Abstract: Pharmaceutically active compounds of the formula ##STR1## wherein --OR.sub.1, --OR.sub.2, --OR.sub.3 and --OR.sub.4, which may be the same or different, each represents a free or esterified hydroxyl group and --COOR.sub.5 represents a free or esterified carboxyl group, are provided together with processes for their production and pharmaceutical compositions containing them. Compounds of formula II and III possess valuable cicatrizing and anti-inflammatory properties.
Abstract: The invention provides 3-(2-formyl-3-hydroxy-5-oxocyclopent-1-enyl)-p ropanoic acid and derivatives thereof having anti-thrombotic activity coupled with low toxicity. Also provided is a method for preparing such compounds by subjecting a 3-[3-hydroxy-5-oxo-2-(.beta.-styryl)cyclopent-1-enyl]-propanoic acid or derivative thereof to oxidative cleavage.
Type:
Grant
Filed:
March 2, 1977
Date of Patent:
July 11, 1978
Assignee:
Lilly Industries Ltd.
Inventors:
William Dawson, Michael John Foulis, Norman James Albert Gutteridge, Colin William Smith
Abstract: A compound of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, in which formula the group R.sup.o is trifluoromethyl.Pharmaceutical compositions containing these compounds are useful for treatment of depressive disorders.
Type:
Grant
Filed:
August 30, 1976
Date of Patent:
July 4, 1978
Assignee:
Astra Lakemedel Aktiebolag
Inventors:
Ulf Henrik Anders Lindberg, Svante Bertil Ross, Seth Olov Thorberg, Sven Ove Ogren
Abstract: 3.alpha.-Hydroxy and 3.alpha.-acyloxy- .DELTA..sup.9(11) -5.alpha.-D-homo-20-ketopregnenes of the formula ##STR1## wherein R is hydrogen or acyl, R.sub.1 is hydrogen or methyl and R.sub.2 is methyl or ethyl, are produced by esterifying a corresponding 3.beta.-hydroxy-5.alpha.-20-keto pregnane of the formula ##STR2## wherein R.sub.1 and R.sub.2 have the values given above, with m-iodo-benzoic acid with inversion of the 3.beta.-oxy group to a 3.alpha.-oxy group; chlorinating the thus-produced 3.alpha.-m-iodobenzoyl ester with dichloroiodobenzene under irradiation; and treating the reaction product with a dehydrohalogenating silver salt. Optionally thereafter, the 3.alpha.-iodobenzoyl group is split off in a conventional manner to produce the corresponding 3.alpha.-hydroxy steroid and optionally the thus-produced 3.alpha.-hydroxy steroid is esterified to produce a desired 3-ester thereof.
Type:
Grant
Filed:
June 8, 1976
Date of Patent:
June 27, 1978
Assignee:
Schering Aktiengesellschaft
Inventors:
Ulrich Kerb, Rudolf Wiechert, Otto Engelfried
Abstract: A conjugated diolefin is reacted with a carboxylic acid, a carboxylic acid anhydride, or a mixture thereof, in the presence of oxygen and a catalyst comprising a compound of bismuth, an alkali metal compound and a source of nitrate ion.
Abstract: A conjugated diolefin is reacted with at least one compound selected from the group consisting of a carboxylic acid and a carboxylic acid anhydride in the presence of oxygen and a catalyst comprising a rare earth metal compound, an alkali metal compound and a halide compound.
Abstract: This invention comprises an alkylation, reduction and transesterification process for the preparation of ester substituted phenols. The products are useful as antioxidants and may be prepared in high yields and with a high degree of purity.
Abstract: The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH.sub.2) is a straight or branched chain alkyl radical, n is 1-6, m is 0 or 1 and R.sup.5 and R.sup.6 may be the same or different and may be hydrogen, alkyl, arylalkyl, and R.sup.5', R.sup.5 and R.sup.6 may be the same or different and may be the nitrogen to which they are attached may be pyrrolidino, piperidino or N'-alkyl piperazino;R.sup.1, r.sup.2, r.sup.3 or R.sup.4 may be the same or different and may be hydrogen; alkyl, trifluoromethyl; alkanoyl; haloalkanoyl; alkoxycarbonyl of the formula ##STR4## wherein R is an alkyl radical; alkoxyalkyl; aminoalkanoyl of the formula ##STR5## wherein R.sup.5 and R.sup.6 are as previously defined and p is 0-3; 2-, 3-, or 4-pyridylcarbonyl; phenyl; monosubstituted phenyl wherein the substituent is alkyl, alkoxy, hydroxy, nitro, amino, or dialkylamino; alkenoyl; or aroyl; radical of 1-6 carbon atoms;R.sup.7 and R.sup.
Type:
Grant
Filed:
December 17, 1976
Date of Patent:
March 7, 1978
Assignee:
E. R. Squibb & Sons, Inc.
Inventors:
Frederic Peter Hauck, Joseph E. Sundeen
Abstract: New N,N'-tetrasubstituted ureas of the formula ##STR1## in which X is oxygen, sulfur or an NR.sup.5 -- or SO.sub.2 --group,R is alkyl or an optionally substituted aryl group, or an optionally substituted aralkyl group,R.sup.1 and R.sup.4 are individually optionally substituted hydrocarbyl which may contain oxygen or sulfur,R.sup.2 is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkoxy or cycloalkyl,R.sup.3 is alkyl, which may optionally be substituted by halogen, or is alkenyl, orR.sup.2 and R.sup.3 conjointly form an alkylene bridge, which can be interrupted by a hetero-atom, such as O, or N-alkyl group and which forms a heterocyclic ring with the adjoining nitrogen atom,R.sup.1 and R.sup.
Type:
Grant
Filed:
September 10, 1973
Date of Patent:
November 15, 1977
Assignee:
Bayer Aktiengesellschaft
Inventors:
Rudolf Thomas, Wolfgang Kramer, Ludwig Eue, Carl Metzger, Gerhard Jager