Cyclic Alcohol Moiety Patents (Class 560/193)
  • Patent number: 5710232
    Abstract: Compounds having the formulaH--A--(BA).sub.n --OHwhereinn is 1-20;A is ##STR1## B is ##STR2## R.sub.1 is alkyl having 1-6 carbon atoms; R.sub.2 is an alkylene having 1-6 carbon atoms, alkenylene having 2-6 carbon atoms, cyclo-alkylene or cycloalkenylene having 5-8 carbon atoms or phenylene having 6-10 carbon atoms;a is 1-6; andb is 2-6.These compounds are useful for making polyurethanes.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: January 20, 1998
    Assignee: Imperial Chemical Industries PLC
    Inventors: Steve Carter, Christopher Phanopoulos
  • Patent number: 5698722
    Abstract: A Koch functionalized product which is the reaction product of at least one polymer having a number average molecular weight of at least 500 and at least ethylenic double bond per polymer chain, with carbon monoxide and a nucleophilic trapping agent. The invention includes functionalized polymer, derivatives thereof and methods of making the same.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Joseph Victor Cusumano, William Daniel Diana, Jacob Emert, Keith Raymond Gorda, Richard H. Schlosberg, David A. Young, William Bernard Eckstrom, Edris Eileen Manry, Michael John Keenan
  • Patent number: 5650536
    Abstract: A continuous process for functionalizing olefins, especially polymer olefins in a CSTR or pipe reactor. Esters are preferably produced by continuous reaction of the olefin with carbon monoxide and a nucleophilic trapping agent. The liquid-filled pipe reactor operates in plug flow with static mixers and the CSTR is operated in the substantial absence of air at constant liquid level.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: July 22, 1997
    Assignee: Exxon Chemical Patents Inc.
    Inventors: David C. Dankworth, William H. Cross, Joseph V. Cusumano, William D. Diana, William B. Eckstrom, Jacob I. Emert, Keith R. Gorda, Robert M. Koros, Harold W. Margo, Jon E. Stanat
  • Patent number: 5608090
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: March 4, 1997
    Assignees: Northwestern University, Warner-Lambert Company
    Inventors: Richard B. Silverman, Ryszard Andruszkiewicz, Po-Wai Yuen, Denis M. Sobieray, Lloyd C. Franklin, Mark A. Schwindt
  • Patent number: 5606101
    Abstract: A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## and intermediates thereof.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: February 25, 1997
    Assignee: Banyu Pharmaceutical Co., Ltd.
    Inventors: Takashi Nomoto, Masahiro Hayashi, Jun Shibata, Yoshikazu Iwasawa, Morihiro Mitsuya, Yoshiaki IIda, Katsumasa Nonoshita, Yasufumi Nagata
  • Patent number: 5563290
    Abstract: A method for preparing an optically active succinic acid compound involves hydrogenating an itaconic acid compound in the presence of a rhodium compound and a 2,2"-bis(1-(hydrocarbon residue-substituted) phosphine-substituted alkyl)-1,1"-biferrocene compound.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: October 8, 1996
    Assignee: Nippon Oil Co. Ltd.
    Inventor: Yoshihiko Ito
  • Patent number: 5557007
    Abstract: Novel unsaturated polylactone acrylates are produced by the reaction of an unsaturated polylactone, such as that produced in the reaction of a lactone with tetrahydrobenzyl alcohol, and a lower-alkyl acrylate under transesterification conditions. The unsaturated polylactone acrylate product may be subsequently epoxidized to form novel 3,4-epoxy polylactone acrylates.
    Type: Grant
    Filed: September 28, 1990
    Date of Patent: September 17, 1996
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventor: James P. Stanley
  • Patent number: 5516934
    Abstract: The present invention aims at providing a process for economically producing mono-p-nitrobenzyl malonate while recovering the excessive malonic acid and treating the by-product. The process of the present invention for producing mono-p-nitrobenzyl malonate comprises reacting p-nitrobenzyl-alcohol with malonic acid in an organic solvent, which may contain di-p-nitrobenzyl malonate if necessary, cooling the reaction mixture thus obtained to 35.degree. to 100.degree. C., separating the malonic acid thus precipitated and treating the reaction mixture with a basic aqueous solution at 35.degree. to 80.degree. C. The di-p-nitrobenzyl malonate formed as the by-product is effectively utilized by hydrolyzing or reacting with malonic acid to thereby give mono-p-nitrobenzyl malonate.
    Type: Grant
    Filed: June 27, 1995
    Date of Patent: May 14, 1996
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventor: Kenji Kunikata
  • Patent number: 5510402
    Abstract: The novel compounds of the formula I ##STR1## in which n is an integer from the range from 4 to 8 and m is an integer from the range from 1 to 4,A is the aliphatic, aromatic, araliphatic or heterocyclic radical of a monobasic to tetrabasic carboxylic acid, andR.sup.1 and R.sup.1', independently of one another, are C.sub.1 -C.sub.24 alkyl or C.sub.5 -C.sub.8 cycloalkyl, are suitable for stabilizing organic material against thermal, oxidative or actinic degradation.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: April 23, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Paul Dubs, Rita Pitteloud
  • Patent number: 5488132
    Abstract: The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: January 30, 1996
    Assignee: Monsanto Company
    Inventor: John J. Talley
  • Patent number: 5482523
    Abstract: Mannich condensation products prepared by the condensation of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxy, lower alkyl or lower alkoxy; R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl; R.sub.5 is hydrogen, alkyl, phenyl, aralkyl, alkaryl, or an acyl group of the formula: ##STR2## wherein R.sub.6 is alkyl, phenyl, aralkyl or alkaryl; R.sub.7 is alkyl; u is an integer from 1 to 10; n is an integer from 5 to 100; and x is an integer from 0 to 10;with an aldehyde and a nitrogen base selected from ammonia, lower alkylamine, a polyamine and mixtures thereof.The Mannich condensation products and their fuel soluble salts are useful as fuel additives for the prevention and control of engine deposits.
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: January 9, 1996
    Assignee: Chevron Chemical Company
    Inventor: Richard E. Cherpeck
  • Patent number: 5468263
    Abstract: The present invention relates to an alkylphenyl poly(oxyalkylene) polyamine acid ester fuel detergent effective for controlling deposit generated in an automobile engine, prepared by reacting polyamine and alkylphenyl poly(oxyalkylene) maleate derivative prepared by reaction of alkylphenyl poly(oxyalkylene) alcohol and maleic anhydride, through Michael reaction. A fuel detergent diluted solution comprising 5-70 wt % of said fuel detergent and an inert organic solvent, and a hydrocarbon fuel composition comprising thereof are prepared. The present invention does not use deadly toxic phosgene gas used in preparation of a deposit control additive for conventional polyether amine deposit control additive and prevents generation of amine salt to eliminate the process for removing amine salt.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: November 21, 1995
    Assignee: Yukong Limited
    Inventors: Hyun-jong Chung, Sang-chul Yim, Bon-chul Ku, Ho-young Guen, Duk-han Kim
  • Patent number: 5442096
    Abstract: A homopolymer or a copolymer comprises a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)wherein R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 -- wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5; m is an integer of 1 to 10; and 1 is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --. Additionally, disclosed are processes of preparing the homopolymer or copolymer as well as the polymerizable compound.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: August 15, 1995
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Satoshi Urano, Kei Aoki, Nobuaki Tomita, Hirohiko Mori
  • Patent number: 5395971
    Abstract: A process for making unsaturated .alpha.-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general formula LL'MoO.sub.2, L.sub.2 L'MoO.sub.2, or LL'MoO(X--Y).
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: March 7, 1995
    Assignee: The Board of Regents of The University of Oklahoma
    Inventors: Kenneth M. Nicholas, Anurag S. Srivastava
  • Patent number: 5391814
    Abstract: A fluorine-containing alkylsuccinic acid diester of the formula: ##STR1## wherein R.sub.1 is an aliphatic alkyl or alkenyl group, and one of R.sub.2 and R.sub.3 is a fluoroalkylether group and the other is a fluoroalkyl group, a fluoroalkenyl group, a fluorophenyl group, an aliphatic alkyl group or-an aliphatic alkenyl group, which has excellent lubricity in an atmosphere having low to high humidity.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: February 21, 1995
    Assignee: Matsushita Electric Industrial Co., Ltd.
    Inventors: Yoshiaki Kai, Naoko Mizuno
  • Patent number: 5385902
    Abstract: Antimicrobial compounds of the formula ##STR1## wherein A is selected from the group consisting of alkyl; phenyl; alkoxy; phenoxy; benzyloxy; monoalkylamino; dialkylamino; cyclic amino, anilino; heterocyclic; amino substituted with heterocyclic ring, methods of making and using said compounds, and compositions comprising said compounds are disclosed.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: January 31, 1995
    Assignee: Rohm and Haas Company
    Inventor: Adam C. Hsu
  • Patent number: 5374767
    Abstract: Cyclohexyladipates are formed in a staged reactor, e.g. a reactive distillation column. A mixture containing a major amount of benzene and a minor amount of cyclohexene is fed to the lower portion of the reaction zone and adipic acid is fed to the upper portion of the reaction zone, cyclohexyladipates are formed and removed from the lower portion of the reaction zone and benzene is removed from the upper portion of the reaction zone. The reaction zone also contains an acid catalyst.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: December 20, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: William C. Drinkard, Gerald C. Grunewald, Ronald Reimer
  • Patent number: 5364956
    Abstract: The compound described in the present invention is represented by the following general formula: R.sub.1 (OCH.sub.2 CH.sub.2).sub.n O(COACOOXO).sub.m COACO(OCH.sub.2 CH.sub.2).sub.k OR.sub.2 wherein A is C.sub.2 -C.sub.4 alkylene group or a residual group of aromatic dicarboxylic acid, namely a group formed by removing two carboxylic groups from an aromatic dicarboxylic acid,X is straight or branched chain alkylene group, a residual group of glycols (namely a group formed by removing two hydroxyl groups from a glycol) selected from the group consisting of diethylene glycol, triethylene glycol, dipropylene glycol, and tripropylene glycol, or a residual group of thiodiethanol,n is 1 to 3,R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.10 alkyl or benzyl,R.sub.2 is C.sub.1 -C.sub.8 alkyl or benzyl,m is 0 to 13 andk is 0 to 3.
    Type: Grant
    Filed: November 18, 1992
    Date of Patent: November 15, 1994
    Inventor: Satoshi Matsumoto
  • Patent number: 5364961
    Abstract: The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: November 15, 1994
    Assignee: Monsanto Company
    Inventor: John J. Talley
  • Patent number: 5350867
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: September 27, 1994
    Assignee: Merck & Co., Inc.
    Inventor: Sheo B. Singh
  • Patent number: 5349109
    Abstract: A process for making unsaturated .alpha.-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general formula LL'MoO.sub.2, L.sub.2 L'MoO.sub.2, or LL'MoO(X-Y).
    Type: Grant
    Filed: August 26, 1993
    Date of Patent: September 20, 1994
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Kenneth M. Nicholas, Anurag S. Srivastava
  • Patent number: 5342860
    Abstract: This invention relates to alk-1-enyl ether-polyester block prepolymers which are curable by cationically initiated radiation and which are defined by the formula ##STR1## wherein m has a value of from 1 to 25;A is C.sub.2 to C.sub.12 alkylene, C.sub.6 to C.sub.14 aryl, both groups optionally substituted with lower alkyl, halo lower alkyl, alkyleneoxy, halogen or aryl;R.sub.1 is alkylene containing from 1 to 6 carbon atoms;R.sub.2 is a saturated or unsaturated divalent radical containing from 1 to 14 carbon atoms and is selected from the group of alkylene, alkenylene and arylene, each group optionally substituted with oxygen, halogen, lower alkyl and/or hydroxy;R.sub.3 is hydrogen or C.sub.1 to C.sub.6 alkyl;R.sub.4 is C.sub.1 to C.sub.6 alkylene, C.sub.6 to C.sub.14 arylene, lower alkyl substituted phenylene or xylylene andR.sub.5 and R.sub.6 are independently hydrogen or C.sub.1 to C.sub.4 alkyl.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: August 30, 1994
    Assignee: ISP Investments Inc.
    Inventors: Jeffrey S. Plotkin, Mark M. Miller
  • Patent number: 5338879
    Abstract: A composition comprising a lactone-modified alicyclic compound (I), or an epoxidized lactone-modified alicyclic compound (II) of the following formulae: ##STR1## wherein R is an alkyl group, an aromatic group or an alkenyl group having carbon number of from 1 to 30, Y.sup.1 is at least one of the structural groups; ##STR2## Y.sup.2 is at least one of the structural group; ##STR3## X is the structural group; ##STR4## and R.sup.a and R.sup.b each independently is hydrogen or a methyl group, c and c' represent a number of from 4 to 8, from n1 to nL represents 0 or a number of more than 0, respectively, and n1+n2+n3+ . . . +nL corresponds to the total mole numbers of a lactone introduced into one molecule.These compositions can be made into a heat-curable composition, a photo-curable composition, a polymerizable composition and another photo-curable composition.
    Type: Grant
    Filed: August 13, 1992
    Date of Patent: August 16, 1994
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Takaaki Fujiwa, Shin Takemoto, Tomohisa Isobe, Yoshiyuki Harano
  • Patent number: 5332858
    Abstract: The invention relates to a method for preparing an ester composition in which at least one activated phenolic ether group of a molecule is reacted with at least one haloformyl group of another molecule.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: July 26, 1994
    Assignee: Shell Oil Company
    Inventors: Feike De Jong, Jan H. H. Meurs
  • Patent number: 5321155
    Abstract: Cyclohexyladipates are produced by reacting a mixture containing a major amount of benzene and minor amounts of cyclohexene, adipic acid and an acid catalyst.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: June 14, 1994
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: William C. Drinkard, Gerald C. Grunewald
  • Patent number: 5319056
    Abstract: The present invention relates to polyester polyols which have a hydroxyl number of 80 to 250 and are the reaction product ofa) 52 to 60 mole % of a polyol component containingi) 10 to 50 mole % of one or more dihydric aliphatic alcohols having at least two carbon atoms, other than neopentyl glycol,ii) 5 to 40 mole % of one or more trihydric or higher functional aliphatic alcohols having at least 3 carbon atoms,iii) 10 to 40 mole % of one or more cycloaliphatic diols andiv) 10 to 60 mole % of neopentyl glycol, withb) 40 to 48 mole % of a dicarboxylic acid component containingv) 0 to 49.9 mole % of one or more saturated aliphatic dicarboxylic acids or an anhydrides thereof having at least 2 carbon atoms andvi) 50.1 to 100 mole % of one or more unsaturated aliphatic dicarboxylic acids or anhydrides thereof having at least 4 carbon atoms,wherein the percentages of a) and b), i) to iv) and v to vi) add up to 100.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: June 7, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christian Wamprecht, Wolfgang Henning, Joachim Petzoldt, Jurgen Meixner
  • Patent number: 5312999
    Abstract: Propoxybenzene derivatives represented by the following formula ##STR1## wherein Ra represents a nitro group, an amino group which may have a protecting group or an --NHCH.dbd.C(COO--C.sub.1-6 -Alkyl).sub.2 group, Rb represents a hydrogen atom, a protecting group for the hydroxyl group or a substituted sulfonyl group and Xa and Xb, which may be the same or different, each represents a halogen atom, and processes for preparation thereof are disclosed. These derivatives are useful in preparing antibacterial agents.
    Type: Grant
    Filed: March 2, 1992
    Date of Patent: May 17, 1994
    Assignee: Daiichi Seiyaku Co., Ltd.
    Inventors: Toshihiro Fujiwara, Tutomu Ebata
  • Patent number: 5296003
    Abstract: Poly(oxyalkylene) hydroxyaromatic ethers having the formula: ##STR1## or a fuel-soluble salt thereof; where n is an integer from 5 to 100; x is an integer from 0 to 10; R.sub.1 and R.sub.2 are each independently hydrogen, hydroxy, lower alkyl having 1 to 6 carbon atoms, or lower alkoxy having 1 to 6 carbon atoms; R.sub.3 and R.sub.4 are each independently hydrogen or lower alkyl having 1 to 6 carbon atoms; R.sub.5 is an acyl group of the formula: ##STR2## wherein y is 1, 2 or 3; R.sub.6 is a divalent hydrocarbyl radical, when y is 1, a trivalent hydrocarbyl radical, when y is 2, or tetravalent hydrocarbyl radical, when y is 3, said hydrocarbyl radicals having 1 to about 20 carbon atoms; and each Z is independently selected from the group consisting of: ##STR3## where each R.sub.7 is independently alkyl having 1 to 30 carbon atoms, phenyl, aralkyl having 7 to 36 carbon atoms or alkaryl having 7 to 36 carbon atoms.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: March 22, 1994
    Assignee: Chevron Research and Technology Company
    Inventor: Richard E. Cherpeck
  • Patent number: 5281645
    Abstract: The present invention relates to new hydroxybenzophenones containing an ester functional group and to the use of these compounds as UV absorbers in organic polymers. More precisely, the new hydroxybenzophenones are 1,3-di(4-benzoyl-3-hydroxyphenoxy)-2-propanol carboxylates which preferably have a molecular mass of at least 500.These benzophenones can be employed as anti-UV agents in organic polymers, either by themselves or jointly with known benzophenones of lower molecular mass, such as 2-hydroxy-4-alkoxybenzophenones.
    Type: Grant
    Filed: July 24, 1992
    Date of Patent: January 25, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventors: Philippe Chicart, Michel Gay
  • Patent number: 5274161
    Abstract: New derivatives of cyclohexane in substantially pure form suitable as a pharmaceutical, foodstuff or as a stabilizer.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: December 28, 1993
    Assignee: Perstorp AB
    Inventors: Matti Siren, Lars Perrson
  • Patent number: 5274170
    Abstract: Compounds of the formula ##STR1## in which R is hydrogen or hydroxyl, R.sub.1 is alkyl, alkoxy, amino or aryl, and R.sub.2 is hydrocarbylcarbonyl or hydrocarbylsulfonyl, are highly suitable for stabilizing magenta couplers in photographic materials.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: December 28, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: David G. Leppard, David H. Steinberg, Henri Dubas
  • Patent number: 5262552
    Abstract: An optically active (S)- or (R)-pentane compound of the general formula (11): ##STR1## wherein R.sub.11, R.sub.12 and R.sub.13 independently represent a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, R.sub.14 represents a hydroxy, protected hydroxy or oxo group, if R.sub.14 is an oxo group, the ring denoting benzene in the above formula (11) is benzoquinone, R.sub.15 represents a hydrogen atom, hydroxy or acyloxy group, R.sub.16 represents a hydroxy or acyloxy group, and the chiral central carbon marked with a symbol * in said formula (11) alternatively has one of an R-configuration and an S-configuration, is disclosed. Further, intermediate products of the compound of the formula (11) are also disclosed. Still further, a process for manufacturing the above compounds is disclosed. The compound of the formula (11) is easily synthesized from an easily available optically active starting material.
    Type: Grant
    Filed: February 20, 1991
    Date of Patent: November 16, 1993
    Assignee: Asahi Denka Kogyo K.K.
    Inventors: Seiichi Takano, Kunio Ogasawara
  • Patent number: 5260479
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: November 9, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Sheo B. Singh
  • Patent number: 5248749
    Abstract: A homopolymer or a copolymer comprises a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)whereinR.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group;X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 --whereinR.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group;A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group;Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5; m is an integer of 1 to 10; and l is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --. Additionally, disclosed are processes of preparing the homopolymer or copolymer as well as the polymerizable compound.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: September 28, 1993
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Urano Satoshi, Aoki Kei, Tomita Nobuaki, Mori Hirohiko
  • Patent number: 5245061
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and method for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: December 16, 1991
    Date of Patent: September 14, 1993
    Assignee: Merck & Co., Inc.
    Inventor: Sheo B. Singh
  • Patent number: 5241105
    Abstract: In one embodiment this invention provides smoking compositions which contain a novel oxalate ester flavorantrelease additive.Under cigarette smoking conditions, a combustible filler additive such as methyl 4-oxo-.beta.-ionyl oxalate pyrolyzes and releases megastigma-5,7,9-trien-4-one as a natural flavorant component of the cigarette smoke.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: August 31, 1993
    Assignees: Philip Morris Incorporated, Philip Morris Products Inc.
    Inventor: W. Geoffrey Chan
  • Patent number: 5214195
    Abstract: The present invention provides new allyl esters of the general formula:X--CH.sub.2 --CR.sup.1 .dbd.CR.sup.2 --CO--Y--R.sup.3 --A (I)wherein R.sup.1 and R.sup.2, which can be the same or different, are hydrn or halogen atoms or alkyl or aryl radicals, R.sup.3 is a linking grouping (spacer), X is an acyloxy radical in which acyl in the acyloxy radical is the residue of an aliphatic carboxylic acid or is the radical RCO-- in which R is an organic radical, Y is an oxygen or sulphur atom or especially an --NH-- group and A is a grouping which can react with a solid carrier material F, which contains appropriate functional groups B, either after selective deblocking or directly, whereby A and B are atom groupings which react with one another with condensation and/or addition and formation of a linkage between the solid carrier material and the radical X--CH.sub.2 --CR.sup.1 .dbd.CR.sup.2 --CO--Y--R.sup.3 --.The present invention also provides processes for the preparation of these new allyl esters.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: May 25, 1993
    Assignee: Orpegen Medizinisch-Molekular Biologische Forschungsgesellschaft mbH
    Inventors: Horst Kung, Winfried Kosch, Joachim Marz
  • Patent number: 5214199
    Abstract: A malonic monoester is prepared in a good yield by a single step reaction by reacting malonic acid with an alcohol in the presence of a base and an activator of malonic acid selected from the group consisting of an acyl halide or halocarbonate and an acid anhydride or dicarbonate.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: May 25, 1993
    Assignee: Kanegafuchi Chemical Industries Co., Ltd.
    Inventors: Teruyoshi Koga, Noboru Ueyama, Kenji Inoue, Satomi Takahashi
  • Patent number: 5210280
    Abstract: A process for the preparation of alkanedioic acid derivatives comprising reacting an alkenoic acid derivative with carbon monoxide and a nucleophilic compound having a mobile hydrogen atom in the presence of a catalyst system comprising a source of a Group VIII metal, a source of a bidentate diphosphine liquid, a source of an anion and a source of a quinone promoter.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: May 11, 1993
    Assignee: Shell Oil Company
    Inventor: Eit Drent
  • Patent number: 5189198
    Abstract: A process for efficiently preparing an unsaturated dicarboxylic acid diester, which comprises reacting a conjugated diene, carbon monoxide, an alcohol and oxygen in the presence of a catalyst comprising (a) a platinum metal, a salt thereof or a complex compound of a platinum metal, (b) at least one metal salt selected from the group consisting of a copper salt, an iron salt and a manganese salt and (C) at least one compound selected from the group consisting of (1) an alkali metal compound or an alkaline earth metal compound, (2) a rare earth metal compound, (3) a metal compound of the groups IIIA, IVA, IVB, VA, VB or VIA, and (4) a metal carbonyl complex. The unsaturated dicarboxylic acid diester is useful as an intermediate material in industrial chemical processes and can be efficiently prepared without the use of a dehydrating agent.
    Type: Grant
    Filed: May 6, 1991
    Date of Patent: February 23, 1993
    Assignee: Idemitsu Petrochemical Co., Ltd.
    Inventors: Takashi Kumazawa, Tetsuo Ishibashi, Mitsugu Kanzawa
  • Patent number: 5185459
    Abstract: Cyclobutanols of the formula ##STR1## wherein P is a hydroxy protecting group are useful intermediates in the preparation of antiviral compounds.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: February 9, 1993
    Assignee: E. R. Squibb & Sons Inc.
    Inventors: William A. Slusarchyk, Robert Zahler
  • Patent number: 5177249
    Abstract: The present invention relates to compounds comprising ester groups having at least three ester functions, to processes for the production thereof, and to the use of the products.Compounds having at least three functional ester groups of the general formula: ##STR1## are described, wherein the abbreviations have the following meanings: X=--CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--,Y=bivalent, saturated aliphatic hydrocarbon residue optionally substituted,Z=optionally substituted acyl residue --CO--RR.sub.1 =the residue of an alcohol, or a group from an alkylene-oxide-adduct taking the alcohol function in the ester grouping.n=1 to 3 andm=1 to 3.
    Type: Grant
    Filed: November 20, 1990
    Date of Patent: January 5, 1993
    Assignee: Chemische Fabrik Stockhausen GmbH
    Inventor: Reinmar Peppmoller
  • Patent number: 5169896
    Abstract: A curable composition comprises a compound having at least two hydroxyl groups and a homopolymer or a copolymer of a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)wherein R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 -- wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralykyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl groups; Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5;m is an integer of 1 to 10; and 1 is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: December 8, 1992
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Satoshi Urano, Kei Aoki, Nobuaki Tomita, Hirohiko Mori
  • Patent number: 5152916
    Abstract: Aqueous aldehyde solutions for trapping hydrogen sulfide comprising 5 to 50% by weight of an aldehyde and 1 to 5% by weight, relative to the aldehyde solution of a formulation comprising10 to 80% by weight of an ester of oxalkylated alkylalkylenediamines, which may be quaternized and 20 to 90% by weight of water or of a C.sub.1 -C.sub.4 -alcohol.
    Type: Grant
    Filed: August 21, 1990
    Date of Patent: October 6, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hermann Hoffmann, Frederic Mabire
  • Patent number: 5142098
    Abstract: The invention relates to novel monoesters and diesters of 9,10-endoethano-9,10-dihydroanthracene-11,11-dicarboxylic acid.These novel monoesters and diesters correspond to the following structural chemical formula (II): ##STR1## in which R.sup.1 and R.sup.2 are identical or different and can represent H, an alkali metal or alkaline earth metal atom, a linear or branched alkyl group having from 1 to 6 carbon atoms, an alicyclic group having form 3 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, defined in their cis or trans variety, or an alkynyl group having from 2 to 6 carbon atoms, the said groups optionally being substituted by one or more functional groups such as ether, epoxide, halogeno, cyano, ester, aldehyde, ketone, aryl etc., where R.sup.1 and R.sup.2 cannot be H or ethyl simultaneously. These addition products constitute valuable intermediates for the preparation of methylidenemalonates in high yields and with a high purity.
    Type: Grant
    Filed: March 23, 1990
    Date of Patent: August 25, 1992
    Assignee: Laboratoires UPSA
    Inventors: Nicole Bru-Magniez, Christian De Cock, Jacques Poupaert, Jean-Luc De Keyser, Pierre Dumont
  • Patent number: 5117044
    Abstract: The invention provides a polymerizable compound represented by the formula (I):A--X--COCOOR.sub.1wherein A represents a C.sub.1 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented bywherein R.sub.2 and R.sub.3, which are the same or different, represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, Y represents an oxygen atom or --NR.sub.4 --, in which R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, n is an integer of 1 to 5, m is an integer of 1 to 10 and 1 is 0 or an integer of 1 to 20;R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; andX represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 --, in which R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, provided that if Y is present, X is not --NR.sub.5 --,its production and polymers prepared therefrom.
    Type: Grant
    Filed: January 12, 1990
    Date of Patent: May 26, 1992
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Satoshi Urano, Kei Aoki, Nobuaki Tomita, Hirohiko Mori
  • Patent number: 5087734
    Abstract: The present invention provides a crystal modification of magnesium salt of mono-p-nitrobenzyl malonate (hereinunder referred to as ".beta.-type crystal") which is characterized by an X-ray diffraction pattern having strong peaks at angles of diffraction of (2.theta.) [.degree.] 4.5, 8.9 and 13.3 according to X-ray diffractometry with Cu-K.alpha. line, and a process for producing the .beta.-type crystal modification of magnesium salt of mono-p-nitrobenzyl malonate comprising the step of reacting a water-soluble magnesium salt with an alkali metal salt or ammonium salt of mono-p-nitrobenzyl malonate. This process facilitates the production of the .beta.-type crystal modification having a higher purity than a known .alpha.-type crystal modification. The .beta.-type crystal is a very useful intermediate as a starting material of pharmaceutical.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: February 11, 1992
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Tsukasa Ishikura, Shigeru Matsuyama
  • Patent number: 5075024
    Abstract: A synthetic traction fluid comprising, as a base oil, at least one ester or its derivative selected from monoesters or their derivatives, and triesters or their derivatives represented by the formula ##STR1## wherein Y is independently selected from ##STR2## and --OH with A' being an ester linkage and R.sub.1 being independently selected from hydrogen and C.sub.1 to C.sub.8 alkyl groups, with the proviso that at least one Y is ##STR3## and R.sub.2 is independently selected from hydrogen and C.sub.1 to C.sub.3 alkyl groups.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: December 24, 1991
    Assignee: Toa Nenryo Kogyo, K.K.
    Inventors: Narihiko Yoshimura, Hirotaka Tomizawa, Yasuji Komatsu
  • Patent number: 5051447
    Abstract: Oxime ethers of the general formula ##STR1## where R.sup.1 and R.sup.2 are hydrogen or alkyl,R.sup.3 is hydrogen, halogen, cyano, aryl or aryloxy, the aromatic ring being unsubstituted or substituted, or R.sup.3 is heteroaryl, adamantyl, fluorenyl or cycloalkyl or cycloalkenyl, these radicals being unsubstituted or substituted,X is saturated or unsaturated C.sub.1 -C.sub.12 -alkylene which is unsubstituted or substituted, andn is 0 or 1,and fungicides containing these compounds.
    Type: Grant
    Filed: July 20, 1989
    Date of Patent: September 24, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Wenderoth, Franz Schuetz, Siegbert Brand, Hubert Sauter, Eberhard Ammermann, Gisela Lorezn
  • Patent number: 5039440
    Abstract: A traction fluid comprising at least one compound selected from diesters or monoesters represented by general formulas ##STR1## wherein: A is an ester linkage ##STR2## n.sub.1 and n.sub.2 are independently integers having a value of from 0 to 5 inclusive;R.sub.1 is hydrogen or a C.sub.1 -C.sub.8 alkyl; andR.sub.2 is a C.sub.1 to C.sub.3 alkyl group.
    Type: Grant
    Filed: March 31, 1988
    Date of Patent: August 13, 1991
    Assignee: Toa Nenryo Kogyo, K.K.
    Inventors: Narihiko Yoshimura, Hirotaka Tomizawa