Cyclic Alcohol Moiety Patents (Class 560/220)
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Patent number: 4363817Abstract: Disclosed are C-9 enol acylate analogs of E.sub.1 and E.sub.2 prostaglandins which are variously useful as bronchodilators, gastric anti-secretory agents and cyto-protective agents.Type: GrantFiled: August 27, 1981Date of Patent: December 14, 1982Assignee: Miles Laboratories, Inc.Inventor: William G. Biddlecom
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Patent number: 4360693Abstract: Dimethacrylates are provided having the following chemical structure: ##STR1## where ##STR2## is a saturated, 6 membered, monocyclic, hydrocarbyl ring system; and R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl or alkoxy groups having 1 to 12 carbon atoms. These compounds are useful in dental material which cures to form polymes having high mechanical strength, low water sorption, resistance to staining, good color stability when exposed to short-wave radiation (e.g., sunlight) and good chemical resistance to the oral environment. Also provided are a method for polymerizing this compound in situ on teeth and a tooth comprising a polymer of this compound.Type: GrantFiled: April 7, 1981Date of Patent: November 23, 1982Assignee: Scientific Pharmaceuticals, Inc.Inventor: Jan A. Orlowski
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Patent number: 4336349Abstract: Chlorinated cycloaliphatic (meth) acrylate compositions are prepared by the reaction of chlorine at a temperature in the range from -30.degree. C. to 50.degree. C. with compositions made by reacting (meth) acrylic acid with crude dicyclopentadiene in the presence of a Friedel-Crafts catalyst such as BF.sub.3. The chlorinated compositions have a pleasant fruity odor and are useful to make homopolymers or copolymers which find use as metal coatings, inks, ultraviolet light curable coatings and the like.Type: GrantFiled: December 22, 1980Date of Patent: June 22, 1982Assignee: The Dow Chemical CompanyInventors: Hans R. Friedli, Clinton J. Boriack
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Patent number: 4332964Abstract: Diacrylate and dimethacrylate esters corresponding to the formula ##STR1## wherein R and R' are hydrogen or methyl and A is either a sigma (.sigma.) bond; a (CH.sub.2).eta. radical where .eta. is an interger that may vary from one through four; or phenylene, or an alkyl derivative thereof. The new adamantane containing difunctional olefinic monomers can then be polymerized, or copolymerized with other acrylic type olefinic monomers to produce polymers with unusual physical properties, including unusual hardness, inertness to degradable agents, and resistance to heat.Type: GrantFiled: May 18, 1981Date of Patent: June 1, 1982Assignee: Battelle Development CorporationInventors: Gunter Bellmann, Nguyen Van Tao
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Patent number: 4323696Abstract: The invention relates to (meth)acrylic acid esters of compounds of Formula (I) as defined infra and methods for their preparation. The esters formed can be used to provide dental repair material and also to provide adhesive or sealing agents. In addition, the invention includes a process for preparing compositions which harden in the absence of oxygen by admixing a compound of the invention with an initiator.Type: GrantFiled: August 1, 1980Date of Patent: April 6, 1982Assignee: Bayer AktiengesellschaftInventors: Robert Schmitz-Josten, Manfred Dietrich, Bruno Bomer
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Patent number: 4311852Abstract: New oxygen containing derivatives of tricyclo[6.2.1.0.sup.2,7 ]undecane useful as perfuming or flavor-modifying ingredients in the manufacture of perfumes, perfumed articles, artificial flavors, foodstuffs, feedstuffs, beverages, pharmaceutical preparations or tobacco products.Perfume or flavoring compositions containing same as organoleptically active ingredients.Type: GrantFiled: July 2, 1979Date of Patent: January 19, 1982Assignee: Firmenich SAInventors: Werner Skorianetz, Gunther Ohloff
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Patent number: 4310688Abstract: The level of hydrolyzable chloride-containing impurities in an isocyanatoalkyl ester of an organic carboxylic acid is reduced by reacting the impurities with a vicinal epoxide-containing compound and then fractionally distilling the mixture to recover the isocyanatoalkyl ester. As an example, crude 2-isocyanatoethyl methacrylate (IEM) in a methylene chloride solution containing 0.084 weight percent of hydrolyzable chloride is contacted with a diglycidyl ether of bisphenol A at 23.degree. C. This reaction mixture is then fractionally distilled to separate the IEM from the methylene chloride first cut and the epoxy resin residue. The hydrolyzable chloride level of the distilled IEM product is only 0.03 weight percent.Type: GrantFiled: October 22, 1979Date of Patent: January 12, 1982Assignee: The Dow Chemical CompanyInventor: Abel Mendoza
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Patent number: 4304893Abstract: Dimethacrylates are provided having the following chemical structure: ##STR1## where ##STR2## is a saturated, 6 membered, monocyclic, hydrocarbyl ring system; and R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen or alkyl or alkoxy groups having 1 to 12 carbon atoms.These compounds are useful in dental material which cures to form polymers having high mechanical strength, low water sorption, resistance to staining, good color stability when exposed to short-wave radiation (e.g., sunlight) and good chemical resistance to the oral environment. Also provided are a method for polymerizing this compound in situ on teeth and a tooth comprising a polymer of this compound.Type: GrantFiled: June 11, 1980Date of Patent: December 8, 1981Assignee: Scientific Pharmaceuticals, Inc.Inventor: Jan A. Orlowski
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Patent number: 4287100Abstract: Esters of 1,2,3,6-tetrahydrobenzyl alcohol have been found to exhibit powerful odorous notes such as floral, woody and fruity notes, rendering such compounds valuable as fragrance materials either alone or in compositions. These 1,2,3,6-tetrahydrobenzyl alcohol esters are prepared by reacting 1,2,3,6-tetrahydrobenzyl alcohol with an appropriate organic acid.Type: GrantFiled: March 14, 1978Date of Patent: September 1, 1981Assignee: Fritzsche Dodge & Olcott Inc.Inventors: Kurt Kulka, Teodosij Zazula, John M. Yurecko, Jr.
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Patent number: 4283414Abstract: The invention concerns novel pesticidal esters of the pyrethrin or pyrethroid type in which the methylene group bonded to the ester carbonyl and/or ester oxygen bears a fluorine substituent. The compounds of the invention are active against insect pests including flies, moths, aphids and beetles and acarina pests including ticks.Type: GrantFiled: June 8, 1979Date of Patent: August 11, 1981Assignee: ICI Australia LimitedInventors: Donald W. G. Harney, Peter G. Lehman, Joseph C. Rundle
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Patent number: 4256745Abstract: Prostan-1-ol esters and intermediates for their preparation are described; the former compounds exhibit improved organ specificity and a longer duration of activity at lower dosages than the corresponding non-esterified prostaglandins and are useful, inter alia, in triggering abortion, inducing labor and regulating the menstrual cycle.Type: GrantFiled: March 2, 1978Date of Patent: March 17, 1981Assignee: Schering AktiengesellschaftInventors: Werner Skuballa, Bernd Raduchel, Helmut Vorbruggen, Walter Elger, Olaf Loge, Eckehard Schillinger
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Patent number: 4218348Abstract: Esters of 1,5-dimethylbicyclo[3,2,1]octan-8-ol of the general formula: ##STR1## wherein R represents hydrogen or an aliphatic or an aromatic hydrocarbon group optionally substituted with an amino group; are useful as aroma chemicals.Type: GrantFiled: May 8, 1979Date of Patent: August 19, 1980Assignee: Shell Oil CompanyInventors: Albertus J. Mulder, Aaldert J. de Jong
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Patent number: 4209604Abstract: Polymerizable acrylic monomers, and anaerobic adhesives which contain such monomers, wherein the acrylic monomers contain internal chain unsaturation in addition to terminal acrylic unsaturation.Type: GrantFiled: January 7, 1976Date of Patent: June 24, 1980Assignee: Estech Specialty Chemicals CorporationInventor: Gerhardt P. Werber
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Patent number: 4204073Abstract: A process for producing trimethyl oxo or hydroxy substituted cycopentenone food coloring agents including intermediates in this process.Type: GrantFiled: April 6, 1979Date of Patent: May 20, 1980Assignee: Hoffmann-La Roche Inc.Inventor: Frank Kienzle
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Patent number: 4139716Abstract: The present disclosure relates to D-homosteroids. More particularly, the disclosure is concerned with 19-nor-D-homopregnanes, a process for the manufacture thereof and pharmaceutical preparations containing same.Type: GrantFiled: March 25, 1976Date of Patent: February 13, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Andor Furst, Jurg A. W. Gutzwiller, Marcel Muller, Ulrich Kerb, Rudolf Wiechert
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Patent number: 4138497Abstract: Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxylakylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.Type: GrantFiled: July 29, 1977Date of Patent: February 6, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joseph E. Sundeen, Joyce Reid
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Patent number: 4113726Abstract: Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q-. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.Type: GrantFiled: February 28, 1974Date of Patent: September 12, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic Peter Hauck, Christopher Michael Cimarusti
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Patent number: 4113863Abstract: Prostenoic acid derivatives of the general formula ##STR1## wherein R.sup.1 is H or alkyl of 1-4 carbon atoms;R.sup.2 is alkyl of 5 - 9 carbon atoms, phenoxymethyl or phenoxymethyl substituted by up to 3 of F, Cl, Br, CH.sub.3, CF.sub.3, or OCH.sub.3 ;R.sup.3 is H or alkyl of 1 - 5 carbon atoms, and physiologically acceptable salts thereof, as well as intermediates therefore are blood-pressure lowering, vasodilatory, diuretic, and nasal mucosa decongesting agents and are produced from intermediates of the formula ##STR2## wherein R.sup.4 is H or acyl of up to 5 carbon atoms and A is CH.sub.2 D or CH.dbd.C(OR.sup.5); D is carbonyl or dialkoxypolymethylene of up to 7 carbon atoms.Type: GrantFiled: November 5, 1976Date of Patent: September 12, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Manfred Baumgarth, Hans-Eckart Radunz, Dieter Orth, Reinhard Lissner, Hans-Joachim Enenkel, Filippus Johannes Zeelen
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Patent number: 4103025Abstract: Pharmaceutically active compounds of the formula ##STR1## wherein --OR.sub.1, --OR.sub.2, --OR.sub.3 and --OR.sub.4, which may be the same or different, each represents a free or esterified hydroxyl group and --COOR.sub.5 represents a free or esterified carboxyl group, are provided together with processes for their production and pharmaceutical compositions containing them. Compounds of formula II and III possess valuable cicatrizing and anti-inflammatory properties.Type: GrantFiled: March 17, 1977Date of Patent: July 25, 1978Assignee: Inverni Della Beffa S.p.A.Inventor: Giuseppe Mustich
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Patent number: 4098805Abstract: The present invention relates in part to novel amido, cycloamido, carbonylamido and sulfonylamido derivatives and p-substituted phenyl esters of 9-deoxy-9-methylene-PGF-type compounds. These novel amides produce surprisingly prolonged oral activity as pharmacological agents, as compared to the previously known 9-deoxy-9-methylene-PGF-type compounds.Further, the novel p-substituted phenyl esters provide more stable pharmaceutical formulations as compared to known 9-deoxy-9-methylene-PGF-type esters.Additionally, a novel series of 16-phenyl-9-deoxy-9-methylene-PGF-type compounds in free acid, ester, C-1 alcohol, and C-1 amine form is provided. Such compounds exhibit characteristic prostaglandin-type pharmacological actions.Type: GrantFiled: April 11, 1977Date of Patent: July 4, 1978Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4097677Abstract: The invention is concerned with novel unsaturated compounds having extremely low volatility having a single monoethylenically unsaturated group of the formula H.sub.2 C = C < whereby they are capable of polymerization to produce linear homopolymers and copolymers with copolymerizable monomers containing such a group, and having autoxidizable characteristics by virtue of a different type of unsaturated group. These new compounds are useful for the production of polymers, alone or in admixture with other polymers or monomers to modify the characteristics of the components of the mixture. They are useful in coating or impregnating compositions and/or in the molding, casting, or otherwise forming of shaped articles.Type: GrantFiled: July 7, 1976Date of Patent: June 27, 1978Assignee: Rohm and Haas CompanyInventors: William D. Emmons, Kayson Nyi
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Patent number: 4086151Abstract: Linear copolymers of glycidol, glycidyl esters of unsaturated fatty acids and, optionally, alkylene oxides, are made by the reaction of an unsaturated fatty acid with a polymer or copolymer of tert.-butyl glycidyl ether in the presence of an acid catalyst. The products are polymerizable and copolymerizable with vinyl monomers and are useful as curable resins.Type: GrantFiled: June 30, 1977Date of Patent: April 25, 1978Assignee: The Dow Chemical CompanyInventors: Violete L. Stevens, Arthur R. Sexton, Frederick P. Corson
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Patent number: 4077992Abstract: A high temperature lubricant comprising a gem disubstituted cyclic compound in which one radical is a short chain alkyl group and the other radical is a methylene group substituted by an alkyl, alkylene or aryl amido radical or an alkyl, alkylene or aryl carboxylate radical.Type: GrantFiled: October 4, 1976Date of Patent: March 7, 1978Assignee: Milliken Research CorporationInventor: Anthony M. Fusco
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Patent number: 4078066Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.Type: GrantFiled: December 17, 1976Date of Patent: March 7, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic Peter Hauck, Joseph E. Sundeen
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Patent number: 4069258Abstract: Cyclopentene derivatives (I) ##STR1## where R.sup.1 is isopropyl or isopropenyl, R.sup.2 is alkyl of 1 to 3 carbon atoms, X is --CHO, a dialkyl acetal or 1,2- or 1,3-alkylene acetal thereof where the acetal radical is of 2 to 6 carbon atoms, --CH.sub.2 OH or --CH.sub.2 OCOR.sup.3 where R.sup.3 is hydrogen or alkyl or alkenyl of up to 3 carbon atoms. The manufacture of I from the corresponding halomethyl cyclopentenes and aldehydes R.sup.2 --CH(CH.sub.3)--CHO in the presence of a base and a quaternary ammonium salt, followed if desired by acetalization or conversion of the --CHO group to the --CH.sub.2 OH or --CH.sub.2 O--CO--R.sup.3 groups. The compounds are useful as fragrance materials.Type: GrantFiled: March 15, 1976Date of Patent: January 17, 1978Assignee: BASF AktiengesellschaftInventors: Werner Hoffmann, Karl VON Fraunberg