Benzene Ring Bonded Directly To The Isocyanate Group Patents (Class 560/358)
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Patent number: 11118002Abstract: The invention generally relates to novel poly-substituted cis stilbenes, their synthesis, their purification, and their use in thermoset resins. These novel cis stilbenes give rise to thermoset resins with greatly improved processing characteristics such as lower melting temperature and lower viscosity; resulting in polymers and composites having greatly improved thermal stability.Type: GrantFiled: April 20, 2020Date of Patent: September 14, 2021Assignee: The United States of America, as represented by the Secretary of the NavyInventor: Matthew C. Davis
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Patent number: 9279029Abstract: The invention relates to a method for producing light-coloured polyisocyanates by phosgenation of mixtures comprising MDA and polycyclic aromatic polyamines that have o-phenylenediamine units incorporated via methylene bridges. The invention further relates to the polyisocyanate mixtures obtainable by this method.Type: GrantFiled: October 18, 2012Date of Patent: March 8, 2016Assignee: Bayer Intellectual Property GmbHInventors: Thomas Ernst Mueller, Christoph Guertler, Axel Scherer-Werke, Stefan Wershofen, Henning Vogt, Walter Leitner
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Patent number: 8987316Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.Type: GrantFiled: September 18, 2012Date of Patent: March 24, 2015Assignee: DoubleHill GmbHInventor: Jochen Kalbe
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Patent number: 8889789Abstract: The present disclosure provides a low dielectric constant resin formulation comprising 20-150 parts by weight of diisocyanate, 20-400 parts by weight of poly(2,6-dialkyl-1,4-phenylene oxide), and 200-650 parts by weight of a solvent. The present disclosure also provides a low dielectric constant resin prepolymer, composition, and composite produced from the above formulation, and a method for preparing the low dielectric constant resin prepolymer solution.Type: GrantFiled: April 27, 2012Date of Patent: November 18, 2014Assignee: Industrial Technology Research InstituteInventors: Lu-Shih Liao, Kuo-Chan Chiou
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Publication number: 20140228419Abstract: The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.Type: ApplicationFiled: September 18, 2012Publication date: August 14, 2014Applicant: DoubleHill GmbHInventors: Jochen Kalbe, Olaf Hansen
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Patent number: 8802890Abstract: The present invention relates to a process for manufacturing isocyanates from an amine compound. The process comprises the steps of a) Providing chlorine; b) Providing carbon monoxide; c) Reacting said chlorine and said carbon monoxide for providing phosgene, the carbon monoxide being provided in an adjustable molar excess; d) Providing an amine compound and phosgenating said amine compound using said phosgene thereby providing said isocyanate; the process further comprises adjusting said adjustable molar excess, i.e. the molar excess of carbon monoxide, for adjusting the color of the isocyanate.Type: GrantFiled: November 5, 2009Date of Patent: August 12, 2014Assignee: Huntsman International LLCInventors: Robert Henry Carr, Johannes Lodewijk Koole, Udo Brian Dave Mike Rodger Bruinsma
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Patent number: 8691069Abstract: The present disclosure is a system and method for producing a first product from a first region of an electrochemical cell having a cathode and a second product from a second region of the electrochemical cell having an anode. The method may include a step of contacting the first region with a catholyte including carbon dioxide and contacting the second region with an anolyte including a recycled reactant. The method may further include applying an electrical potential between the anode and the cathode sufficient to produce carbon monoxide recoverable from the first region and a halogen recoverable from the second region.Type: GrantFiled: December 21, 2012Date of Patent: April 8, 2014Assignee: Liquid Light, Inc.Inventors: Kyle Teamey, Jerry J. Kaczur, Robert Page Shirtum
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Publication number: 20130296460Abstract: A biocompatible tissue-bonding adhesive composition having a polyol of functionality N. The polyol being terminated has at least one polyisocyanate in solution with at least (N?1)% of the solution having free polyisocyanate. N may be in the range 1.5-8. The polyol may be a branched polypropylene/polyethylene oxide copolymer.Type: ApplicationFiled: July 3, 2013Publication date: November 7, 2013Applicant: Promethean Surgical Devices, LLCInventor: Michael T. Milbocker
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Patent number: 8501355Abstract: Provided are an electrolyte which may prevent the degradation of the battery performance by including a functional group which can react with a side reaction site which is responsible for decomposition of negative electrode material components and a functional group which can react with moisture which is responsible for decomposition of positive electrode material components in an electrolyte of the battery to ensure the stability of the battery at high temperatures, and a secondary battery manufactured by adding the same. The present invention may employ a compound including a functional group which can react with a side reaction site of a negative electrode material and a functional group which can react with moisture to maximize the improvement of the storage performance of a secondary battery at high temperatures.Type: GrantFiled: March 2, 2010Date of Patent: August 6, 2013Assignee: LG Chem, Ltd.Inventors: Yo Jin Kim, Han Ho Lee, Seung Don Choi
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Publication number: 20130165544Abstract: The present invention pertains to the field of polyurethane, especially relates to an isocyanate-terminated prepolymer, the method for preparing the same and the use thereof. The present invention adjusts the reaction components and the ratios thereof to obtain an isocyanate-terminated prepolymer suitable for preparing flexible polyurethane foam under a relative low mold temperature. The method for preparing flexible polyurethane foam by using the isocyanate-terminated prepolymer provided in this present invention can reduce the mold temperature, production time and energy consumption, as well as to obtain a polyurethane flexible foam processing good physical and mechanical properties.Type: ApplicationFiled: February 15, 2013Publication date: June 27, 2013Applicant: Bayer Intellectual Property GmbHInventor: Bayer Intellectual Property GmhH
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Patent number: 8455679Abstract: A prepolymer system has a monomeric isocyanate content of no greater than about 10% by weight based on 100 parts by weight of the prepolymer system. The prepolymer system comprises a diluent component and a prepolymer component different than and separate from the diluent component. The diluent component has an excess of isocyanate (NCO) functional groups, and comprises the reaction product of a monohydric isocyanate-reactive component and an excess of a first isocyanate component. The first isocyanate component comprises monomeric isocyanates reactive with the monohydric isocyanate-reactive component. The prepolymer component also has an excess of NCO functional groups, and comprises the reaction product of a polyol component and an excess of a second isocyanate component. The prepolymer system can be used to prepare foams via reaction with water. The foams have low density and have excellent adhesion and sound dampening properties for use in cavities of automobile bodies.Type: GrantFiled: December 12, 2008Date of Patent: June 4, 2013Assignee: BASF SEInventors: Thomas G. Savino, Nikolay Lebedinski, Rajesh Kumar, Calvin T. Peeler
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Publication number: 20130101858Abstract: The present disclosure provides a low dielectric constant resin formulation comprising 20-150 parts by weight of diisocyanate, 20-400 parts by weight of poly(2,6-dialkyl-1,4-phenylene oxide), and 200-650 parts by weight of a solvent. The present disclosure also provides a low dielectric constant resin prepolymer, composition, and composite produced from the above formulation, and a method for preparing the low dielectric constant resin prepolymer solution.Type: ApplicationFiled: April 27, 2012Publication date: April 25, 2013Inventors: Lu-Shih LIAO, Kuo-Chan Chou
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Publication number: 20130012704Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Inventors: Qiang DING, Nathanael Schiander GRAY, Bing LI, Yi LIU, Taebo SIM, Tetsuo UNO, Guobao ZHANG, Carole Pissot Soldermann, Werner BREITENSTEIN, Guido BOLD, Giorgio CARAVATTI, Pascal FURET, Vito GUAGNANO, Marc LANG, Paul W. MANLEY, Joseph SCHOEPFER, Carsten SPANKA
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Publication number: 20120271049Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.Type: ApplicationFiled: June 28, 2012Publication date: October 25, 2012Applicant: BASF AKTIENGESELLSCHAFTInventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
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Patent number: 8293948Abstract: A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.Type: GrantFiled: January 9, 2012Date of Patent: October 23, 2012Assignee: Jitsubo Co., Ltd.Inventors: Kazuhiro Chiba, Shokaku Kim, Yusuke Kono
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Patent number: 8232421Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.Type: GrantFiled: September 21, 2010Date of Patent: July 31, 2012Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
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Publication number: 20120031775Abstract: The present invention relates to the synthesis of lipophilic or immobilized monobasic phosphate (H2PO4) ionophores (7, 8a, 8b and 11) to be used as ion recognition molecules for monobasic phosphate (H2PO4?) in the cocktail preparation of hydrophobic polymer membranes in ion selective electrode (ISE) or ion-sensitive field effect transistor (ISFET) chemical sensors for detection of monobasic phosphate (H2PO4) ionic species in soil, synthetic media, hydrophonic liquid, tree sap, ground water and rivers.Type: ApplicationFiled: October 27, 2009Publication date: February 9, 2012Applicant: MIMOS BERHADInventor: Mohd Rais Ahmad
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Patent number: 8110704Abstract: Stable NCO prepolymers are produced from polyisocyanates having a melting point greater than 70° C., preferably, naphthalene diisocyanate, having advantageous physical properties. An important feature of the process of the present invention is the rapid cooling of the prepolymer. The process of the present invention may be carried out on a continuous or batch basis. The prepolymers of the present invention are particularly suitable for the production of cast polyurethane elastomers.Type: GrantFiled: November 2, 2006Date of Patent: February 7, 2012Assignees: Bayer MaterialScience LLC, Bayer MaterialScince AGInventors: James Michael Barnes, Hartmut Nefzger, Erika Bauer, Stefan Penninger, Thomas Schultz, Heinrich Lutz, Horst Di Mews, Charles S. Gracik
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Publication number: 20120028133Abstract: Provided are an electrolyte which may prevent the degradation of the battery performance by including a functional group which can react with a side reaction site which is responsible for decomposition of negative electrode material components and a functional group which can react with moisture which is responsible for decomposition of positive electrode material components in an electrolyte of the battery to ensure the stability of the battery at high temperatures, and a secondary battery manufactured by adding the same. The present invention may employ a compound including a functional group which can react with a side reaction site of a negative electrode material and a functional group which can react with moisture to maximize the improvement of the storage performance of a secondary battery at high temperatures.Type: ApplicationFiled: March 2, 2010Publication date: February 2, 2012Applicant: LG CHEM, LTD.Inventors: Yo Jin Kim, Han Ho Lee, Seung Don Choi
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Patent number: 8044235Abstract: A monomer is provided which is excellent in reactivity, can give high heat resistance and high refractive index, and has two or more polymerizable functional groups with different polymerization properties and an aromatic ring in the molecule. An industrial advantageous process for producing the monomer is also provided. The monomer is an aromatic isocyanate compound containing a (meth)acryloyl group, and is represented by Formula (I): wherein R1 is a single bond or a linear or branched alkylene group of 1 to 5 carbon atoms, R2 is a hydrogen atom or a methyl group, R3 is a single bond or a linear or branched alkylene group of 1 to 3 carbon atoms, X is independently a halogen atom or an electron-withdrawing group, m is an integer ranging from 0 to 4, n is an integer ranging from 1 to 3, and 1?m+n?5.Type: GrantFiled: March 15, 2006Date of Patent: October 25, 2011Assignee: Showa Denko K.K.Inventors: Kaneo Nozawa, Katsutoshi Ohno, Yotaro Hattori
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Publication number: 20110190535Abstract: Process for the preparation of polyaromatic polyamines comprising the step of reacting formaldehyde with at least one monoaromatic monoamine and at least one monoaromatic compound containing at least two amino functions in the presence of an acidic catalyst where a) the total amount of di-aromatic compounds in the polyaromatic polyamine mixture is in the range from about 25 wt % to about 50 wt % and b) the amount of monoaromatic compound containing at least two amine functions is in the range 5 to 30 mole % relative to 100 mole % of the total amount of monoaromatic monoamines and c) the amount of acidic catalyst used in the preparation of the polyaromatic polyamine mixture is less than about 0.4 moles per mole of formaldehyde or formaldehyde equivalents.Type: ApplicationFiled: July 11, 2008Publication date: August 4, 2011Applicant: Huntsman International LLCInventors: Robert Henry Carr, Rabah Mouazer, Willem Van Der Borden
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Patent number: 7893301Abstract: The present invention provides a method of preparing polymethylene-polyphenyl-polyamine (briefly referred to as polyamine, DAM), in which a high gravity rotating bed is used as the mixing reactor of formaldehyde and aniline hydrochloride, the mixing solution of aniline hydrochloride and circulation solution and the formaldehyde are fed into the high gravity rotating bed reactor proportionally to carry out mixing and condensation reaction under a condition of a very high gravity; the materials leaving the high gravity rotating bed reactor is introduced into a stirred vessel to proceed with the pre-condensation reaction and obtain a condensation solution; and the process steps of heating, molecular rearrangement, neutralization, water washing and purification, etc. are completed to obtain the refined DAM.Type: GrantFiled: October 16, 2007Date of Patent: February 22, 2011Assignees: Ningbo Wanhua Polyurethanes Co., Ltd., Beijing University of Chemical TechnologyInventors: Jiansheng Ding, Jianfeng Chen, Hongke Zhang, Haikui Zou, Weiqi Hua, Pengyuan Zhang, Shuchang Sun, Guangwen Chu, Limin Xu
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Patent number: 7893184Abstract: Dendritic or hyperbranched polyurethanes are prepared by 1) reacting diols or polyols having at least one tertiary nitrogen atom and at least two hydroxyl groups of differing reactivity toward isocyanate groups with diisocyanates or polyisocyanates to form an addition product, with the diols or polyols and diisocyanates or polyisocyanates being selected so that the addition product has, on average, one isocyanate group and more than one hydroxyl group or one hydroxyl group and more than one isocyanate group, 2) converting the addition product from step 1) into a polyaddition product by intermolecular reaction of the hydroxyl groups with the isocyanate groups, and with a reaction with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups also being able to be carried out first, 3) if desired reacting the polyaddition product from step 2) with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups.Type: GrantFiled: May 14, 2004Date of Patent: February 22, 2011Assignee: BASF AktiengesellschaftInventors: Bernd Bruchmann, Jean-Francois Stumbe
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Publication number: 20110009640Abstract: A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim 1 is described. Moreover, the invention relates to the use of the phenyl iso(thio)cyanates for preparing crop protection agents.Type: ApplicationFiled: September 21, 2010Publication date: January 13, 2011Applicant: BASF AKTIENGESELLSCHAFTInventors: Gerhard Hamprecht, Michael Puhl, Bernd Wolf, Norbert Götz, Michael Keil, Robert Reinhard, Ingo Sagasser, Werner Seitz
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Publication number: 20100260702Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or moreType: ApplicationFiled: June 25, 2010Publication date: October 14, 2010Applicant: Bezwada Biomedical LLCInventor: Rao S. Bezwada
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Patent number: 7795467Abstract: Bioabsorbable, polyurethane-based stent coatings that comprise non-fouling coatings with polyethylene glycol and hyaluronic acid are disclosed. In addition to these coatings, medical devices comprising these coatings and methods of applying the coatings are disclosed.Type: GrantFiled: April 26, 2005Date of Patent: September 14, 2010Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Stephen Dirk Pacetti, Charles Claude, Irina Astafieva
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Publication number: 20100158849Abstract: A novel macromer or mixture thereof is described herein, comprising isocyanatophenyl ether terminal moieties and at least two residues of a water-soluble polymer having a molecular weight ranging from 80 to 10,000 adjacent to the ether group of the isocyanatophenyl ether terminal isocyanate moieties, thereby forming at least two ether linkages in the macromer or mixture thereof. A method for making a polyisocyanate macromer is also described herein.Type: ApplicationFiled: December 19, 2008Publication date: June 24, 2010Inventors: Chetan Anirudh Khatri, Benjamin D. Fitz, Joseph Zavatsky
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Patent number: 7682439Abstract: The invention relates to a dispersing agent comprising: the reaction product of A one or more polyisocyanates having an average functionality of from 2.0 to 5, with B a mixture from B1 monohydroxyl compounds, and B2 monohydroxy-, monocarboxylic acid compounds to form an intermediate, followed by reacting the intermediate with C an unsaturated monohydroxy functional anchoring group.Type: GrantFiled: February 15, 2007Date of Patent: March 23, 2010Assignee: Ciba Corporation TarrytownInventors: Arend Noordam, Lothar Alexander Engelbrecht, Marcelles Van Der Sluis, Wendy Gezina Hof
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Patent number: 7662822Abstract: This invention relates to substituted azaquinazolines, to a process for their preparation, to pharmaceutical compositions containing them, and to their use for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, in particular against cytomegaloviruses.Type: GrantFiled: April 23, 2005Date of Patent: February 16, 2010Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Tobias Wunberg, Judith Baumeister, Mario Jeske, Frank Süβmeier, Holger Zimmermann, Kerstin Henninger, Dieter Lang
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Publication number: 20090242831Abstract: The present invention provides a monomer composition comprising an aromatic halosulfonyl isocyanate having structure I wherein “m” is an integer from 2 to 5; “n” is an integer from 1 to 5; Ar is a C3-C40 aromatic radical which is free of aliphatic carbon-hydrogen bonds; and X is halogen. The monomer compositions comprising aromatic halosulfonyl isocyanate I are useful in the preparation of polymeric materials useful as membranes.Type: ApplicationFiled: March 27, 2008Publication date: October 1, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Gary William Yeager, Michael Todd Luttrell, Jiang Ji
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Publication number: 20090082540Abstract: The present invention relates to the discovery of new class of linear and multiarmed hydrolysable linkers and cross linkers for use in the synthesis of biodegradable polymers such as, polyesters, polyurethanes, polyamides, polyureas and degradable epoxy amine resin. The linear and multiarmed hydrolysable linkers of the present invention include symmetrical and/or unsymmetrical ether carboxylic acids, amines, amide diols, amine polyols and isocyanates.Type: ApplicationFiled: September 17, 2008Publication date: March 26, 2009Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Patent number: 7495124Abstract: The present invention relates to a process for the production of MDI fractions containing 2,4?-MDI, and in which the 2,2?-MDI component from the MDA production is largely removed from the isomer mixture. Highly reactive monomeric MDI products can be produced in this way. These MDI products are characterised in their processing by significantly reduced emissions of MDI monomers.Type: GrantFiled: February 1, 2005Date of Patent: February 24, 2009Assignee: Bayer MaterialScience AGInventors: Hans-Georg Pirkl, Jeffrey Bolton, Walter Meckel, Ulrich Wolf, Matthias Wintermantel, Jochen Mahrenholtz
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Patent number: 7339020Abstract: High-functionality polyisocyanates are prepared by a process which comprises (i) preparation of an addition product (A) which contains one group which is reactive toward isocyanate and at least two isocyanate groups by reacting (a) a diisocyanate or polyisocyanate I with (b1) compounds having at least three groups which are reactive toward isocyanate or (b2) compounds containing two groups which are reactive toward isocyanate or mixtures of (b1) and (b2), where at least one of the components (a) or (b) has functional groups having differing reactivities toward the functional groups of the other component and the reaction ratio is selected so that the addition product (A) contains an average of one group which is reactive toward isocyanate, (ii) if desired, intermolecular addition reaction of the addition product (A) to form a polyaddition product (P) containing an average of one group which is reactive toward isocyanate and an average of more than two isocyanate groups, and (iii) reaction of the additionType: GrantFiled: March 19, 2001Date of Patent: March 4, 2008Assignee: BASF AktiengesellschaftInventors: Bernd Bruchmann, Hans Renz, Rainer Königer, Ulrike Ehe, Ulrich Treuling, Rudolf Müller-Mall
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Patent number: 7297752Abstract: The invention concerns a method for preparing polyisocyanates by cyclodimerization of isocyanate functions borne by initial monomer isocyanates. The invention is characterised in that it comprises steps which consist in: a) providing a reaction medium comprising initial monomer isocyanates, optionally in the presence of a solvent; b) adding to said reaction mixture a (cyclo)dimerization catalyst comprising a compound of the family of super acids; c) heating the reaction medium to a temperature ranging between 0° C. and 300° C., advantageously between 20° C. and 200° C. until the desired rate of transformation is obtained; d) optionally inactivating or eliminating the reaction catalyst; and e) optionally eliminating the unreacted monomer.Type: GrantFiled: November 20, 2001Date of Patent: November 20, 2007Assignee: Rhodia ChimieInventor: Jean-Marie Bernard
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Patent number: 7253321Abstract: The invention provides a process for the preparation of polyamines of the diphenylmethane series. This process comprises a) reacting aniline and formaldehyde in a molar ratio of 1.5:1 to 6:1, in the presence of an acid catalyst at temperatures of 20° C. to 100° C., in which the water content in the acid reaction mixture is <20 wt. % and a degree of protonation of <15% is established, and b) increasing the temperature of the reaction to a temperature of 110° C. to 250° C. when the ratio of the weight contents of p-aminobenzylaniline to 4,4?-MDA in the reaction mixture falls below a value of 1.00.Type: GrantFiled: June 29, 2005Date of Patent: August 7, 2007Assignee: Bayer MaterialScience AGInventors: Torsten Hagen, Daniel Koch, Hans-Georg Pirkl, Fritz Pohl, Stefan Wershofen, Rudolf Uchdorf, Richard Adamson
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Patent number: 7230130Abstract: A process for preparing methylenedianiline by reacting aniline with formaldehyde in the presence of acid catalysts comprising, in a semicontinuous process, introducing aniline with or without acid catalyst, feeding formaldehyde with or without acid catalyst through a mixing element into a circuit in which aniline with or without acid catalyst and with or without previously added formaldehyde is circulated and, after feeding in at least 50% of the total amount of formaldehyde to be fed in, heating the reaction mixture to a temperature above 75° C. In addition, the invention relates to a process for preparing polyisocyanates by phosgenation of amines obtainable in this manner and to the polyisocyanates obtainable by this process.Type: GrantFiled: May 11, 2004Date of Patent: June 12, 2007Assignee: BASF AktiengesellschaftInventors: Eckhard Ströfer, Jan Jacobs, Wilfried Seyfert, Hans Volkmar Schwarz, Olaf Schweers, Volker Scharr, Ulrich Penzel
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Patent number: 7199207Abstract: A polyurethane prepolymer obtainable by reacting at least one aromatic polyisocyanate having symmetrical substitution of NCO groups and at least one aromatic polyisocyanate having asymmetric substitution of NCO groups, the fraction of aromatic polyisocyanate having symmetrical substitution of NCO groups being higher than the fraction of polyisocyanate having asymmetric substitution of NCO groups, and at least one polyol having an OH functionality of more than 2.5 and at least one polyol having an OH functionality of less than 2.5.Type: GrantFiled: November 12, 2004Date of Patent: April 3, 2007Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Bernhard Gruenewaelder, Werner Haller, Birgit Ness, Thomas Empt
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Patent number: 7129312Abstract: Polyurethane compositions are produced in a two-stage method. In a first step, a diol component with a molecular weight of less than 2000 is reacted with a monomeric diisocyanate with a molecular weight of less than 500 and the unreacted monomeric diisocyanate is removed from this reaction product. In a second step, the resulting high-molecular diisocyanate is reacted with a polyol to produce a reactive prepolymer with isocyanate and groups. The addition of polyisocyanates which are capable of migration and which have a substantially lower vapor pressure than diphenylmethanediisocyanate, improves the addition behavior of the invention polyurethane compositions. Reactive polyurethane compositions of this type are suitable for using as binding agents for reactive one or two component adhesives/sealants, which may optionally contain solvents. These compositions are also suitable for producing reactive hot melt adhesives when suitable polyols are selected.Type: GrantFiled: November 25, 2000Date of Patent: October 31, 2006Assignee: Henkel Kommanditgesellschaft Auf Aktien (Henkel KGAA)Inventors: Michael Krebs, Christoph Lohr, Andreas Brenger
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Patent number: 7038002Abstract: A fraction of diisocyanates of the diphenylmethane series containing at least 95 wt. % binuclear methylenediphenyl diisocyanate is obtained by a) reacting aniline and formaldehyde in the presence of an acid catalyst to produce diamines and polyamines of the diphenylmethane series containing binuclear methylenediphenyl diamine, b) phosgenating the diamines and polyamines produced in a), optionally in the presence of a solvent, to produce a crude diisocyanate and polyisocyanate, and c) separating a fraction containing at least 95 wt. % binuclear methylenediphenyl diisocyanate with a 4,4?-MDI content of over 60 wt. %, a 2,4?-MDI content of 4 to 35 wt. % and a 2,2?-MDI content of 0.01 to 10 wt. %, relative to the mass of the fraction, and a maximum of 20 ppm phenyl isocyanate and optionally a maximum of 50 ppm solvent from the crude diisocyanate and polyisocyanate produced in b) in a single distillation step with optional upstream and/or downstream separation of low-boiling components.Type: GrantFiled: July 21, 2004Date of Patent: May 2, 2006Assignee: Bayer Materialscience AGInventors: Hans-Georg Pirkl, Ulrich Liman, Robert Vieler, Ralf Echterhoff
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Patent number: 6949672Abstract: The present invention relates to a process for preparing arylsulfonyl isocyanates by reacting an arylsulfonamide with phosgene in the presence of a catalytically effective amount of an alkyl isocyanate.Type: GrantFiled: October 10, 2002Date of Patent: September 27, 2005Assignee: BASF AktiengesellschaftInventors: Horst Mayer, Dieter Golsch
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Patent number: 6831192Abstract: A process for preparing methylenedianiline by reacting aniline with formaldehyde in the presence of acid catalysts comprising, in a semicontinuous process, introducing aniline with or without acid catalyst, feeding formaldehyde with or without acid catalyst through a mixing element into a circuit in which aniline with or without acid catalyst and with or without previously added formaldehyde is circulated and, after feeding in at least 50% of the total amount of formaldehyde to be fed in, heating the reaction mixture to a temperature above 75° C. In addition, the invention relates to a process for preparing polyisocyanates by phosgenation of amines obtainable in this manner and to the polyisocyanates obtainable by this process.Type: GrantFiled: May 21, 2002Date of Patent: December 14, 2004Assignee: BASF AktiengesellschaftInventors: Eckhard Ströfer, Jan Jacobs, Wilfried Seyfert, Hans Volkmar Schwarz, Olaf Schweers, Volker Scharr, Ulrich Penzel
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Patent number: 6777524Abstract: Disclosed is a polyether polyurethane comprising (A) at least one polyisocyanate having two or more isocyanate groups, which is selected from the group consisting of an aromatic polyisocyanate and an aliphatic polyisocyanate; (B) a polyoxytetramethylene glycol (PTMG) having a number average molecular weight of from 500 to 4,000, a molecular weight distribution (Mw/Mn) of 1.75 or less, and a content of high molecular weight PTMG molecules of 10% by weight or less; and (C) at least one chain extender selected from the group consisting of a C2-C10 polyol having two or more hydroxyl groups and a C2-C10 polyamine having two or more amino groups. Also disclosed is a urethane prepolymer which comprises the above-mentioned components (A) and (B) and which has terminal isocyanate groups.Type: GrantFiled: February 19, 2002Date of Patent: August 17, 2004Assignee: Asahi Kasei Kabushiki KaishaInventors: Atsushi Shimizu, Mutsuhisa Furukawa, Kiyoo Kato, Yoshiyuki Asahina
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Publication number: 20040152898Abstract: The present invention relates to a process for preparing perfluoroalkylanilines and to their use for preparing active ingredients, in particular for agrochemicals.Type: ApplicationFiled: November 6, 2003Publication date: August 5, 2004Inventors: Albrecht Marhold, Axel Pleschke
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Publication number: 20040142983Abstract: Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury.Type: ApplicationFiled: October 14, 2003Publication date: July 22, 2004Inventors: M. Amin Khan, Ravindra B. Upasani, Paul L. Wood
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Patent number: 6750367Abstract: The present invention relates to novel aromatic isocyanates obtained by partially hydrogenating naphthalene as well as the processes for preparing the same, and to their use as an isocyanate component in the production of polyurethanes.Type: GrantFiled: May 9, 2002Date of Patent: June 15, 2004Assignee: Bayer Polymers LLCInventors: Rick L. Adkins, Harold R. Parsons
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Publication number: 20040087810Abstract: In one embodiment, this invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). The SARM compounds have unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. In one embodiment, the SARM compounds bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are androgen receptor antagonists which bind irreversibly to the androgen receptor. In another embodiment, the SARM compounds are alkylating agents.Type: ApplicationFiled: February 24, 2003Publication date: May 6, 2004Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Leonid I. Kirkovsky, Arnab Mukherjee, Dong Jin Hwang
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Patent number: 6673970Abstract: Disclosed herein is a process for preparing a reaction product containing methylene diphenylamine, comprising reacting aniline and formaldehyde in the presence of an acid catalyst wherein the acid level of the resulting reaction mixture is reduced during digestion of the reaction mixture.Type: GrantFiled: December 29, 1999Date of Patent: January 6, 2004Assignee: Bayer Polymers LLCInventors: Louis Renbaum, Mark S. Solomon, William D. Tippins
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Patent number: 6667413Abstract: The present invention relates to an uracil compound of the formula [I]: wherein W represents oxygen, sulfur, imino or C1 to C3 alkylimino; Y represents oxygen, sulfur, imino or C1 to C3 alkylimino; R1 represents C1 to C3 alkyl or C1 to C3 haloalkyl; R2 represents C1 to C3 alkyl; R4 represents hydrogen or methyl; R5 represents C1 to C6 alkyl, C1 to C6 haloalkyl, or the like; X1 represents halogen, cyano or nitro; X2 represents hydrogen or halogen; and each of X3 and X4 independently represents hydrogen, halogen, C1 to C6 alkyl, or the like. The present compound has an excellent herbicidal activity.Type: GrantFiled: July 12, 2002Date of Patent: December 23, 2003Assignee: Sumitomo Chemical Company, LimitedInventors: Yoshitomo Tohyama, Yuzuru Sanemitsu, Tomohiko Gotou
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Publication number: 20030187233Abstract: Perfluoroisopropylbenzene derivatives of the general formula (I) or salts thereof, useful as intermediates or raw materials in the synthesis of various industrial materials including agricultural chemicals, drugs and surfactants, wherein X1 is H, halogeno, formyl, optionally halogenated C1-6 alkyl, —C(═O)—R1 (wherein R1 is H, halogeno, hydroxyl, C1-6 alkyl, or NR2R3, with R2 and R3 being each H, C1-6 alkyl, or the like), or the like; X3 is H, halogeno, hydroxyl, cyano, isocyanato, hydrazino, diazo, —C(═O)—R1, —SO2—R4 (wherein R4 is halogeno, hydroxyl, C1-6 alkyl, or NR5R6, with R5 and R6 being each H or C1-6 alkyl), or the like; and X4 is H, halogeno, C1-6 alkyl, or C1-6 alkoxy, with publicly known compounds being excepted.Type: ApplicationFiled: September 11, 2002Publication date: October 2, 2003Inventors: Masanobu Onishi, Kenichi Ikeda, Takashi Shimaoka, Masanori Yoshida
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Publication number: 20030120073Abstract: Protein tyrosine phosphatases (PTPs) are implicated in a number of disease processes, including autoimmune diseases, glucose intolerance, diabetes, obesity and certain types of proliferative diseases such as cancer and psoriasis. The present invention discloses novel &agr;-ketocarboxylic acid inhibitors of PTPs, methods for synthesizing said inhibitors, and methods for using pharmaceutical compositions of the inhibitors to treat PTP-mediated disorders, diseases or dysfunctions. The compositions described herein can also be used as diagnostic and screening tools to elucidate complex signal transduction pathways involving PTPs or to identify PTP-mediated disease states.Type: ApplicationFiled: April 5, 2002Publication date: June 26, 2003Inventor: Christopher T. Seto