the closed cell spray foam insulation against the first layer within 5 minutes of spraying the first layer.Type: GrantFiled: September 30, 2020Date of Patent: August 8, 2023Assignee: Johns ManvilleInventors: Chanel Charbonneau, Yusheng Zhao, Elam Leed, Kathryn Miks
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Patent number: 10474030Abstract: A resist composition comprising a base polymer and a metal salt of carboxylic acid or sulfonamide is provided, the metal being selected from calcium, strontium, barium, cerium, aluminum, indium, gallium, thallium scandium, and yttrium. The resist composition exhibits a sensitizing effect and an acid diffusion suppressing effect and forms a pattern having improved resolution, LWR and CDU.Type: GrantFiled: October 5, 2017Date of Patent: November 12, 2019Assignee: SHIN-ETSU CHEMICAL CO., LTD.Inventors: Jun Hatakeyama, Masaki Ohashi, Takeshi Sasami
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Publication number: 20150072028Abstract: The present invention relates to extracts, compounds isolated from Cakile arabica for use in the treatment of ulcer and to pharmaceutical compositions thereof.Type: ApplicationFiled: September 4, 2014Publication date: March 12, 2015Applicant: KING SAUD UNIVERSITYInventors: Awaad Amani SHAFEEK, Reham Moustafa EL-MELIGY, Mohammed Sobhy MARZOUK, Shroog Mohamed ALOTAIBY
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Publication number: 20140316157Abstract: The invention relates to etherified lactate esters of formula (I), in which R represents alkyl and RI an alkoxylated alkyl radical and to the use thereof for enhancing the effect of plant protecting agents.Type: ApplicationFiled: July 23, 2012Publication date: October 23, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Peter Baur, Klaus Lorenz, Jörg Hofmann
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Patent number: 8829229Abstract: New polyol ether compounds and a process for their preparation. The process comprises reacting a polyol, a carbonyl compound, and hydrogen in the presence of hydrogenation catalyst, to provide the polyol ether. The molar ratio of polyol to carbonyl compound in the process is greater than 5:1.Type: GrantFiled: August 19, 2009Date of Patent: September 9, 2014Assignee: Dow Global Technologies LLCInventors: Michael L. Tulchinsky, John R. Briggs, Cynthia L. Rand
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Publication number: 20140120058Abstract: The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.Type: ApplicationFiled: April 12, 2012Publication date: May 1, 2014Inventors: Michael Shane O'Shea, Florian Hans Maximillian Graichen, Russell John Tait, Andrew Craig Donohue, Sarah Man Yee Ng, Asha Marina D'Souza
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Patent number: 8653131Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.Type: GrantFiled: August 21, 2009Date of Patent: February 18, 2014Assignees: Baxter Healthcare S.A., Baxter International Inc.Inventors: Guohan Yang, Ton That Hai, Bennett P. Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
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Publication number: 20130190523Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates firmed thereby.Type: ApplicationFiled: March 12, 2013Publication date: July 25, 2013Applicant: Vascular Biogenics Ltd.Inventor: Vascular Biogenics Ltd.
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Publication number: 20130158283Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: ApplicationFiled: December 10, 2012Publication date: June 20, 2013Applicant: Vascular Biogenics Ltd.Inventor: Vascular Biogenics Ltd.
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Publication number: 20130096322Abstract: A method of production of value-added, biobased chemicals, derivative products, and/or purified glycerin from bioglycerin of recycled oil, grease, and/or fat origin is described herein. A method of purification of bioglycerin of recycled oil, grease, and/or fat origin is also described herein. The method of purification of bioglycerin of recycled oil, grease, and/or fat origin described provides methods for desalinating, decolorizing, and/or concentrating bioglycerin of recycled oil, grease, and/or fat origin for the production of biobased chemicals, derivative products, and/or purified glycerin.Type: ApplicationFiled: January 12, 2012Publication date: April 18, 2013Applicant: THESIS CHEMISTRY, LLCInventors: John R. Peterson, Christopher M. Yost
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Patent number: 8420109Abstract: The present invention provides an oily base for a cosmetic comprising an ester compound made from a multivalent alcohol and a fatty acid, characterized in that the ester compound is made from dipentaerythritol and at least one fatty acid selected from the group consisting of fatty acids having 5 to 16 carbon atoms and a molar ratio of a dipentaerythritol residue to a fatty acid residue having 5 to 16 carbon atoms in the ester compound is 1.0:3.0 to 1.0:6.0. The aforesaid oily base for a cosmetic has proper oily feeling with moistness, no uncomfortable sticky feeling, excellent safety to the skin and adhesion to the skin, excellent gloss-holding ability after application to the skin, and excellent compatibility with various oil agents. In addition, upon blending the ester compound in various cosmetics, the cosmetics also have proper emollient property.Type: GrantFiled: August 5, 2010Date of Patent: April 16, 2013Assignee: Kokyo Alcohol Kogyo Co., Ltd.Inventors: Naoki Sasaki, Yuki Kokeguchi, Kiyotaka Kawai
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Patent number: 8357736Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.Type: GrantFiled: February 1, 2012Date of Patent: January 22, 2013Assignee: Kusumoto Chemicals, Ltd.Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
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Patent number: 8299293Abstract: A method for preparing ?-keto acids, especially ?-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting ?,?-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the ?-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.Type: GrantFiled: July 9, 2008Date of Patent: October 30, 2012Assignee: Evonik Degussa GmbHInventors: Christoph Kobler, Martin Hateley, Philipp Roth, Barbara Jaeger, Christoph Weckbecker, Klaus Huthmacher
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Publication number: 20120095254Abstract: The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.Type: ApplicationFiled: December 22, 2011Publication date: April 19, 2012Inventors: Royal D. Hathaway, JR., Joseph R. Sclafani, JR.
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Patent number: 8143325Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or moreType: GrantFiled: June 25, 2010Date of Patent: March 27, 2012Assignee: Bezwada Biomedical, LLCInventor: Rao S. Bezwada
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Patent number: 8133945Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.Type: GrantFiled: March 20, 2009Date of Patent: March 13, 2012Assignee: Kusumoto Chemicals, Ltd.Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
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Patent number: 8124800Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: GrantFiled: August 24, 2010Date of Patent: February 28, 2012Assignee: Vascular Biogenics Ltd.Inventors: Gideon Halperin, Eti Kovalevski-Ishai
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Publication number: 20120004385Abstract: Disclosed is a maintenance liquid for property carrying out imprints excellent in patternability. The maintenance liquid for imprints of an ink-jet discharging device comprises a compound comprising an ester group and/or an ether group.Type: ApplicationFiled: June 29, 2011Publication date: January 5, 2012Applicant: FUJIFILM CORPORATIONInventors: Kunihiko KODAMA, Kenichi KODAMA
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Publication number: 20110237770Abstract: The present invention relates to a process for the preparation of a polyurethane, comprising the process steps: i) provision of a polyisocyanate component comprising at least one polyisocyanate; ii) provision of a polyol component comprising at least one polyether polyol, one polyester polyol or a mixture of a polyether polyol and a polyester polyol, wherein the polyol component comprises a polyol ester of a polyol and a monocarboxylic acid; iii) bringing of the polyisocyanate component into contact with the polyol component to form a polyurethane.Type: ApplicationFiled: August 28, 2009Publication date: September 29, 2011Inventors: Peter Daute, Bernhard Bartnick
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Publication number: 20110217245Abstract: The present invention is related to substituted butanol derivatives of the formula: wherein R is an unsubstituted or substituted C1-6 straight chain alkyl, an unsubstituted or substituted C3-6 branched chain alkyl, an unsubstituted or substituted C3-6 straight chain alkenyl, an unsubstituted or substituted C3-6 branched chain alkenyl, an unsubstituted or substituted C3-6 cycloalkyl, an unsubstituted or substituted C1-6 alkoxy, nitrile, halo, amino, an unsubstituted or substituted C1-6 alkylamino, an unsubstituted or substituted C1-6 dialkylamino, carboxy-C1-6 alkylamino, carboxy-C1-6 dialkylamino, an unsubstituted or substituted acetoxy, carboxy, an unsubstituted or substituted carboxyethyl, an unsubstituted or substituted C1-6 alkylcarbonyl, an unsubstituted or substituted C1-6 alkylcarboxy, an unsubstituted or substituted C1-6 alkylthio, an unsubstituted or substituted C1-6 alkyloxy, carboxamido, an unsubstituted or substituted C1-6 alkylcarboxamido or an unsubstituted or substituted C1-6 dialkylcarboxaType: ApplicationFiled: December 30, 2010Publication date: September 8, 2011Inventors: Frank Derosa, Michael E. Lankin, Andrew T. Lupo, JR.
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Publication number: 20110184207Abstract: A new method for fabricating glycol monoalkyl ether acetate (GMAEA) is provided. A Bronsted acidic ionic liquid is used. After some reactions, two layers of materials are formed. A product of GMAEA is obtained at the upper layer. The lower layer is the ionic liquid. Thus, the ionic liquid is reusable for re-fabricating the product. And, furthermore, waste acid is reduced.Type: ApplicationFiled: May 17, 2010Publication date: July 28, 2011Applicant: CPC CORPORATIONInventors: Jung-Chung Wu, Ming-Yu Huang, Jen-Chun Chang, Jann-Chen Lin
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Publication number: 20110082200Abstract: Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.Type: ApplicationFiled: December 14, 2010Publication date: April 7, 2011Applicant: ALCON, INC.Inventors: Peter G. KLIMKO, Mark R. HELLBERG, David P. BINGAMAN, Daviel A. GAMACHE
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Patent number: 7888083Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: April 27, 2010Date of Patent: February 15, 2011Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20110034723Abstract: The present invention provides an oily base for a cosmetic comprising an ester compound made from a multivalent alcohol and a fatty acid, characterized in that the ester compound is made from dipentaerythritol and at least one fatty acid selected from the group consisting of fatty acids having 5 to 16 carbon atoms and a molar ratio of a dipentaerythritol residue to a fatty acid residue having 5 to 16 carbon atoms in the ester compound is 1.0:3.0 to 1.0:6.0. The aforesaid oily base for a cosmetic has proper oily feeling with moistness, no uncomfortable sticky feeling, excellent safety to the skin and adhesion to the skin, excellent gloss-holding ability after application to the skin, and excellent compatibility with various oil agents. In addition, upon blending the ester compound in various cosmetics, the cosmetics also have proper emollient property.Type: ApplicationFiled: August 5, 2010Publication date: February 10, 2011Inventors: Naoki Sasaki, Yuki Kokeguchi, Kiyotaka Kawai
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Publication number: 20110021680Abstract: Triglyceride and other polyol ester PVC plasticizers can be produced by recovery of branched C6 to C9 aldehydes from a hydroformylation product, optional hydrogenation to the alcohol, oxidation to the acid with oxygen and/or air, recovery of the resulting acid, and esterification with glycerol, ethylene glycol, propylene glycol or mixtures thereof. The branched alkyl chains comprise at least 10% methyl branching. Special triglycerides are derived from branched aliphatic acids having alkyl chains with average carbon numbers from 6 to 9 and at least 10% methyl branching. These triglycerides are fast fusing plasticisers if before esterification with glycerol, an aryl acid is introduced together with the aliphatic acids.Type: ApplicationFiled: March 18, 2009Publication date: January 27, 2011Inventors: Karla S. Colle, Phillippe Louis Buess, Eddy Theophile Van Driessche, Allen D. Godwin, Ramzi Yanni Saleh, Jon E.R. Stanat, Raphael Frans Caers
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Patent number: 7858821Abstract: The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.Type: GrantFiled: January 22, 2008Date of Patent: December 28, 2010Assignee: INKE, S.A.Inventors: Juan Antonio Pérez Andrés, Pere Dalmases Barjoan, Joan Huguet Clotet
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Publication number: 20100317881Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.Type: ApplicationFiled: August 24, 2010Publication date: December 16, 2010Applicant: Vascular Biogenics Ltd.Inventors: Gideon HALPERIN, Eti Kovalevski-Ishai
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Publication number: 20100317886Abstract: All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.Type: ApplicationFiled: June 11, 2010Publication date: December 16, 2010Inventor: Rodolfo A. Martinez
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Publication number: 20100227865Abstract: The invention provides Beta-blocker drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the Beta-blocker drug not attached to the water soluble oligomer.Type: ApplicationFiled: March 12, 2008Publication date: September 9, 2010Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte, Aaron S. Hammons
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Publication number: 20100217031Abstract: The present invention relates to a continuous process for preparing alkyl 3,3-dialkoxy-propionates of the formula (RO)2CHCH2CO2R, wherein R is C1-6 alkyl, by reacting ketene with an ortho formate of formula (RO)3CH in the presence of an acidic catalyst, characterized in that the reaction is carried out in a loop reactor.Type: ApplicationFiled: October 29, 2008Publication date: August 26, 2010Inventors: Wolfgang Wenger, Cornelia Zur Täschler, Daniel Zollinger
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Publication number: 20100209723Abstract: There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R1 and R2 each independently represents an alkyl group having 1 to 10 carbon atoms and R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.Type: ApplicationFiled: August 29, 2008Publication date: August 19, 2010Applicant: THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD.Inventors: Shinichi Tanaka, Hideki Kageyama, Hiroyuki Ono, Akiko Kuruma
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Patent number: 7772352Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or moreType: GrantFiled: October 20, 2005Date of Patent: August 10, 2010Assignee: Bezwada Biomedical LLCInventor: Rao S. Bezwada
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Publication number: 20100172996Abstract: Disclosed is a chain-end functionalized methoxy poly(ethylene glycol) (mPEG), a process of preparing the same, a living methoxy poly(ethylene glycol) for preparing the functionalized methoxy poly(ethylene glycol), a nano-particles of transition metal or metal salt encapsulated in the micelle structure formed by the chain-end functionalized methoxy poly(ethylene glycol), and a method for preparing the nano-particles of transition metal or metal salt.Type: ApplicationFiled: May 29, 2008Publication date: July 8, 2010Applicant: Youl Chon Chemical Co., Ltd.Inventors: Dong-Youn Shin, Ji Hee Kim
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Patent number: 7732171Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: July 23, 2008Date of Patent: June 8, 2010Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20100123269Abstract: A photosensitive resin composition and a method for forming an organic film on a substrate are provided. Because the photosensitive resin composition for imprinting includes an erythrotol-based monomer or oligomer, an organic film formed by the photosensitive resin composition for imprinting has improved restoring force. Therefore, the photosensitive resin composition is appropriate for imprinting processes.Type: ApplicationFiled: November 12, 2009Publication date: May 20, 2010Inventors: Yeon Heui NAM, Jin Wuk Kim, Tae Joon Song, Seong Pil Cho, Byung Uk Kim, Seung Hyup Shin, Jun Yong Song, Myoung Soo Lee
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Publication number: 20100117022Abstract: A polyol ester suitable for use as a lubricant or a lubricant base stock has a kinematic viscosity at 40° C. less than or equal to 22 cSt and a viscosity index of greater than or equal to 140. The ester comprises a reaction product of (a) at least one polyhydric alcohol having at least 2 primary hydroxyl groups, (b) at least one monocarboxylic acid having 2 to 15 carbon atoms and (c) at least one polycarboxylic acid having 2 to 15 carbon atoms, wherein the number of acid groups derived from the polycarboxylic acid(s) is at least 25% of the total number of acid groups derived from the monocarboxylic and polycarboxylic acids.Type: ApplicationFiled: October 8, 2009Publication date: May 13, 2010Applicant: CHEMTURA CORPORATIONInventors: Dale Carr, Jeffrey Hutter, Edward T. Hessell, Richard Kelley
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Publication number: 20100099788Abstract: The present invention relates to a process for the preparation of polyether ester polyols starting from fatty acid esters and starter compounds having Zerewitinoff-active hydrogen atoms, and to their use in the production of solid or foamed polyurethane materials.Type: ApplicationFiled: October 15, 2009Publication date: April 22, 2010Applicant: Bayer MaterialScience AGInventors: Klaus Lorenz, Reinhard Albers, Frank Otto
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Publication number: 20100093757Abstract: A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.Type: ApplicationFiled: August 4, 2009Publication date: April 15, 2010Applicant: AstraZeneca ABInventors: Stuart Norman Lile BENNETT, Roger John Butlin, Leonie Campbell, Robert Darren Morse Davies, Graeme Richard Robb, Rolf Peter Walker, Michael James Waring, Helen Claire Pointon, Mikael Dan Brink, Jonas Rickard Fägerhag, Ulrik Jurva, Volker Schnecke, Anette Marie Svensson Henriksson, Christer Ralf Westerlund, Peter Gustaf Bonn
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Publication number: 20100048940Abstract: New polyol ether compounds and a process for their preparation. The process comprises reacting a polyol, a carbonyl compound, and hydrogen in the presence of hydrogenation catalyst, to provide the polyol ether. The molar ratio of polyol to carbonyl compound in the process is greater than 5:1.Type: ApplicationFiled: August 19, 2009Publication date: February 25, 2010Inventors: Michael L. Tulchinsky, John R. Briggs, Cynthia L. Rand
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Publication number: 20100048483Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.Type: ApplicationFiled: August 21, 2009Publication date: February 25, 2010Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.Inventors: Guohan Yang, Ton T. Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
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Patent number: 7662861Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.Type: GrantFiled: January 31, 2007Date of Patent: February 16, 2010Assignee: IDEXX Laboratories, Inc.Inventors: Yerramilli V. S. N. Murthy, Robert H. Suva
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Patent number: 7550617Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.Type: GrantFiled: October 2, 2007Date of Patent: June 23, 2009Assignees: Medical College of Georgia Research Institute, Board of Regents, The University of Texas SystemInventors: John D. Imig, John R. Falck
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Patent number: 7550625Abstract: The invention relates to compounds of formula (I): wherein R is —C(O)CH2OCH2CH2OCH3 or —C(O)CH2N(CH3)2. The invention also relates to pharmaceutical compositions comprising a compound formula (I) and methods of treating or preventing a condition in an animal comprising administering to an animal in need thereof a compound of formula (I).Type: GrantFiled: October 13, 2008Date of Patent: June 23, 2009Assignee: IDEXX LaboratoriesInventor: Yerramilli V. S. N. Murthy
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Patent number: 7531688Abstract: A method for making fatty acid esters by reacting triglycerides with an excess of alcohol in a pressurized environment, where the unreacted alcohol component is separated from the reaction product by a flash purification techniques. In this manner, the pressure of the product stream is significantly reduced to vaporize unreacted alcohol, which is then condensed for later reuse. The invention provides a cost-effective and convenient mechanism to simultaneously recycle excess alcohol and to purify ester product and/or glycerol product streams.Type: GrantFiled: June 12, 2007Date of Patent: May 12, 2009Assignee: Orbitek, Inc.Inventor: Christian A. Fleisher
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Publication number: 20080312468Abstract: A method for making fatty acid esters by reacting triglycerides with an excess of alcohol in a pressurized environment, where the unreacted alcohol component is separated from the reaction product by a flash purification techniques. In this manner, the pressure of the product stream is significantly reduced to vaporize unreacted alcohol, which is then condensed for later reuse. The invention provides a cost-effective and convenient mechanism to simultaneously recycle excess alcohol and to purify ester product and/or glycerol product streams.Type: ApplicationFiled: June 12, 2007Publication date: December 18, 2008Inventor: Christian A. Fleisher
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Publication number: 20080249306Abstract: The present invention relates to a process for the production of statins, which are known as HMG-CoA reductase inhibitors. A few of the intermediate compounds for use in the process in accordance with the invention are novel compounds and the invention also relates to these novel intermediate compounds.Type: ApplicationFiled: April 28, 2006Publication date: October 9, 2008Inventors: Vitali Tararov, Armin Boerner, Gerd Koenig, Andrei Korostylev
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Patent number: 7416865Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.Type: GrantFiled: April 27, 2006Date of Patent: August 26, 2008Assignee: AstraZeneca UK LimitedInventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
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Publication number: 20080146663Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.Type: ApplicationFiled: October 2, 2007Publication date: June 19, 2008Inventors: John D. Imig, John R. Falck
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Publication number: 20080114185Abstract: A method for producing an unsaturated vicinal diol compound represented by the formula (2): wherein R1, R2, R3, R4, R5 and R are the same or different and each independently represent a hydrogen atom; a C1-C20 alkyl group which may be substituted with a halogen atom or atoms, a C1-C6 alkoxy group or groups, a C2-C7 alkoxycabonyl group or groups, a C6-C10 aryl group or groups, or a carboxyl group or groups; or a C6-C10 aryl group which may be substituted with a halogen atom or atoms, a C1-C6 alkoxy group or groups, a C6-C10 aryl group or groups, or a carboxyl group or groups; which comprises reacting an unsaturated epoxy compound represented by the formula (1): wherein R1, R2, R3, R4, R5 and R6 are the same as defined above, with water in the presence of a silicate containing at least one element selected from a group 5 element and a group 6 element of the long periodic table as a constituent.Type: ApplicationFiled: September 9, 2005Publication date: May 15, 2008Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Koji Hagiya